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T. Okuno · SciRah

Researcher profile · Semantic Scholar

T. Okuno

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T. Okuno — researcher profile on SciRah

h-index: 28
Works: 99
Citations: 2,509

Most-cited papers

G2A Is a Proton-sensing G-protein-coupled Receptor Antagonized by Lysophosphatidylcholine*
N. Murakami, T. Yokomizo, T. Okuno, T. Shimizu
2004Journal of Biological Chemistry239 citations Open access
Semantic Scholar
Brief Definitive Report 12(s)-hydroxyheptadeca-5z, 8e, 10e – Trienoic Acid Is a Natural Ligand for Leukotriene B 4 Receptor 2
T. Okuno, Yoshiko Iizuka, H. Okazaki, T. Yokomizo +2 more
167 citations
Semantic Scholar
The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders
Airi Jo-Watanabe, T. Okuno, T. Yokomizo
2019International Journal of Molecular Sciences136 citations Open access
Semantic Scholar
12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor
Min Liu, Kazuko Saeki, Takehiko Matsunobu, T. Okuno +8 more
2014Journal of Experimental Medicine126 citations Open access
Semantic Scholar
Delphilin: a Novel PDZ and Formin Homology Domain-Containing Protein that Synaptically Colocalizes and Interacts with Glutamate Receptor δ2 Subunit
Y. Miyagi, T. Yamashita, M. Fukaya, T. Sonoda +8 more
2002Journal of Neuroscience119 citations Open access
Semantic Scholar
Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis
Yoshiko Iizuka, T. Okuno, Kazuko Saeki, H. Uozaki +10 more
2010The FASEB Journal103 citations
Semantic Scholar
Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1.
T. Hori, T. Okuno, K. Hirata, K. Yamashita +8 more
2018Nature Chemical Biology86 citations
Semantic Scholar
Determination of Double Bond Positions in Polyunsaturated Fatty Acids Using the Photochemical Paternò-Büchi Reaction with Acetone and Tandem Mass Spectrometry.
R. Murphy, T. Okuno, Christopher A. Johnson, R. Barkley
2017Analytical Chemistry70 citations
Semantic Scholar
Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2
S. Iwamoto, T. Koga, Mai Ohba, T. Okuno +4 more
2017Scientific Reports64 citations Open access
Semantic Scholar
Leukotriene B4 Receptor and the Function of Its Helix 8*
T. Okuno, T. Yokomizo, T. Hori, M. Miyano +1 more
2005Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand[S]
Takehiko Matsunobu, T. Okuno, Chieko Yokoyama, T. Yokomizo
2013Journal of Lipid Research59 citations Open access
Semantic Scholar
Helix 8 of the Leukotriene B4 Receptor Is Required for the Conformational Change to the Low Affinity State after G-protein Activation*
T. Okuno, H. Ago, K. Terawaki, M. Miyano +2 more
2003Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia
Y. Matsunaga, S. Fukuyama, T. Okuno, Fumiyuki Sasaki +11 more
2013The FASEB Journal53 citations
Semantic Scholar
Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins
Y. Ishii, Kazuko Saeki, Min Liu, Fumiyuki Sasaki +5 more
2016The FASEB Journal47 citations
Semantic Scholar
Eicosanoids in Skin Wound Healing
K. Yasukawa, T. Okuno, T. Yokomizo
2020International Journal of Molecular Sciences46 citations Open access
Semantic Scholar
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.
Fumiyuki Sasaki, T. Koga, Mai Ohba, Kazuko Saeki +12 more
2018JCI Insight45 citations Open access
Semantic Scholar
From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis
S. Koutsogiannaki, M. Schaefers, T. Okuno, Mai Ohba +5 more
2016Toxicological Sciences45 citations Open access
Semantic Scholar
n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy
A. Suzumura, H. Kaneko, Y. Funahashi, K. Takayama +13 more
2020Diabetes43 citations
Semantic Scholar
内因性自然免疫と炎症炎症・細胞傷害シクロオキシゲナーゼ代謝物12-HHTはBLT2の内在性リガンドである(12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor)
T. Okuno, T. Yokomizo
200843 citations
Semantic Scholar
Identification of the Intracellular Region of the Leukotriene B4 Receptor Type 1 That Is Specifically Involved in Gi Activation*
Kanako Kuniyeda, T. Okuno, K. Terawaki, M. Miyano +2 more
2006Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Silver‐gold compound metal island films prepared by using a two‐step evaporation method
K. Baba, T. Okuno, M. Miyagi, M. Cada +28 more
199339 citations
Semantic Scholar
Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses
Toshiaki Hirakata, Hyeon-Cheol Lee, Mai Ohba, Kazuko Saeki +4 more
2018The FASEB Journal37 citations Open access
Semantic Scholar
Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis
Yosuke Ono, T. Kawakita, O. Yoshino, Erina Sato +16 more
2021Biomedicines34 citations Open access
Semantic Scholar
Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll‐like receptor 4 system
T. Okuno, S. Koutsogiannaki, Lifei Hou, W. Bu +4 more
2019The FASEB Journal34 citations Open access
Semantic Scholar
Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions[S]
Hideru Obinata, S. Gutkind, J. Stitham, T. Okuno +3 more
2014Journal of Lipid Research33 citations Open access
