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F. Sorrell · SciRah

Researcher profile · Semantic Scholar

F. Sorrell

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F. Sorrell — researcher profile on SciRah

h-index: 14
Works: 80
Citations: 1,213

Most-cited papers

Structural basis of Keap1 interactions with Nrf2
P. Canning, F. Sorrell, A. Bullock
2015Free Radical Biology & Medicine566 citations Open access
Semantic Scholar
Family-wide Structural Analysis of Human Numb-Associated Protein Kinases
F. Sorrell, M. Szklarz, K. Abdul Azeez, J. Elkins +1 more
2016Structure143 citations Open access
Semantic Scholar
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases
D. Pinkas, C. Sanvitale, J. Bufton, F. Sorrell +4 more
2017Biochemical Journal95 citations Open access
Semantic Scholar
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
Megan J. Agajanian, M. Walker, Alison D. Axtman, Roberta R. Ruela de Sousa +23 more
2019Cell Reports82 citations Open access
Semantic Scholar
Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation
Frances-Rose Schumacher, F. Sorrell, D. Alessi, A. Bullock +1 more
2014Biochemical Journal68 citations Open access
Semantic Scholar
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
Sven Verdonck, Szu-Yuan Pu, F. Sorrell, J. Elkins +11 more
2019Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein.
F. Sorrell, G. Greenwood, K. Birchall, Bei-Ning Chen
2010Journal of Pharmaceutical and Biomedical Analysis30 citations
Semantic Scholar
Structure–Activity Relationship Refinement and Further Assessment of Indole‐3‐glyoxylamides as a Lead Series against Prion Disease
M. J. Thompson, Jennifer C. Louth, S. Ferrara, F. Sorrell +4 more
2011ChemMedChem25 citations
Semantic Scholar
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model
C. Fromont, Alessio Atzori, D. Kaur, Lubna Hashmi +30 more
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity.
M. J. Thompson, Jennifer C. Louth, S. Ferrara, Matthew P. Jackson +7 more
2011European journal of medicinal chemistry24 citations
Semantic Scholar
Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1
Theis S. Wilbek, T. Skovgaard, F. Sorrell, S. Knapp +2 more
2014ChemBioChem22 citations Open access
Semantic Scholar
Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis
F. Sorrell, Lena Kilian, J. Elkins
2019Biochemical Journal16 citations Open access
Semantic Scholar
Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors
S. H. Henderson, F. Sorrell, J. Bennett, O. Fedorov +9 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Improved 2,4‐Diarylthiazole‐Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency
M. J. Thompson, Jennifer C. Louth, G. Greenwood, F. Sorrell +3 more
2010ChemMedChem14 citations
Semantic Scholar
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
R. A. M. Serafim, F. Sorrell, Benedict-Tilman Berger, Ross Collins +8 more
2021Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.
S. H. Henderson, F. Sorrell, J. Bennett, Marcus Hanley +4 more
2020ACS Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
S. H. Henderson, F. Sorrell, James M. Bennett, Oleg Fedorov +7 more
2024European journal of medicinal chemistry7 citations Open access
Semantic Scholar
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase
Zhuo-Yao Chen, Jin-Wei Zhang, Adrián R. Murillo-de-Ozores, María Castañeda-Bueno +10 more
2020bioRxiv4 citations Open access
Semantic Scholar
STK32A is a dual-specificity AGC kinase with a preference for acidic substrates
F. Sorrell, F. Miranda, K. Abdul Azeez, A. Chaikuad +5 more
2020bioRxiv3 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity
Sven Verdonck, Szuyuan Pu, F. Sorrell, J. Elkins +14 more
20192 citations
Semantic Scholar
Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2
H. Bailey, L. Shrestha, E. Rembeza, F. Sorrell +8 more
20181 citations
Semantic Scholar
AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6
Megan J. Agajanian, M. Walker, Alison D. Axtman, Roberta R. Ruela de Sousa +20 more
2018bioRxiv1 citations Open access
Semantic Scholar
Human With No Lysine Kinase 3 (WNK3): A Target Enabling Package (TEP)
D. Pinkas, J. Bufton, S. G. Bartual, Z. Chen +8 more
