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L. Serghides · SciRah

Researcher profile · Semantic Scholar

L. Serghides

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L. Serghides — researcher profile on SciRah

h-index: 35
Works: 107
Citations: 3,323

Most-cited papers

CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages.
Samir N. Patel, L. Serghides, T. G. Smith, M. Febbraio +4 more
2004Journal of Infectious Diseases138 citations Open access
Semantic Scholar
CD36 and malaria: friends or foes?
L. Serghides, T. G. Smith, Samir N. Patel, K. Kain
2003Trends in Parasitology136 citations
Semantic Scholar
HIV Protease Inhibitor Use During Pregnancy Is Associated With Decreased Progesterone Levels, Suggesting a Potential Mechanism Contributing to Fetal Growth Restriction
Eszter Papp, H. Mohammadi, M. Loutfy, M. Yudin +6 more
2014Journal of Infectious Diseases124 citations Open access
Semantic Scholar
Pyruvate kinase deficiency and malaria.
K. Ayi, G. Min-Oo, L. Serghides, M. Crockett +4 more
2008New England Journal of Medicine123 citations
Semantic Scholar
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria
Samir N. Patel, J. Berghout, F. Lovegrove, K. Ayi +10 more
2008Journal of Experimental Medicine109 citations Open access
Semantic Scholar
Adjunctive therapy for severe malaria: a review and critical appraisal
R. Varo, Valerie M. Crowley, A. Sitoe, L. Madrid +3 more
2018Malaria Journal104 citations Open access
Semantic Scholar
HIV Impairs Opsonic Phagocytic Clearance of Pregnancy-Associated Malaria Parasites
Jessica Keen, L. Serghides, K. Ayi, Samir N. Patel +5 more
2007PLoS Medicine97 citations Open access
Semantic Scholar
Mechanism of protection induced by vitamin A in falciparum malaria.
L. Serghides, K. Kain
2002The Lancet88 citations
Semantic Scholar
Disruption of CD36 Impairs Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol and Confers Susceptibility to Severe and Fatal Malaria In Vivo1
Samir N. Patel, Ziyue Lu, K. Ayi, L. Serghides +2 more
2007Journal of Immunology85 citations
Semantic Scholar
C5a Enhances Dysregulated Inflammatory and Angiogenic Responses to Malaria In Vitro: Potential Implications for Placental Malaria
A. Conroy, L. Serghides, Constance A. M. Finney, S. Owino +5 more
2009PLoS ONE83 citations Open access
Semantic Scholar
CD36-Mediated Nonopsonic Phagocytosis of Erythrocytes Infected with Stage I and IIA Gametocytes of Plasmodium falciparum
T. G. Smith, L. Serghides, Samir N. Patel, M. Febbraio +2 more
2003Infection and Immunity81 citations Open access
Semantic Scholar
Evaluation of OX40 Ligand as a Costimulator of Human Antiviral Memory CD8 T Cell Responses: Comparison with B7.1 and 4-1BBL1
L. Serghides, J. Bukczynski, T. Wen, Chao Wang +6 more
2005Journal of Immunology78 citations Open access
Semantic Scholar
Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria
L. Serghides, Hani Kim, Ziyue Lu, Dylan C. Kain +5 more
2011PLoS ONE75 citations Open access
Semantic Scholar
Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial.
A. Boggild, S. Krudsood, Samir N. Patel, L. Serghides +6 more
2009Clinical Infectious Diseases71 citations Open access
Semantic Scholar
Rosiglitazone modulates innate immune responses to Plasmodium falciparum and improves outcome in experimental cerebral malaria
L. Serghides, Samir N. Patel, K. Ayi, Ziyue Lu +3 more
2009Journal of Infectious Diseases69 citations Open access
Semantic Scholar
A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop
D. Roberts, A. Edlow, R. Romero, Carolyn B. Coyne +7 more
2021American Journal of Obstetrics and Gynecology63 citations Open access
Semantic Scholar
Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes.
