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Maria L. Freilino · SciRah

Researcher profile · Semantic Scholar

Maria L. Freilino

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Maria L. Freilino — researcher profile on SciRah

h-index: 20
Works: 36
Citations: 2,834

Most-cited papers

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
V. W. Lui, Matthew L. Hedberg, Hua Li, Bhavana S. Vangara +25 more
2013Cancer Discovery579 citations Open access
Semantic Scholar
Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting
J. Sok, Francesca M. Coppelli, S. Thomas, M. Lango +9 more
2006Clinical Cancer Research508 citations Open access
Semantic Scholar
First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy
Malabika Sen, S. Thomas, Seungwon Kim, Joanne I. Yeh +22 more
2012Cancer Discovery297 citations Open access
Semantic Scholar
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.
Matthew L. Hedberg, Gerald Goh, S. Chiosea, J. Bauman +9 more
2016Journal of Clinical Investigation178 citations Open access
Semantic Scholar
c-Fos Expression in Rat Brain and Brainstem Nuclei in Response to Treatments That Alter Food Intake and Gastric Motility.
B. Olson, Maria L. Freilino, G. Hoffman, E. Stricker +2 more
1993Molecular and cellular neurosciences161 citations
Semantic Scholar
Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma.
S. Thomas, N. Bhola, Qing Zhang, S. Contrucci +6 more
2006Cancer Research144 citations Open access
Semantic Scholar
Combined Inhibition of c-Src and Epidermal Growth Factor Receptor Abrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma
Priya Koppikar, Seung-Ho Choi, A. Egloff, Q. Cai +7 more
2008Clinical Cancer Research114 citations Open access
Semantic Scholar
Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3.
Rebecca J. Leeman-Neill, S. Wheeler, Shivendra V. Singh, S. Thomas +11 more
2009Carcinogenesis105 citations Open access
Semantic Scholar
Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities are Enhanced by Suppression of Mcl-1 or Autophagy
Y. Zang, S. Thomas, E. Chan, C. Kirk +5 more
2012Clinical Cancer Research84 citations Open access
Semantic Scholar
Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck
Amanda L. Boehm, Malabika Sen, R. Seethala, W. Gooding +5 more
2008Molecular Pharmacology77 citations Open access
Semantic Scholar
JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth
Malabika Sen, Netanya I Pollock, J. Black, Kara A. DeGrave +7 more
2015Neoplasia72 citations Open access
Semantic Scholar
Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting Signal Transducer and Activator of Transcription (STAT) 3: The Role of STAT1
V. W. Lui, Amanda L. Boehm, Priya Koppikar, Rebecca J. Leeman +5 more
2007Molecular Pharmacology72 citations
Semantic Scholar
The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4
Y. Zang, S. Thomas, E. Chan, C. Kirk +5 more
2012Autophagy68 citations Open access
Semantic Scholar
Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma
Rebecca J. Leeman-Neill, R. Seethala, Shivendra V. Singh, Maria L. Freilino +8 more
2010Cancer Prevention Research64 citations Open access
Semantic Scholar
Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer
Noah D. Peyser, Maria L. Freilino, Lin Wang, Yan Zeng +3 more
2015Oncogene49 citations Open access
Semantic Scholar
Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models.
A. Cassell, Maria L. Freilino, Jessica Lee, Sharon M. Barr +4 more
2012Neoplasia43 citations Open access
Semantic Scholar
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.
Matthew L. Hedberg, Gerald Goh, S. Chiosea, J. Bauman +9 more
2016Journal of Clinical Investigation40 citations Open access
Semantic Scholar
Systemic Administration of a Cyclic Signal Transducer and Activator of Transcription 3 (STAT3) Decoy Oligonucleotide Inhibits Tumor Growth without Inducing Toxicological Effects
Malabika Sen, K. Paul, Maria L. Freilino, Hua Li +5 more
2014Molecular Medicine39 citations Open access
Semantic Scholar
Targeting GPCR-mediated p70S6K activity may improve head and neck cancer response to cetuximab
N. Bhola, S. Thomas, Maria L. Freilino, S. Joyce +5 more
2011Clinical Cancer Research28 citations Open access
Semantic Scholar
Anti-tumor mechanisms of targeting the PDK1 pathway in head and neck cancer
N. Bhola, Maria L. Freilino, S. Joyce, Malabika Sen +5 more