Semantic Scholar
Helix 8 of leukotriene B4 receptor 1 inhibits ligand‐induced internalization
Yoshifusa Aratake, T. Okuno, Takehiko Matsunobu, Kazuko Saeki +3 more
2012The FASEB Journal33 citations
Semantic Scholar
A high-affinity monoclonal antibody against the FLAG tag useful for G-protein-coupled receptor study.
Fumiyuki Sasaki, T. Okuno, Kazuko Saeki, Liu Min +4 more
2012Analytical Biochemistry33 citations
Semantic Scholar
Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE)
Takako Ichiki, T. Koga, T. Okuno, Kazuko Saeki +4 more
2016The FASEB Journal29 citations
Semantic Scholar
Helix 8 of leukotriene B4type‐2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum
Daisuke Yasuda, T. Okuno, T. Yokomizo, T. Hori +5 more
2009The FASEB Journal28 citations
Semantic Scholar
Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle
Noriaki Kawanishi, Kana Takagi, Hyeon-Cheol Lee, Daiki Nakano +3 more
2018American Journal of Physiology. Regulatory Integrative and Comparative Physiology26 citations Open access
Semantic Scholar
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury
M. Shigematsu, T. Koga, Ayako Ishimori, Kazuko Saeki +12 more
2016Scientific Reports25 citations Open access
Semantic Scholar
Biochemical Characterization of Three BLT Receptors in Zebrafish
T. Okuno, T. Ishitani, T. Yokomizo
2015PLoS ONE25 citations Open access
Semantic Scholar
TTN oxidation of mixed halogenated phenols: Synthesis of vancomycin model diaryl ether possessing a chlorine atom
H. Konishi, T. Okuno, S. Nishiyama, S. Yamamura +2 more
199625 citations
Semantic Scholar
Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2
T. Okuno, T. Yokomizo
2018Inflammation and Regeneration24 citations Open access
Semantic Scholar
The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain–Fas‐associated death domain interaction
S. Koutsogiannaki, Lifei Hou, H. Babazada, T. Okuno +4 more
2019The FASEB Journal23 citations Open access
Semantic Scholar
What is the natural ligand of GPR55?
T. Okuno, T. Yokomizo
2011Journal of Biochemistry (Tokyo)23 citations Open access
Semantic Scholar
CHEMICAL STUDY ON HAPALOSIN, A CYCLIC DEPSIPEPTIDE POSSESSING MULTIDRUG RESISTANCE REVERSING ACTIVITIES : SYNTHESIS, STRUCTURE AND BIOLOGICAL ACTIVITY
T. Okuno, K. Ohmori, S. Nishiyama, S. Yamamura +3 more
199623 citations
Semantic Scholar
Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation
T. Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya +15 more
2020Cellular & Molecular Immunology21 citations Open access
Semantic Scholar
Altered eicosanoid production and phospholipid remodeling during cell culture[S]
T. Okuno, M. Gijón, S. Zarini, Sarah A. Martin +5 more
2018Journal of Lipid Research21 citations Open access
Semantic Scholar
Resonance wavelengths of silver–gold compound metal island films
K. Baba, T. Okuno, M. Miyagi
199520 citations
Semantic Scholar
A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy
Keisuke Jimbo, T. Okuno, Ryuichi Ohgaki, Kou Nishikubo +7 more
2020PLoS ONE19 citations Open access
Semantic Scholar
Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method.
Mai Ohba, Kazuko Saeki, T. Koga, T. Okuno +2 more
2018Biochemical and Biophysical Research Communications - BBRC19 citations
Semantic Scholar
Synthetic study on hapalosin, a cyclic depsipeptide possessing multidrug resistance reversing activities
K. Ohmori, T. Okuno, S. Nishiyama, S. Yamamura
199618 citations
Semantic Scholar
Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction
Yuma Horii, Michio Nakaya, Hiroki Ohara, Hiroaki Nishihara +9 more
2020The FASEB Journal17 citations Open access
Semantic Scholar
Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury
Airi Jo-Watanabe, Toshiki Inaba, Takahiro Osada, Ryota Hashimoto +8 more
2024Nature Communications16 citations Open access
Semantic Scholar
Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competition
Erika Ishihara, Yuya Nagaoka, T. Okuno, S. Kofuji +9 more
2020Genes to Cells15 citations Open access
Semantic Scholar
Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1
Fumiyuki Sasaki, T. Koga, Kazuko Saeki, T. Okuno +4 more
2017PLoS ONE14 citations Open access
Semantic Scholar
Intravenous anesthetic propofol binds to 5‐lipoxygenase and attenuates leukotriene B4 production
T. Okuno, S. Koutsogiannaki, Mai Ohba, M. Chamberlain +5 more
2017The FASEB Journal14 citations Open access
Semantic Scholar
The leukotriene B4/BLT1‐dependent neutrophil accumulation exacerbates immune complex‐mediated glomerulonephritis
Ryotaro Shioda, Airi Jo-Watanabe, T. Okuno, Kazuko Saeki +3 more
2023The FASEB Journal11 citations Open access
Semantic Scholar
Biosynthetic Crossover of 5-Lipoxygenase and Cyclooxygenase-2 Yields 5-Hydroxy-PGE2 and 5-Hydroxy-PGD2
Fumie Nakashima, Takashi Suzuki, Odaine N. Gordon, D. Golding +4 more
2021JACS Au11 citations Open access
Semantic Scholar

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