S. Nathoo, L. Serghides, K. Kain
2003The Lancet63 citations
Semantic Scholar
PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria
L. Serghides, Chloe R. McDonald, Ziyue Lu, Miriam Friedel +5 more
2014PLoS Pathogens59 citations Open access
Semantic Scholar
A phase I clinical study of inhaled nitric oxide in healthy adults.
Chris C. Miller, Minna Miller, B. McMullin, G. Regev +4 more
2012Journal of Cystic Fibrosis57 citations Open access
Semantic Scholar
Functional Roles for C5a and C5aR but Not C5L2 in the Pathogenesis of Human and Experimental Cerebral Malaria
Hani Kim, Laura K. Erdman, Ziyue Lu, L. Serghides +7 more
2013Infection and Immunity54 citations Open access
Semantic Scholar
Cerebral malaria: human versus mouse studies.
M. Stevenson, P. Gros, M. Olivier, A. Fortin +1 more
2010Trends in Parasitology53 citations
Semantic Scholar
Disruption of JNK2 Decreases the Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol In Vitro and Confers Protection in a Cerebral Malaria Model1
Ziyue Lu, L. Serghides, Samir N. Patel, N. Degousée +5 more
2006Journal of Immunology51 citations
Semantic Scholar
Nonopsonic Phagocytosis of Erythrocytes Infected with Ring-Stage Plasmodium falciparum
K. Ayi, Samir N. Patel, L. Serghides, T. G. Smith +1 more
2005Infection and Immunity47 citations Open access
Semantic Scholar
The importance of motherhood in HIV-positive women of reproductive age in Ontario, Canada
V. L. Kennedy, L. Serghides, J. Raboud, Desheng Su +8 more
2013AIDS Care44 citations
Semantic Scholar
Caspase-12 Dampens the Immune Response to Malaria Independently of the Inflammasome by Targeting NF-κB Signaling
K. Labbé, J. Miu, G. Yeretssian, L. Serghides +7 more
2010Journal of Immunology44 citations Open access
Semantic Scholar
Perinatal outcomes in women living with HIV‐1 and receiving antiretroviral therapy—a systematic review and meta‐analysis
S. Shinar, S. Agrawal, M. Ryu, S. Walmsley +3 more
2021Acta Obstetricia et Gynecologica Scandinavica41 citations Open access
Semantic Scholar
CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo
K. Ayi, Ziyue Lu, L. Serghides, J. Ho +4 more
2016Infection and Immunity41 citations Open access
Semantic Scholar
HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation
H. Mohammadi, Eszter Papp, L. Cahill, Monique Y. Rennie +7 more
2018Scientific Reports40 citations Open access
Semantic Scholar
Surviving and Thriving—Shifting the Public Health Response to HIV-Exposed Uninfected Children: Report of the 3rd HIV-Exposed Uninfected Child Workshop
A. Slogrove, R. Becquet, E. Chadwick, H. Côté +13 more
2018Frontiers in Pediatrics37 citations Open access
Semantic Scholar
Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels
H. Mohan, Monica S. Guzman Lenis, E. Y. Laurette, O. Tejada +8 more
2020EBioMedicine35 citations Open access
Semantic Scholar
HIV Infection Deregulates Tim-3 Expression on Innate Cells: Combination Antiretroviral Therapy Results in Partial Restoration
Constance A. M. Finney, K. Ayi, J. Wasmuth, P. Sheth +4 more
2013Journal of Acquired Immune Deficiency Syndromes35 citations Open access
Semantic Scholar
Placental chondroitin sulfate A-binding malarial isolates evade innate phagocytic clearance.
L. Serghides, Samir N. Patel, K. Ayi, K. Kain
2006Journal of Infectious Diseases30 citations Open access
Semantic Scholar
Low Prolactin and High 20-α-Hydroxysteroid Dehydrogenase Levels Contribute to Lower Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease Inhibitor-Based Combination Antiretroviral Therapy.
Eszter Papp, K. Balogun, Nicole S. Banko, H. Mohammadi +8 more
2016Journal of Infectious Diseases29 citations Open access
Semantic Scholar
