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I. Kou · SciRah

Researcher profile · Semantic Scholar

I. Kou

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I. Kou — researcher profile on SciRah

h-index: 31
Works: 58
Citations: 4,312

Most-cited papers

An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis
H. Kizawa, I. Kou, A. Iida, A. Sudo +11 more
2005Nature Genetics468 citations
Semantic Scholar
Large scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
K. Ishigaki, M. Akiyama, M. Kanai, A. Takahashi +85 more
2020Nature Genetics462 citations Open access
Semantic Scholar
The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage.
T. Ikeda, Satoru Kamekura, A. Mabuchi, I. Kou +6 more
2004Arthritis & Rheumatism380 citations Open access
Semantic Scholar
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation
T. Murakami, A. Saito, S. Hino, S. Kondo +16 more
2009Nature Cell Biology344 citations
Semantic Scholar
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis
I. Kou, Yohei Takahashi, Todd A. Johnson, A. Takahashi +37 more
2013Nature Genetics268 citations
Semantic Scholar
A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis
Yohei Takahashi, I. Kou, A. Takahashi, Todd A. Johnson +20 more
2011Nature Genetics251 citations
Semantic Scholar
Mechanisms for Asporin Function and Regulation in Articular Cartilage*
M. Nakajima, H. Kizawa, M. Saitoh, I. Kou +2 more
2007Journal of Biological Chemistry165 citations Open access
Semantic Scholar
De novo SOX11 mutations cause Coffin–Siris syndrome
Y. Tsurusaki, Eriko Koshimizu, H. Ohashi, S. Phadke +16 more
2014Nature Communications143 citations Open access
Semantic Scholar
A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females
Swarkar Sharma, D. Londono, W. Eckalbar, Xiao-Chong Gao +14 more
2015Nature Communications139 citations Open access
Semantic Scholar
New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study
M. Nakajima, A. Takahashi, I. Kou, C. Rodriguez-Fontenla +14 more
2010PLoS ONE127 citations Open access
Semantic Scholar
A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis.
Yoji Ogura, I. Kou, S. Miura, A. Takahashi +31 more
2015American Journal of Human Genetics120 citations Open access
Semantic Scholar
SOX9-dependent and -independent Transcriptional Regulation of Human Cartilage Link Protein*
I. Kou, S. Ikegawa
2004Journal of Biological Chemistry107 citations Open access
Semantic Scholar
A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups
D. Londono, I. Kou, Todd A. Johnson, Swarkar Sharma +25 more
2014Journal of Medical Genetics87 citations
Semantic Scholar
Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin–Siris syndrome
Annmarie Hempel, A. Pagnamenta, M. Blyth, S. Mansour +16 more
2015Journal of Medical Genetics79 citations Open access
Semantic Scholar
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese
I. Kou, N. Otomo, K. Takeda, Y. Momozawa +43 more
2019Nature Communications76 citations Open access
Semantic Scholar
Identification of a Susceptibility Locus for Severe Adolescent Idiopathic Scoliosis on Chromosome 17q24.3
Atsushi Miyake, I. Kou, Yohei Takahashi, Todd A. Johnson +27 more
2013PLoS ONE73 citations Open access
Semantic Scholar
SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese
Yan-Hui Fan, You-Qiang Song, D. Chan, Yohei Takahashi +7 more
2012Journal of Human Genetics72 citations
Semantic Scholar
Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation
Long Guo, Hiroshi Yamashita, I. Kou, Aki Takimoto +9 more
2016PLoS Genetics58 citations Open access
Semantic Scholar
Expression and Regulation of the Osteoarthritis-associated Protein Asporin*
I. Kou, M. Nakajima, S. Ikegawa
2007Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.
M. Nakajima, I. Kou, H. Ohashi, S. Ikegawa
2016American Journal of Human Genetics57 citations Open access
Semantic Scholar
Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis
K. Takeda, I. Kou, N. Kawakami, A. Iida +12 more
2017Human Mutation52 citations Open access
Semantic Scholar
Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations
Zheng Wang, A. Iida, N. Miyake, K. Nishiguchi +21 more
2016PLoS ONE47 citations Open access
Semantic Scholar
Genome‐wide meta‐analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci
Anas M. Khanshour, I. Kou, Yan-Hui Fan, E. Einarsdottir +22 more
2018Human Molecular Genetics45 citations Open access
Semantic Scholar
A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis
Yoji Ogura, I. Kou, Yohei Takahashi, K. Takeda +34 more
2017Human Molecular Genetics43 citations
Semantic Scholar
Binding characteristics of the osteoarthritis-associated protein asporin
I. Kou, M. Nakajima, S. Ikegawa
2010Journal of Bone and Mineral Metabolism43 citations
Semantic Scholar
Asporin Expression Is Highly Regulated in Human Chondrocytes
