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Wilian A. Cortopassi · SciRah

Researcher profile · Semantic Scholar

Wilian A. Cortopassi

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Wilian A. Cortopassi — researcher profile on SciRah

h-index: 18
Works: 45
Citations: 1,251

Most-cited papers

Small molecule inhibitors of bromodomain-acetyl-lysine interactions.
M. Brand, Angelina R Measures, Brian G. Wilson, Wilian A. Cortopassi +6 more
2015ACS Chemical Biology164 citations
Semantic Scholar
Cation–π interactions in protein–ligand binding: theory and data-mining reveal different roles for lysine and arginine
Kiran Kumar, Shin M Woo, Thomas Siu, Wilian A. Cortopassi +2 more
2018Chemical Science160 citations Open access
Semantic Scholar
Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies
J. Penna-Coutinho, Wilian A. Cortopassi, Aline A Oliveira, T. França +1 more
2011PLoS ONE160 citations Open access
Semantic Scholar
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction
T. Rooney, P. Filippakopoulos, O. Fedorov, S. Picaud +16 more
2014Angewandte Chemie112 citations Open access
Semantic Scholar
Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity
A. C. Aguiar, Erika Murce, Wilian A. Cortopassi, A. S. Pimentel +5 more
2018International Journal for Parasitology: Drugs and Drug Resistance93 citations Open access
Semantic Scholar
Progranulin stimulates the in vitro maturation of pro-cathepsin D at acidic pH
Victoria J. Butler, Wilian A. Cortopassi, A. Argouarch, S. Ivry +3 more
2019Journal of Molecular Biology63 citations Open access
Semantic Scholar
Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling
W. K. Lin, Emma L. Bolton, Wilian A. Cortopassi, Yanwen Wang +10 more
2017Journal of Biological Chemistry50 citations Open access
Semantic Scholar
Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites
A. C. Aguiar, Raquel de Meneses Santos, F. J. Figueiredo, Wilian A. Cortopassi +4 more
2012PLoS ONE45 citations Open access
Semantic Scholar
Multi-granulin Domain Peptides Bind to Pro-cathepsin D and Stimulate its Enzymatic Activity in vitro
Victoria J. Butler, Wilian A. Cortopassi, Sushmitha Gururaj, Austin L. Wang +3 more
2019Biochemistry39 citations Open access
Semantic Scholar
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
Srinivasa P. S. Rao, M. Gould, J. Noeske, Manuel Saldivia +38 more
2023Science35 citations Open access
Semantic Scholar
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response
Victoria J. Butler, Fuying Gao, Christian I Corrales, Wilian A. Cortopassi +7 more
2019PLoS Genetics30 citations Open access
Semantic Scholar
ATP-competitive inhibitors midostaurin and avapritinib have distinct resistance profiles in exon 17-mutant KIT
B. Winger, Wilian A. Cortopassi, D. G. Ruiz, Lucky Ding +6 more
2019Cancer Research26 citations Open access
Semantic Scholar
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain
M. Brand, J. Clayton, M. Moroglu, M. Schiedel +24 more
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Cation-π interactions in CREBBP bromodomain inhibition: an electrostatic model for small-molecule binding affinity and selectivity.
Wilian A. Cortopassi, Kiran Kumar, Robert S Paton
2016Organic and biomolecular chemistry20 citations Open access
Semantic Scholar
Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment.
Wilian A. Cortopassi, Robert A. Simion, Charles E Honsby, T. França +1 more
2015Chemistry20 citations
Semantic Scholar
Applications of docking and molecular dynamic studies on the search for new drugs against the biological warfare agents Bacillus anthracis and Yersinia pestis.
T. França, A. P. Guimarães, Wilian A. Cortopassi, Aline A Oliveira +1 more
2013Current Computer - Aided Drug Design20 citations
Semantic Scholar
Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1
S. Kholodar, G. Lang, Wilian A. Cortopassi, Yoshie Iizuka +3 more
2021bioRxiv19 citations Open access
Semantic Scholar
Docking Studies on the Binding of Quinoline Derivatives and Hematin to Plasmodium Falciparum Lactate Dehydrogenase
Wilian A. Cortopassi, Aline A Oliveira, A. P. Guimarães, M. N. Rennó +2 more
2011Journal of Biomolecular Structure and Dynamics19 citations
Semantic Scholar
Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum
Wilian A. Cortopassi, J. Penna-Coutinho, A. C. Aguiar, A. S. Pimentel +5 more
2014PLoS ONE16 citations Open access
Semantic Scholar
Topology and dynamics of the interaction between 5-nitroimidazole radiosensitizers and duplex DNA studied by a combination of docking, molecular dynamic simulations and NMR spectroscopy
Teodorico C. Ramalho, T. França, Wilian A. Cortopassi, Arlan da Silva Gonçalves +2 more
201115 citations
Semantic Scholar
Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness
David T. Barkan, Keira Garland, Lei Zhang, Richard T. Eastman +24 more
2024Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System
C. Pliotas, Samuel C. Grayer, Silvia Ekkerman, Anthony K N Chan +14 more
2017Biochemistry13 citations Open access
