K. Handley

Most-cited papers

1. Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer.

   G. Hutchins, K. Southward, K. Handley, L. Magill +8 more

   2011Journal of Clinical Oncology705 citations Open access

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2. aTTom: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer.

   R. Gray, D. Rea, K. Handley, S. Bowden +17 more

   2013Journal of Clinical Oncology520 citations

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3. Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer.

   R. Gray, P. Quirke, K. Handley, M. Lopatin +9 more

   2011Journal of Clinical Oncology379 citations

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4. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial

   D. Morton, M. Seymour, L. Magill, K. Handley +9 more

   2023Journal of Clinical Oncology328 citations Open access

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5. HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials

   S. Richman, K. Southward, P. Chambers, D. Cross +15 more

   2016Journal of Pathology238 citations Open access

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6. Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

   S. Bach, A. Gilbert, K. Brock, S. Korsgen +149 more

   2020The Lancet Gastroenterology and Hepatology172 citations Open access

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7. Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial)

   R. Ravikumar, D. Bartlett, D. Morton, L. Berkman +274 more

   2017British medical journal150 citations Open access

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8. Accuracy of radiological staging in identifying high‐risk colon cancer patients suitable for neoadjuvant chemotherapy: a multicentre experience

   S. Dighe, I. Swift, L. Magill, K. Handley +6 more

   2012Colorectal Disease114 citations

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9. Evaluation of the efficacy and safety of adjuvant treatment to levodopa therapy in Parkinson s disease patients with motor complications.

   R. Stowe, N. Ives, C. Clarke, Katherine H. O. Deane +4 more

   2010Cochrane Database of Systematic Reviews113 citations Open access

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10. Can we Save the rectum by watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC study)?: protocol for a multicentre, randomised feasibility study

    A. Rombouts, I. al-Najami, N. Abbott, A. Appelt +21 more

    2017BMJ Open105 citations Open access

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11. Meta‐analysis of the comparative efficacy and safety of adjuvant treatment to levodopa in later Parkinson's disease

    R. Stowe, N. Ives, Carl E. Clarke, K. Handley +5 more

    2011Movement Disorders97 citations

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12. Intravenous remifentanil patient-controlled analgesia versus intramuscular pethidine for pain relief in labour (RESPITE): an open-label, multicentre, randomised controlled trial.

    Matthew J A Wilson, C. MacArthur, C. Hewitt, K. Handley +3 more

    2018The Lancet75 citations Open access

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13. aTTom (adjuvant Tamoxifen--To offer more?): Randomized trial of 10 versus 5 years of adjuvant tamoxifen among 6,934 women with estrogen receptor-positive (ER+) or ER untested breast cancer--Preliminary results

    R. Gray, D. Rea, K. Handley, A. Marshall +6 more

    200873 citations Open access

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14. Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial

    Aneel Dmitri Natalie Laura James Colm Thue Kelly Samir D Bhangu Nepogodiev Ives Magill Glasbey Forde Bisgaa, A. Bhangu, D. Nepogodiev, N. Ives +394 more

    2020The Lancet56 citations Open access

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15. CREST: Randomised phase III study of stenting as a bridge to surgery in obstructing colorectal cancer--Results of the UK ColoRectal Endoscopic Stenting Trial (CREST).

    James O. Hill, C. Kay, D. Morton, L. Magill +2 more

    201638 citations

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16. Anal fistula plug versus surgeon's preference for surgery for trans-sphincteric anal fistula: the FIAT RCT.

    D. Jayne, J. Scholefield, D. Tolan, R. Gray +7 more

    2019Health Technology Assessment37 citations Open access

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17. Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial

    Y. Acherman, N. Arebi, Elizabeth A. Arthurs, Willem A. Bemelman +58 more

    2025The Lancet Gastroenterology and Hepatology30 citations Open access

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18. A multicentre randomised controlled trial comparing safety, efficacy, and cost-effectiveness of the Surgisis® anal fistula plug versus surgeon’s preference for transsphincteric fistula-in-ano: the FIAT trial.

