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L. Chachi · SciRah

Researcher profile · Semantic Scholar

L. Chachi

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L. Chachi — researcher profile on SciRah

h-index: 15
Works: 46
Citations: 765

Most-cited papers

Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.
Richard J. Russell, L. Chachi, J. FitzGerald, V. Backer +20 more
2018The Lancet Respiratory Medicine113 citations Open access
Semantic Scholar
Mechanisms of glucocorticoid action and insensitivity in airways disease.
C. Boardman, L. Chachi, A. Gavrila, Christine R. Keenan +4 more
2014Pulmonary Pharmacology & Therapeutics70 citations
Semantic Scholar
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment
R. Saunders, Himanshu Kaul, R. Berair, S. Gonem +13 more
2019Science Translational Medicine66 citations Open access
Semantic Scholar
HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4
L. Dicandia, E. Gomez, E. Vénéreau, L. Chachi +5 more
2017Journal of Allergy and Clinical Immunology53 citations Open access
Semantic Scholar
NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma
W. Y. Wan, F. Hollins, L. Haste, L. Woodman +13 more
2016Chest52 citations Open access
Semantic Scholar
Computational modelling prediction and clinical validation of impact of benralizumab on airway smooth muscle mass in asthma
L. Chachi, S. Diver, Himanshu Kaul, M. Rebelatto +4 more
2019European Respiratory Journal50 citations Open access
Semantic Scholar
In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss
I. Chernyavsky, Richard J. Russell, R. Saunders, G. E. Morris +12 more
2018European Respiratory Journal47 citations Open access
Semantic Scholar
CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
C. Emson, S. Diver, L. Chachi, A. Megally +6 more
2020Respiratory Research42 citations Open access
Semantic Scholar
Validation of antibodies for the specific detection of human TRPA1
H. Virk, M. Rekas, M. Biddle, A. Wright +5 more
2019Scientific Reports36 citations Open access
Semantic Scholar
Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells
L. Chachi, A. Shikotra, S. Duffy, O. Tliba +3 more
2013Journal of Immunology33 citations Open access
Semantic Scholar
Bidirectional counter-regulation of human lung mast cell and airway smooth muscle β2-adrenoceptors
Rebecca J. Lewis, L. Chachi, C. Newby, Y. Amrani +1 more
2015Journal of Immunology32 citations Open access
Semantic Scholar
Pathophysiological regulation of lung function by the free fatty acid receptor FFA4
R. Prihandoko, Davinder Kaur, C. Wiegman, Elisa Alvarez-Curto +14 more
2020Science Translational Medicine25 citations Open access
Semantic Scholar
Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma
L. Chachi, Mahnaz Abbassian, A. Gavrila, A. Alzahrani +5 more
2016Allergy. European Journal of Allergy and Clinical Immunology21 citations Open access
Semantic Scholar
Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor.
G. Cruse, Weidong Yang, S. Duffy, L. Chachi +3 more
2010Journal of Allergy and Clinical Immunology19 citations
Semantic Scholar
Effect of the plant derivative Compound A on the production of corticosteroid-resistant chemokines in airway smooth muscle cells.
A. Gavrila, L. Chachi, O. Tliba, C. Brightling +1 more
2015American Journal of Respiratory Cell and Molecular Biology16 citations Open access
Semantic Scholar
Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab
L. George, A. Wright, V. Mistry, Amanda Sutcliffe +8 more
2019International Journal of COPD15 citations Open access
Semantic Scholar
Interleukin‐18, IL‐18 binding protein and IL‐18 receptor expression in asthma: a hypothesis showing IL‐18 promotes epithelial cell differentiation
Davinder Kaur, L. Chachi, E. Gomez, N. Sylvius +1 more
2021Clinical & Translational Immunology13 citations Open access
Semantic Scholar
ST2 expression and release by the bronchial epithelium is downregulated in asthma
Davinder Kaur, L. Chachi, E. Gomez, N. Sylvius +4 more
2020Allergy. European Journal of Allergy and Clinical Immunology13 citations Open access
Semantic Scholar
The Plant Derivative Compound A Inhibits the Production of Corticosteroid-resistant Chemokines by Airway Smooth Muscle Cells.
A. Gavrila, L. Chachi, O. Tliba, C. Brightling +1 more
201511 citations
Semantic Scholar
Fevipiprant (qaw039) Reduces Airway Smooth Muscle Mass In Asthma Via Antagonism Of The Prostaglandin D2 Receptor 2 (dp2)
R. Saunders, Himanshu Kaul, R. Berair, A. Singapuri +14 more
201710 citations
Semantic Scholar
Fibrocyte localisation to the ASM bundle in asthma: bidirectional effects on cell phenotype and behaviour
R. Saunders, Davinder Kaur, D. Desai, R. Berair +4 more
2020Clinical & Translational Immunology9 citations Open access
Semantic Scholar
Abnormal corticosteroid signalling in airway smooth muscle: mechanisms and perspectives for the treatment of severe asthma
L. Chachi, A. Gavrila, O. Tliba, Y. Amrani
2015Clinical and Experimental Allergy9 citations Open access
Semantic Scholar
Bronchial Thermoplasty leads to rapid and persistent improvements in airway remodeling
Richard J. Russell, M. Aubier, M. Pretolani, M. Laviolette +12 more
