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Xinxu Yuan · SciRah

Researcher profile · Semantic Scholar

Xinxu Yuan

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Xinxu Yuan — researcher profile on SciRah

h-index: 17
Works: 61
Citations: 848

Most-cited papers

Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate
Xinxu Yuan, Lei Wang, O. Bhat, H. Lohner +1 more
2018Redox Biology140 citations Open access
Semantic Scholar
Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia
Saisudha Koka, Min Xia, Yang Chen, O. Bhat +3 more
2017Redox Biology96 citations Open access
Semantic Scholar
Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice
Mingjun Cao, Qingjie Pan, Huan-Sheng Dong, Xinxu Yuan +4 more
2015Stem cell research & therapeutics79 citations Open access
Semantic Scholar
NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ
Yu Chen, Xing-Xiang He, Xinxu Yuan, Jinni Hong +4 more
2018Oxidative Medicine and Cellular Longevity51 citations Open access
Semantic Scholar
Control of Lysosomal TRPML1 Channel Activity and Exosome Release by Acid Ceramidase in Mouse Podocytes.
Guang-Bi Li, Dandan Huang, Jinni Hong, O. Bhat +2 more
2019American Journal of Physiology - Cell Physiology46 citations Open access
Semantic Scholar
Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases
O. Bhat, Xinxu Yuan, Guang-Bi Li, Rami Lee +1 more
2018Antioxidants and Redox Signaling41 citations Open access
Semantic Scholar
Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38−/− mice
Xiaoyang Xu, Xinxu Yuan, Ning-Jun Li, W. Dewey +2 more
2016Journal of Cellular and Molecular Medicine36 citations Open access
Semantic Scholar
Medial calcification in the arterial wall of smooth muscle cell‐specific Smpd1 transgenic mice: A ceramide‐mediated vasculopathy
O. Bhat, Xinxu Yuan, Chad K. Cain, Fadi N. Salloum +1 more
2019Journal of Cellular and Molecular Medicine34 citations Open access
Semantic Scholar
Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries.
Xinxu Yuan, O. Bhat, Nan Meng, H. Lohner +1 more
2018American Journal of Pathology33 citations Open access
Semantic Scholar
Arterial Medial Calcification through Enhanced small Extracellular Vesicle Release in Smooth Muscle-Specific Asah1 Gene Knockout Mice
O. Bhat, Guang-Bi Li, Xinxu Yuan, Dandan Huang +3 more
2020Scientific Reports30 citations Open access
Semantic Scholar
Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation
Xinxu Yuan, O. Bhat, Arun Samidurai, Anindita Das +2 more
2020Frontiers in Cell and Developmental Biology26 citations Open access
Semantic Scholar
Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture
Yao Zou, O. Bhat, Xinxu Yuan, Guang-Bi Li +4 more
2021Journal of Inflammation Research24 citations Open access
Semantic Scholar
CONTRIBUTION OF GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 TO NLRP3 INFLAMMASOME ACTIVATION IN MOUSE PODOCYTES DURING HYPERHOMOCYSTEINEMIA
S. Conley, Justine M. Abais‐Battad, Xinxu Yuan, Qinghua Zhang +2 more
2017Free Radical Biology & Medicine24 citations Open access
Semantic Scholar
Abnormal Lysosomal Positioning and Small Extracellular Vesicle Secretion in Arterial Stiffening and Calcification of Mice Lacking Mucolipin 1 Gene
O. Bhat, Xinxu Yuan, S. Camus, Fadi N. Salloum +1 more
2020International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Endothelial Acid Ceramidase in Exosome-Mediated Release of NLRP3 Inflammasome Products during Hyperglycemia: Evidence from Endothelium-Specific Deletion of Asah1 Gene
Xinxu Yuan, O. Bhat, H. Lohner, Yang Zhang +1 more
2019Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids22 citations Open access
Semantic Scholar
Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation
Qinghua Zhang, S. Conley, Guang-Bi Li, Xinxu Yuan +1 more
2019Kidney & Blood Pressure Research19 citations Open access
Semantic Scholar
Regulatory Role of mTOR Signaling in Exosome Secretion and Osteogenic Changes in Smooth Muscle Cells Lacking Acid Ceramidase Gene
O. Bhat, Xinxu Yuan, R. Kukreja, Pin-Lan Li
