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B. Raaka · SciRah

Researcher profile · Semantic Scholar

B. Raaka

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B. Raaka — researcher profile on SciRah

h-index: 31
Works: 49
Citations: 4,254

Most-cited papers

Evaluation of gene expression measurements from commercial microarray platforms.
P. Tan, Thomas J. Downey, E. Spitznagel, Pin Xu +5 more
2003Nucleic Acids Research743 citations Open access
Semantic Scholar
Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells
M. Gershengorn, A. Hardikar, Chi-Ju Wei, E. Geras‐Raaka +2 more
2004Science458 citations
Semantic Scholar
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets
Kai Hsieh, Y. Lee, C. Londos, B. Raaka +2 more
2012Journal of Cell Science236 citations Open access
Semantic Scholar
Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.
B. M. Forman, Juan Casanova, B. Raaka, J. Ghysdael +1 more
1992Molecular Endocrinology194 citations Open access
Semantic Scholar
Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates
A. Hardikar, B. Marcus‐Samuels, E. Geras‐Raaka, B. Raaka +1 more
2003Proceedings of the National Academy of Sciences of the United States of America176 citations Open access
Semantic Scholar
Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking
M. Schapira, B. Raaka, Sharmistha Das, L. Fan +5 more
2003Proceedings of the National Academy of Sciences of the United States of America155 citations Open access
Semantic Scholar
Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.
I. G. Tikhonova, C. Sum, S. Neumann, Stanislav Engel +3 more
2008Journal of Medicinal Chemistry141 citations Open access
Semantic Scholar
The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation
M. Au-Fliegner, E. Helmer, Juan Casanova, B. Raaka +1 more
1993Molecular and Cellular Biology135 citations Open access
Semantic Scholar
Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
Juan Casanova, E. Helmer, S. Selmi‐Ruby, Jian-Shen Qi +6 more
1994Molecular and Cellular Biology130 citations Open access
Semantic Scholar
Identification of Residues Important for Agonist Recognition and Activation in GPR40*
C. Sum, I. G. Tikhonova, S. Neumann, Stanislav Engel +3 more
2007Journal of Biological Chemistry124 citations Open access
Semantic Scholar
The glucocorticoid receptor in GH1 cells. Evidence from dense amino acid labeling and whole cell studies for an equilibrium model explaining the influence of hormone on the intracellular distribution of receptor.
B. Raaka, H. Samuels
1983Journal of Biological Chemistry114 citations Open access
Semantic Scholar
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice
S. Neumann, Wen-Wei Huang, Steve Titus, G. Krause +11 more
2009Proceedings of the National Academy of Sciences of the United States of America111 citations Open access
Semantic Scholar
A 10-amino-acid sequence in the N-terminal A/B domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB
E. Hadzic, V. Desai-Yajnik, E. Helmer, S. Guo +5 more
1995Molecular and Cellular Biology111 citations Open access
Semantic Scholar
Rational discovery of novel nuclear hormone receptor antagonists
M. Schapira, B. Raaka, H. Samuels, R. Abagyan
2000Proc. Natl. Acad. Sci. USA108 citations Open access
Semantic Scholar
A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.
S. Neumann, G. Kleinau, S. Costanzi, Susanna Moore +5 more
2008Endocrinology98 citations Open access
Semantic Scholar
A Low Molecular Weight Agonist Signals by Binding to the Transmembrane Domain of Thyroid-stimulating Hormone Receptor (TSHR) and Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)*
H. Jäschke, S. Neumann, Susanna Moore, C. Thomas +8 more
2006Journal of Biological Chemistry98 citations Open access
Semantic Scholar
Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.
I. G. Tikhonova, C. Sum, S. Neumann, C. Thomas +3 more
2007Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition
Olubunmi Afonja, B. Raaka, A-Min Huang, Sharmistha Das +4 more
2002Oncogene88 citations Open access
Semantic Scholar
The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation
Jian-Shen Qi, V. Desai-Yajnik, M. E. Greene, B. Raaka +1 more
1995Molecular and Cellular Biology85 citations Open access
Semantic Scholar
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.
Susanna Moore, H. Jaeschke, G. Kleinau, S. Neumann +9 more
2006Journal of Medicinal Chemistry82 citations Open access
Semantic Scholar
Nonsecreted Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Can Induce Apoptosis in Human Prostate Cancer Cells by IGF-independent Mechanisms without Being Concentrated in the Nucleus*
N. Bhattacharyya, K. Pechhold, Hanief M. Shahjee, G. Zappalá +5 more
2006Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Regulation of thyroid hormone nuclear receptor levels in GH1 cells by 3,5,3'-triiodo-L-thyronine. Use of dense amino acid labeling to determine the influence of hormone on the receptor half-life and the rate of appearance of newly synthesized receptor.
B. Raaka, H. Samuels
1981Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells.
R. A. Morton, E. Geras‐Raaka, Leah M. Wilson, B. Raaka +1 more
2007Molecular and Cellular Endocrinology69 citations Open access
Semantic Scholar
In silico discovery of novel Retinoic Acid Receptor agonist structures
M. Schapira, B. Raaka, H. Samuels, R. Abagyan
2001BMC Structural Biology58 citations Open access
Semantic Scholar
