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T. Higenbottam · SciRah

Researcher profile · Semantic Scholar

T. Higenbottam

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T. Higenbottam — researcher profile on SciRah

h-index: 50
Works: 254
Citations: 15K

Most-cited papers

Inhaled iloprost for severe pulmonary hypertension.
H. Olschewski, G. Simonneau, N. Galie', T. Higenbottam +19 more
2002New England Journal of Medicine1,628 citations Open access
Semantic Scholar
Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology.
N. Galie', A. Torbicki, R. Barst, P. Dartevelle +28 more
2004European Heart Journal1,094 citations Open access
Semantic Scholar
Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group.
L. Abenhaim, Y. Moride, F. Brénot, S. Rich +8 more
1996New England Journal of Medicine925 citations Open access
Semantic Scholar
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family
J. Thomson, R. Machado, M. Pauciulo, N. Morgan +18 more
2000Journal of Medical Genetics749 citations Open access
Semantic Scholar
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
D. Shaw, A. Sousa, S. Fowler, L. Fleming +51 more
2015European Respiratory Journal529 citations Open access
Semantic Scholar
Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study.
S. Kudoh, H. Kato, Y. Nishiwaki, M. Fukuoka +12 more
2008American Journal of Respiratory and Critical Care Medicine412 citations
Semantic Scholar
Clinical exercise testing with reference to lung diseases: indications, standardization and interpretation strategies. ERS Task Force on Standardization of Clinical Exercise Testing. European Respiratory Society.
J. Roca, B. Whipp, A. Agustí, S. D. Anderson +13 more
1997European Respiratory Journal355 citations Open access
Semantic Scholar
Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease.
J. Barberà, N. Roger, J. Roca, R. Rodríguez-Roisín +2 more
1996The Lancet278 citations
Semantic Scholar
Long term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension
T. Higenbottam, A. Butt, A. McMahon, R. Westerbeck +1 more
1998Heart209 citations Open access
Semantic Scholar
[Guidelines on diagnosis and treatment of pulmonary arterial hypertension].
N. Galie', A. Torbicki, R. Barst, P. Dartevelle +7 more
2005Revista Española de Cardiología171 citations
Semantic Scholar
Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD
K. Vonbank, R. Ziesche, T. Higenbottam, L. Stiebellehner +4 more
2003Thorax170 citations Open access
Semantic Scholar
Exhaled nitric oxide in isolated pig lungs.
G. Cremona, T. Higenbottam, M. Takao, L. Hall +1 more
1995Journal of applied physiology135 citations
Semantic Scholar
The role of thrombosis in severe pulmonary hypertension.
A. Chaouat, E. Weitzenblum, T. Higenbottam
1996European Respiratory Journal134 citations Open access
Semantic Scholar
Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost
T. Higenbottam, A. Butt, A. T. Dinh-Xaun, M. Takao +2 more
1998Heart115 citations Open access
Semantic Scholar
Relationship between respiratory symptoms and medical treatment in exacerbations of COPD
P. Calverley, R. Pauwels, Clas-Göran Löfdahl, K. Svensson +3 more
2005European Respiratory Journal101 citations Open access
Semantic Scholar
Understanding the mechanisms of drug-associated interstitial lung disease
T. Higenbottam, K. Kuwano, B. Nemery, Y. Fujita
2004British Journal of Cancer88 citations Open access
Semantic Scholar
Exhaled nitric oxide is reduced in infants with cystic fibrosis
Heather E. Elphick, Eric A. G. Demoncheaux, S. Ritson, T. Higenbottam +1 more
2001Thorax84 citations Open access
Semantic Scholar
Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension.
D. Langleben, B. Christman, R. Barst, V. C. Dias +17 more
2002American Heart Journal82 citations
Semantic Scholar
Eradication of house dust mite from homes of atopic asthmatic subjects: a double-blind trial.
T. Htut, T. Higenbottam, Gordon W. Gill, Ruth Darwin +2 more
2001Journal of Allergy and Clinical Immunology80 citations Open access
Semantic Scholar
Chronic cough and the cough reflex in common lung diseases.
T. Higenbottam
2002Pulmonary Pharmacology & Therapeutics68 citations
Semantic Scholar
Bronchiolitis obliterans syndrome in heart-lung transplantation: surveillance biopsies.
M. Tamm, L. Sharples, T. Higenbottam, S. Stewart +1 more
1997American Journal of Respiratory and Critical Care Medicine62 citations
Semantic Scholar
Caution with use of inhaled nitric oxide.
J. Warren, T. Higenbottam
1996The Lancet62 citations
Semantic Scholar
Personalized medicine and proteomics: lessons from non-small cell lung cancer.
G. Marko-Varga, A. Ogiwara, T. Nishimura, T. Kawamura +23 more
2007Journal of Proteome Research56 citations
Semantic Scholar
Interaction between smoking and genetic factors in the development of chronic bronchitis.
J. Hallberg, A. Dominicus, Ulrika K. Eriksson, Maria Gerhardsson de Verdier +5 more
2008American Journal of Respiratory and Critical Care Medicine53 citations Open access
Semantic Scholar
Pulmonary hypertension and chronic obstructive pulmonary disease: a case for treatment.
T. Higenbottam
2005Proceedings of the American Thoracic Society51 citations
Semantic Scholar
Circulating nitrite anions are a directly acting vasodilator and are donors for nitric oxide.
Eric A. G. Demoncheaux, T. Higenbottam, P. J. Foster, C. Borland +5 more
2002Clinical science51 citations
