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R. Staack · SciRah

Researcher profile · Semantic Scholar

R. Staack

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R. Staack — researcher profile on SciRah

h-index: 28
Works: 90
Citations: 2,362

Most-cited papers

Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry.
Frank T. Peters, Simone Schaefer, R. Staack, T. Kraemer +1 more
2003Journal of Mass Spectrometry168 citations
Semantic Scholar
Chemistry, Pharmacology, Toxicology, and Hepatic Metabolism of Designer Drugs of the Amphetamine (Ecstasy), Piperazine, and Pyrrolidinophenone Types: A Synopsis
H. Maurer, T. Kraemer, D. Springer, R. Staack
2004Therapeutic Drug Monitoring153 citations
Semantic Scholar
Metabolism of designer drugs of abuse.
R. Staack, H. Maurer
2005Current drug metabolism136 citations
Semantic Scholar
Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time-of-flight mass spectrometry.
L. Signor, E. Varesio, R. Staack, V. Starke +2 more
2007Journal of Mass Spectrometry105 citations Open access
Semantic Scholar
Studies on the metabolism and toxicological detection of the new designer drug N-benzylpiperazine in urine using gas chromatography-mass spectrometry.
R. Staack, G. Fritschi, H. Maurer
2002Journal of chromatography. B, Analytical technologies in the biomedical and life sciences99 citations
Semantic Scholar
Quality requirements for critical assay reagents used in bioanalysis of therapeutic proteins: what bioanalysts should know about their reagents.
R. Staack, J. Stracke, K. Stubenrauch, Rudolf Vogel +2 more
2011Bioanalysis76 citations
Semantic Scholar
2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, B
S. Piccoli, Devangi Mehta, A. Vitaliti, J. Allinson +69 more
2019Bioanalysis75 citations Open access
Semantic Scholar
New designer drug 1-(3-trifluoromethylphenyl) piperazine (TFMPP): gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry studies on its phase I and II metabolism and on its toxicological detection in rat urine.
R. Staack, Gieselher Fritschi, H. Maurer
2003Journal of Mass Spectrometry72 citations
Semantic Scholar
New analytical strategies in studying drug metabolism
R. Staack, G. Hopfgartner
2007Analytical and Bioanalytical Chemistry62 citations Open access
Semantic Scholar
2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays).
Shalini Gupta, S. Richards, L. Amaravadi, S. Piccoli +63 more
2017Bioanalysis53 citations Open access
Semantic Scholar
Characterization of a re‐engineered, mesothelin‐targeted Pseudomonas exotoxin fusion protein for lung cancer therapy
F. Bauss, M. Lechmann, Ben-Fillippo Krippendorff, R. Staack +16 more
2016Molecular Oncology52 citations Open access
Semantic Scholar
2015 White Paper on recent issues in bioanalysis: focus on new technologies and biomarkers (Part 3--LBA, biomarkers and immunogenicity).
L. Amaravadi, An Song, H. Myler, T. Thway +45 more
2015Bioanalysis51 citations Open access
Semantic Scholar
Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition.
Rebecca Croasdale, K. Wartha, J. Schanzer, K. Kuenkele +19 more
2012Archives of Biochemistry and Biophysics51 citations
Semantic Scholar
Piperazine designer drugs of abuse.
R. Staack
2007The Lancet51 citations
Semantic Scholar
Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone.
R. Staack, H. Maurer
2003Journal of Analytical Toxicology51 citations
Semantic Scholar
New designer drug p-methoxymethamphetamine: studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry.
R. Staack, J. Fehn, H. Maurer
2003Journal of chromatography. B, Analytical technologies in the biomedical and life sciences49 citations
Semantic Scholar
Proof of a 1-(3-chlorophenyl)piperazine (mCPP) intake: use as adulterant of cocaine resulting in drug-drug interactions?
R. Staack, L. D. Paul, D. Schmid, G. Roider +1 more
2007Journal of chromatography. B, Analytical technologies in the biomedical and life sciences48 citations
Semantic Scholar