Semantic Scholar
Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH
Rabab A. Charafeddine, Wilian A. Cortopassi, P. Lak, Ruensern Tan +4 more
2019Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Mechanisms of histone lysine-modifying enzymes: A computational perspective on the role of the protein environment.
Wilian A. Cortopassi, Kiran Kumar, Fernanda Duarte, A. S. Pimentel +1 more
2016Journal of Molecular Graphics and Modelling12 citations Open access
Semantic Scholar
A systems biology approach to antimalarial drug discovery
Wilian A. Cortopassi, Tanos Celmar Costa Franca, A. U. Krettli
2018Expert Opinion on Drug Discovery10 citations
Semantic Scholar
Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.
Wan-Chen Tsai, Ansari M. Aleem, Christi L. Whittington, Wilian A. Cortopassi +7 more
2021Biochemistry9 citations Open access
Semantic Scholar
Docking and molecular dynamics studies of new potential inhibitors of the human epidermal receptor 2
Wilian A. Cortopassi, Rafael José Cavalieri Feital, Diogo de Jesus Medeiros, T. R. C. Guizado +2 more
20128 citations
Semantic Scholar
Structure-based identification of novel CK2 inhibitors with a linear 2-propenone scaffold as anti-cancer agents.
Xiaoqiang Qi, Na Zhang, Li-Jiao Zhao, Li-Ming Hu +4 more
2019Biochemical and Biophysical Research Communications - BBRC7 citations
Semantic Scholar
Challenges in the Regulation of High-Cost Treatments-An Overview From Brazil.
L. C. Pereira, Daniela V R Sturzenegger, J. Ortiz, N. Ayad +3 more
2019Value in Health Regional Issues6 citations Open access
Semantic Scholar
Structure‐based Discovery of Novel CK2α‐Binding Cyclic Peptides with Anti‐cancer Activity
Shan Tang, Na Zhang, Yue Zhou, Wilian A. Cortopassi +3 more
2018Molecular Informatics6 citations
Semantic Scholar
Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues
Wilian A. Cortopassi, Emma L. Gunderson, Yasmin Annunciato, Antony.E.S. Silva +11 more
2022International Journal for Parasitology: Drugs and Drug Resistance5 citations Open access
Semantic Scholar
Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium
Y. Pikman, Sarah K. Tasian, M. Sulis, Kristen E. Stevenson +49 more
2021Cancer Discovery5 citations Open access
Semantic Scholar
ITP Adjuster 1.0: A New Utility Program to Adjust Charges in the Topology Files Generated by the PRODRG Server
Diogo de Jesus Medeiros, Wilian A. Cortopassi, T. França, A. S. Pimentel
20135 citations Open access
Semantic Scholar
Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions.
M. Brand, Angelina R Measures, Brian G. Wilson, Wilian A. Cortopassi +6 more
2016ACS Chemical Biology4 citations
Semantic Scholar
Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment.
Wilian A. Cortopassi, Robert A. Simion, Charles E Honsby, T. França +1 more
2015Chemistry2 citations Open access
Semantic Scholar
The Scope Concept: Defined Chemical Space for Identifying Ligand-Efficient, Tractable Hits Applied to Drug Discovery Targets Trypanosomal CLK1, 14-3-3/Estrogen Receptor-α, and SARS-CoV-2 Mpro.
J. Jansen, Wilian A. Cortopassi, Daniel Fuller, P. Ertl +24 more
2026Journal of Chemical Information and Modeling1 citations Open access
Semantic Scholar
Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH.
Rabab A. Charafeddine, Wilian A. Cortopassi, Parnian Lak, Ruensern Tan +5 more
20191 citations
Semantic Scholar
C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition
Victoria J. Butler, Wilian A. Cortopassi, A. Argouarch, M. Pierce +13 more
20181 citations Open access
Semantic Scholar
Intracellular CD38 Mediates Cardiac Synthesis of NAADP and CADPR
W. K. Lin, Emma L. Bolton, Matylda K. Maciejewska, Yanwen Wang +7 more
20161 citations Open access
Semantic Scholar
BUBONIC PLAGUE: HISTORICAL ASPECTS AND THERAPY
Wilian A. Cortopassi, Teodorico C. Ramalho, C. A. Fraga, I. Mangas +2 more
20151 citations Open access
Semantic Scholar
Progress in Antimalarial Drug Discovery and Development
A. C. Aguiar, Wilian A. Cortopassi, A. U. Krettli
2019Medicinal Chemistry of Neglected and Tropical Diseases0 citations
Semantic Scholar
Conserved tau microtubule-binding repeat histidines confer pH-dependent tau-microtubule association
Rabab A. Charafeddine, Wilian A. Cortopassi, P. Lak, M. Jacobson +2 more
2018bioRxiv0 citations Open access
Semantic Scholar
AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system
C. Pliotas, Samuel C. Grayer, Silvia Ekkerman, Anthony K N Chan +14 more
20170 citations
Semantic Scholar
Cover Picture: Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment (Chem. Eur. J. 52/2015)
Wilian A. Cortopassi, Robert A. Simion, Charles E Honsby, T. França +1 more
20150 citations
Semantic Scholar
Temporal RMSD values for the LQB223, DNA an Pf TopoI (upper) an Hss RopoI (lower). These values were counted in the time range of 0–15,000 ps, at each 20 ps.
Wilian A. Cortopassi, J. Penna-Coutinho, A. C. Aguiar, A. S. Pimentel +5 more
20140 citations Open access
Semantic Scholar

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