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B. Britigan · SciRah

Researcher profile · Semantic Scholar

B. Britigan

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B. Britigan — researcher profile on SciRah

h-index: 45
Works: 320
Citations: 7,750

Most-cited papers

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria
Dao Nguyen, Amruta Joshi-Datar, F. Lépine, E. Bauerle +8 more
2011Science924 citations Open access
Semantic Scholar
The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity.
Yukihiro Kaneko, Matthew J. Thoendel, Oyebode Olakanmi, B. Britigan +1 more
2007Journal of Clinical Investigation609 citations Open access
Semantic Scholar
Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections
C. Goss, Yukihiro Kaneko, Lisa Khuu, G. Anderson +17 more
2018Science Translational Medicine326 citations Open access
Semantic Scholar
Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells.
Y. O'Malley, K. Reszka, D. Spitz, G. Denning +1 more
2004American Journal of Physiology - Lung cellular and Molecular Physiology183 citations
Semantic Scholar
Modulation of lung epithelial functions by Pseudomonas aeruginosa.
Gee W. Lau, D. Hassett, B. Britigan
2005Trends in Microbiology136 citations
Semantic Scholar
Hepatitis C virus‐core and non structural proteins lead to different effects on cellular antioxidant defenses
Maher Y. Abdalla, I. Ahmad, D. Spitz, W. Schmidt +1 more
2005Journal of Medical Virology125 citations
Semantic Scholar
Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxide.
K. Reszka, Y. O'Malley, M. McCormick, G. Denning +1 more
2004Free Radical Biology & Medicine119 citations
Semantic Scholar
Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein.
Maher Y. Abdalla, B. Britigan, F. Wen, M. Icardi +5 more
2004Journal of Infectious Diseases95 citations
Semantic Scholar
Dual Inhibition of Klebsiella pneumoniae and Pseudomonas aeruginosa Iron Metabolism using Gallium Porphyrin and Gallium Nitrate
Seoung‐ryoung Choi, B. Britigan, P. Narayanasamy
2019ACS Infectious Diseases77 citations Open access
Semantic Scholar
Pyocyanin and Its Precursor Phenazine-1-Carboxylic Acid Increase IL-8 and Intercellular Adhesion Molecule-1 Expression in Human Airway Epithelial Cells by Oxidant-Dependent Mechanisms1
D. Look, L. L. Stoll, Sara A. Romig, Alicia L. Humlicek +2 more
2005Journal of Immunology76 citations Open access
Semantic Scholar
Pseudomonas aeruginosa OxyR Is Required for Full Virulence in Rodent and Insect Models of Infection and for Resistance to Human Neutrophils
Gee W. Lau, B. Britigan, D. Hassett
2005Infection and Immunity75 citations Open access
Semantic Scholar
Prolonged-acting, Multi-targeting Gallium Nanoparticles Potently Inhibit Growth of Both HIV and Mycobacteria in Co-Infected Human Macrophages
P. Narayanasamy, B. Switzer, B. Britigan
2015Scientific Reports67 citations Open access
Semantic Scholar
Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages
Seoung‐ryoung Choi, B. Britigan, David Moran, P. Narayanasamy
2017PLoS ONE66 citations Open access
Semantic Scholar
Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process.
A. Uc, J. Stokes, B. Britigan
2004American Journal of Physiology - Gastrointestinal and Liver Physiology63 citations
Semantic Scholar
Direct oxidation of 2',7'-dichlorodihydrofluorescein by pyocyanin and other redox-active compounds independent of reactive oxygen species production.
Y. O'Malley, K. Reszka, B. Britigan
2004Free Radical Biology & Medicine60 citations
Semantic Scholar
Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells
Maher Y. Abdalla, I. Ahmad, B. Switzer, B. Britigan
2015Redox Biology58 citations Open access
Semantic Scholar
The Nature of Extracellular Iron Influences Iron Acquisition by Mycobacterium tuberculosis Residing within Human Macrophages
Oyebode Olakanmi, L. Schlesinger, Ambar Ahmed, B. Britigan
2004Infection and Immunity48 citations Open access
Semantic Scholar
Gallium Nitrate Is Efficacious in Murine Models of Tuberculosis and Inhibits Key Bacterial Fe-Dependent Enzymes
Oyebode Olakanmi, Banu Kesavalu, R. Pasula, Maher Y. Abdalla +2 more
2013Antimicrobial Agents and Chemotherapy47 citations Open access
Semantic Scholar
Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co‐expressing HCV core protein and CYP2E1