Wave reflections in the umbilical artery measured by Doppler ultrasound as a novel predictor of placental pathology
L. Cahill, Greg Stortz, A. RAVI CHANDRAN, N. Milligan +22 more
2021EBioMedicine27 citations Open access
Semantic Scholar
In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes
M. McHenry, K. Balogun, B. McDonald, R. Vreeman +2 more
2019Journal of the International AIDS Society26 citations Open access
Semantic Scholar
NITRIC OXIDE FOR THE ADJUNCTIVE TREATMENT OF SEVERE MALARIA: HYPOTHESIS AND RATIONALE
M. Hawkes, R. Opoka, S. Namasopo, Chris C. Miller +7 more
2011Medical Hypotheses26 citations Open access
Semantic Scholar
Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta
J. Gilmore, M. T. Hoque, Wan-An Dai, H. Mohan +3 more
2021EBioMedicine25 citations Open access
Semantic Scholar
Estradiol Levels Are Altered in Human Immunodeficiency Virus–Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy
Chloe R. McDonald, A. Conroy, Joel L. Gamble, Eszter Papp +10 more
2017Clinical Infectious Diseases23 citations Open access
Semantic Scholar
Protease inhibitor-based antiretroviral therapy in pregnancy: effects on hormones, placenta, and decidua
C. Dunk, L. Serghides
2021The Lancet HIV22 citations
Semantic Scholar
HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy
Constance A. M. Finney, K. Ayi, J. Wasmuth, P. Sheth +4 more
2013AIDS (London)22 citations Open access
Semantic Scholar
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies
Smriti Kala, C. Dunk, Sebastian Acosta, L. Serghides
2020Human Reproduction21 citations Open access
Semantic Scholar
Placental vascular abnormalities in the mouse alter umbilical artery wave reflections.
L. Cahill, Yu-Qing Zhou, Johnathan Hoggarth, Lisa X. Yu +8 more
2019American Journal of Physiology. Heart and Circulatory Physiology20 citations Open access
Semantic Scholar
Improving the clinical relevance of a mouse pregnancy model of antiretroviral toxicity; a pharmacokinetic dosing‐optimization study of current HIV antiretroviral regimens
Smriti Kala, B. Watson, J. Zhang, Eszter Papp +5 more
2018Antiviral Research20 citations
Semantic Scholar
Reflected hemodynamic waves influence the pattern of Doppler ultrasound waveforms along the umbilical arteries.
J. Sled, Greg Stortz, L. Cahill, N. Milligan +9 more
2019American Journal of Physiology. Heart and Circulatory Physiology19 citations Open access
Semantic Scholar
Elevated Levels of Estradiol in Human Immunodeficiency Virus–Infected Pregnant Women on Protease Inhibitor–Based Regimens
K. Balogun, M. G. Guzman Lenis, Eszter Papp, M. Loutfy +5 more
2017Clinical Infectious Diseases19 citations Open access
Semantic Scholar
Role of HIV and Antiretroviral Therapy on the Expression of Placental Transporters in Women with HIV
D. Kojovic, Ragia H. Ghoneim, L. Serghides, M. Piquette-Miller
2020AAPS Journal18 citations
Semantic Scholar
Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria
R. Varo, Valerie M. Crowley, A. Sitoe, L. Madrid +6 more
2017Malaria Journal17 citations Open access
Semantic Scholar
Exploring the impact of HIV infection and antiretroviral therapy on placenta morphology.
M. Yampolsky, O. Shlakhter, Dianna Deng, Smriti Kala +7 more
2020Placenta16 citations Open access
Semantic Scholar
Wharton’s jelly area and its association with placental morphometry and pathology
Sarah K Debebe, L. Cahill, J. Kingdom, C. Whitehead +6 more
2020Placenta14 citations Open access
Semantic Scholar
Unique profile of inflammation and immune activation in pregnant people with HIV in the United States.
Stephanie Shiau, Denise L. Jacobson, Yan-Ling Huo, D. Kacanek +8 more
2023Journal of Infectious Diseases13 citations Open access
Semantic Scholar

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