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B. Kovačech · SciRah

Researcher profile · Semantic Scholar

B. Kovačech

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B. Kovačech — researcher profile on SciRah

h-index: 22
Works: 68
Citations: 2,029

Most-cited papers

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial.
P. Novak, R. Schmidt, E. Kontseková, N. Žilka +17 more
2017Lancet Neurology239 citations
Semantic Scholar
First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model
E. Kontseková, N. Žilka, B. Kovačech, P. Novak +1 more
2014Alzheimer's Research & Therapy227 citations Open access
Semantic Scholar
ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer’s disease
P. Novak, B. Kovačech, S. Katina, R. Schmidt +33 more
2021Nature Aging161 citations Open access
Semantic Scholar
FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease
P. Novak, R. Schmidt, E. Kontseková, B. Kovačech +16 more
2018Alzheimer's Research & Therapy122 citations Open access
Semantic Scholar
Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease
E. Kontseková, N. Žilka, B. Kovačech, R. Škrabana +1 more
2014Alzheimer's Research & Therapy108 citations Open access
Semantic Scholar
AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development
P. Novak, N. Žilka, M. Zilkova, B. Kovačech +6 more
2018The journal of prevention of Alzheimer's disease94 citations Open access
Semantic Scholar
EGT2 gene transcription is induced predominantly by Swi5 in early G1
B. Kovačech, Kim Nasmyth, Tillman Schuster
1996Molecular and Cellular Biology86 citations Open access
Semantic Scholar
Microglia display modest phagocytic capacity for extracellular tau oligomers
P. Majerová, M. Zilkova, Zuzana Kazmerova, A. Kováč +4 more
2014Journal of Neuroinflammation82 citations Open access
Semantic Scholar
Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load
P. Koson, N. Žilka, A. Kováč, B. Kovačech +3 more
2008European Journal of Neuroscience76 citations
Semantic Scholar
Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease.
B. Kovačech, M. Novák
2010Current Alzheimer Research75 citations
Semantic Scholar
Mortalin - a multipotent chaperone regulating cellular processes ranging from viral infection to neurodegeneration.
Z. Flachbartova, B. Kovačech
2013Acta virologica62 citations Open access
Semantic Scholar
The self-perpetuating tau truncation circle.
N. Žilka, B. Kovačech, P. Baráth, E. Kontseková +1 more
2012Biochemical Society Transactions52 citations
Semantic Scholar
Transition of Tau Protein from Disordered to Misordered in Alzheimer’s Disease
B. Kovačech, R. Škrabana, M. Novák
2010Neurodegenerative Diseases51 citations
Semantic Scholar
N-terminal Truncation of Microtubule Associated Protein Tau Dysregulates its Cellular Localization
Kristina Paholikova, B. Salingova, A. Opattova, R. Škrabana +6 more
2014Journal of Alzheimer's Disease46 citations
Semantic Scholar
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease
Zuzana Stozicka, N. Žilka, P. Novak, B. Kovačech +2 more
2010Journal of Neuroinflammation46 citations Open access
Semantic Scholar
Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias
Jozef Hanes, A. Kováč, H. Kvartsberg, E. Kontseková +14 more
2020Neurology43 citations Open access
Semantic Scholar
Efficacy assessment of an active tau immunotherapy in Alzheimer’s disease patients with amyloid and tau pathology: a post hoc analysis of the “ADAMANT” randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trial
Nicholas C. Cullen, Petr Novak, D. Tosun, B. Kovačech +8 more
2023EBioMedicine41 citations Open access
Semantic Scholar
Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans
P. Weisová, O. Cehlár, R. Škrabana, M. Zilkova +9 more
2019Acta Neuropathologica Communications38 citations Open access
Semantic Scholar
Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.
N. Kruse, Staffan Persson, D. Alcolea, Justyna M. C. Bahl +37 more
2015Neurobiology of Aging35 citations Open access
Semantic Scholar
Hyperphosphorylated Truncated Protein Tau Induces Caspase-3 Independent Apoptosis-Like Pathway in the Alzheimer's Disease Cellular Model
M. Zilkova, N. Žilka, A. Kováč, B. Kovačech +3 more
2011Journal of Alzheimer's Disease35 citations
Semantic Scholar
Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation
M. Zilkova, A. Nolle, B. Kovačech, E. Kontseková +11 more
2020Acta Neuropathologica Communications27 citations Open access
Semantic Scholar
Profiling of Amino Acids in Urine Samples of Patients Suffering from Inflammatory Bowel Disease by Capillary Electrophoresis-Mass Spectrometry
J. Piešťanský, Dominika Olešová, J. Galba, K. Maráková +6 more
2019Molecules25 citations Open access
Semantic Scholar
The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells
C. Di Primio, V. Quercioli, G. Siano, Matteo Rovere +3 more
2017Frontiers in Molecular Neuroscience22 citations Open access
Semantic Scholar
New Age of Neuroproteomics in Alzheimer’s Disease Research
B. Kovačech, N. Žilka, M. Novák
2009Cellular and molecular neurobiology22 citations
Semantic Scholar
A simple and rapid LC-MS/MS and CE-MS/MS analytical strategy for the determination of therapeutic peptides in modern immunotherapeutics and biopharmaceutics.
J. Piešťanský, P. Baráth, P. Majerová, J. Galba +3 more
2020Journal of Pharmaceutical and Biomedical Analysis20 citations
Semantic Scholar
Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics
Natalia Lelental, S. Brandner, O. Kofanova, K. Blennow +38 more
2016Journal of Alzheimer's Disease20 citations Open access
Semantic Scholar
Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217
B. Kovačech, Nicholas C. Cullen, Petr Novak, Jozef Hanes +10 more
2024Alzheimer's Research & Therapy19 citations Open access
Semantic Scholar
Capillary electrophoresis and ultra-high performance liquid chromatography methods in clinical monitoring of creatinine in human urine: a comparative study.
J. Piešťanský, J. Galba, B. Kovačech, V. Parrák +2 more
2020Biomedical chromotography19 citations
Semantic Scholar
Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern
B. Kovačech, L. Fialova, P. Filipcik, R. Škrabana +41 more
2022EBioMedicine16 citations Open access
Semantic Scholar
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.
P. Filipcik, M. Cente, N. Žilka, T. Smolek +5 more
2015Biochimica et Biophysica Acta16 citations Open access
Semantic Scholar
CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy
N. Žilka, M. Korenova, B. Kovačech, K. Iqbal +1 more
2010Acta Neuropathologica16 citations Open access
Semantic Scholar
Crystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments.
O. Cehlár, R. Škrabana, A. Kováč, B. Kovačech +1 more
2012Acta Crystallographica. Section F : Structural Biology and Crystallization Communications11 citations Open access
Semantic Scholar
A novel monoclonal antibody DC63 reveals that inhibitor 1 of protein phosphatase 2A is preferentially nuclearly localised in human brain
B. Kovačech, E. Kontseková, N. Žilka, P. Novak +4 more
2007FEBS Letters11 citations
Semantic Scholar
Determination of immunogenic proteins in biopharmaceuticals by UHPLC–MS amino acid analysis
J. Piešťanský, J. Galba, Dominika Olešová, B. Kovačech +1 more
2019BMC Chemistry9 citations Open access
Semantic Scholar
dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments
Kristine Kitoka, Alons Lends, Gytis Kučinskas, A. Bula +7 more
2024Angewandte Chemie8 citations Open access
Semantic Scholar
Environmental Enrichment Rescues Functional Deficit and Alters Neuroinflammation in a Transgenic Model of Tauopathy
Zuzana Stozicka, M. Korenova, I. Uhrínová, V. Cubinkova +9 more
2020Journal of Alzheimer's Disease8 citations
Semantic Scholar
Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis
R. Škrabana, B. Kovačech, P. Filipcik, N. Žilka +4 more
2017Journal of Alzheimer's Disease8 citations
Semantic Scholar
Immunomodulation of Memory-Impairing Protein Tau in Alzheimer’s Disease
N. Žilka, Zuzana Stozicka, M. Cente, Zuzana Kazmerova +2 more
2012Neurodegenerative Diseases7 citations
Semantic Scholar
Preparation, crystallization and preliminary X-ray analysis of the Fab fragment of monoclonal antibody MN423, revealing the structural aspects of Alzheimer's paired helical filaments.
N. Csokova, R. Škrabana, Ľ. Urbániková, B. Kovačech +3 more
2006Protein Peptide Letters7 citations Open access
Semantic Scholar
The engagement of microglia in tau-targeted immunotherapy in Alzheimer's disease.
Denisa Palova, Natalia Turic Csokova, Karina Markova, E. Kontseková +2 more
2021General Physiology and Biophysics6 citations Open access
Semantic Scholar
New cell cycle-regulated genes in the yeast Saccharomyces cerevisiae.
T. Schuster, C. Price, W. Rossoll, B. Kovačech
1997Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer4 citations
Semantic Scholar
Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological context
C. Di Primio, Valentina Quercioli, G. Siano, B. Kovačech +2 more
2016bioRxiv3 citations Open access
Semantic Scholar
Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS.
Š. Zorad, M. Skrabanova, M. Zilkova, M. Cente +4 more
2024Physiological Research1 citations Open access
Semantic Scholar
First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model
E. Kontseková, N. Žilka, B. Kovačech, P. Novak +1 more
2014Alzheimer's Research & Therapy1 citations Open access
Semantic Scholar
F3‐02‐03: Tau truncation: The most productive post‐translational modification
Michal Novak, N. Žilka, B. Kovačech, Peter Baráth +1 more
20121 citations Open access
Semantic Scholar
Characterization of Unexpected By-Products in a Recombinant TAU Protein by Capillary LC Coupled to MALDI-Top-Down-Sequencing (LCMALDI-TDS)
B. Kovačech, A. Kovac, D. Suckau, A. Asperger
20111 citations
Semantic Scholar
Generation, accumulation and degradation of aberrant tau proteins in cortical neurons of transgenic rat during pathogenesis of chronic neurodegenerative disease
P. Filipcik, G. Krajciova, M. Cente, R. Škrabana +3 more
20081 citations
Semantic Scholar
When Proteins Go MAD—Misfolded, Amplified, Detected: Advances in α-Synuclein Pathophysiology and RT-QuIC Detection
Naďa Labajová, Adam Polák, O. Cehlár, P. Križan +6 more
2026Molecular Neurobiology0 citations Open access
Semantic Scholar
Structure of DC11 Fab fragment specific for the pre-aggregation conformation of intrinsically disordered protein tau
O. Cehlár, S. Njemoga, A. Polak, R. Škrabana +4 more
2026Acta Crystallographica Section A: Foundations and Advances0 citations
Semantic Scholar
Structure and epitope mapping of the conformational anti tau antibody DC11
S. Njemoga, Leon Jenner, V. Volko, Adam Polák +13 more
2026bioRxiv0 citations Open access
Semantic Scholar

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R. Škrabana×18
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