2012Molecular Cancer Therapeutics27 citations Open access
Semantic Scholar
Protein kinase C inhibition blocks the early appearance of vestibular compensation.
C. Balaban, Maria L. Freilino, G. Romero
1999Brain Research20 citations
Semantic Scholar
Serum Biomarker Modulation Following Molecular Targeting of Epidermal Growth Factor and Cycloxygenase Pathways: a Pilot Randomized Trial in Head and Neck Cancer
H. Moskowitz, W. Gooding, S. Thomas, Maria L. Freilino +4 more
2012Oral Oncology13 citations Open access
Semantic Scholar
Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines
Malabika Sen, P. Johnston, Netanya I Pollock, Kara A. DeGrave +8 more
2017Journal of chemical biology12 citations Open access
Semantic Scholar
Antitumor Mechanisms of Systemically Administered Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck
S. Thomas, Michelene Ogagan, Maria L. Freilino, S. Strychor +4 more
2008Molecular Pharmacology12 citations
Semantic Scholar
STAT3 as a chemoprevention target in carcinogen-induced head and neck squamous cell carcinoma
Noah D. Peyser, Lin Wang, Yan Zeng, Marie B. Acquafondata +8 more
2016Cancer Prevention Research11 citations Open access
Semantic Scholar
Inhibition of EGFR-STAT 3 Signaling with Erlotinib Prevents Carcinogenesis in a Chemically-Induced Mouse Model of Oral Squamous Cell Carcinoma
N. Bastide, Fabrice H. F. Pierre, D. Corpet, M. Hildebrandt +18 more
20119 citations
Semantic Scholar
Combined Targeting of EGFR , STAT 3 , and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck
Amanda L. Boehm, Malabika Sen, R. Seethala, W. Gooding +6 more
20086 citations
Semantic Scholar
Prostaglandin E2 and Bradykinin contribute to head and neck squamous cell carcinoma carcinogenesis via EGFR dependent and independent mechanisms.
S. Thomas, Abbey L. Wentzel, Qing Zhang, Maria L. Freilino +4 more
20052 citations
Semantic Scholar
Abstract 2011: The PI3K pathway is the most frequently mutated mitogenic pathway in HNSCC.
Matthew L. Hedberg, V. W. Lui, Hua Li, Bhavana S. Vangara +11 more
20131 citations
Semantic Scholar
Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting STAT3: the Role of STAT1*
Vivian W. Y. Lui, Amanda L. Boehm, Priya Koppikar, Rebecca J. Leeman +6 more
20071 citations
Semantic Scholar
Abstract 5243: STAT3 inhibition as chemoprevention in a chemically induced mouse model of HNSCC
Noah D. Peyser, Lin Wang, Marie B. Acquafondata, Maria L. Freilino +6 more
20160 citations
Semantic Scholar
Title Frequent promoter hypermethylation of PTPRT increases STAT 3 activation and sensitivity to STAT 3 inhibition in head and neck cancer
Noah D. Peyser, Maria L. Freilino, Lin Wang, Yan Zeng +3 more
20160 citations
Semantic Scholar
Abstract 985: The mutational landscape of LN metastasis and recurrence in HNSCC
Matthew L. Hedberg, Gerald Goh, Maria L. Freilino, Yan Zeng +4 more
20140 citations
Semantic Scholar
Abstract 4668: Antitumor efficacy of AZD1480 in head and neck squamous cell carcinoma.
Malabika Sen, J. Black, S. Wheeler, Maria L. Freilino +5 more
20130 citations
Semantic Scholar
HIF-1 promotes invasion and metastasis of head and neck squamous cell carcinoma.
E. Childs, Maria L. Freilino, J. Grandis, S. Lai
20060 citations
Semantic Scholar
STAT3 decoy disrupts STAT1 signaling without mitigating antitumor efficacy
Vivian W. Y. Lui, Amanda L. Boehm, S. Xi, Priya Koppikar +5 more
20060 citations
Semantic Scholar

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W. Gooding×14
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Daniel E. Johnson×12
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Malabika Sen — researcher profile on SciRah

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Yan Zeng — researcher profile on SciRah

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Lin Wang — researcher profile on SciRah

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S. Joyce — researcher profile on SciRah

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V. W. Lui — researcher profile on SciRah

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R. Seethala — researcher profile on SciRah

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Hua Li — researcher profile on SciRah

Noah D. Peyser×6

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Noah D. Peyser — researcher profile on SciRah