New designer drug 1-(3,4-methylenedioxybenzyl) piperazine (MDBP): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry.
R. Staack, H. Maurer
2004Journal of Mass Spectrometry48 citations
Semantic Scholar
Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes.
R. Staack, L. D. Paul, D. Springer, T. Kraemer +1 more
2004Biochemical Pharmacology46 citations
Semantic Scholar
The combination of liquid chromatography/tandem mass spectrometry and chip-based infusion for improved screening and characterization of drug metabolites.
R. Staack, E. Varesio, G. Hopfgartner
2005Rapid Communications in Mass Spectrometry43 citations Open access
Semantic Scholar
Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges
S. Schadt, Simon Hauri, Filipe Lopes, Martin R. Edelmann +7 more
2019Drug Metabolism And Disposition40 citations Open access
Semantic Scholar
2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 3 - LBA, biomarkers and immunogenicity).
S. Richards, L. Amaravadi, R. Pillutla, H. Birnboeck +49 more
2016Bioanalysis40 citations Open access
Semantic Scholar
In vivo metabolism of the new designer drug 1-(4-methoxyphenyl)piperazine (MeOPP) in rat and identification of the human cytochrome P450 enzymes responsible for the major metabolic step
R. Staack, Denis S. Theobald, L. D. Paul, D. Springer +2 more
2004Xenobiotica; the fate of foreign compounds in biological systems40 citations
Semantic Scholar
Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.
R. Staack, H. Maurer
2003Journal of chromatography. B, Analytical technologies in the biomedical and life sciences37 citations
Semantic Scholar
New designer drug 2,5-dimethoxy-4-ethylthio-beta-phenethylamine (2C-T-2): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry.
Denis S. Theobald, R. Staack, M. Puetz, H. Maurer
2005Journal of Mass Spectrometry35 citations
Semantic Scholar
Identification of human cytochrome P450 2D6 as major enzyme involved in the O-demethylation of the designer drug p-methoxymethamphetamine.
R. Staack, Denis S. Theobald, L. D. Paul, D. Springer +2 more
2004Drug Metabolism And Disposition35 citations
Semantic Scholar
2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays).
Lauren F. Stevenson, S. Richards, R. Pillutla, A. Torri +68 more
2018Bioanalysis33 citations
Semantic Scholar
Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes.
D. Springer, L. D. Paul, R. Staack, T. Kraemer +1 more
2003Drug Metabolism And Disposition29 citations
Semantic Scholar
The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance
Eugenia Opolka-Hoffmann, Gregor Jordan, Michael B. Otteneder, Robin Kieferle +3 more
2021mAbs27 citations Open access
Semantic Scholar
Mathematical simulations for bioanalytical assay development: the (un-)necessity and (im-)possibility of free drug quantification.
R. Staack, Gregor Jordan, Julia Heinrich
2012Bioanalysis26 citations
Semantic Scholar
New designer drugs N-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA) and N-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA): Studies on their metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques.
C. Sauer, Frank T. Peters, R. Staack, G. Fritschi +1 more
2008Journal of Mass Spectrometry24 citations
Semantic Scholar
Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine.
L. D. Paul, D. Springer, R. Staack, T. Kraemer +1 more
2004European Journal of Pharmacology23 citations
Semantic Scholar
Identification of cytochrome P450 enzymes involved in the metabolism of 4′-methoxy-α-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomes
D. Springer, R. Staack, L. D. Paul, T. Kraemer +1 more
200323 citations
Semantic Scholar
Free analyte QC concept: a novel approach to prove correct quantification of free therapeutic protein drug/biomarker concentrations.
R. Staack, Gregor Jordan, Uwe Dahl, Julia Heinrich
2014Bioanalysis21 citations
Semantic Scholar
Investigating the in vitro metabolism of fipexide: characterization of reactive metabolites using liquid chromatography/mass spectrometry.
