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A. Labro · SciRah

Researcher profile · Semantic Scholar

A. Labro

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A. Labro — researcher profile on SciRah

h-index: 19
Works: 89
Citations: 1,037

Most-cited papers

Gating of Shaker-type Channels Requires the Flexibility of S6 Caused by Prolines*
A. Labro, A. Raes, Iris Bellens, Natacha Ottschytsch +1 more
2003Journal of Biological Chemistry93 citations Open access
Semantic Scholar
Kv Channel Gating Requires a Compatible S4-S5 Linker and Bottom Part of S6, Constrained by Non-interacting Residues
A. Labro, A. Raes, A. Grottesi, D. Van Hoorick +2 more
2008The Journal of General Physiology81 citations Open access
Semantic Scholar
Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization
A. Labro, M. F. Priest, J. Lacroix, D. Snyders +1 more
2015Nature Communications68 citations Open access
Semantic Scholar
Being Flexible: The Voltage-Controllable Activation Gate of Kv Channels
A. Labro, D. Snyders
2012Frontiers in Pharmacology61 citations Open access
Semantic Scholar
The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure*
A. Labro, I. Boulet, F. Choveau, E. Mayeur +4 more
2010Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Properties of deactivation gating currents in Shaker channels.
J. Lacroix, A. Labro, F. Bezanilla
2011Biophysical Journal50 citations Open access
Semantic Scholar
KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain*
F. Choveau, N. Rodriguez, Fayal Abderemane Ali, A. Labro +10 more
2010Journal of Biological Chemistry47 citations Open access
Semantic Scholar
A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol
I. Kopljar, A. Labro, E. Cuypers, H. Johnson +3 more
2009Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Molecular mechanism for depolarization-induced modulation of Kv channel closure
A. Labro, J. Lacroix, C. Villalba-Galea, D. Snyders +1 more
2012The Journal of General Physiology44 citations Open access
Semantic Scholar
Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel.
N. Rodriguez, M. Amarouch, J. Montnach, Julien Piron +5 more
2010Biophysical Journal40 citations Open access
Semantic Scholar
Dual Effect of Phosphatidyl (4,5)-Bisphosphate PIP2 on Shaker K+ Channels*
F. Abderemane-Ali, Z. Es-Salah-Lamoureux, L. Delemotte, M. Kasimova +6 more
2012Journal of Biological Chemistry38 citations Open access
Semantic Scholar
The Electrically Silent Kv6.4 Subunit Confers Hyperpolarized Gating Charge Movement in Kv2.1/Kv6.4 Heterotetrameric Channels
Elke Bocksteins, A. Labro, D. Snyders, D. Mohapatra
2012PLoS ONE31 citations Open access
Semantic Scholar
Conserved Negative Charges in the N-terminal Tetramerization Domain Mediate Efficient Assembly of Kv2.1 and Kv2.1/Kv6.4 Channels*
Elke Bocksteins, A. Labro, E. Mayeur, T. Bruyns +3 more
2009Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations
Lena Möller, Glenn Regnier, A. Labro, R. Blunck +1 more
2020Proceedings of the National Academy of Sciences of the United States of America28 citations Open access
Semantic Scholar
Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.
J. Saenen, A. Labro, A. Raes, D. Snyders
2006Biophysical Journal26 citations Open access
Semantic Scholar
The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state
I. Kopljar, A. Labro, T. de Block, J. Rainier +2 more
2013The Journal of General Physiology25 citations Open access
Semantic Scholar
Modulation of Closed−State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4−AP Induced Potentiation
Jeroen I. Stas, Elke Bocksteins, A. Labro, D. Snyders
2015PLoS ONE23 citations Open access
Semantic Scholar
iPSC-Cardiomyocyte Models of Brugada Syndrome—Achievements, Challenges and Future Perspectives
A. Nijak, J. Saenen, A. Labro, D. Schepers +2 more
2021International Journal of Molecular Sciences22 citations Open access
Semantic Scholar
Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling
R. Arora, Kenny M. Van Theemsche, S. Van Remoortel, D. Snyders +2 more
2021International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels
Kenny M. Van Theemsche, D. V. Van de Sande, D. Snyders, A. Labro
2020Frontiers in Pharmacology18 citations Open access
Semantic Scholar
Coupling of Voltage Sensing to Channel Opening Reflects Intrasubunit Interactions in Kv Channels
A. Labro, A. Raes, D. Snyders
2005The Journal of General Physiology17 citations Open access
Semantic Scholar
Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1
Elke Bocksteins, Natacha Ottschytsch, J. Timmermans, A. Labro +1 more
2011European Biophysics Journal15 citations
Semantic Scholar
Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae
Chloé Bars, Jente Hoyberghs, Allan Valenzuela, L. Buyssens +5 more
2021International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells
D. V. Van de Sande, I. Kopljar, A. Maaike, A. Teisman +6 more
2021Channels14 citations Open access
Semantic Scholar
A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.
A. Labro, A. Grottesi, M. Sansom, A. Raes +1 more
2008American Journal of Physiology - Cell Physiology13 citations