2021The FASEB Journal17 citations Open access
Semantic Scholar
Inhibitory effects of growth differentiation factor 11 on autophagy deficiency-induced dedifferentiation of arterial smooth muscle cells.
Xinxu Yuan, O. Bhat, H. Lohner, Ning-Jun Li +2 more
2019American Journal of Physiology. Heart and Circulatory Physiology17 citations Open access
Semantic Scholar
Simvastatin promotes NPC1‐mediated free cholesterol efflux from lysosomes through CYP7A1/LXRα signalling pathway in oxLDL‐loaded macrophages
Xiaoyang Xu, Aolin Zhang, M. Halquist, Xinxu Yuan +5 more
2016Journal of Cellular and Molecular Medicine16 citations Open access
Semantic Scholar
Downregulation of Lysosomal Acid Ceramidase Mediates HMGB1-Induced Migration and Proliferation of Mouse Coronary Arterial Myocytes
Xinxu Yuan, O. Bhat, H. Lohner, Yang Zhang +1 more
2020Frontiers in Cell and Developmental Biology15 citations Open access
Semantic Scholar
Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia
Xinxu Yuan, O. Bhat, Yao Zou, Xiang Li +2 more
2022Journal of Lipid Research14 citations Open access
Semantic Scholar
Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective Autophagy
Jun-Xiang Bao, Guang-Bi Li, Xinxu Yuan, Pin-Lan Li +1 more
2017Cellular Physiology and Biochemistry8 citations Open access
Semantic Scholar
Contribution of Hepatic Steatosis-intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice.
Xinxu Yuan, O. Bhat, Yao Zou, Yang Zhang +1 more
2023American Journal of Pathology6 citations Open access
Semantic Scholar
Differential Effects of Short Chain Fatty Acids on Endothelial NLRP3 Inflammasome Activation and Neointima Formation
Xinxu Yuan, Lei Wang, O. Bhat, H. Lohner +2 more
2017The FASEB Journal6 citations Open access
Semantic Scholar
Protective Role of Autophagy in NLRP3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries
O. Bhat, Nan Meng, Xinxu Yuan, H. Lohner +1 more
2017The FASEB Journal5 citations
Semantic Scholar
Testicular fat deposition attenuates reproductive performance via decreased follicle-stimulating hormone level and sperm meiosis and testosterone synthesis in mouse
M. Du, Shikun Chen, Yang Chen, Xinxu Yuan +1 more
2023Animal bioscience4 citations Open access
Semantic Scholar
Regulation of exosome release by lysosomal acid ceramidase in coronary arterial endothelial cells: Role of TRPML1 channel
Guang-Bi Li, Dandan Huang, Peng-Yang Li, Xinxu Yuan +2 more
2022Current topics in membranes4 citations Open access
Semantic Scholar
Regulatory Role of Ceramide/mTOR Signaling in Exosome Secretion from Smooth Muscle Cells during Arterial Stiffening and Medial Calcification
O. Bhat, Xinxu Yuan, Guang-Bi Li, S. Camus +3 more
2020The FASEB Journal2 citations Open access
Semantic Scholar
Lysosome Dysfunction and Medial Calcification in the Arterial Wall of Smooth Muscle Cell‐Specific Smpd1 Transgenic Mice: A Ceramide‐Mediated Vasculopathy
O. Bhat, Xinxu Yuan, H. Lohner, Pin-Lan Li
2019The FASEB Journal2 citations
Semantic Scholar
Renomedullary exosomes produce antihypertensive effects in reversible two-kidney one-clip renovascular hypertensive mice
Gai-Zun Hu, Guang-Bi Li, Dandan Huang, Yao Zou +4 more
2022Biochemical Pharmacology1 citations Open access
Semantic Scholar
Subendothelial Accumulation of Exosomes and Coronary Microvascular Dysfunction in Mice Lacking Acid Ceramidase
Xinxu Yuan, Guang-Bi Li, O. Bhat, Pin-Lan Li
2021The FASEB Journal1 citations Open access
Semantic Scholar
Control of Instant Membrane Resealing by Lysosomal Acid Ceramidase in Endothelial Cells
Dandan Huang, Guang-Bi Li, Xinxu Yuan, Yao Zou +1 more
2020The FASEB Journal1 citations Open access
Semantic Scholar
Contribution of Ceramide Signaling to Activation of the mTORC1 Pathway and Calcification Nidus Formation in Coronary Arterial Smooth Muscle Cells
O. Bhat, Dandan Huang, Xinxu Yuan, R. Kukreja +1 more
2019The FASEB Journal1 citations
Semantic Scholar
Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in Asc–/– and Nlrp3–/– Mice
