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S. Isaacs · SciRah

Researcher profile · Semantic Scholar

S. Isaacs

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S. Isaacs — researcher profile on SciRah

h-index: 35
Works: 78
Citations: 4,499

Most-cited papers

Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022
Agam K. Rao, B. Petersen, Florence Whitehill, J. Razeq +7 more
2022MMWR. Morbidity and mortality weekly report372 citations Open access
Semantic Scholar
Inhibition of the complement cascade by the major secretory protein of vaccinia virus.
G. Kotwal, S. Isaacs, R. McKenzie, M. Frank +1 more
1990Science326 citations
Semantic Scholar
Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence.
S. Isaacs, G. Kotwal, B. Moss
1992Proceedings of the National Academy of Sciences of the United States of America258 citations Open access
Semantic Scholar
Monkeypox virus and insights into its immunomodulatory proteins
J. Weaver, S. Isaacs
2008Immunological Reviews236 citations Open access
Semantic Scholar
Deletion of the vaccinia virus B5R gene encoding a 42-kilodalton membrane glycoprotein inhibits extracellular virus envelope formation and dissemination
E. Wolffe, S. Isaacs, B. Moss
1993Journal of Virology207 citations Open access
Semantic Scholar
Characterization of a vaccinia virus-encoded 42-kilodalton class I membrane glycoprotein component of the extracellular virus envelope
S. Isaacs, E. J. Wolffe, L. Payne, Bernard Moss
1992Journal of Virology195 citations Open access
Semantic Scholar
HIV Gag mRNA Transfection of Dendritic Cells (DC) Delivers Encoded Antigen to MHC Class I and II Molecules, Causes DC Maturation, and Induces a Potent Human In Vitro Primary Immune Response1
D. Weissman, Hou-Ping Ni, David Scales, Annie M. Dude +6 more
2000Journal of Immunology180 citations
Semantic Scholar
Enzyme-Linked Immunosorbent Assay (ELISA) and Blocking with Bovine Serum Albumin (BSA) - Not all BSAs are alike
Yuhong Xiao, S. Isaacs
2012JIM - Journal of Immunological Methods166 citations Open access
Semantic Scholar
Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway.
A. Sahu, S. Isaacs, A. Soulika, John D Lambris
1998Journal of Immunology156 citations
Semantic Scholar
Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin.
E. Bell, M. Shamim, J. Whitbeck, G. Sfyroera +2 more
2004Virology136 citations Open access
Semantic Scholar
Role of CXCR4 in Cell-Cell Fusion and Infection of Monocyte-Derived Macrophages by Primary Human Immunodeficiency Virus Type 1 (HIV-1) Strains: Two Distinct Mechanisms of HIV-1 Dual Tropism
Y. Yi, S. Isaacs, Darlisha A. Williams, I. Frank +4 more
1999Journal of Virology128 citations Open access
Semantic Scholar
Regression of Established Human Papillomavirus Type 16 (HPV-16) Immortalized Tumors In Vivo by Vaccinia Viruses Expressing Different Forms of HPV-16 E7 Correlates with Enhanced CD8+ T-Cell Responses That Home to the Tumor Site
A. Lamikanra, Zhen-Kun Pan, S. Isaacs, T. Wu +1 more
2001Journal of Virology108 citations Open access
Semantic Scholar
Epitope-Mapping Studies Define Two Major Neutralization Sites on the Vaccinia Virus Extracellular Enveloped Virus Glycoprotein B5R
L. Aldaz-Carroll, J. Whitbeck, Manuel Ponce de León, H. Lou +5 more
2005Journal of Virology102 citations Open access
Semantic Scholar
Elucidating the Role of the Complement Control Protein in Monkeypox Pathogenicity
P. Hudson, Joshua S. Self, Sonja Weiss, Zachary H. Braden +8 more
2012PLoS ONE96 citations Open access
Semantic Scholar
A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge
G. Buchman, M. E. Cohen, Yuhong Xiao, N. Richardson-Harman +6 more
