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D. Gems · SciRah

Researcher profile · Semantic Scholar

D. Gems

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D. Gems — researcher profile on SciRah

h-index: 61
Works: 171
Citations: 19K

Most-cited papers

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
M. Murphy, H. Bayır, V. Belousov, Christopher J. Chang +21 more
2022Nature Metabolism1,303 citations Open access
Semantic Scholar
Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan
C. Selman, Jennifer M. A. Tullet, D. Wieser, E. Irvine +18 more
2009Science1,141 citations Open access
Semantic Scholar
Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
F. Cabreiro, Catherine Au, K. Leung, Nuria Vergara-Irigaray +6 more
2013Cell936 citations Open access
Semantic Scholar
Unravelling the Biological Roles of Reactive Oxygen Species
M. Murphy, A. Holmgren, N. Larsson, B. Halliwell +10 more
2011Cell Metabolism755 citations Open access
Semantic Scholar
Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila
Camilla Burnett, S. Valentini, F. Cabreiro, M. Goss +19 more
2011Nature635 citations Open access
Semantic Scholar
Interventions to Slow Aging in Humans: Are We Ready?
V. Longo, Adam Antebi, A. Bartke, N. Barzilai +26 more
2015Aging Cell551 citations Open access
Semantic Scholar
Genetics of longevity in model organisms: debates and paradigm shifts.
D. Gems, L. Partridge
2013Annual Review of Physiology551 citations
Semantic Scholar
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans.
Ryan Doonan, J. McElwee, F. Matthijssens, G. Walker +5 more
2008Genes & Development500 citations Open access
Semantic Scholar
Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix
Helena M. Cochemé, C. Quin, Stephen J. McQuaker, F. Cabreiro +15 more
2011Cell Metabolism302 citations Open access
Semantic Scholar
Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?
D. Gems, Ryan Doonan
2009Cell Cycle288 citations Open access
Semantic Scholar
Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans
F. Cabreiro, D. Gems
2013EMBO Molecular Medicine206 citations Open access
Semantic Scholar
C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies
Marina Ezcurra, Alexandre Benedetto, Thanet Sornda, A. F. Gilliat +10 more
2018Current Biology176 citations Open access
Semantic Scholar
The SKN‐1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms
Jennifer M. A. Tullet, James W. M. Green, Catherine Au, Alexandre Benedetto +6 more
2017Aging Cell170 citations Open access
Semantic Scholar
Stress-response hormesis and aging: "that which does not kill us makes us stronger".
D. Gems, Linda Partridge
2008Cell Metabolism169 citations Open access
Semantic Scholar
Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?
D. Gems, Y. de la Guardia
2013Antioxidants and Redox Signaling155 citations Open access
Semantic Scholar
Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage
F. Cabreiro, D. Ackerman, Ryan Doonan, Caroline Araiz +4 more
2011Free Radical Biology & Medicine150 citations Open access
Semantic Scholar
DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO
Eugene F Schuster, J. McElwee, Jennifer M. A. Tullet, Ryan Doonan +6 more
2010Molecular Systems Biology134 citations Open access
Semantic Scholar
Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans
Cassandra Coburn, Erik Allman, Parag Mahanti, Alexandre Benedetto +17 more
2013PLoS Biology133 citations Open access
Semantic Scholar
Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model
B. Virk, Gonçalo Correia, D. Dixon, Inna Feyst +8 more
2012BMC Biology133 citations Open access
Semantic Scholar
The ‘mitoflash’ probe cpYFP does not respond to superoxide
M. Schwarzländer, Stephan Wagner, Yulia G. Ermakova, V. Belousov +24 more
2014Nature120 citations Open access
Semantic Scholar
The hyperfunction theory: an emerging paradigm for the biology of aging
D. Gems
2021Ageing Research Reviews114 citations Open access
Semantic Scholar
The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm
D. Gems, J. D. de Magalhães
2021Ageing Research Reviews113 citations Open access
Semantic Scholar
Two forms of death in ageing Caenorhabditis elegans
Yuan Zhao, A. F. Gilliat, Matthias Ziehm, M. Turmaine +9 more
2017Nature Communications109 citations Open access
Semantic Scholar
Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor
Dhaval S. Patel, A. Garza-Garcia, M. Nanji, J. McElwee +3 more
2008Genetics107 citations Open access
Semantic Scholar
Dietary Restriction of Caenorhabditis elegans by Axenic Culture Reflects Nutritional Requirement for Constituents Provided by Metabolically Active Microbes
Isabelle Lenaerts, G. Walker, L. Van Hoorebeke, D. Gems +1 more
2008The journals of gerontology. Series A, Biological sciences and medical sciences101 citations Open access
