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Hua-Kan Zhao · SciRah

Researcher profile · Semantic Scholar

Hua-Kan Zhao

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Hua-Kan Zhao — researcher profile on SciRah

h-index: 21
Works: 50
Citations: 5,172

Most-cited papers

Inflammation and tumor progression: signaling pathways and targeted intervention
Hua-Kan Zhao, Lei Wu, Guifang Yan, Yu Chen +3 more
2021Signal Transduction and Targeted Therapy2,596 citations Open access
Semantic Scholar
Mitochondrial dynamics in health and disease: mechanisms and potential targets
Wen Chen, Hua-Kan Zhao, Yong-Sheng Li
2023Signal Transduction and Targeted Therapy1,233 citations Open access
Semantic Scholar
RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis
Lei Wu, X. Zhang, Lu Zheng, Hua-Kan Zhao +14 more
2020Cancer immunology research228 citations Open access
Semantic Scholar
A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis.
Guifang Yan, Hua-Kan Zhao, Qi Zhang, Yu Zhou +11 more
2018Cancer Research108 citations Open access
Semantic Scholar
FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation
Hua-Kan Zhao, F. Lv, Gui-zhao Liang, Xiao-Bin Huang +5 more
2015OncoTarget103 citations Open access
Semantic Scholar
STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma
Hua-Kan Zhao, Guifang Yan, Lu Zheng, Yu Zhou +13 more
2020Theranostics80 citations Open access
Semantic Scholar
FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4-GSK3β-Nrf2 Signaling.
Yong Teng, Hua-Kan Zhao, Li-Xia Gao, Wenfa Zhang +2 more
2017Cancer Research79 citations Open access
Semantic Scholar
Spatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective
Yang Xiao, Yong-Sheng Li, Hua-Kan Zhao
2024Molecular Cancer58 citations Open access
Semantic Scholar
Cancer metabolism and intervention therapy
Hua-Kan Zhao, Yong-Sheng Li
2021Molecular Biomedicine57 citations Open access
Semantic Scholar
The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression
Yi-Guo Zhang, Shao-Jun Li, Yuan-Cai Xiang, L. Qiu +2 more
2015Scientific Reports54 citations Open access
Semantic Scholar
Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases
Luyao Shen, Yong-Sheng Li, Hua-Kan Zhao
2024Frontiers in Immunology53 citations Open access
Semantic Scholar
FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells
Jing-Chun Wang, Hua-Kan Zhao, Lu Zheng, Yu Zhou +17 more
2021Theranostics47 citations Open access
Semantic Scholar
An NAD+-Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39
Ling Dong, Le-xing Yu, Hui Li, Lei Shi +6 more
2020iScience42 citations Open access
Semantic Scholar
DNASE1L3-mediated PANoptosis enhances the efficacy of combination therapy for advanced hepatocellular carcinoma
Jing-Chun Wang, Yu Chen, Yanquan Xu, Jian-Gang Zhang +8 more
2024Theranostics34 citations Open access
Semantic Scholar
The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer
Qi Zhang, Guifang Yan, Juan Lei, Yu Chen +11 more
2020Molecular Medicine32 citations Open access
Semantic Scholar
RNase T2 in Inflammation and Cancer: Immunological and Biological Views
Lei Wu, Yanquan Xu, Hua-Kan Zhao, Yong-Sheng Li
2020Frontiers in Immunology32 citations Open access
Semantic Scholar
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
Lei Wu, Xu-Dong Liu, Juan Lei, Nan Zhang +4 more
2023Journal for ImmunoTherapy of Cancer29 citations Open access
Semantic Scholar
Critical role of DEK and its regulation in tumorigenesis and metastasis of hepatocellular carcinoma
Le-xing Yu, Xiao-Bin Huang, Wenfa Zhang, Hua-Kan Zhao +4 more