F. Wen, Maher Y. Abdalla, C. Aloman, J. Xiang +8 more
2004Journal of Medical Virology47 citations
Semantic Scholar
Gallium Porphyrin and Gallium Nitrate Synergistically Inhibit Mycobacterial species by Targeting Different Aspects of Iron/Heme Metabolism.
Seoung‐ryoung Choi, B. Switzer, B. Britigan, P. Narayanasamy
2020ACS Infectious Diseases46 citations
Semantic Scholar
Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase‐1 inhibition
Maher Y. Abdalla, I. Ahmad, S. Rachagani, Kasturi Banerjee +6 more
2019Translational Research: The Journal of Laboratory and Clinical Medicine45 citations
Semantic Scholar
Gallium Disrupts Iron Uptake by Intracellular and Extracellular Francisella Strains and Exhibits Therapeutic Efficacy in a Murine Pulmonary Infection Model
Oyebode Olakanmi, J. Gunn, Shengchang Su, S. Soni +2 more
2009Antimicrobial Agents and Chemotherapy45 citations Open access
Semantic Scholar
Cleavage of Human Transferrin by Porphyromonas gingivalis Gingipains Promotes Growth and Formation of Hydroxyl Radicals
V. Goulet, B. Britigan, K. Nakayama, D. Grenier
2004Infection and Immunity44 citations Open access
Semantic Scholar
Gallium Compounds Exhibit Potential as New Therapeutic Agents against Mycobacterium abscessus
Maher Y. Abdalla, B. Switzer, C. Goss, M. Aitken +2 more
2015Antimicrobial Agents and Chemotherapy40 citations Open access
Semantic Scholar
In vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-tetraphenylporphyrine Against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice
Seoung‐ryoung Choi, B. Britigan, B. Switzer, Traci A. Hoke +2 more
2018Molecular Pharmaceutics38 citations Open access
Semantic Scholar
Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells
Maher Y. Abdalla, Traci A. Hoke, J. Seravalli, B. Switzer +4 more
2017Infection and Immunity38 citations Open access
Semantic Scholar
Iron/Heme Metabolism-Targeted Gallium(III) Nanoparticles Are Active against Extracellular and Intracellular Pseudomonas aeruginosa and Acinetobacter baumannii
Seoung‐ryoung Choi, B. Britigan, P. Narayanasamy
2019Antimicrobial Agents and Chemotherapy35 citations Open access
Semantic Scholar
Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity
F. Wen, K. Brown, B. Britigan, W. Schmidt
2008Cell Biology and Toxicology33 citations
Semantic Scholar
The Peptidoglycan-Associated Lipoprotein OprL Helps Protect a Pseudomonas aeruginosa Mutant Devoid of the Transactivator OxyR from Hydrogen Peroxide-Mediated Killing during Planktonic and Biofilm Culture
Warunya Panmanee, F. Gómez, D. Witte, V. Pancholi +2 more
2008Journal of Bacteriology32 citations Open access
Semantic Scholar
Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages
Seoung‐ryoung Choi, B. Britigan, P. Narayanasamy
2017Antimicrobial Agents and Chemotherapy29 citations Open access
Semantic Scholar
Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma
I. Ahmad, Alicia J Dafferner, Kelly A. O'Connell, Kamiya Mehla +3 more
2021Cancers28 citations Open access
Semantic Scholar
Airway Delivery of Silica Increases Susceptibility to Mycobacterial Infection in Mice: Potential Role of Repopulating Macrophages
R. Pasula, B. Britigan, J. Turner, W. Martin
2009Journal of Immunology28 citations Open access
Semantic Scholar
Photosensitized Oxidation and Inactivation of Pyocyanin, a Virulence Factor of Pseudomonas aeruginosa
K. Reszka, G. Denning, B. Britigan
2006Photochemistry and Photobiology26 citations
Semantic Scholar
Nanoparticulate β-Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against Mycobacteroides abscessus and Mycobacterium avium.
Seoung‐ryoung Choi, G. Talmon, B. Britigan, P. Narayanasamy
2021ACS Infectious Diseases24 citations
Semantic Scholar
Combining Gallium Protoporphyrin and Gallium Nitrate Enhances In Vitro and In Vivo Efficacy against Pseudomonas aeruginosa: Role of Inhibition of Bacterial Antioxidant Enzymes and Resultant Increase in Cytotoxic Reactive Oxygen Species.
Z. Scott, Seoung‐ryoung Choi, G. Talmon, B. Britigan +1 more
2022ACS Infectious Diseases23 citations
Semantic Scholar
Doxorubicin inhibits oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) by a lactoperoxidase/H(2)O(2) system by reacting with ABTS-derived radical.
K. Reszka, B. Britigan
2007Archives of Biochemistry and Biophysics23 citations Open access
