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D. Degrandi · SciRah

Researcher profile · Semantic Scholar

D. Degrandi

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D. Degrandi — researcher profile on SciRah

h-index: 22
Works: 53
Citations: 2,607

Most-cited papers

Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS
D. Pilla, J. Hagar, A. Haldar, Ashley K Mason +6 more
2014Proceedings of the National Academy of Sciences of the United States of America351 citations Open access
Semantic Scholar
Guanylate-binding proteins promote AIM2 inflammasome activation during Francisella novicida infection by inducing cytosolic bacteriolysis and DNA release
E. Meunier, Pierre Wallet, R. F. Dreier, Stéphanie Costanzo +11 more
2015Nature Immunology308 citations Open access
Semantic Scholar
LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation
José Carlos Santos, Mathias S. Dick, B. Lagrange, D. Degrandi +6 more
2018EMBO Journal232 citations Open access
Semantic Scholar
Extensive Characterization of IFN-Induced GTPases mGBP1 to mGBP10 Involved in Host Defense1
D. Degrandi, Carolin Konermann, Cornelia Beuter-Gunia, A. Kresse +4 more
2007Journal of Immunology217 citations Open access
Semantic Scholar
The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses.
Yang Wang, S. Subudhi, R. Anders, James C. Lo +9 more
2005Journal of Clinical Investigation213 citations Open access
Semantic Scholar
Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii
E. Selleck, Sarah J. Fentress, W. Beatty, D. Degrandi +4 more
2013PLoS Pathogens190 citations Open access
Semantic Scholar
Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication
D. Degrandi, E. Kravets, Carolin Konermann, Cornelia Beuter-Gunia +6 more
2012Proceedings of the National Academy of Sciences of the United States of America190 citations Open access
Semantic Scholar
The Proinflammatory Cytokine-Induced IRG1 Protein Associates with Mitochondria
D. Degrandi, R. Hoffmann, Cornelia Beuter-Gunia, K. Pfeffer
2009Journal of Interferon and Cytokine Research140 citations
Semantic Scholar
Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes
E. Kravets, D. Degrandi, Qijun Ma, Thomas O. Peulen +6 more
2016eLife126 citations Open access
Semantic Scholar
Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies
A. Kresse, Carolin Konermann, D. Degrandi, Cornelia Beuter-Gunia +3 more
2008BMC Genomics88 citations Open access
Semantic Scholar
The catalytic PI3K isoforms p110γ and p110δ contribute to B cell development and maintenance, transformation, and proliferation
S. Beer-Hammer, E. Zebedin, Max von Holleben, J. Alferink +9 more
2010Journal of Leukocyte Biology71 citations
Semantic Scholar
The GTPase Activity of Murine Guanylate-binding Protein 2 (mGBP2) Controls the Intracellular Localization and Recruitment to the Parasitophorous Vacuole of Toxoplasma gondii*
E. Kravets, D. Degrandi, S. Weidtkamp-Peters, Britta Ries +8 more
2012Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Host Cell Responses to Persistent Mycoplasmas - Different Stages in Infection of HeLa Cells with Mycoplasma hominis
Miriam Hopfe, R. Deenen, D. Degrandi, K. Köhrer +1 more
2013PLoS ONE54 citations Open access
Semantic Scholar
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling
Shou-Ya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing +14 more
2022Nature Communications49 citations Open access
Semantic Scholar
Balanced splicing at the Tat-specific HIV-1 3′ss A3 is critical for HIV-1 replication
Steffen Erkelenz, Frank Hillebrand, Marek Widera, S. Theiss +4 more
2015Retrovirology48 citations Open access
Semantic Scholar
Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐NLRP3 inflammasomes
Daniel Enosi Tuipulotu, Shou-Ya Feng, Abhimanu Pandey, Anyang Zhao +25 more
2023EMBO Journal29 citations Open access
Semantic Scholar
Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs)
K. Spekker, M. Leineweber, D. Degrandi, V. Ince +12 more
2013Medical Microbiology and Immmunology29 citations Open access
Semantic Scholar
Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever
Lisa Kohl, Md Nur A. Alam Siddique, Barbara Bodendorfer, Raffaela S. Berger +27 more
2022EMBO Molecular Medicine28 citations Open access
Semantic Scholar
Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection
Nora Steffens, Cornelia Beuter-Gunia, E. Kravets, A. Reich +3 more
2020mBio26 citations Open access
Semantic Scholar
Broad recruitment of mGBP family members to Chlamydia trachomatis inclusions
Valesca Lindenberg, Katja Mölleken, E. Kravets, S. Stallmann +3 more
2017PLoS ONE23 citations Open access
Semantic Scholar
Cytokine‐dependent regulation of dendritic cell differentiation in the splenic microenvironment
Theresa Globisch, Nancy Steiner, Lorenz Fülle, Veronika Lukacs-Kornek +11 more
2014European Journal of Immunology22 citations Open access
Semantic Scholar
Immediate lymphotoxin beta receptor-mediated transcriptional response in host defense against L. monocytogenes.
Stefanie Kutsch, D. Degrandi, K. Pfeffer
2008Immunobiology22 citations Open access
Semantic Scholar
Gymnotic Delivery of LNA Mixmers Targeting Viral SREs Induces HIV-1 mRNA Degradation
Frank Hillebrand, P. Ostermann, L. Müller, D. Degrandi +4 more
2019International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level
M. Skowron, K. Eul, A. Stephan, G. F. Ludwig +16 more