2016OncoTarget27 citations Open access
Semantic Scholar
Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion.
Yu Chen, Yanquan Xu, Hua-Kan Zhao, Yu Zhou +9 more
2023Cancer Letters26 citations
Semantic Scholar
Microbiota-derived SSL6 enhances the sensitivity of hepatocellular carcinoma to sorafenib by down-regulating glycolysis.
Xiao Zhang, Lei Wu, Yanquan Xu, Hua Yu +10 more
2020Cancer Letters25 citations
Semantic Scholar
Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5
Yu Zhou, Juan Lei, Qichao Xie, Lei Wu +15 more
2019Science Advances25 citations Open access
Semantic Scholar
Stabilization of SETD3 by deubiquitinase USP27 enhances cell proliferation and hepatocellular carcinoma progression
Tingting Zou, Yang Wang, Ling Dong, Tiantian Che +3 more
2022Cellular and Molecular Life Sciences21 citations Open access
Semantic Scholar
OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression
Shuai Yang, Jian-Gang Zhang, Yanquan Xu, Jing-Chun Wang +9 more
2022Cancer Immunology and Immunotherapy21 citations Open access
Semantic Scholar
The interplay between gut bacteria and targeted therapies: implications for future cancer treatments
Juan He, Yu Chen, Hua-Kan Zhao, Yong-Sheng Li
2025Molecular Medicine18 citations Open access
Semantic Scholar
FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape
Lei Wu, Yanquan Xu, Hua-Kan Zhao, Yu Zhou +7 more
2022Theranostics18 citations Open access
Semantic Scholar
GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma
Yu Zhou, Hua-Kan Zhao, Ran Ren, Min Zhou +7 more
2024Theranostics17 citations Open access
Semantic Scholar
STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma
Ran Ren, Yu Chen, Yu Zhou, Luyao Shen +8 more
2024Genes and Diseases16 citations
Semantic Scholar
Integrated LC-MS metabolomics with dual derivatization for quantification of FFAs in fecal samples of hepatocellular carcinoma patients
Jian-Gang Zhang, Shuai Yang, Jing-Chun Wang, Yanquan Xu +8 more
2021Journal of Lipid Research16 citations Open access
Semantic Scholar
Integrative multiomics analysis identifies molecular subtypes and potential targets of hepatocellular carcinoma
Shuai Yang, Lu Zheng, Ling-Ling Li, Jian-Gang Zhang +11 more
2024Clinical and Translational Medicine15 citations Open access
Semantic Scholar
Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production
Juan Lei, Yu Zhou, Hua-Kan Zhao, Yu Chen +8 more
2021Theranostics15 citations Open access
Semantic Scholar
Pleiotropic Regulation of PGC-1α in Tumor Initiation and Progression
Yan Zhang, Hua-Kan Zhao, Yong-Sheng Li
2024Antioxidants and Redox Signaling12 citations
Semantic Scholar
Equivalent carbon number-based targeted odd-chain fatty acyl lipidomics reveals triacylglycerol profiling in clinical colon cancer
Jian-Gang Zhang, Shuai Yang, Jing-Chun Wang, Yanquan Xu +6 more
2023Journal of Lipid Research12 citations Open access
Semantic Scholar
Cholesterol 25‐Hydroxylase Enhances Myeloid‐Derived Suppressor Cell (MDSC) Immunosuppression via the Stimulator of Interferon Genes (STING)‐Tank‐Binding Kinase 1 (TBK1)‐Receptor‐Interacting Protein Kinase 3 (RIPK3) Pathway in Colorectal Cancer
Dong-Qin Zhou, Yu Chen, Xu-Dong Liu, Juan He +11 more
2025MedComm10 citations Open access
Semantic Scholar
A real-world analysis of survival and cost-effectiveness of sintilimab plus bevacizumab biosimilar regimen in patients with advanced hepatocellular carcinoma
Xiang-Hua Zeng, Yingxin Jia, Hongmei Chen, Qinli Luo +4 more
2023Journal of Cancer Research and Clinical Oncology10 citations Open access