Semantic Scholar
Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP2 on Shaker K+ channels.
F. Abderemane-Ali, Z. Es-Salah-Lamoureux, L. Delemotte, M. Kasimova +6 more
2013Journal of Biological Chemistry11 citations Open access
Semantic Scholar
Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model
D. V. Van de Sande, I. Kopljar, A. Teisman, D. Gallacher +3 more
2019Frontiers in Pharmacology10 citations Open access
Semantic Scholar
The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.
A. Labro, I. Boulet, J. Timmermans, Natacha Ottschytsch +1 more
2010Journal of Molecular and Cellular Cardiology10 citations
Semantic Scholar
Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity
Špela Gubič, L. Hendrickx, Xiaoyi Shi, Žan Toplak +9 more
2022Cancers9 citations Open access
Semantic Scholar
Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels
I. Kopljar, A. Grottesi, T. de Block, J. Rainier +3 more
2016Neuropharmacology9 citations Open access
Semantic Scholar
Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.
E. Martínez-Morales, D. Snyders, A. Labro
2014Biophysical Journal8 citations Open access
Semantic Scholar
Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes
A. Nijak, E. Simons, B. Vandendriessche, D. V. Van de Sande +13 more
2022Biology Open7 citations Open access
Semantic Scholar
Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report
A. Nijak, A. Labro, H. De Wilde, W. Dewals +11 more
2020Frontiers in Cardiovascular Medicine7 citations Open access
Semantic Scholar
The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels
Laura Coonen, E. Mayeur, Nicolas De Neuter, D. Snyders +2 more
2020Biophysical Journal7 citations Open access
Semantic Scholar
Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population
E. Sieliwonczyk, M. Alaerts, E. Simons, D. Snyders +12 more
2023Orphanet Journal of Rare Diseases5 citations Open access
Semantic Scholar
The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels
Laura Coonen, E. Martínez-Morales, D. V. Van de Sande, D. Snyders +3 more
2022Science Advances4 citations Open access
Semantic Scholar
Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil Syndrome patient.
S. Déri, J. Borbás, Teodóra Hartai, L. Haţegan +12 more
2020Cardiovascular Research4 citations Open access
Semantic Scholar
Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore
E. Martínez-Morales, I. Kopljar, J. Rainier, J. Tytgat +2 more
2016Toxicon4 citations Open access
Semantic Scholar
Immunosuppressive effects of new thiophene-based KV1.3 inhibitors.
Špela Gubič, Alberto Montalbano, C. Sala, A. Becchetti +12 more
2023European journal of medicinal chemistry3 citations Open access
Semantic Scholar
Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach.
Rym Hassiki, A. Labro, Z. Benlasfar, C. Vincke +5 more
2016International Journal of Biological Macromolecules3 citations Open access
Semantic Scholar
Alkanols inhibit voltage-gated K+ channels via a distinct gating modifying mechanism that prevents gate opening
E. Martínez-Morales, I. Kopljar, D. Snyders, A. Labro
2015Scientific Reports3 citations Open access
Semantic Scholar
A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5
S. Déri, Teodóra Hartai, L. Virág, N. Jost +5 more
2022Pharmaceuticals2 citations Open access
Semantic Scholar
Molecular autopsy and subsequent functional analysis reveal de novo DSG2 mutation as cause of sudden death.
E. Simons, A. Labro, J. Saenen, A. Nijak +8 more
2021European Journal of Medical Genetics2 citations Open access
Semantic Scholar
Relevance of KCNE1, SCN5A and eNOS gene polymorphisms in Tunisian atrial fibrillation patients
Nejia Tounsi, A. Labro, E. Kerkeni, M. Grissa +7 more
20182 citations
Semantic Scholar
Reply to Pisupati et al.: Evaluating single subunit counting data to find the correct stoichiometry
Lena Möller, Glenn Regnier, A. Labro, D. Snyders +1 more
2020Proceedings of the National Academy of Sciences of the United States of America1 citations Open access
Semantic Scholar
Exploring distinct zebrafish (Danio rerio) cytochrome P450 biotransformation activity for proteratogen investigation
Chloé Bars, L. Buyssens, Allan Valenzuela, M. Ayuso +5 more
2019Reproductive Toxicology1 citations
Semantic Scholar
Dual Effect of PIP2 on Shaker K+ Channels
F. Abderemane-Ali, Z. Es-Salah-Lamoureux, L. Delemotte, M. Kasimova +6 more
20131 citations Open access
Semantic Scholar
A Gating Modulator Peptide Toxin for Shaker-Type KV1 Channels Derived from the Sea Anemone Bunodosoma cangicum
Jeroen I. Stas, I. Kopljar, A. Labro, S. Peigneur +3 more
20131 citations Open access
Semantic Scholar
110. Voltage Sensor Trapping in Voltage-Gated K-Channels by the Marine Neurotoxin Gambierol
I. Kopljar, A. Labro, J. Rainier, J. Tytgat +1 more
20121 citations
Semantic Scholar
Cloning and Sequence Analysis of the Voltage-Gated Muscle Na+ Channel from the Poison Dart Frog Phyllobates aurotaenia
S. Castaño, Ludivine Frezza, A. Labro, L. Fierro +2 more
20091 citations Open access
Semantic Scholar

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