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C. Freise · SciRah

Researcher profile · Semantic Scholar

C. Freise

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C. Freise — researcher profile on SciRah

h-index: 17
Works: 36
Citations: 739

Most-cited papers

Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis
H. Prommer, J. Maurer, K. von Websky, C. Freise +7 more
2018Scientific Reports65 citations Open access
Semantic Scholar
The matrix metalloproteinases 2 and 9 initiate uraemic vascular calcifications.
Eva Hecht, C. Freise, K. V. Websky, Hamoud Nasser +4 more
2016Nephrology, Dialysis and Transplantation61 citations
Semantic Scholar
Wideband MRE and static mechanical indentation of human liver specimen: sensitivity of viscoelastic constants to the alteration of tissue structure in hepatic fibrosis.
Rolf Reiter, C. Freise, K. Jöhrens, C. Kamphues +7 more
2014Journal of Biomechanics49 citations
Semantic Scholar
The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity.
C. Freise, U. Erben, M. Muche, R. Farndale +3 more
2009Matrix Biology47 citations
Semantic Scholar
The Elongated First Fibronectin Type III Domain of Collagen XIV Is an Inducer of Quiescence and Differentiation in Fibroblasts and Preadipocytes*
M. Ruehl, U. Erben, D. Schuppan, C. Wagner +9 more
2005Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Wnt signaling contributes to vascular calcification by induction of matrix metalloproteinases
C. Freise, Nadja Kretzschmar, U. Querfeld
2016BMC Cardiovascular Disorders38 citations Open access
Semantic Scholar
An active extract of Lindera obtusiloba inhibits adipogenesis via sustained Wnt signaling and exerts anti-inflammatory effects in the 3T3-L1 preadipocytes.
C. Freise, U. Erben, Ulf Neuman, Kiyoung Kim +3 more
2010Journal of Nutritional Biochemistry37 citations
Semantic Scholar
Inhibition of vascular calcification by block of intermediate conductance calcium-activated potassium channels with TRAM-34.
C. Freise, U. Querfeld
2014Pharmacological Research36 citations
Semantic Scholar
A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines
C. Freise, M. Ruehl, U. Erben, U. Neumann +6 more
2011BMC Complementary and Alternative Medicine33 citations Open access
Semantic Scholar
Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42
M. Ruehl, M. Muche, C. Freise, U. Erben +7 more
2011Fibrogenesis & Tissue Repair32 citations Open access
Semantic Scholar
K+‐channel inhibition reduces portal perfusion pressure in fibrotic rats and fibrosis associated characteristics of hepatic stellate cells
C. Freise, S. Heldwein, U. Erben, J. Hoyer +7 more
2015Liver international (Print)31 citations
Semantic Scholar
Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-beta-mediated profibrotic gene expression pattern.
M. Ruehl, U. Erben, Kiyoung Kim, C. Freise +7 more
2009Journal of Nutritional Biochemistry29 citations
Semantic Scholar
The lignan (+)‐episesamin interferes with TNF‐α‐induced activation of VSMC via diminished activation of NF‐ĸB, ERK1/2 and AKT and decreased activity of gelatinases
C. Freise, U. Querfeld
2015Acta Physiologica28 citations
Semantic Scholar
(+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS.
C. Freise, W. Trowitzsch-Kienast, U. Erben, D. Seehofer +4 more
2013Journal of Nutritional Biochemistry27 citations
Semantic Scholar
Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT‐1 expression
C. Freise, U. Querfeld, Antje Ludwig, B. Hamm +2 more
2021Journal of Cellular and Molecular Medicine24 citations Open access
Semantic Scholar
The inhibitor of Ca2+-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB
C. Freise, M. Ruehl, D. Seehofer, J. Hoyer +1 more
2013Investigational new drugs18 citations
Semantic Scholar
(+)-Episesamin exerts anti-neoplastic effects in human hepatocellular carcinoma cell lines via suppression of nuclear factor-kappa B and inhibition of MMP-9
C. Freise, W. Trowitzsch-Kienast, M. Ruehl, U. Erben +4 more
2012Investigational new drugs17 citations
Semantic Scholar
Visualization of Inflammation in Experimental Colitis by Magnetic Resonance Imaging Using Very Small Superparamagnetic Iron Oxide Particles
L. Golusda, A. Kühl, Malte Lehmann, K. Dahlke +13 more
2022Frontiers in Physiology16 citations Open access
Semantic Scholar