Semantic Scholar
RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol‐Triggered MET Activation
Yanquan Xu, Yu Chen, Jian-Gang Zhang, Jing-Chun Wang +11 more
2025Advancement of science9 citations Open access
Semantic Scholar
Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Luyao Shen, Cong Wang, Ran Ren, Xu-Dong Liu +8 more
2024Inflammation Research7 citations
Semantic Scholar
Single-cell analysis of post-translational modifications identifies immunosuppressive macrophage subtypes in the HBV-positive hepatocellular carcinoma microenvironment.
Hua-Kan Zhao, Ran Ren, Xi Zhang, Mengtao Zhan +12 more
2025Cancer immunology research5 citations
Semantic Scholar
Stromal interaction molecule 1/microtubule‐associated protein 1A/1B‐light chain 3B complex induces metastasis of hepatocellular carcinoma by promoting autophagy
Jing-Chun Wang, Qichao Xie, Lei Wu, Yu Zhou +7 more
2024MedComm5 citations Open access
Semantic Scholar
FGF19/FGFR4 axis drives immunosuppressive macrophage plasticity in hepatocellular carcinoma
Yan Zhang, Yang Xiao, Cong Wang, Xi Liu +5 more
2026Fundamental Research2 citations Open access
Semantic Scholar
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
Y. Yi, Xi Liu, Xi Zhang, Yongsheng Li +1 more
2026MedComm - Oncology1 citations Open access
Semantic Scholar
Pharmacokinetics comparison of aumolertinib, osimertinib, gefitinib and their major metabolites in mouse model and NSCLC patients
Ran Ren, Jian-Gang Zhang, Yong-Peng He, Xianghua Zeng +5 more
2024MedComm - Oncology1 citations Open access
Semantic Scholar
Editorial: Macrophage immunity and metabolism in cancer: Novel diagnostic and therapeutic strategies
J. Leavenworth, Xin Lai, Hong-Ming Miao, Dingxiang Wang +2 more
2022Frontiers in Immunology1 citations Open access
Semantic Scholar
Nomogram for Prediction of Hepatocellular Carcinoma Prognosis
Shuai Yang, Jian-Gang Zhang, Jing-Chun Wang, Kun Yu +10 more
2021Current Bioinformatics1 citations Open access
Semantic Scholar
Multi-tissue transcriptomic atlas reveals systemic effects of FGF19 on metabolism and immunity.
Yang Xiao, Li-Wen Kuang, Juan He, Xu-Dong Liu +12 more
2026Biochemical Pharmacology0 citations
Semantic Scholar
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
Miao-Yu Song, Xi Liu, Yang Xiao, Yong-Sheng Li +1 more
2026MedComm0 citations Open access
Semantic Scholar
Alistipes-derived monomethyl branched-chain fatty acid iso-15:0 suppresses hepatocellular carcinoma progression by inhibiting Gβγ/PI3K/AKT signaling
Juan He, Yu Chen, Li-Wen Kuang, Yang Xiao +15 more
2026Molecular Biomedicine0 citations Open access
Semantic Scholar
STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma: Erratum
Hua-Kan Zhao, Guifang Yan, Lu Zheng, Yu Zhou +13 more
2025Theranostics0 citations
Semantic Scholar
Abstract 4732: Myeloid-derived suppressor cells potentiate colorectal carcinogenesis: Identification of a novel RIPK3-PGE2 circuit in tumor microenvironment
Yong-Sheng Li, Guifang Yan, Hua-Kan Zhao, Qi Zhang
2018Immunology0 citations
Semantic Scholar
Compound for inhibiting proliferation of breast cancer and application thereof
Y. Teng, Gui-zhao Liang, Xiao-Bin Huang, F. Lv +4 more
20150 citations
Semantic Scholar
University of Dundee The selective post-translational processing of transcription factor Nrf 1 yields distinct isoforms that dictate its ability to differentially regulate gene expression
Yi-Guo Zhang, Shao-Jun Li, Yuan-Cai Xiang, L. Qiu +2 more
20150 citations
Semantic Scholar

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