S. Diano

Most-cited papers

Ghrelin
T. Müller, R. Nogueiras, M. Andermann, Z. Andrews +53 more
2015Molecular Metabolism582 citations Open access
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Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
T. Horvath, B. Sármán, C. García-Cáceres, P. Enriori +12 more
2010Proceedings of the National Academy of Sciences of the United States of America435 citations Open access
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Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
G. Leinninger, Y. Jo, R. Leshan, Gwendolyn W. Louis +15 more
2009Cell Metabolism429 citations Open access
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Nicotine Decreases Food Intake Through Activation of POMC Neurons
Y. Mineur, A. Abizaid, Yan Rao, R. Salas +7 more
2011Science421 citations Open access
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UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
Z. Andrews, Zhong-Wu Liu, Nicholas Walllingford, D. Erion +10 more
2008Nature421 citations Open access
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Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
Qian Gao, G. Mezei, Y. Nie, Yan Rao +11 more
2007Nature Medicine414 citations
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Hypothalamic POMC neurons promote cannabinoid-induced feeding
M. Koch, L. Varela, Jae Geun Kim, J. D. Kim +14 more
2015Nature397 citations Open access
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UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
Z. Andrews, Zhong-Wu Liu, Nicholas Walllingford, D. Erion +10 more
2009Nature391 citations Open access
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Leptin signaling in GFAP-expressing adult glia cells regulates hypothalamic neuronal circuits and feeding
Jae Geun Kim, Shigetomo Suyama, M. Koch, Sung-Ho Jin +16 more
2014Nature Neuroscience314 citations Open access
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Peroxisome proliferation-related ROS control sets melanocortin tone and feeding in diet-induced obesity
S. Diano, Zhong-Wu Liu, J. Jeong, Marcelo O. Dietrich +15 more
2011Nature Medicine256 citations Open access
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Agrp neurons mediate Sirt1’s action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity
Marcelo O. Dietrich, C. Antunes, Geliang Gan, Zhong-Wu Liu +8 more
2010Journal of Neuroscience232 citations Open access
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Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding
J. D. Kim, N. Yoon, Sung-Ho Jin, S. Diano
2019Cell Metabolism215 citations Open access
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Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism.
S. Diano, T. Horvath
2012Trends in Molecular Medicine214 citations
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UCP2 regulates mitochondrial fission and ventromedial nucleus control of glucose responsiveness
C. Toda, J. D. Kim, D. Impellizzeri, S. Cuzzocrea +2 more
2016Cell168 citations Open access
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Fuel utilization by hypothalamic neurons: roles for ROS.
T. Horvath, Z. Andrews, S. Diano
2009Trends in endocrinology and metabolism158 citations
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POMC Neurons: From Birth to Death
C. Toda, A. Santoro, J. D. Kim, S. Diano
2017Annual Review of Physiology155 citations Open access
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Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents.
N. Wallingford, B. Perroud, Qian Gao, Anna Coppola +11 more
2009Journal of Clinical Investigation152 citations Open access
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POMC neuronal heterogeneity in energy balance and beyond: an integrated view
C. Quarta, M. Claret, L. Zeltser, Kevin W. Williams +5 more
2021Nature Metabolism151 citations Open access
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Central anorexigenic actions of bile acids are mediated by TGR5
A. Perino, L. A. Velázquez-Villegas, Nadia Bresciani, Yu Sun +14 more
2021Nature Metabolism136 citations Open access
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Mitochondrial UCP2 in the central regulation of metabolism.
C. Toda, S. Diano
2014Best practice & research. Clinical endocrinology & metabolism126 citations
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Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice
A. Lama, C. Pirozzi, I. Severi, M. Morgese +13 more
2022Brain, behavior, and immunity106 citations Open access
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Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.
X. Xie, J. Wisor, J. Hara, T. L. Crowder +8 more
2008Journal of Clinical Investigation100 citations Open access
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2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism
Kwang-Mook Jung, Jason R. Clapper, Jin Fu, G. D'Agostino +9 more
2012Cell Metabolism95 citations Open access
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DRP1 suppresses leptin and glucose sensing of POMC neurons
A. Santoro, M. Campolo, Chen Liu, Hiromi Sesaki +4 more
2017Cell Metabolism90 citations Open access
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Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice.