Semantic Scholar
Nitric oxide decreases the stability of DMPO spin adducts.
K. Reszka, M. McCormick, G. Buettner, C. Hart +1 more
2006Nitric oxide23 citations
Semantic Scholar
Inactivation of anthracyclines by cellular peroxidase.
K. Reszka, B. Wagner, L. Teesch, B. Britigan +2 more
2005Cancer Research21 citations Open access
Semantic Scholar
Acetaminophen stimulates the peroxidative metabolism of anthracyclines.
K. Reszka, Laura H Britigan, G. T. Rasmussen, B. Wagner +2 more
2004Archives of Biochemistry and Biophysics21 citations
Semantic Scholar
Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens.
Z. Scott, Seoung‐ryoung Choi, B. Britigan, P. Narayanasamy
2023ACS Infectious Diseases20 citations
Semantic Scholar
Treatment of Virulent Mycobacterium tuberculosis and HIV Coinfected Macrophages with Gallium Nanoparticles Inhibits Pathogen Growth and Modulates Macrophage Cytokine Production
Seoung‐ryoung Choi, B. Britigan, P. Narayanasamy
2019Msphere18 citations Open access
Semantic Scholar
Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite.
K. Reszka, Ye Xiong, L. Sallans, R. Pasula +3 more
2012American Journal of Physiology - Lung cellular and Molecular Physiology18 citations
Semantic Scholar
Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells.
Oyebode Olakanmi, Banu Kesavalu, Maher Y. Abdalla, B. Britigan
2013Microbial Pathogenesis17 citations
Semantic Scholar
Peroxidative Metabolism of β2-Agonists Salbutamol and Fenoterol and Their Analogs
K. Reszka, D. McGraw, B. Britigan
2009Chemical Research in Toxicology17 citations Open access
Semantic Scholar
Copper egress is induced by PMA in human THP-1 monocytic cell line
S. Afton, J. Caruso, B. Britigan, Zhenyu Qin
2009Biometals17 citations
Semantic Scholar
Inactivation of anthracyclines by serum heme proteins.
B. Wagner, L. Teesch, G. Buettner, B. Britigan +2 more
2007Chemical Research in Toxicology17 citations Open access
Semantic Scholar
Oxidation of Thiols and Modification of Redox-Sensitive Signaling in Human Lung Epithelial Cells Exposed to Pseudomonas pyocyanin
I. Ahmad, B. Britigan, Maher Y. Abdalla
2010Journal of Toxicology and Environmental Health, Part A16 citations
Semantic Scholar
Combination Therapy with Gallium Protoporphyrin and Gallium Nitrate Exhibits Enhanced Antimicrobial Activity In Vitro and In Vivo against Methicillin-Resistant Staphylococcus aureus.
Seoung‐ryoung Choi, G. Talmon, Ken Hearne, Jennifer C. Woo +3 more
2023Molecular Pharmaceutics15 citations
Semantic Scholar
Airway Peroxidases Catalyze Nitration of the β2-Agonist Salbutamol and Decrease Its Pharmacological Activity
K. Reszka, L. Sallans, S. Macha, Kari M. Brown +3 more
2011Journal of Pharmacology and Experimental Therapeutics12 citations Open access
Semantic Scholar
Hemin induces active chloride secretion in Caco-2 cells.
A. Uc, R. Husted, Radhamma L Giriyappa, B. Britigan +1 more
2005American Journal of Physiology - Gastrointestinal and Liver Physiology12 citations
Semantic Scholar

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K. Reszka×12
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K. Reszka — researcher profile on SciRah
P. Narayanasamy×12
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P. Narayanasamy — researcher profile on SciRah
Maher Y. Abdalla×11
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Maher Y. Abdalla — researcher profile on SciRah
Seoung‐ryoung Choi×11
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Seoung‐ryoung Choi — researcher profile on SciRah

Oyebode Olakanmi

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Oyebode Olakanmi — researcher profile on SciRah

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I. Ahmad — researcher profile on SciRah

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B. Switzer — researcher profile on SciRah

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D. Hassett — researcher profile on SciRah

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G. Denning — researcher profile on SciRah

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W. Schmidt — researcher profile on SciRah

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M. McCormick — researcher profile on SciRah

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