Semantic Scholar
Decreased Whole Body Endogenous Nitric Oxide Production in Patients with Primary Pulmonary Hypertension
Eric A. G. Demoncheaux, T. Higenbottam, D. Kiely, J. Wong +6 more
2005Journal of Vascular Research50 citations
Semantic Scholar
Randomized controlled trials define shape of dose response for Pollinex Quattro Birch allergoid immunotherapy
Margitta Worm, T. Higenbottam, O. Pfaar, R. Mösges +8 more
2018Allergy. European Journal of Allergy and Clinical Immunology39 citations Open access
Semantic Scholar
Detection of COPD Exacerbations and Compliance With Patient-Reported Daily Symptom Diaries Using a Smartphone-Based Information System
N. Johnston, K. Lambert, P. Hussack, M. G. de Verdier +7 more
2013Chest39 citations Open access
Semantic Scholar
Nitric oxide gas decreases endothelin-1 mRNA in cultured pulmonary artery endothelial cells.
Adrian P. L. Smith, Eric A. G. Demoncheaux, T. Higenbottam
2002Nitric oxide38 citations
Semantic Scholar
National differences in reporting ‘pneumonia’ and ‘pneumonia interstitial’: an analysis of the WHO International Drug Monitoring Database on 15 drugs in nine countries for seven pulmonary conditions
L. C. Koo, John A. Clark, Charles P. Quesenberry, T. Higenbottam +4 more
2005Pharmacoepidemiology and Drug Safety36 citations
Semantic Scholar
A trial of beclomethasone/formoterol in COPD using EXACT-PRO to measure exacerbations
Dave Singh, J. Kampschulte, J. Wedzicha, P. Jones +5 more
2012European Respiratory Journal34 citations Open access
Semantic Scholar
Genetic and environmental influence on lung function impairment in Swedish twins
J. Hallberg, A. Iliadou, Martin Anderson, M. G. de Verdier +5 more
2010Respiratory Research34 citations Open access
Semantic Scholar
Induction of nitric oxide synthase II does not account for excess vascular nitric oxide production in experimental cirrhosis.
Philippe Sogni, Adrian P. L. Smith, A. Gadano, D. Lebrec +1 more
1997Journal of Hepatology33 citations
Semantic Scholar
The Innovative Medicines Initiative (IMI): a new opportunity for scientific collaboration between academia and industry at the European level
N. Kamel, Chris Compton, R. Middelveld, T. Higenbottam +1 more
2008European Respiratory Journal32 citations Open access
Semantic Scholar
Quantifying of severity of exacerbations in chronic obstructive pulmonary disease: adaptations to the definition to allow quantification.
P. Jones, T. Higenbottam
2007Proceedings of the American Thoracic Society31 citations
Semantic Scholar
Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status.
Á. Cruz, J. Riley, A. Bansal, E. Ponte +144 more
2019Respiratory Medicine28 citations Open access
Semantic Scholar
UK guidelines for the use of inhaled nitric oxide therapy in adult ICUs
B. Cuthbertson, P. Dellinger, O. Dyar, T. Evans +6 more
1997Intensive Care Medicine27 citations Open access
Semantic Scholar
Breathomics for Assessing the Effects of Treatment and Withdrawal With Inhaled Beclomethasone/Formoterol in Patients With COPD
P. Montuschi, G. Santini, N. Mores, A. Vignoli +11 more
2018Frontiers in Pharmacology25 citations Open access
Semantic Scholar
Proteomic Biomarkers for Acute Interstitial Lung Disease in Gefitinib-Treated Japanese Lung Cancer Patients
F. Nyberg, A. Ogiwara, C. Harbron, T. Kawakami +21 more
2011PLoS ONE25 citations Open access
Semantic Scholar
Treatments for severe pulmonary hypertension.
T. Higenbottam, K. Stenmark, G. Simonneau
1999The Lancet23 citations
Semantic Scholar
Patterns of Physical Activity Progression in Patients With COPD.
M. Koreny, H. Demeyer, M. Benet, A. Arbillaga-Etxarri +52 more
2020Archivos de Bronconeumologia18 citations Open access
Semantic Scholar
NMR-based metabolomics for the assessment of inhaled pharmacotherapy in Chronic Obstructive Pulmonary Disease patients.
A. Vignoli, G. Santini, L. Tenori, G. Macis +6 more
2019Journal of Proteome Research18 citations Open access
Semantic Scholar
The Christmas season as a risk factor for chronic obstructive pulmonary disease exacerbations.
N. Johnston, A. McIvor, N. KimLambertReg, J. Greene +7 more
2010Canadian Respiratory Journal18 citations Open access
Semantic Scholar
Transcriptome analysis and safety profile of the early-phase clinical response to an adjuvanted grass allergoid immunotherapy
S. Starchenka, M. Heath, Alyson Lineberry, T. Higenbottam +1 more
2019The World Allergy Organization Journal16 citations Open access
Semantic Scholar
Trials of inhaled iloprost and other new vasodilating prostaglandins.
T. Higenbottam, T. Siddons
2001European Respiratory Journal16 citations Open access
Semantic Scholar
Effects of an NO-Synthase Inhibitor L-NMMA in the Hepatopulmonary Syndrome
M. Maniscalco, M. Sofia, T. Higenbottam
2001Respiration15 citations
Semantic Scholar
Bronchiolitis obliterans following the ingestion of an Asian shrub leaf
T. Higenbottam
1997Thorax14 citations Open access
Semantic Scholar
U-BIOPRED: evaluation of the value of a public-private partnership to industry.
J. Riley, V. Erpenbeck, J. Matthews, C. Holweg +6 more
2018Drug Discovery Today13 citations
Semantic Scholar
A therapeutic role for chronic inhaled nitric oxide?
T. Higenbottam, T. Siddons, Eric A. G. Demoncheaux
2000The Lancet12 citations
Semantic Scholar

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Eric A. G. Demoncheaux×5
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