E. Gyengesi, Zhong-Wu Liu, G. D'Agostino, Ge-Liang Gan +3 more
2010Endocrinology82 citations Open access
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Hypothalamic glucose-sensing mechanisms
N. Yoon, S. Diano
2021Diabetologia77 citations Open access
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alpha-Melanocyte stimulating hormone: production and degradation
G. D'Agostino, S. Diano
2010Journal of molecular medicine77 citations Open access
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Hormonal regulation of the hypothalamic melanocortin system
J. D. Kim, Stephanie Leyva, S. Diano
2014Frontiers in Physiology76 citations Open access
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Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels
Amandeep Singh, Martin Wirtz, N. Parker, M. Hogan +8 more
2009Proceedings of the National Academy of Sciences of the United States of America70 citations Open access
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Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse
Tomas Deierborg Olsson, T. Wieloch, S. Diano, C. Warden +2 more
2008Journal of Cerebral Blood Flow and Metabolism68 citations Open access
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Effects of chronic weight perturbation on energy homeostasis and brain structure in mice.
Y. Ravussin, Roee Gutman, S. Diano, M. Shanabrough +7 more
2011American Journal of Physiology. Regulatory Integrative and Comparative Physiology56 citations Open access
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NEW ASPECTS OF MELANOCORTIN SIGNALING: A ROLE FOR PRCP IN ALPHA-MSH DEGRADATION
S. Diano
2010Frontiers in neuroendocrinology (Print)54 citations Open access
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PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding.
Li-Hong Long, C. Toda, J. Jeong, T. Horvath +1 more
2014Journal of Clinical Investigation53 citations Open access
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Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats.
G. M. Raso, A. Santoro, R. Russo, R. Simeoli +5 more
2014Endocrinology53 citations Open access
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AgRP neurons regulate bone mass
Jae Geun Kim, Ben-hua Sun, Marcelo O. Dietrich, M. Koch +4 more
2015Cell Reports46 citations Open access
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MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression.
G. Bruschetta, Sung-Ho Jin, Zhong-Wu Liu, J. D. Kim +1 more
2020Cell Reports43 citations Open access
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Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells
J. Song, T. Alves, B. Stutz, Matija Šestan-Peša +5 more
2021Metabolites40 citations Open access
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Mitochondrial Dynamics and Hypothalamic Regulation of Metabolism.
Sung-Ho Jin, S. Diano
2018Endocrinology39 citations Open access
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Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform
Li, Tie-Feng Cao, Xiaoli Sun, Sung-Ho Jin +7 more
2020Nature Communications36 citations Open access
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Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses
G. Matarese, C. Procaccini, C. Menale, Jae Geun Kim +6 more
2013Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
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Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism
W. H. Brown, M. Gillum, Hui-Young Lee, J. Camporez +10 more
2012Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
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Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.
J. Jeong, Györgyi Szabó, G. M. Raso, R. Meli +1 more
2012American Journal of Physiology. Endocrinology and Metabolism35 citations Open access
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Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior
Yuki Yasumoto, M. Stoiljkovic, J. D. Kim, Matija Šestan-Peša +3 more
2020bioRxiv31 citations Open access
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Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure
G. Bruschetta, J. D. Kim, S. Diano, L. Chan
2018Molecular Metabolism30 citations Open access
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Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice
J. D. Kim, C. Toda, G. D'Agostino, C. Zeiss +10 more
2014Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
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Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory.
G. D'Agostino, J. D. Kim, Zhong-Wu Liu, J. Jeong +5 more
2013Cerebral Cortex30 citations Open access
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Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism
S. Diano
2013Endocrinology and Metabolism30 citations Open access
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Prolyl carboxypeptidase regulates energy expenditure and the thyroid axis.
J. Jeong, Györgyi Szabó, Kaitlin Kelly, S. Diano
2012Endocrinology28 citations Open access
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Anticonvulsant effects of leptin in epilepsy.
S. Diano, T. Horvath
2008Journal of Clinical Investigation28 citations Open access
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Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism
Ming-Liang Lee, Hirokazu Matsunaga, Y. Sugiura, Takahiro Hayasaka +8 more
2020Nature Communications26 citations Open access
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