    D. Jayne, J. Scholefield, D. Tolan, R. Gray +9 more

    202128 citations

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19. Intratumoral stromal morphometry predicts disease recurrence but not response to 5‐fluorouracil—results from the QUASAR trial of colorectal cancer

    G. Hutchins, D. Treanor, A. Wright, K. Handley +7 more

    2018Histopathology28 citations Open access

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20. Overall and subgroup findings of the aTTom trial: A randomised comparison of continuing adjuvant tamoxifen to 10 years compared to stopping after 5 years in 6953 women with ER positive or ER untested early breast cancer

    D. Rea, R. Gray, S. Bowden, K. Handley +6 more

    201326 citations

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21. Prognostic and Predictive Value of Tumor Budding in Colorectal Cancer.

    Bojan Mitrović, K. Handley, N. Assarzadegan, H. Chang +8 more

    2021Clinical colorectal cancer20 citations

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22. Dexamethasone reduces emesis after major gastrointestinal surgery (DREAMS)

    E. Hamilton, R. Ravikumar, D. Bartlett, E. Hepburn +8 more

    2013Trials20 citations Open access

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23. A Multicenter Randomized Controlled Trial Comparing Safety, Efficacy, and Cost-effectiveness of the Surgisis Anal Fistula Plug Versus Surgeon's Preference for Transsphincteric Fistula-in-Ano

    D. Jayne, J. Scholefield, D. Tolan, R. Gray +7 more

    2020Annals of Surgery19 citations Open access

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24. Study protocol for a randomised controlled trial of carvedilol versus variceal band ligation in primary prevention of variceal bleeding in liver cirrhosis (CALIBRE trial)

    D. Tripathi, P. Hayes, P. Richardson, I. Rowe +10 more

    2019BMJ Open Gastroenterology18 citations Open access

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25. Confirmation that somatic mutations of beta‐2 microglobulin correlate with a lack of recurrence in a subset of stage II mismatch repair deficient colorectal cancers from the QUASAR trial

    P. Barrow, S. Richman, A. Wallace, K. Handley +7 more

    2019Histopathology15 citations Open access

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26. Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision

    A. Gilbert, Victoria Homer, K. Brock, S. Korsgen +149 more

    2022The Lancet Healthy Longevity13 citations Open access

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27. The RESPITE trial: remifentanil intravenously administered patient-controlled analgesia (PCA) versus pethidine intramuscular injection for pain relief in labour: study protocol for a randomised controlled trial

    Matthew J A Wilson, C. MacArthur, Fang Gao Smith, Leanne Homer +2 more

    2016Trials13 citations Open access

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28. Effect of renal artery revascularization upon cardiac structure and function in atherosclerotic renal artery stenosis: cardiac magnetic resonance sub-study of the ASTRAL trial

    J. Ritchie, D. Green, T. Chrysochou, J. Hegarty +15 more

    2016Nephrology, Dialysis and Transplantation11 citations Open access

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29. Mixed effect modelling of proteomic mass spectrometry data by using Gaussian mixtures

    W. Browne, I. Dryden, K. Handley, S. Mian +1 more

    201011 citations Open access

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30. Prognostic and predictive value of tumour budding in stage II colorectal carcinoma.

    Bojan Mitrović, K. Handley, N. Assarzadegan, H. Chang +8 more

    20155 citations

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31. Cardiac structure and function after revascularization versus medical therapy for renal artery stenosis: the ASTRAL heart echocardiographic sub-study

    D. Green, D. Vassallo, K. Handley, N. Ives +15 more

    2019BMC Nephrology3 citations Open access

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32. FOxTROT: Randomized phase II study of neoadjuvant chemotherapy (CT) with or without an anti-EGFR monoclonal antibody for locally advanced, operable colon cancer: Planned interim report.