Reduced Microvascular Density in Omental Biopsies of Children with Chronic Kidney Disease
D. Burkhardt, M. Bartosova, Betti Schaefer, N. Grabe +13 more
2016PLoS ONE15 citations Open access
Semantic Scholar
Non-contact monitoring of agitation and use of a sheltering device in patients with dementia in emergency departments: a feasibility study
Lisa Kroll, Nikolaus Böhning, H. Müssigbrodt, M. Stahl +9 more
2020BMC Psychiatry14 citations Open access
Semantic Scholar
Collagen XIV and a related recombinant fragment protect human vascular smooth muscle cells from calcium‐/phosphate‐induced osteochondrocytic transdifferentiation
C. Freise, Veronika Bobb, U. Querfeld
2017Experimental Cell Research14 citations
Semantic Scholar
Arterial tissue transcriptional profiles associate with tissue remodeling and cardiovascular phenotype in children with end-stage kidney disease
C. Freise, Betti Schaefer, M. Bartosova, A. Bayazıt +15 more
2019Scientific Reports13 citations Open access
Semantic Scholar
A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-κB
C. Freise, K. Y. Kim, U. Querfeld
2015Evidence-Based Complementary and Alternative Medicine11 citations Open access
Semantic Scholar
Absolute Configuration of Antifi brotic (+)-Episesamin Isolated from Lindera obtusiloba BLUME
W. Trowitzsch-Kienast, M. Rühl, K. Y. Kim, F. Emmerling +3 more
2011Zeitschrift für Naturforschung C - A Journal of Biosciences11 citations Open access
Semantic Scholar
The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 promotes enzymatic activity of matrixmetalloproteinase-2 in vitro.
C. Freise, M. Ruehl, Ulrike Erben, R. Farndale +2 more
2012European Journal of Microbiology & Immunology10 citations Open access
Semantic Scholar
The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 ameliorates acute DSS colitis.
M. Heimesaat, Katja Heilmann, A. Kühl, Ulrike Erben +8 more
2012European Journal of Microbiology & Immunology9 citations Open access
Semantic Scholar
Alpha-single chains of collagen type VI inhibit the fibrogenic effects of triple helical collagen VI in hepatic stellate cells
C. Freise, Hyunho Lee, Christopher Chronowski, Doug W. Chan +10 more
2021PLoS ONE6 citations Open access
Semantic Scholar
Protective effects of the polyphenols (+)-episesamin and sesamin against PDGF-BB-induced activation of vascular smooth muscle cells are mediated by induction of haem oxygenase-1 and inhibition of mitogenic signalling
C. Freise, K. Sommer, U. Querfeld
20156 citations Open access
Semantic Scholar
Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis
H. Prommer, J. Maurer, K. von Websky, C. Freise +7 more
2018Scientific Reports0 citations Open access
Semantic Scholar
Additional file 1: Figure S1. of Wnt signaling contributes to vascular calcification by induction of matrix metalloproteinases
C. Freise, Nadja Kretzschmar, U. Querfeld
20160 citations
Semantic Scholar
210 (+)-EPISESAMIN BLOCKS TUMOR CELL INVASIVENESS VIA SUPPRESSED ACTIVATION OF NUCLEAR FACTOR-κB AND ACTIVATOR PROTEIN-1 ALONG WITH DECREASED IL-6 RELEASE AND ENZYMATIC INHIBITION OF MMP-9
C. Freise, U. Erben, U. Neumann, D. Seehofer +5 more
20110 citations Open access
Semantic Scholar
attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines
C. Freise, M. Ruehl, U. Erben, D. Seehofer +7 more
20110 citations
Semantic Scholar
514 TRAM-34 BLOCKS THE INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL (IKCA) IN HUMAN HEPATOMA CELL LINES RESULTING IN REDUCED INVASION AND MIGRATION
C. Freise, U. Erben, M. Ruehl, R. Somasundaram
20090 citations
Semantic Scholar
472 THE TRIPLEHELICAL PEPTIDE (GPO)10 INTERACTS WITH THE CBD OF MMP-2 RESULTING IN A DIMINISHED BINDING OF MMP-2 TO FIBRILLAR LIVER COLLAGENS AND ENHANCED MATRIX DEGRADATION
C. Freise, M. Ruehl, U. Erben, M. Seja +3 more
20080 citations
Semantic Scholar
GPO10, a collagen analog, effectively promotes activation of collagen‐bound pro‐Matrix‐Metalloproteinase‐2 in fibrotic liver tissue stimulating cell proliferation and migration
M. Ruehl, C. Freise, M. Seja, U. Erben +4 more
20070 citations
Semantic Scholar
340 GPO10, a collagen mimetic effectively promotes activation of collagen-bound pro-matrix-metalloproteinase-2 in fibrotic liver tissue
M. Ruehl, C. Freise, M. Seja, U. Erben +4 more
20060 citations Open access
Semantic Scholar

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