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F. Stivala · SciRah

Researcher profile · Semantic Scholar

F. Stivala

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F. Stivala — researcher profile on SciRah

h-index: 39
Works: 113
Citations: 9,879

Most-cited papers

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.
J. McCubrey, L. Steelman, W. H. Chappell, S. Abrams +12 more
2007Biochimica et Biophysica Acta2,344 citations Open access
Semantic Scholar
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
J. McCubrey, L. Steelman, S. Abrams, John T. Lee +10 more
2006Advances in Enzyme Regulation690 citations
Semantic Scholar
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
L. Steelman, W. H. Chappell, S. Abrams, C. Kempf +21 more
2011Aging684 citations Open access
Semantic Scholar
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
W. H. Chappell, L. Steelman, Jacquelyn M. Long, Ruth Kempf +22 more
2011OncoTarget581 citations Open access
Semantic Scholar
Akt as a therapeutic target in cancer
L. Steelman, Kristin M. Stadelman, W. H. Chappell, S. Horn +7 more
2008Expert opinion on therapeutic targets494 citations
Semantic Scholar
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia
L. Steelman, S. Abrams, Jarrett T. Whelan, Fred E. Bertrand +10 more
2008Leukemia402 citations
Semantic Scholar
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy
L. Steelman, R. Franklin, S. Abrams, W. H. Chappell +12 more
2011Leukemia265 citations Open access
Semantic Scholar
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
J. McCubrey, L. Steelman, SL Abrams, FE Bertrand +9 more
2008Leukemia249 citations Open access
Semantic Scholar
PIK3CA mutations in human solid tumors: Role in sensitivity to various therapeutic approaches
G. Ligresti, Loredana Militello, L. Steelman, A. Cavallaro +5 more
2009Cell Cycle221 citations Open access
Semantic Scholar
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
Negin Misaghian, G. Ligresti, L. Steelman, Fred E. Bertrand +9 more
2008Leukemia204 citations Open access
Semantic Scholar
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway
A. Martelli, C. Evangelisti, W. H. Chappell, S. Abrams +11 more
2011Leukemia198 citations Open access
Semantic Scholar
Altered plasma cytokine levels in Alzheimer's disease: correlation with the disease progression.
M. Motta, R. Imbesi, M. Di Rosa, F. Stivala +1 more
2007Immunology Letters179 citations
Semantic Scholar
Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways
J. McCubrey, L. Steelman, C. Kempf, W. H. Chappell +12 more
2011Journal of Cellular Physiology177 citations
Semantic Scholar
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors
L. Steelman, P. M. Navolanic, M. Sokolosky, J. R. Taylor +12 more
2008Oncogene168 citations Open access
Semantic Scholar
State of the art in antigen retrieval for immunohistochemistry.
F. D'Amico, E. Skarmoutsou, F. Stivala
2009JIM - Journal of Immunological Methods160 citations
Semantic Scholar
Melanoma: molecular pathogenesis and emerging target therapies (Review).
A. Russo, E. Torrisi, Y. Bevelacqua, R. Perrotta +5 more
2009International Journal of Oncology159 citations Open access
Semantic Scholar
Uterine cervical carcinoma: role of matrix metalloproteinases (review).
M. Libra, A. Scalisi, Nadia Vella, S. Clementi +4 more
2009International Journal of Oncology149 citations Open access
Semantic Scholar
The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy.
S. Abrams, L. Steelman, John G. Shelton, E. W. T. Wong +8 more
2010Cell Cycle131 citations Open access
Semantic Scholar
Activation of the Osteopontin/Matrix Metalloproteinase-9 Pathway Correlates with Prostate Cancer Progression
G. Castellano, G. Malaponte, M. C. Mazzarino, M. Figini +6 more
2008Clinical Cancer Research125 citations Open access
Semantic Scholar
Targeting prostate cancer based on signal transduction and cell cycle pathways
John T. Lee, B. Lehmann, D. Terrian, W. H. Chappell +5 more
2008Cell Cycle117 citations Open access
Semantic Scholar
Amplified Centrosomes in Breast Cancer: A Potential Indicator of Tumor Aggressiveness
Antonino B. D’Assoro, S. Barrett, Christopher Folk, V. Negron +6 more
2002Breast Cancer Research and Treatment114 citations
Semantic Scholar
Analysis of BRAF Mutation in Primary and Metastatic Melanoma
M. Libra, G. Malaponte, P. Navolanic, P. Gangemi +7 more
2005Cell Cycle111 citations Open access
Semantic Scholar
Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons.
S. Cavallaro, A. Copani, V. D'Agata, Simone Musco +5 more
1996Molecular Pharmacology109 citations
Semantic Scholar
Long pentraxin 3: a marker of inflammation in untreated psoriatic patients.
V. Bevelacqua, M. Libra, M. C. Mazzarino, P. Gangemi +9 more
2006International Journal of Molecular Medicine97 citations Open access
Semantic Scholar
Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells
L. Steelman, P. Navolanic, W. H. Chappell, S. Abrams +9 more
2011Cell Cycle83 citations Open access
Semantic Scholar
Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease
Massimo Libra, S. Signorelli, Y. Bevelacqua, P. Navolanic +6 more
2006Journal of Clinical Pathology83 citations Open access
Semantic Scholar
Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
J. McCubrey, L. Steelman, R. Franklin, S. Abrams +9 more
2007Advances in Enzyme Regulation81 citations Open access
Semantic Scholar
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
M. Sokolosky, Kristin M. Stadelman, W. H. Chappell, S. Abrams +8 more
2011OncoTarget80 citations Open access
Semantic Scholar
Blood levels of transforming growth factor‐beta 1 (TGF‐β1) are elevated in both relapsing remitting and chronic progressive multiple sclerosis (MS) patients and are further augmented by treatment with interferon‐beta 1b (IFN‐β1b)