20181 citations
Semantic Scholar
Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762
F. Sorrell, J. Elkins, T. Krojer, P. Savitsky +6 more
20141 citations
Semantic Scholar
Human CSNK2A2 bound to ERB-041
K. Abdul Azeez, F. Sorrell, T. Krojer, C. Bountra +4 more
20200 citations
Semantic Scholar
Human CSNK2A1 bound to ERB-041
K. Abdul Azeez, F. Sorrell, T. Krojer, C. Bountra +4 more
20200 citations
Semantic Scholar
Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)
F. Sorrell, A. Kraemer, S. Butterworth, A. Edwards +3 more
20200 citations
Semantic Scholar
Apo Human Calcium/Calmodulin-dependent kinase type 1D
F. Sorrell, S. Knapp
20200 citations
Semantic Scholar
Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 19 (CS640)
A. Kraemer, F. Sorrell, S. Butterworth, A. Edwards +3 more
20190 citations
Semantic Scholar
Human AURKC INCENP complex bound to BRD-7880
K. Abdul Azeez, F. Sorrell, F. von Delft, C. Bountra +4 more
20190 citations
Semantic Scholar
Human CSNK2A2 bound to a Pyrrolo[2,3-d]pyrimidinyl inhibitor
K. Abdul Azeez, F. Sorrell, T. Krojer, C. Bountra +4 more
20190 citations
Semantic Scholar
Human AURKC INCENP complex bound to VX-680
K. Abdul Azeez, F. Sorrell, F. von Delft, C. Bountra +4 more
20190 citations
Semantic Scholar
Human AURKA bound to BRD-7880
K. Abdul Azeez, F. Sorrell, F. von Delft, C. Bountra +4 more
20190 citations
Semantic Scholar
Crystal Structure of DYRK1A with small molecule inhibitor
F. Sorrell, S. H. Henderson, C. Redondo, N. Burgess-Brown +5 more
20190 citations
Semantic Scholar
Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 18 (CS587)
A. Kraemer, F. Sorrell, S. Butterworth, A. Edwards +3 more
20190 citations
Semantic Scholar
Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
H. Bailey, A. Chaikuid, E. Krysztofinska, D. Froese +6 more
20190 citations
Semantic Scholar
Crystal structure of the Kelch domain of human KLHL17
Z. Chen, E. Williams, F. Sorrell, J. Newman +7 more
20180 citations
Semantic Scholar
Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366
V. Srikannathasan, C. Johansson, C. Gileadi, L. Shrestha +8 more
20180 citations
Semantic Scholar
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)
P. Filippakopoulos, S. Picaud, T. Krojer, F. Sorrell +5 more
20180 citations
Semantic Scholar
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated ATRX peptide (K1030ac/K1033ac)
P. Filippakopoulos, S. Picaud, J. Newman, F. Sorrell +4 more
20180 citations
Semantic Scholar
Thiophosphorylated PAK3 kinase domain
F. Sorrell, D. Wang, F. von Delft, C. Bountra +2 more
20180 citations
Semantic Scholar
Human SLK bound to a maleimide inhibitor
F. Sorrell, Benedict-Tilman Berger, E. Salah, R. A. M. Serafim +11 more
20180 citations
Semantic Scholar
Human STK10 bound to a maleimide inhibitor
F. Sorrell, E. Salah, R. A. M. Serafim, P. Savitsky +10 more
20180 citations
Semantic Scholar
human sEH Phosphatase in complex with 3-4-3,4-dichlorophenyl-5-phenyl-1,3-oxazol-2-yl-benzoic-acid
J. Kramer, D. Pogoryelov, F. Sorrell, N. Fox +3 more
20180 citations
Semantic Scholar
Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn
C. Johansson, Vincent Fagan, P. Brennan, F. Sorrell +5 more
20180 citations
Semantic Scholar
Human STK10 bound to BIRB-796
Benedict-Tilman Berger, F. Sorrell, F. von Delft, C. Bountra +4 more
20180 citations
Semantic Scholar
Crystal structure of Spindlin1 in complex with the inhibitor TD001851a
C. Johansson, Vincent Fagan, P. Brennan, F. Sorrell +5 more
20180 citations
Semantic Scholar
A Transcription-uncoupled Negative Feedback Loop for the 1 WNT Pathway: WNT Activates the AAK1 Kinase to Promote Clathrin-mediated Endocytosis of LRP6
Megan J. Agajanian, M. Walker, Alison D. Axtman, Roberta R. Ruela de Sousa +21 more
20180 citations
Semantic Scholar
Crystal structure of human pyridoxine 5-phophate oxidase, R116Q variant
S. Mackinnon, M. Wilson, L. Shrestha, G. A. Bezerra +9 more
20180 citations
Semantic Scholar
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated BAZ1B peptide (K221ac)
P. Filippakopoulos, S. Picaud, J. Newman, F. Sorrell +4 more
20180 citations
Semantic Scholar

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