2022Molecular Oncology15 citations Open access
Semantic Scholar
Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration.
U. Sorg, K. Behnke, D. Degrandi, M. Reich +10 more
2016Journal of Hepatology13 citations
Semantic Scholar
Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2
Jennifer Loschwitz, Nora Steffens, Xue Wang, Moritz Schäffler +3 more
2022bioRxiv11 citations Open access
Semantic Scholar
Carboxypeptidase D: A Novel TGF-β Target Gene Dysregulated in Patients with Lupus Erythematosus
N. Hoff, D. Degrandi, U. Hengge, K. Pfeffer +1 more
2007Journal of Clinical Immunology10 citations
Semantic Scholar
Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail.
Larissa Legewie, Jennifer Loschwitz, Nora Steffens, Martin Prescher +6 more
2019Biochemical Journal9 citations
Semantic Scholar
Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay
Shishir Singh, Mateo Murillo-Léon, Aura María Bastidas Quintero, Florence Melbert +3 more
2025Frontiers in Immunology4 citations Open access
Semantic Scholar
Integrative modeling of guanylate binding protein dimers
Wibke Schumann, Jennifer Loschwitz, Jens Reiners, D. Degrandi +6 more
2022bioRxiv4 citations Open access
Semantic Scholar
In Astrocytes the Accumulation of the Immunity-Related GTPases Irga6 and Irgb6 at the Vacuole of Toxoplasma gondii Is Dependent on the Parasite Virulence
Felix P. Lubitz, D. Degrandi, K. Pfeffer, Anne K. Mausberg
2013TheScientificWorldJournal4 citations Open access
Semantic Scholar
In Silico and In Vitro Characterization of mGBP4 Splice Variants
Carolin Konermann, A. Kresse, Cornelia Beuter-Gunia, J. Würthner +3 more
2007DNA and Cell Biology4 citations
Semantic Scholar
Lymphotoxin β Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii
A. Tersteegen, U. Sorg, Richard Virgen-Slane, M. Helle +6 more
2021Infection and Immunity3 citations Open access
Semantic Scholar
mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii
E. Kravets, G. Poschmann, S. Hänsch, Veronica Raba +4 more
2025PLoS ONE1 citations Open access
Semantic Scholar
Intra-strain genetic heterogeneity in Toxoplasma gondii ME49: Oxford Nanopore long-read sequencing reveals copy number variation in the ROP8-ROP2A locus
Yomna Gohar, Marie Neumann, Lisanna Hülse, D. Wind +7 more
2025bioRxiv1 citations Open access
Semantic Scholar
Lymphotoxin β receptor: A crucial role in Toxoplasma gondii infection
Anne Wichert, U. Sorg, D. Degrandi, K. Pfeffer
2019Journal of Immunology1 citations
Semantic Scholar
Author response: Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes
E. Kravets, D. Degrandi, Qijun Ma, Thomas O. Peulen +6 more
20161 citations Open access
Semantic Scholar
APEX2 proximity labeling maps the mGBP2-proximal proteome at the Toxoplasma gondii parasitophorous vacuole
Imke Bradtmöller, G. Poschmann, K. Stühler, D. Degrandi +1 more
2026bioRxiv0 citations Open access
Semantic Scholar
Lymphotoxin beta receptor-/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after Toxoplasma gondii infection
M. Helle, Ursula R Sorg, J. Ptok, Rachel Thomas +7 more
2025Infection and Immunity0 citations Open access
Semantic Scholar
1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors
Flaminia Mazzone, A. Hoeppner, Jens Reiners, C. Gertzen +8 more
2024Biochemical Journal0 citations Open access
Semantic Scholar
Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever
Lisa Kohl, Md. Nur A. Alam Siddique, Barbara Bodendorfer, Raffaela S. Berger +24 more
2022bioRxiv0 citations Open access
Semantic Scholar
GBP2 engages Galectin-9 for immunity against Toxoplasma gondii
E. Kravets, G. Poschmann, S. Hänsch, Veronica Raba +4 more
2021bioRxiv0 citations Open access
Semantic Scholar
mGBP 2 engages Galectin-9 and Cytoskeleton-associated Protein 4 1 for immunity against Toxoplasma gondii 2 3
E. Kravets, G. Poschmann, S. Hänsch, S. Weidtkamp-Peters +4 more
20210 citations
Semantic Scholar
Characterization of the function of murine guanylate-binding protein 9 in the context of bacterial and parasitic infections
Jens Lichte, D. Degrandi, Valesca Lindenberg, Katja Mölleken +2 more
2019Journal of Immunology0 citations
Semantic Scholar
Analysis of mGBPs in host defense against the obligate parasite Toxoplasma gondii
Nora Steffens, Larissa Legewie, Cornelia Beuter-Gunia, Philipp T Hanisch +4 more
2019Journal of Immunology0 citations
Semantic Scholar
mGBP7 interacting proteins in Toxoplasma gondii infection and biochemical characteristics of mGBP7
Larissa Legewie, Jennifer Loschwitz, S. Smits, Martin Prescher +6 more
2019Journal of Immunology0 citations
Semantic Scholar
ID: 165: Parasite control by cytokine-induced guanylate-binding proteins
K. Pfeffer, D. Degrandi, E. Kravets
20150 citations
Semantic Scholar
Balanced splicing at the Tat-specific HIV-1 3′ss A3 is critical for HIV-1 replication
Steffen Erkelenz, Frank Hillebrand, Marek Widera, S. Theiss +4 more
2015Retrovirology0 citations Open access
Semantic Scholar
Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs)
K. Spekker, M. Leineweber, D. Degrandi, V. Ince +12 more
2012Medical Microbiology and Immmunology0 citations Open access
Semantic Scholar
Analyses of murine GBP homology clusters based on , and studies-4
A. Kresse, Carolin Konermann, D. Degrandi, Cornelia Beuter-Gunia +3 more
20110 citations
Semantic Scholar

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