2010Vaccine95 citations Open access
Semantic Scholar
ICTV Virus Taxonomy Profile: Poxviridae 2023
C. McInnes, I. Damon, Geoffrey L. Smith, G. McFadden +7 more
2023Journal of General Virology92 citations Open access
Semantic Scholar
A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost.
Yuhong Xiao, L. Aldaz-Carroll, Alexandra M. Ortiz, J. Whitbeck +7 more
2007Vaccine92 citations Open access
Semantic Scholar
Functional Analysis of Vaccinia Virus B5R Protein: Essential Role in Virus Envelopment Is Independent of a Large Portion of the Extracellular Domain
Elizabeth Herrera, María del Mar Lorenzo, R. Blasco, S. Isaacs
1998Journal of Virology90 citations Open access
Semantic Scholar
Human 12(R)-Lipoxygenase and the Mouse Ortholog
Du-Xin Sun, M. Mcdonnell, Xin-Sheng Chen, M. Lakkis +5 more
1998Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virus.
D. Kaslow, S. Isaacs, I. Quakyi, R. Gwadz +2 more
1991Science81 citations
Semantic Scholar
Smallpox subunit vaccine produced in planta confers protection in mice
M. Golovkin, S. Spitsin, V. Andrianov, Yuriy Smirnov +7 more
2007Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Electrostatic Modeling Predicts the Activities of Orthopoxvirus Complement Control Proteins1
G. Sfyroera, M. Katragadda, D. Morikis, S. Isaacs +1 more
2005Journal of Immunology79 citations Open access
Semantic Scholar
The Envelope G3L Protein Is Essential for Entry of Vaccinia Virus into Host Cells
R. A. Izmailyan, Cheng-Yen Huang, Shamim Mohammad, S. Isaacs +1 more
2006Journal of Virology73 citations Open access
Semantic Scholar
Identifying Host Factors Associated with DNA Replicated During Virus Infection*
Emigdio D. Reyes, Katarzyna Kulej, Neha J Pancholi, Lisa N Akhtar +9 more
2017Molecular & Cellular Proteomics60 citations Open access
Semantic Scholar
Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge.
C. Empig, J. Kenner, M. Perret-Gentil, Bryan E. Youree +13 more
2006Vaccine56 citations
Semantic Scholar
Activity of vaccinia virus-neutralizing antibody in the sera of smallpox vaccinees.
Kendra M. Viner, S. Isaacs
2005Microbes and infection56 citations Open access
Semantic Scholar
Cell Surface Expression of the Vaccinia Virus Complement Control Protein Is Mediated by Interaction with the Viral A56 Protein and Protects Infected Cells from Complement Attack
N. Girgis, Brian C Dehaven, Xin Fan, Kendra M. Viner +2 more
2008Journal of Virology50 citations Open access
Semantic Scholar
Treating tumors with a vaccinia virus expressing IFNβ illustrates the complex relationships between oncolytic ability and immunogenicity.
Liang-Chuan S. Wang, Rachel C. Lynn, G. Cheng, E. Alexander +7 more
2012Molecular Therapy49 citations Open access
Semantic Scholar
The vaccinia virus A56 protein: a multifunctional transmembrane glycoprotein that anchors two secreted viral proteins.
Brian C Dehaven, K. Gupta, S. Isaacs
2011Journal of General Virology48 citations Open access
Semantic Scholar
Antibody against Extracellular Vaccinia Virus (EV) Protects Mice through Complement and Fc Receptors
M. E. Cohen, Yuhong Xiao, R. Eisenberg, G. Cohen +1 more
2011PLoS ONE46 citations Open access
Semantic Scholar
Reverse guanine phosphoribosyltransferase selection of recombinant vaccinia viruses.
S. Isaacs, G. Kotwal, B. Moss
1990Virology46 citations
Semantic Scholar
The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection
N. Girgis, Brian C Dehaven, Yuhong Xiao, E. Alexander +2 more
2010Journal of Virology45 citations Open access
Semantic Scholar
Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies
R. Roper, A. Garzino-Demo, C. Del Rio, C. Bréchot +23 more
2023Vaccine44 citations Open access