F. Nicoletti, R. Di Marco, Francesco Patti, E. Reggio +5 more
1998Clinical and Experimental Immunology80 citations Open access
Semantic Scholar
Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint
Antonino B. D’Assoro, R. Busby, Kelly Suino, Emmanuella Delva +7 more
2004Oncogene72 citations Open access
Semantic Scholar
Role of hypoxia and autophagy in MDA‐MB‐231 invasiveness
M. Indelicato, B. Pucci, L. Schito, V. Reali +6 more
2010Journal of Cellular Physiology71 citations
Semantic Scholar
Emerging MEK inhibitors
J. McCubrey, L. Steelman, S. Abrams, W. H. Chappell +12 more
2010Expert Opinion on Emerging Drugs68 citations
Semantic Scholar
Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs
L. Steelman, S. Abrams, John G. Shelton, W. H. Chappell +7 more
2010Cell Cycle46 citations Open access
Semantic Scholar
Targeting the cancer initiating cell: the ultimate target for cancer therapy.
J. McCubrey, L. Steelman, S. Abrams, Negin Misaghian +15 more
2012Current pharmaceutical design45 citations Open access
Semantic Scholar
'Genetic profiling' and ovarian cancer therapy (review).
Nadia Vella, M. Aiello, A. Russo, A. Scalisi +5 more
2011Molecular Medicine Reports40 citations Open access
Semantic Scholar
Extrahepatic disorders of HCV infection: a distinct entity of B-cell neoplasia?
M. Libra, J. Polesel, A. Russo, V. De Re +6 more
2010International Journal of Oncology40 citations Open access
Semantic Scholar
Inflammatory status in patients with chronic renal failure: the role of PTX3 and pro-inflammatory cytokines.
G. Malaponte, M. Libra, Y. Bevelacqua, Paola Merito +7 more
2007International Journal of Molecular Medicine40 citations Open access
Semantic Scholar
Understanding rituximab function and resistance: implications for tailored therapy.
A. Amoroso, Sameh Hafsi, Loredana Militello, A. Russo +4 more
2011Frontiers in Bioscience39 citations Open access
Semantic Scholar
Paradoxical Antidiabetogenic Effect of γ-Interferon in DP-BB Rats
F. Nicoletti, P. Zaccone, R. Di Marco, G. Magro +6 more
1998Diabetes38 citations
Semantic Scholar
Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review).
M. Aiello, Nadia Vella, Calogero Cannavò, A. Scalisi +5 more
2011Molecular Medicine Reports35 citations Open access
Semantic Scholar
Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas.
M. Libra, A. Gloghini, G. Malaponte, P. Gangemi +7 more
2008Journal of Hepatology35 citations
Semantic Scholar
Detection of BRAF gene mutation in primary choroidal melanoma tissue
G. Malaponte, M. Libra, P. Gangemi, V. Bevelacqua +6 more
2006Cancer Biology & Therapy35 citations Open access
Semantic Scholar
Emerging Raf inhibitors
J. McCubrey, L. Steelman, S. Abrams, W. H. Chappell +12 more
2009Expert Opinion on Emerging Drugs34 citations
Semantic Scholar
Co-regulated expression of matrix metalloproteinase-2 and transforming growth factor-beta in melanoma development and progression.
G. Malaponte, Alessandra Zacchia, Y. Bevelacqua, Andrea Marconi +4 more
2010Oncology Report31 citations Open access
Semantic Scholar
Impaired p53 function leads to centrosome amplification, acquired ERα phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts
AB D'Assoro, R. Busby, ID Acu, C. Quatraro +7 more
2008Oncogene31 citations Open access
Semantic Scholar
Liver immunolocalization and plasma levels of MMP-9 in non-alcoholic steatohepatitis (NASH) and hepatitis C infection.
F. D'Amico, M. Consolo, A. Amoroso, E. Skarmoutsou +6 more
2010Acta Histochemica29 citations
Semantic Scholar
Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy.
S. Abrams, L. Steelman, John G. Shelton, W. H. Chappell +7 more
2010Cell Cycle29 citations Open access
Semantic Scholar
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
J. McCubrey, M. Sokolosky, B. Lehmann, Jackson R. Taylor +21 more
2008Advances in Enzyme Regulation28 citations Open access
Semantic Scholar
Elevated serum levels of osteopontin in HCV-associated lymphoproliferative disorders
M. Libra, M. Indelicato, V. De Re, A. Zignego +7 more
2005Cancer Biology & Therapy28 citations Open access
Semantic Scholar
Breast cancer: Molecular basis and therapeutic strategies (Review).
G. Ligresti, M. Libra, Loredana Militello, S. Clementi +6 more
2008Molecular Medicine Reports26 citations Open access
Semantic Scholar

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M. Libra×36
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M. Libra — researcher profile on SciRah
J. McCubrey×26
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J. McCubrey — researcher profile on SciRah
L. Steelman×23
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L. Steelman — researcher profile on SciRah
W. H. Chappell×19
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W. H. Chappell — researcher profile on SciRah

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S. Abrams — researcher profile on SciRah

A. Martelli×17

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A. Martelli — researcher profile on SciRah

F. Nicoletti×17

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F. Nicoletti — researcher profile on SciRah

J. Bäsecke×16

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J. Bäsecke — researcher profile on SciRah

M. C. Mazzarino×14

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M. C. Mazzarino — researcher profile on SciRah

G. Malaponte×11

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G. Malaponte — researcher profile on SciRah

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M. Milella — researcher profile on SciRah

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A. Tafuri — researcher profile on SciRah