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C. Kaschula · SciRah

Researcher profile · Semantic Scholar

C. Kaschula

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C. Kaschula — researcher profile on SciRah

h-index: 19
Works: 53
Citations: 2,082

Most-cited papers

Health benefits of resveratrol: Evidence from clinical studies
A. P. Singh, Rachna Singh, S. Verma, Vipin Rai +3 more
2019Medicinal research reviews (Print)452 citations
Semantic Scholar
Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.
T. Egan, R. Hunter, C. Kaschula, H. Marques +2 more
2000Journal of Medicinal Chemistry305 citations
Semantic Scholar
Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position.
C. Kaschula, T. Egan, R. Hunter, N. Basilico +4 more
2002Journal of Medicinal Chemistry218 citations
Semantic Scholar
The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention
Georgia Schäfer, C. Kaschula
2014Anti-Cancer Agents in Medicinal Chemistry194 citations Open access
Semantic Scholar
Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not μ-oxo dimer formation
K. D. de Villiers, C. Kaschula, T. Egan, H. Marques
2006JBIC Journal of Biological Inorganic Chemistry145 citations
Semantic Scholar
Garlic‐derived anticancer agents: Structure and biological activity of ajoene
C. Kaschula, R. Hunter, M. Parker
2010Biofactors76 citations
Semantic Scholar
Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide*
Su-Hyeong Kim, C. Kaschula, N. Priedigkeit, Adrian V. Lee +1 more
2016Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Strategies to reverse drug resistance in malaria
T. Egan, C. Kaschula
2007Current Opinion in Infectious Diseases60 citations
Semantic Scholar
Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells.
C. Kaschula, R. Hunter, N. Stellenboom, M. Caira +9 more
2012European journal of medicinal chemistry59 citations Open access
Semantic Scholar
The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells
C. Kaschula, Rosanna Tuveri, E. Ngarande, K. Dzobo +8 more
2019BMC Cancer48 citations Open access
Semantic Scholar
The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells
C. Kaschula, R. Hunter, J. Cotton, Rossana Tuveri +9 more
2016Molecular Carcinogenesis44 citations
Semantic Scholar
Substituted ajoenes as novel anti-cancer agents.
R. Hunter, C. Kaschula, I. Parker, M. Caira +4 more
2008Bioorganic & Medicinal Chemistry Letters44 citations
Semantic Scholar
A phenolate-induced trans influence: crystallographic evidence for unusual asymmetric coordination of an alpha-diimine in ternary complexes of iron(III) possessing biologically relevant hetero-donor N-centered tripodal ligands.
Musa S. Shongwe, C. Kaschula, Michael S. Adsetts, E. Ainscough +2 more
2005Inorganic Chemistry43 citations
Semantic Scholar
The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS.
Muneerah Smith, R. Hunter, N. Stellenboom, Daniel A. Kusza +4 more
2016Biochimica et Biophysica Acta38 citations
Semantic Scholar
Anti-Proliferative Activity of Synthetic Ajoene Analogues on Cancer Cell-Lines
C. Kaschula, R. Hunter, H. Hassan, N. Stellenboom +3 more
201133 citations
Semantic Scholar
Acyl CoA:retinol acyltransferase (ARAT) activity is present in bovine retinal pigment epithelium.
C. Kaschula, M. Jin, N. Desmond-Smith, G. Travis
2006Experimental Eye Research28 citations
Semantic Scholar
The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153
Vuyolwethu Siyo, Georgia Schäfer, R. Hunter, A. Grafov +5 more
2017Molecules27 citations Open access
Semantic Scholar
Transition metal-alkenyl complexes [M–(CH2)nCHCH2, n ≥ 2]: Synthesis, structure, reactivity and applications
A. Sivaramakrishna, H. Clayton, C. Kaschula, J. R. Moss
200723 citations
Semantic Scholar
The garlic compound Z-ajoene, S-thiolates COX2 and STAT3 and dampens the inflammatory response in RAW264.7 macrophages.
Jessica Hitchcock, Nonkululeko Mkwanazi, Christopher B. Barnett, Lisa M. Graham +4 more
2020Molecular Nutrition & Food Research22 citations
Semantic Scholar
A novel 4′‐brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/STAT3 pathways in non‐small‐cell lung cancer without any adverse effects in mice
Akash Sabarwal, Jaco C. Rooyen, Jérémy Caburet, Moscos Avgenikos +8 more
2022The FASEB Journal17 citations
Semantic Scholar
In vitro Cytotoxicity of Half‐Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand
A. Burgoyne, C. Kaschula, M. Parker, Gregory S. Smith
201615 citations
Semantic Scholar
Synthesis and anti-prion activity evaluation of aminoquinoline analogues.
Bruno Macedo, C. Kaschula, R. Hunter, Juliana A. P. Chaves +4 more
2010European journal of medicinal chemistry15 citations
Semantic Scholar
Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines.
C. Kaschula, R. Hunter, H. Hassan, N. Stellenboom +3 more
2011Anti-Cancer Agents in Medicinal Chemistry14 citations
Semantic Scholar
Tripodal Half‐Sandwich Rhodium and Iridium Complexes Containing Sulfonate and Pyridinyl Entities as Antitumor Agents
A. Burgoyne, C. Kaschula, M. Parker, Gregory S. Smith
201712 citations
Semantic Scholar