Semantic Scholar
The aging-disease false dichotomy: understanding senescence as pathology
D. Gems
2015Frontiers in Genetics85 citations Open access
Semantic Scholar
DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans
Jennifer M. A. Tullet, Caroline Araiz, M. Sanders, Catherine Au +8 more
2014PLoS Genetics74 citations Open access
Semantic Scholar
Run-on of germline apoptosis promotes gonad senescence in C. elegans
Y. de la Guardia, A. F. Gilliat, J. Hellberg, Peter Rennert +2 more
2016OncoTarget67 citations Open access
Semantic Scholar
Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets
A. Dobson, Marina Ezcurra, Charlotte E. Flanagan, Adam C. Summerfield +3 more
2017Cell Reports66 citations Open access
Semantic Scholar
The mystery of C. elegans aging: An emerging role for fat
D. Ackerman, D. Gems
2012Bioessays66 citations
Semantic Scholar
Insulin/IGF-1 and Hypoxia Signaling Act in Concert to Regulate Iron Homeostasis in Caenorhabditis elegans
D. Ackerman, D. Gems
2012PLoS Genetics60 citations Open access
Semantic Scholar
Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans
S. Valentini, F. Cabreiro, D. Ackerman, Muhammed M. Alam +3 more
2012Mechanisms of Ageing and Development60 citations Open access
Semantic Scholar
Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging
N. Alic, Jennifer M. A. Tullet, T. Niccoli, Susan J. Broughton +4 more
2014Cell Reports57 citations Open access
Semantic Scholar
The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway
Cassandra Coburn, D. Gems
2013Frontiers in Genetics56 citations Open access
Semantic Scholar
Involving Young People in Healthy Ageing: A Crucial Facet to Achieving the Decade of Healthy Ageing (2021–2030)
B. L. Wong, Ines Siepmann, A. Rangan, Omnia El-Omrani +4 more
2021Frontiers in Public Health53 citations Open access
Semantic Scholar
Tragedy and delight: the ethics of decelerated ageing
D. Gems
2011Philosophical Transactions of the Royal Society B: Biological Sciences53 citations Open access
Semantic Scholar
What is an anti-aging treatment?
D. Gems
2014Experimental Gerontology51 citations
Semantic Scholar
Does senescence promote fitness in Caenorhabditis elegans by causing death?
Jennifer N. Lohr, E. Galimov, D. Gems
2019Ageing Research Reviews48 citations Open access
Semantic Scholar
Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"
C. Selman, Steven J. Lingard, D. Gems, L. Partridge +1 more
2008Science48 citations
Semantic Scholar
A fln-2 mutation affects lethal pathology and lifespan in C. elegans
Yuan Zhao, Hongyuan Wang, Richard J. Poole, D. Gems
2019Nature Communications43 citations Open access
Semantic Scholar
The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans
Annette O. Estevez, Kathleen L. Morgan, N. Szewczyk, D. Gems +1 more
2014Neurotoxicology43 citations Open access
Semantic Scholar
C. elegans feed yolk to their young in a form of primitive lactation
Carina C. Kern, StJohn Townsend, Antoine Salzmann, N. Rendell +5 more
2021Nature Communications42 citations Open access
Semantic Scholar
Evolution of sexually dimorphic longevity in humans
D. Gems
2014Aging39 citations Open access
Semantic Scholar
Reproductive Suicide: Similar Mechanisms of Aging in C. elegans and Pacific Salmon
D. Gems, Carina C. Kern, Joseph Nour, Marina Ezcurra
2021Frontiers in Cell and Developmental Biology38 citations Open access
Semantic Scholar
Production of YP170 Vitellogenins Promotes Intestinal Senescence in Caenorhabditis elegans
Thanet Sornda, Marina Ezcurra, Carina C. Kern, E. Galimov +3 more
2019The journals of gerontology. Series A, Biological sciences and medical sciences38 citations Open access
Semantic Scholar
C. elegans ageing is accelerated by a self-destructive reproductive programme
Carina C. Kern, Shivangi Srivastava, Marina Ezcurra, Kuei-Ching Hsiung +8 more
2023Nature Communications36 citations Open access
Semantic Scholar
MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans
Michèle Riesen, Inna Feyst, Nattaphong Rattanavirotkul, Marina Ezcurra +8 more
2014Aging34 citations Open access
Semantic Scholar
Mutation of daf‐2 extends lifespan via tissue‐specific effectors that suppress distinct life‐limiting pathologies
Yuan Zhao, Bruce Zhang, Ioan Marcu, Faria Athar +4 more
2021Aging Cell33 citations Open access
Semantic Scholar
Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death
E. Galimov, Rosina E. Pryor, Sarah E. Poole, Alexandre Benedetto +2 more
2018Cell Reports33 citations Open access
Semantic Scholar
Shorter life and reduced fecundity can increase colony fitness in virtual Caenorhabditis elegans
E. Galimov, D. Gems
2020Aging Cell32 citations Open access
Semantic Scholar

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Jennifer M. A. Tullet

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