A Drug-Like Antagonist Inhibits Thyrotropin Receptor–Mediated Stimulation of cAMP Production in Graves' Orbital Fibroblasts
S. Neumann, Arthur J. Pope, E. Geras‐Raaka, B. Raaka +2 more
2012Thyroid54 citations Open access
Semantic Scholar
Erythropoietin Signaling: A Novel Regulator of White Adipose Tissue Inflammation During Diet-Induced Obesity
M. Alnaeeli, B. Raaka, Oksana Gavrilova, Rui-Feng Teng +2 more
2014Diabetes53 citations Open access
Semantic Scholar
Inhibition of fatty acid oxidation by 2-bromooctanoate. Evidence for the enzymatic formation of 2-bromo-3-ketooctanoyl coenzyme A and the inhibition of 3-ketothiolase.
B. Raaka, J. M. Lowenstein
1979Journal of Biological Chemistry46 citations Open access
Semantic Scholar
TRH Receptor Type 2 Deficient Mice are Euthyroid and Exhibit Increased Depression and Reduced Anxiety Phenotypes
Yu-Hua Sun, Bojana Zupan, B. Raaka, M. Toth +1 more
2008Neuropsychopharmacology45 citations Open access
Semantic Scholar
The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element.
Haengnim Park, D. Davidson, B. Raaka, Herbert H. Samuels
1993Molecular Endocrinology43 citations Open access
Semantic Scholar
Are Better Islet Cell Precursors Generated by Epithelial-to-Mesenchymal Transition?
M. Gershengorn, E. Geras‐Raaka, A. Hardikar, B. Raaka
2005Cell Cycle39 citations Open access
Semantic Scholar
Thyrotropin-Releasing Hormone Receptor Type 1 (TRH-R1), not TRH-R2, Primarily Mediates Taltirelin Actions in the CNS of Mice
N. Thirunarayanan, E. A. Nir, B. Raaka, M. Gershengorn
2013Neuropsychopharmacology31 citations Open access
Semantic Scholar
A Novel Multifunctional Motif in the Amino-terminal A/B Domain of T3Rα Modulates DNA Binding and Receptor Dimerization*
E. Hadzic, Ioanis Habeos, B. Raaka, H. Samuels
1998Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Human TSH receptor ligands as pharmacological probes with potential clinical application
S. Neumann, B. Raaka, M. Gershengorn
2009Expert Review of Endocrinology & Metabolism25 citations Open access
Semantic Scholar
Inhibition of fatty acid oxidation by 2-bromooctanoate. Including effects of bromooctanoate on ketogenesis and gluconeogenesis.
B. Raaka, J. M. Lowenstein
1979Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Constitutively Active Thyrotropin And Thyrotropin-Releasing Hormone Receptors And Their Inverse Agonists
S. Neumann, B. Raaka, M. Gershengorn
2010Methods in Enzymology19 citations Open access
Semantic Scholar
Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor
N. Thirunarayanan, B. Raaka, M. Gershengorn
2012Front. Endocrin.18 citations Open access
Semantic Scholar
Insulin but Not Glucagon Gene is Silenced in Human Pancreas-Derived Mesenchymal Stem Cells
Leah M. Wilson, Stephen H.K. Wong, N. Yu, E. Geras‐Raaka +2 more
2009Stem Cells18 citations Open access
Semantic Scholar
A sequence in the rat Pit-1 gene promoter confers synergistic activation by glucocorticoids and protein kinase-C.
M. T. C. Jong, B. Raaka, Herbert H. Samuels
1994Molecular Endocrinology15 citations
Semantic Scholar
High Levels of TRH Receptors Activate Programmed Cell Death in Human Pancreatic Precursors
Christopher M. Mulla, E. Geras‐Raaka, B. Raaka, M. Gershengorn
2009Pancreas13 citations Open access
Semantic Scholar
Carboxyl Tail Cysteine Mutants of the Thyrotropin-Releasing Hormone Receptor Type 1 Exhibit Constitutive Signaling: Role of Palmitoylation
D. Du, B. Raaka, H. Grimberg, M. Lupu‐Meiri +2 more
2005Molecular Pharmacology10 citations
Semantic Scholar
β‐catenin signalling in mesenchymal islet‐derived precursor cells
L. Ikonomou, E. Geras‐Raaka, B. Raaka, Marvin C. Gershengorn
2008Cell Proliferation9 citations Open access
Semantic Scholar
Role of the conserved C-terminal region of thyroid hormone receptor-alpha in ligand-dependent transcriptional activation.
S. Selmi‐Ruby, J. Casanova, S. Malhotra, Bernard Roussett +2 more
1998Molecular and Cellular Endocrinology9 citations Open access
Semantic Scholar
[42] 2-Bromooctanoate
B. Raaka, J. M. Lowenstein
19813 citations
Semantic Scholar
CHAPTER 4 – Hormonal Regulation of Growth Hormone Synthesis in Cell Cultures: Role of Thyroid and Glucocorticoid Hormone Receptors
H. Samuels, J. Casanova, Z. Horowitz, B. Raaka +4 more
19832 citations
Semantic Scholar
4 – Thyroid Hormone Receptor Synthesis and Degradation and Interaction with Chromatin Components
H. Samuels, A. J. Perlman, B. Raaka, F. Stanley
19832 citations
Semantic Scholar
interaction with the general transcription factor is essential for transcriptional activation and A / B domain of thyroid hormone receptor alpha A 10-amino-acid sequence in the N-terminal
V. Desai-Yajnik, E. Helmer, Si-Hu Guo, Shengji Wu +4 more
19950 citations
Semantic Scholar
Cell specific regulation of transcription from the beta 2 adrenergic receptor promoter by thyroid and glucocorticoid hormones
E. Helmer, B. Raaka, H. Samuels
19900 citations
Semantic Scholar
Molybdate inhibits nuclear accumulation and increases the half life of the estrogen receptor in gh cells
B. Raaka, M. Finnerty, H. Samuels
19850 citations
Semantic Scholar
TITLE : Toward a New Chemotherapy for Breast Cancer : Structural and Functional Mechanism of the Retinoid Receptors Addressed by a Novel Computer Approach
M. Schapira, B. Raaka
0 citations
Semantic Scholar

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Herbert H. Samuels

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