L. Sleno, R. Staack, E. Varesio, G. Hopfgartner
2007Rapid Communications in Mass Spectrometry20 citations Open access
Semantic Scholar
New designer drug N-(1-phenylcyclohexyl)-3-ethoxypropanamine (PCEPA): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques.
C. Sauer, Frank T. Peters, R. Staack, G. Fritschi +1 more
2006Journal of Mass Spectrometry20 citations
Semantic Scholar
Identification of cytochrome P450 enzymes involved in the metabolism of 3′,4′-methylenedioxy-α-pyrrolidinopropiophenone (MDPPP), a designer drug, in human liver microsomes
D. Springer, R. Staack, L. D. Paul, T. Kraemer +1 more
2005Xenobiotica; the fate of foreign compounds in biological systems20 citations
Semantic Scholar
In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.
M. Zell, Christophe Husser, R. Staack, Gregor Jordan +3 more
2016Analytical Chemistry18 citations
Semantic Scholar
Proposal for a harmonized descriptive analyte nomenclature for quantitative large-molecule bioanalysis.
Julia Heinrich, R. Staack, K. Stubenrauch, A. Papadimitriou
2015Bioanalysis18 citations Open access
Semantic Scholar
Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure
A. Spreafico, E. M. Couselo, A. Irmisch, J. Bessa +19 more
2024Frontiers in Oncology17 citations Open access
Semantic Scholar
Toward comparability of anti-drug antibody assays: is the amount of anti-drug antibody-reagent complexes at cut-point (CP-ARC) the missing piece?
Gregor Jordan, R. Staack
2020Bioanalysis17 citations Open access
Semantic Scholar
Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies
Eugenia Hoffmann, Gregor Jordan, Matthias E. Lauer, P. Ringler +6 more
2019Pharmaceutical Research17 citations Open access
Semantic Scholar
Fenproporex N-dealkylation to amphetamine--enantioselective in vitro studies in human liver microsomes as well as enantioselective in vivo studies in Wistar and Dark Agouti rats.
T. Kraemer, Thomas Pflugmann, Michael Bossmann, N. M. Kneller +5 more
2004Biochemical Pharmacology17 citations
Semantic Scholar
Studies on the metabolism and the toxicological analysis of the nootropic drug fipexide in rat urine using gas chromatography-mass spectrometry.
R. Staack, H. Maurer
2004Journal of chromatography. B, Analytical technologies in the biomedical and life sciences17 citations
Semantic Scholar
Studies on the Human Metabolism and the Toxicologic Detection of the Cough Suppressant Dropropizine in Urine Using Gas Chromatography-Mass Spectrometry
R. Staack, Denis S. Theobald, H. Maurer
2004Therapeutic Drug Monitoring16 citations
Semantic Scholar
Metabolism and toxicological detection of a new designer drug, N-(1-phenylcyclohexyl)propanamine, in rat urine using gas chromatography-mass spectrometry.
C. Sauer, Frank T. Peters, R. Staack, G. Fritschi +1 more
2008Journal of Chromatography A15 citations
Semantic Scholar
New Bühlmann ELISA for determination of Amanitins in urine - Are there false positive results due to interferences with ur ine matrix, drugs or their metabolites?
R. Staack, H. Maurer
200015 citations
Semantic Scholar
Validation of a ligand-binding assay for active protein drug quantification following the 'free analyte QC concept'.
Eginhard Schick, R. Staack, Markus Haak, Gregor Jordan +4 more
2016Bioanalysis14 citations
Semantic Scholar
High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths.
Bo An, Ming Zhang, Jie Pu, S. Shen +15 more
2019Analytical Chemistry12 citations
Semantic Scholar
Can LC-MS/MS and ligand-binding assays live in harmony for large-molecule bioanalysis?
A. Papadimitriou, Surendra Bansal, Julia Heinrich, R. Staack
2014Bioanalysis12 citations
Semantic Scholar

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T. Kraemer×9
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D. Springer×9
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L. D. Paul×9
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A. Papadimitriou

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