Yu Chen, J. Kidd, O. Bhat, Xinxu Yuan +3 more
2019Frontiers in Physiology1 citations Open access
Semantic Scholar
Podocyte‐Specific Deletion of Asah1 Gene Produced Podocytopathy without Sclerotic Pathology: A Potential Mouse Model for Steroid‐Insensitive Minimal Change Disease
Guang-Bi Li, H. Lohner, Sara K. Dempsey, Xinxu Yuan +4 more
20181 citations
Semantic Scholar
Enhanced Arterial Medial Calcification in Mice with Smooth Muscle‐Specific Deletion of Lysosomal Acid Ceramidase.
O. Bhat, Xinxu Yuan, Yang Zhang, K. Boini +2 more
20181 citations
Semantic Scholar
Activation of NLRP3 Inflammasomes in Non‐alcoholic Steatohepatitis: A Novel Molecular Target of FTZ Remedy for Metabolic Syndrome
Yu Chen, Xinxiang He, Xinxu Yuan, Jinni Hong +2 more
20181 citations
Semantic Scholar
Inhibitory Effects of Growth Differentiation Factor 11 on Phenotypic Transition Associated with Autophagy Deficiency in Mouse Coronary Arterial Myocytes
Xinxu Yuan, O. Bhat, Rami Lee, H. Lohner +2 more
2017The FASEB Journal1 citations Open access
Semantic Scholar
Generating Hypertrophic Adipocytes from 3T3 L1 Cell Line and Characterizing the Phenotypic Transition
Xinxu Yuan, Xiaoyang Xu, Ning-Jun Li, W. Dewey +2 more
2016The FASEB Journal1 citations Open access
Semantic Scholar
Acceleration of artery stiffness during childhood obesity in mice lacking lysosomal acid ceramidase
Fan Zhang, Fan Zhang, Xinxu Yuan, Guang-Bi Li +3 more
2023Physiology0 citations
Semantic Scholar
Characterization and Ischemic Response of Telecytes in the Mouse Renal Medulla
Yao Zou, Guang-Bi Li, Gai-Zun Hu, Xinxu Yuan +2 more
2022The FASEB Journal0 citations
Semantic Scholar
Antihypertensive Action of Exosomes Released from the Renal Medulla after Unclipping of the Renal Artery of 2 Kidney‐1 Clip Hypertension Mice
Gai-Zun Hu, Guang-Bi Li, Dandan Huang, Yao Zou +2 more
2022The FASEB Journal0 citations
Semantic Scholar
Enhanced Vascular Endothelial NLRP3 Inflammasome Activation by Plasma Exosomes from Liver‐specific Acid Ceramidase Gene Knockout Mice on the High Fat Diet
Xinxu Yuan, Xiaoyuan Wu, Pin-Lan Li
2022The FASEB Journal0 citations
Semantic Scholar
Enhanced Arterial Stiffening in Obese Mice with Smooth Muscle‐Specific Overexpression of Smpd1 gene
O. Bhat, Xinxu Yuan, Fadi N. Salloum, Pin-Lan Li
2021The FASEB Journal0 citations
Semantic Scholar
Contribution of Enhancer of Zeste Homolog 2 gene in Calcification Nidus Formation and Exosome Release in Arterial Smooth Muscle Cells
O. Bhat, Xinxu Yuan, Xiang Li, Pin-Lan Li +1 more
2021The FASEB Journal0 citations
Semantic Scholar
Control of TRPML1 Channel Activity and Lysosome Trafficking by Acid Ceramidase in Mouse Coronary Arterial Endothelial Cells
Guang-Bi Li, Xinxu Yuan, Dandan Huang, S. Camus +1 more
2021The FASEB Journal0 citations
Semantic Scholar
Inflammasome Activation and Exosome Release in the Lung during Chronic Obstructive Pulmonary Disease: Potential Therapeutic Target of Acupuncture
Yao Zou, O. Bhat, Xinxu Yuan, Guang-Bi Li +3 more
2021The FASEB Journal0 citations Open access
Semantic Scholar
Aggravated Endothelial Inflammasome Activation and Neointima Proliferation by Hepatic Steotosis‐intensified Exosome Release in Liver‐Specific Asah1 Gene Knockout Mice
Xinxu Yuan, O. Bhat, Sarah Comus, Yang Zhang +1 more
2020The FASEB Journal0 citations Open access
Semantic Scholar
Importance of Acid Sphingomyelinase in Subendothelial Accumulation of Exosomes and Inflammatory Response in Mouse Carotid Arteries
Xinxu Yuan, O. Bhat, S. Camus, Yang Zhang +2 more
2020The FASEB Journal0 citations Open access
Semantic Scholar
Arterial Stiffening and Calcification Associated with Abnormal Lysosomal Positioning and Exosome Secretion in Mice Lacking Mucolipin 1 Gene
O. Bhat, Xinxu Yuan, S. Camus, Fadi N. Salloum +1 more
2020The FASEB Journal0 citations Open access
Semantic Scholar

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O. Bhat×33
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Guang-Bi Li×18
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