2019Airway pharmacology and treatment3 citations
Semantic Scholar
A comparison of β 2 -adrenoceptor desensitisation induced by olodaterol and formoterol in human lung mast cells and airway smooth muscle cells
Rebecca J. Lewis, L. Chachi, Y. Amrani, P. Bradding
2013European Respiratory Journal3 citations
Semantic Scholar
Clinical and histological effects of Bronchial Thermoplasty in severe asthma
Richard J. Russell, A. Singapuri, R. Berair, L. Chachi +9 more
20171 citations
Semantic Scholar
DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration
R. Saunders, M. Biddle, A. Wright, L. Chachi +3 more
20161 citations
Semantic Scholar
The dissociated steroid receptor ligand from plant origin called compound A (CpdA) inhibits the production of steroid-resistant chemokines induced by TNFα/IFNγ in airway smooth muscle (ASM) cells in both asthma and healthy subjects
L. Chachi, A. Gavrila, O. Tliba, C. Brightling +1 more
20121 citations
Semantic Scholar
T5 KCa3.1 ion channel blockers restore corticosteroid sensitivity in cytokine-treated airway smooth muscle (ASM) cells from both COPD and asthmatic patients
L. Chachi, A. Shikotra, Amanda Sutcliffe, C. Brightling +2 more
2010Thorax1 citations
Semantic Scholar
ß2-adrenoceptor (ß2-AR) dysfunction in airway smooth muscle in severe asthma: possible role of inflammatory cytokines
Jameel Hakeem, L. Chachi, Fahad Alhadian, M. Biddle +3 more
20200 citations
Semantic Scholar
Multiplex immunohistochemistry to investigate inflammatory cell spatial organisation and interactions in severe asthma
L. Chachi, J. Sousa, C. Brightling, Y. Amrani
20200 citations
Semantic Scholar
Evaluation of Idiopathic Pulmonary Fibrosis therapies, Pirfenidone and Nintedanib, in a Human Experimental Model of Fibrosis
K. M. Roach, E. Castells, P. Tongue, G. Elliott +6 more
2019Idiopathic interstitial pneumonias0 citations
Semantic Scholar
The anti-IL-13 biologic tralokinumab did not alter expression of T2 and T17 transcription factors GATA3 and RORyT in bronchial biopsies
L. Chachi, Richard J. Russell, S. Diver, G. Elliott +6 more
2019Airway pharmacology and treatment0 citations
Semantic Scholar
COPD_A_198302 1177..1185
L. George, A. Wright, V. Mistry, Amanda Sutcliffe +8 more
20190 citations
Semantic Scholar
University of Southern Denmark Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS) a multicentre, double-blind, randomised, placebo-controlled phase 2 trial
Richard J. Russell, L. Chachi, J. FitzGerald, V. Backer +20 more
20180 citations
Semantic Scholar
Effect of the interleukin-13 neutralising monoclonal antibody , tralokinumab , on eosinophilic airway inflammation in uncontrolled moderate to severe asthma ( MESOS – a randomised placebo-controlled phase 2 clinical trial )
Richard J. Russell, L. Chachi, J. FitzGerald, V. Backer +19 more
20180 citations
Semantic Scholar
FEVIPIPRANT REDUCES AIRWAY SMOOTH MUSCLE MASS IN ASTHMATICS VIA PGD2 RECEPTOR ANTAGONISM
R. Saunders, Himanshu Kaul, R. Berair, A. Singapuri +14 more
20170 citations Open access
Semantic Scholar
Compound A modulates steroid insensitive chemokines in airway smooth muscle cells via IRF-1 dependent and independent pathways
A. Gavrila, L. Chachi, O. Tliba, C. Brightling +1 more
20150 citations
Semantic Scholar
Role of protein phosphatase 5 (PP5) in mediating corticosteroid insensitivity in airway smooth muscle (ASM) cells in severe asthma
L. Chachi, M. Abbasian, A. Gavrila, O. Tliba +2 more
20150 citations
Semantic Scholar
New insight into the molecular mechanisms of corticosteroid resistance in asthma
L. Chachi
20140 citations
Semantic Scholar
YIM Review PPT 2014
C. Boardman, L. Chachi, A. Gavrila, Christine R. Keenan +4 more
20140 citations
Semantic Scholar
Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFα in airway smooth muscle (ASM) cells from patients with severe asthma
L. Chachi, O. Tliba, A. Gavrila, C. Brightling +1 more
2013European Respiratory Journal0 citations
Semantic Scholar
Compound A (CpdA) suppressed production of corticosteroid-resistant chemokines via GR-independent mechanisms in airway smooth muscle (ASM) cells
A. Gavrila, L. Chachi, O. Tliba, C. Brightling +1 more
2013European Respiratory Journal0 citations
Semantic Scholar
Activation of both transcription factors STAT5 and IRF-1 is insensitive to corticosteroids in asthmatic bronchial smooth muscle cells exposed to TNFα/IFNγ
A. Gavrila, L. Chachi, O. Tliba, C. Brightling +1 more
20120 citations
Semantic Scholar
TNFα stimulates the expression different chemokines including CXCl10, CCL5 and CXCL8 in developing airway smooth muscle (ASM) cells: Modulation by fluticasone and TNFα receptors
H. Pandya, A. Gassama, L. Chachi, Helen Pearson +3 more
20120 citations
Semantic Scholar
Tumor Necrosis Factor Alpha
C. Brightling, L. Chachi, D. Desai, Y. Amrani
20110 citations
Semantic Scholar
Increased TNF-associated NF-kB Signaling Pathway In Human Asthmatic Airway Smooth Muscle Cells: Role Of TRUSS Signaling Molecule
L. Chachi, Mohamed A. Alblihed, O. Tliba, D. Riches +2 more
2010Asian Test Symposium0 citations
Semantic Scholar

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