Semantic Scholar
Restoration of Complement-Enhanced Neutralization of Vaccinia Virus Virions by Novel Monoclonal Antibodies Raised against the Vaccinia Virus Complement Control Protein
S. Isaacs, Emelia Argyropoulos, G. Sfyroera, Shamim Mohammad +1 more
2003Journal of Virology42 citations Open access
Semantic Scholar
Vaccinia virus serpin-1 deletion mutant exhibits a host range defect characterized by low levels of intermediate and late mRNAs.
Joanna L. Shisler, S. Isaacs, Bernard Moss
1999Virology39 citations Open access
Semantic Scholar
Functional analysis of vaccinia virus B5R protein: role of the cytoplasmic tail.
M. Lorenzo, Elizabeth Herrera, Rafael Blasco, S. Isaacs
1998Virology34 citations Open access
Semantic Scholar
A role for the host coatomer and KDEL receptor in early vaccinia biogenesis
Lei-Liang Zhang, Stella Y. Lee, G. Beznoussenko, P. Peters +8 more
2009Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein.
J. Weaver, M. Shamim, E. Alexander, D. Davies +2 more
2007Virus Research29 citations Open access
Semantic Scholar
Separate worlds set to collide: smallpox, vaccinia virus vaccination, and human immunodeficiency virus and acquired immunodeficiency syndrome.
Kenneth H. Mayer, Valerianna K. Amorosa, S. Isaacs
2003Clinical Infectious Diseases29 citations Open access
Semantic Scholar
Therapeutic Vaccines and Antibodies for Treatment of Orthopoxvirus Infections
Yuhong Xiao, S. Isaacs
2010Viruses27 citations Open access
Semantic Scholar
SP6 RNA polymerase containing vaccinia virus for rapid expression of cloned genes in tissue culture.
T. B. Usdin, M. Brownstein, B. Moss, S. Isaacs
1993BioTechniques27 citations
Semantic Scholar
Vaccinia virus and poxvirology : methods and protocols
S. Isaacs
200426 citations
Semantic Scholar
Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus
Yuhong Xiao, Yu-Hong Zeng, Carole E Schanté, S. Joshi +4 more
2020Vaccine25 citations Open access
Semantic Scholar
Poxvirus Complement Control Proteins Are Expressed on the Cell Surface through an Intermolecular Disulfide Bridge with the Viral A56 Protein
Brian C Dehaven, N. Girgis, Yuhong Xiao, P. Hudson +3 more
2010Journal of Virology25 citations Open access
Semantic Scholar
Major Neutralizing Sites on Vaccinia Virus Glycoprotein B5 Are Exposed Differently on Variola Virus Ortholog B6
L. Aldaz-Carroll, Yuhong Xiao, J. Whitbeck, M. P. de Leon +7 more
2007Journal of Virology25 citations Open access
Semantic Scholar
Listeria monocytogenes Delivery of HPV-16 Major Capsid Protein L1 Induces Systemic and Mucosal Cell-Mediated CD4+ and CD8+ T-Cell Responses After Oral Immunization
Waleed Mustafa, P. Maciag, Zhen-Kun Pan, J. Weaver +3 more
2009Viral immunology24 citations Open access
Semantic Scholar
Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant Pfs25.
D. Kaslow, I. Bathurst, S. Isaacs, David B. Keister +2 more
1992Memórias do Instituto Oswaldo Cruz21 citations Open access
Semantic Scholar
Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge
Yuhong Xiao, Yu-Hong Zeng, E. Alexander, S. Mehta +5 more
2012Vaccine19 citations Open access
Semantic Scholar
Improved protection conferred by vaccination with a recombinant vaccinia virus that incorporates a foreign antigen into the extracellular enveloped virion.
Heesun Kwak, Waleed Mustafa, K. Speirs, Asha Abdool +2 more
2004Virology19 citations Open access
Semantic Scholar
Expression of hepatitis E virus putative structural proteins in recombinant vaccinia viruses.
M. Carl, S. Isaacs, M. Kaur, Junkun He +3 more
1994Clinical and Diagnostic Laboratory Immunology17 citations Open access
Semantic Scholar

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