Activity-Based Proteomic Identification of the S-Thiolation Targets of Ajoene in MDA-MB-231 Breast Cancer Cells.
Daniel A. Kusza, R. Hunter, Georgia Schäfer, Muneerah Smith +2 more
2022Journal of Agricultural and Food Chemistry11 citations
Semantic Scholar
Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds
A. Burgoyne, C. Kaschula, M. Parker, Gregory S. Smith
201710 citations
Semantic Scholar
Engaging Organic Chemistry Students in Knowledge Building
M. Blackie, G. Arnott, C. Kaschula
2023Journal of Chemical Education9 citations Open access
Semantic Scholar
Unsymmetrical Organotrisulfide Formation via Low-Temperature Disulfanyl Anion Transfer to an Organothiosulfonate.
D. Ali, R. Hunter, C. Kaschula, Stephen de Doncker +1 more
2019Journal of Organic Chemistry8 citations
Semantic Scholar
Synthesis and Structure–Activity Relations in Allylsulfide and Isothiocyanate Compounds From Garlic and Broccoli Against In Vitro Cancer Cell Growth
C. Kaschula, R. Hunter
20168 citations
Semantic Scholar
Synthesis and study of organometallic PGM complexes containing 2-(2-pyridyl)benzimidazole as antiplasmodial agents
B. Munnik, C. Kaschula, D. Watson, L. Wiesner +2 more
2022Inorganica Chimica Acta7 citations
Semantic Scholar
Anticancer and antibacterial potential of Pd(II) complexes derived from N2O2-donor bidentate Schiff bases: Crystal structural analysis, DFT computational, in vitro and molecular docking investigations
S. Oladipo, E. Akintemi, C. Kaschula, R. Luckay
2025Polyhedron4 citations Open access
Semantic Scholar
Finding the Ajoene Sweet‐Spot: Structure‐Activity Relations that Govern its Blood Stability and Cancer Cytotoxicity
Daniel A. Kusza, G. Venter, Mandla Mabunda, James Biwi +5 more
2024ChemMedChem4 citations Open access
Semantic Scholar
979: The immunomodulating and anti-inflammatory effects of garlic organosulfur compounds in cancer prevention
Jessica Hitchcock, Georgia Schäfer, A. Katz, C. Kaschula
20144 citations
Semantic Scholar
New Excursions Into the Synthesis and Medicinal Chemistry of the Disulfide Bond
R. Hunter, C. Kaschula, N. Stellenboom, J. Cotton +1 more
20133 citations
Semantic Scholar
TOWARDS THE RATIONAL DESIGN OF ANTIMALARIAL DRUGS
T. Egan, R. Hunter, C. Kaschula, H. Marques +1 more
19983 citations
Semantic Scholar
Differential impact of extracts from distinct Sceletium tortuosum chemotypes on central neurotransmitter concentrations in C57BL/6 mice.
C. Kaschula, Anna-Mart Engelbrecht, N. Makunga, Magriet Muller +6 more
2025Journal of Ethnopharmacology2 citations Open access
Semantic Scholar
Synthesis of ferrocenyl benzimidazole derivatives as novel anti-Toxoplasma gondii agents
Malcolm T. Ndlovu, Clare R. Harding, C. Kaschula, P. Chellan
2024New journal of chemistry = Nouveau journal de chimie2 citations Open access
Semantic Scholar
Investigation of new ferrocenyl-artesunate derivatives as antiparasitics
Brandon L Munnik, C. Kaschula, Clare R. Harding, P. Chellan
2023Dalton Transactions2 citations Open access
Semantic Scholar
Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7-Deazahypoxanthine C7/C8 Ring Systems
Aletta E. van der Westhuyzen, Naghmana Ashraf, Daleen Conradie, L. Loots +8 more
2024Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Live In-Cell Visualization of Proteins Using Super Resolution Imaging
C. Kaschula, Dirk M. Lang, M. Parker
20121 citations Open access
Semantic Scholar
6.03 – Mononuclear Compounds with Hydrocarbon Ligands: Compounds with η2–η4 Hydrocarbon Ligands
J. R. Moss, Gregory S. Smith, C. Kaschula
20071 citations
Semantic Scholar
Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds
C. Kaschula
20021 citations
Semantic Scholar
Dodonaea viscosa in Breast Cancer: Phytochemistry, Anticancer Mechanisms, and Emerging Immunotherapeutic and Translational Perspectives
N. Reddy, C. Kaschula, N. Makunga, W. Perold +2 more
2026Cancer Medicine0 citations Open access
Semantic Scholar
A Review of Heterolytic Synthesis Methodologies for Organotri- and Organotetrasulfane Synthesis
R. Hunter, D. Ali, Yasien Amer, Wade F. Petersen +1 more
2021SynOpen0 citations Open access
Semantic Scholar
New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara).
Nashipolo E Uushona, G. Dziwornu, Nonkululeko Mkwanazi, C. Kaschula +2 more
2021Fitoterapia0 citations
Semantic Scholar
Abstract 5227: Synthesis of a biotin probe for identification of the ajoene protein targets in cancer cells ajoene protein targets in cancer cells
C. Kaschula, Daniel A. Kusza, Georgia Schäfer, A. Katz +2 more
20170 citations
Semantic Scholar
More than flavour for food : feature
C. Kaschula
20160 citations
Semantic Scholar
817: Investigations into the anti-cancer mechanism of action of garlic related disulfides
C. Kaschula, Muneerah Smith, R. Hunter, M. Parker
20140 citations
Semantic Scholar
Mononuclear Compounds with C 5 and C 6 Ligands
J. R. Moss, C. Kaschula, Gregory S. Smith
20070 citations
Semantic Scholar
The Colon in Kwashiorkor A . 0
B. Redmond, R., 0., C. Kaschula +2 more
20060 citations
Semantic Scholar

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