Elise Duval, N. Bigot, Magalie Hervieu, I. Kou +4 more
2015Molecular Medicine40 citations Open access
Semantic Scholar
A Replication Study for Association of 53 Single Nucleotide Polymorphisms in a Scoliosis Prognostic Test With Progression of Adolescent Idiopathic Scoliosis in Japanese
Yoji Ogura, Yohei Takahashi, I. Kou, M. Nakajima +17 more
2013Spine38 citations
Semantic Scholar
Common Variants in a Novel Gene, FONG on Chromosome 2q33.1 Confer Risk of Osteoporosis in Japanese
I. Kou, A. Takahashi, T. Urano, N. Fukui +11 more
2011PLoS ONE38 citations Open access
Semantic Scholar
A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
I. Kou, Kota Watanabe, Yohei Takahashi, Y. Momozawa +57 more
2018Scientific Reports35 citations Open access
Semantic Scholar
Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.
C. Cheung, B. Chan, V. Chan, S. Ikegawa +8 more
2009Human Molecular Genetics34 citations Open access
Semantic Scholar
SOX11 variants cause a neurodevelopmental disorder with infrequent ocular malformations and hypogonadotropic hypogonadism and with distinct DNA methylation profile
R. Al-Jawahiri, A. Foroutan, J. Kerkhof, H. McConkey +50 more
2022Genetics in Medicine32 citations Open access
Semantic Scholar
A Replication Study for Association of 5 Single Nucleotide Polymorphisms With Curve Progression of Adolescent Idiopathic Scoliosis in Japanese Patients
Yoji Ogura, Yohei Takahashi, I. Kou, M. Nakajima +17 more
2013Spine30 citations
Semantic Scholar
Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture
Joo-Yeon Hwang, Seung-Hun Lee, M. Go, B. Kim +28 more
2013Journal of Medical Genetics29 citations Open access
Semantic Scholar
Screening of known disease genes in congenital scoliosis
K. Takeda, I. Kou, S. Mizumoto, S. Yamada +20 more
2018Molecular Genetics & Genomic Medicine28 citations Open access
Semantic Scholar
FOXC2 Mutations in Familial and Sporadic Spinal Extradural Arachnoid Cyst
Yoji Ogura, S. Yabuki, A. Iida, I. Kou +9 more
2013PLoS ONE27 citations Open access
Semantic Scholar
An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis
Yoji Ogura, K. Takeda, I. Kou, Anas M. Khanshour +71 more
2018Scientific Reports23 citations Open access
Semantic Scholar
CELSR2 is a candidate susceptibility gene in idiopathic scoliosis
E. Einarsdottir, A. Grauers, Jing-Wen Wang, H. Jiao +13 more
2017PLoS ONE22 citations Open access
Semantic Scholar
Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis
N. Otomo, K. Takeda, Shunsuke Kawai, I. Kou +25 more
2019Journal of Medical Genetics20 citations
Semantic Scholar
Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis
S. Mori, I. Kou, Hidenori Sato, M. Emi +3 more
2008Journal of Human Genetics19 citations
Semantic Scholar
A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis
Kazuki Takeda, I. Kou, N. Otomo, A. Grauers +12 more
2019Journal of Human Genetics17 citations
Semantic Scholar
Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis
S. Mori, I. Kou, Hidenori Sato, M. Emi +3 more
2009Journal of Bone and Mineral Metabolism17 citations
Semantic Scholar
Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst
Yoji Ogura, N. Miyake, I. Kou, A. Iida +14 more
2015PLoS ONE16 citations Open access
Semantic Scholar
Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use
N. Otomo, Hsing-Fang Lu, M. Koido, I. Kou +46 more
2021Journal of Bone and Mineral Research15 citations Open access
Semantic Scholar
Association of Susceptibility Genes for Adolescent Idiopathic Scoliosis and Intervertebral Disc Degeneration With Adult Spinal Deformity.
K. Takeda, I. Kou, N. Hosogane, N. Otomo +20 more
2019Spine14 citations
Semantic Scholar
Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases
K. Ishigaki, M. Akiyama, M. Kanai, A. Takahashi +78 more
2019bioRxiv11 citations Open access
Semantic Scholar
A novel FOXC2 mutation in spinal extradural arachnoid cyst
Yoji Ogura, S. Fujibayashi, A. Iida, I. Kou +8 more
2015Human Genome Variation11 citations Open access
Semantic Scholar
Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function
Lindsey B Lamarche, Christopher Koch, Shareef Khalid, M. Khan +27 more
2024Diabetologia9 citations Open access
Semantic Scholar
A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese
Yohei Takahashi, I. Kou, Yoji Ogura, Atsushi Miyake +34 more
2017Spine8 citations Open access
Semantic Scholar
[Genome-wide association study for adolescent idiopathic scoliosis].
Yoji Ogura, I. Kou, Japan Scoliosis, M. Matsumoto +2 more
2016Clinical calcium7 citations
Semantic Scholar
Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource
Christopher Koch, Shareef Khalid, M. Khan, Shruthi Bandyadka +247 more
2026Nature5 citations Open access
Semantic Scholar

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