    D. Morton, L. Magill, K. Handley, G. Brown +6 more

    2011Journal of Clinical Oncology2 citations

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33. Statistical analysis of proteomic mass spectrometry data

    K. Handley

    20072 citations

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34. Bayesian Analysis of SELDI-TOF data

    K. Handley, W. Browne, I. Dryden

    20052 citations

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35. Pre-operative FOLFOX chemotherapy in advanced colon cancer: Pathology analysis of the FOxTROT trial

    N. West, K. Murakami, L. Magill, R. Gray +4 more

    2019Annals of Oncology1 citations Open access

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36. The ACCURE-UK trial: The effect of appendectomy on the clinical course of ulcerative colitis – A feasibility study

    D. Nepogodiev, R. Howard, S. Pathmakanthan, T. Iqbal +12 more

    20161 citations Open access

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37. Proceedings in Quantitative Biology, Shape Analysis, and Wavelets, LASR2005, University of Leeds

    I. Dryden, S. Main, W. Browne, K. Handley +2 more

    20051 citations

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38. Reply to S. Chakrabarti et al, R. Cohen et al, and D.C. Guven.

    Richard Gray, M. Seymour, L. Magill, K. Handley +3 more

    2023Journal of Clinical Oncology0 citations Open access

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39. PS04 Assessment and management of patients with vitiligo and psychological distress: clinician survey

    R. Barlow, Alia Ahmed, J. Fellows, J. Goulding +7 more

    2023British Journal of Dermatology0 citations Open access

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40. A Multicentre Randomised Controlled Trial Comparing Safety, Efficacy, and Cost-Effectiveness of the Surgisis® Anal Fistula Plug versus Surgeon's Preference for Transsphincteric Fistula-in-Ano: The FIAT Trial

    David Jayne, J. Scholefield, D. Tolan, R. Gray +8 more

    2019Social Science Research Network0 citations

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41. Intravenous Remifentanil Patient-controlled Analgesia Versus Intramuscular Pethidine for Pain Relief in Labour (RESPITE): An Open-label, Multicenter, Randomized Controlled Trial

    Matthew Wilson, Christine MacArthur, Catherine A. Hewitt, K. Handley +3 more

    2019Obstetric Anesthesia Digest0 citations

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42. Comparison of Mutational Status in the EGFR Pathway Across Four Different Platforms in the Fluoropyrimidine Oxaliplatin and Targeted Receptor Pre-Operative Therapy (FOxTROT) Trial

    A. Westwood, D. Bottomley, G. Hemmings, M. Taylor +10 more

    20180 citations

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43. Somatic Mutations of Beta2-Microglobulin are Correlated with a Lack of Disease Recurrence in a Subset of Stage II Mismatch Repair Deficient Colorectal Cancers from the QUASAR Trial

    S. Richman, P. Barrow, A. Wallace, K. Handley +7 more

    20180 citations

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44. Comparison of Mismatch Repair Protein Expression Between Biopsies and Resections in Advanced Colon Cancer from the Phase II Group of the Fluoropyrimidine Oxaliplatin and Targeted Receptor Pre-Operative Therapy (FOxTROT) Trial

    A. Westwood, G. Hemmings, D. Bottomley, K. Handley +6 more

    20180 citations

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45. Sa1943 Histopathologic Grading Using Poorly-Differentiated Clusters Predicts Outcome in Colorectal Carcinoma

    H. Li-Chang, Bojan Mitrović, K. Handley, R. Gray +5 more

    20140 citations Open access

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46. PIK3CA Mutation is Strongly Associated with K-ras 12/13 Mutation in Stage II/III Colorectal Cancer

    K. Southward, M. Taylor, P. Chambers, K. Handley +7 more

    20120 citations

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47. Mismatch Repair Testing in Colorectal Cancer - Is Less More?

    G. Hutchins, K. Southward, K. Handley, E. Magill +5 more

    20120 citations

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48. Histopathological Downstaging of Colon Cancer Following Six Weeks of Pre-operative Chemotherapy: Early Results of the NCRI FOxTROT Trial

    N. West, E. Tinkler-Hundal, K. Handley, L. Magill +8 more

    20120 citations

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49. Assay result variability during determination of mismatch repair deficiency status using immunohistochemistry: A transatlantic comparative study.

    G. Hutchins, K. Handley, F. Baehner, M. Lopatin +6 more

    2011Journal of Clinical Oncology0 citations

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50. Statistical analysis of surface-enhanced laser desorption/ionization (SELDI) protein chip data from breast cancer cell lines exposed to chemotherapeutic agents

    I. Dryden, S. Mian, W. Browne, K. Handley +2 more

    20020 citations

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