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S. Chakrapani · SciRah

Researcher profile · Semantic Scholar

S. Chakrapani

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S. Chakrapani — researcher profile on SciRah

h-index: 25
Works: 96
Citations: 2,540

Most-cited papers

Structural basis for the coupling between activation and inactivation gates in K+ channels
L. G. Cuello, V. Jogini, D. Cortes, Albert C. Pan +6 more
2010Nature289 citations Open access
Semantic Scholar
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease
Xing Guo, Xiao-Yan Sun, Di Hu, Ya-Juan Wang +7 more
2016Nature Communications188 citations Open access
Semantic Scholar
Recovery from Slow Inactivation in K+ Channels is Controlled by Water Molecules
Jared Ostmeyer, S. Chakrapani, Albert C. Pan, E. Perozo +1 more
2013Nature180 citations Open access
Semantic Scholar
Gating Dynamics of the Acetylcholine Receptor Extracellular Domain
S. Chakrapani, Timothy Bailey, A. Auerbach
2004The Journal of General Physiology150 citations Open access
Semantic Scholar
Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor
S. Basak, Yvonne Gicheru, Shanlin Rao, M. Sansom +1 more
2018Nature117 citations Open access
Semantic Scholar
Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM
T. Hughes, D. Lodowski, Kevin W. Huynh, A. Yazici +11 more
2018Nature Structural & Molecular Biology117 citations Open access
Semantic Scholar
A Quantitative Description of KcsA Gating I: Macroscopic Currents
S. Chakrapani, J. Cordero-Morales, E. Perozo
2007The Journal of General Physiology116 citations Open access
Semantic Scholar
Cryo-EM structure of 5-HT3A receptor in its resting conformation
S. Basak, Yvonne Gicheru, A. Samanta, S. Molugu +7 more
2018Nature Communications108 citations Open access
Semantic Scholar
Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs
Arvind Kumar, S. Basak, Shanlin Rao, Yvonne Gicheru +3 more
2020Nature Communications97 citations Open access
Semantic Scholar
A multipoint hydrogen-bond network underlying KcsA C-type inactivation.
J. Cordero-Morales, V. Jogini, S. Chakrapani, E. Perozo
2011Biophysical Journal97 citations Open access
Semantic Scholar
Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer.
S. Chakrapani, L. G. Cuello, D. Cortes, E. Perozo
2008Structure96 citations Open access
Semantic Scholar
A Quantitative Description of KcsA Gating II: Single-Channel Currents
S. Chakrapani, J. Cordero-Morales, E. Perozo
2007The Journal of General Physiology96 citations Open access
Semantic Scholar
On The Structural Basis of Modal Gating Behavior in K+ Channels
S. Chakrapani, J. Cordero-Morales, V. Jogini, Albert C. Pan +3 more
2010Nature Structural &Molecular Biology83 citations Open access
Semantic Scholar
A speed limit for conformational change of an allosteric membrane protein.
S. Chakrapani, A. Auerbach
2005Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
Semantic Scholar
Structural Insight into the Assembly of TRPV Channels
Kevin W. Huynh, Matthew R. Cohen, S. Chakrapani, H. Holdaway +2 more
2013Structure70 citations Open access
Semantic Scholar
The Role of Loop 5 in Acetylcholine Receptor Channel Gating
S. Chakrapani, Timothy Bailey, A. Auerbach
2003The Journal of General Physiology64 citations Open access
Semantic Scholar
Desensitization Mechanism in Prokaryotic Ligand-gated Ion Channel
Phanindra Velisetty, S. Chakrapani
2012Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel
S. Basak, Nicolaus Schmandt, Yvonne Gicheru, S. Chakrapani
2017eLife59 citations Open access
Semantic Scholar
Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor
S. Basak, Yvonne Gicheru, A. Kapoor, Megan L. Mayer +2 more
2019Nature Communications56 citations Open access
Semantic Scholar
The activated state of a sodium channel voltage sensor in a membrane environment
S. Chakrapani, P. Sompornpisut, Pathumwadee Intharathep, B. Roux +1 more
2010Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Conformational Transitions Underlying Pore Opening and Desensitization in Membrane-embedded Gloeobacter violaceus Ligand-gated Ion Channel (GLIC)
Phanindra Velisetty, Sreevatsa V. Chalamalasetti, S. Chakrapani
2012Journal of Biological Chemistry46 citations Open access
Semantic Scholar
High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition
S. Basak, Arvind Kumar, Steven Ramsey, E. Gibbs +3 more
2020bioRxiv40 citations Open access
Semantic Scholar
Structural Basis for Allosteric Coupling at the Membrane-Protein Interface in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC)*
Phanindra Velisetty, Sreevatsa V. Chalamalasetti, S. Chakrapani
2013Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Conformational transitions and allosteric modulation in a heteromeric glycine receptor
E. Gibbs, Emily Klemm, David Seiferth, Arvind Kumar +3 more
2023Nature Communications33 citations Open access
Semantic Scholar
The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation
Soumili Chatterjee, R. Vyas, Sreevatsa V. Chalamalasetti, Indra D. Sahu +5 more
2018The Journal of General Physiology32 citations Open access
Semantic Scholar
Full-length 5-HT3A receptor in a serotonin-bound conformation- State 1
S. Basak, S. Chakrapani
201825 citations
Semantic Scholar
Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs
Arvind Kumar, Kayla J Kindig, Shanlin Rao, A. Zaki +4 more
2022Nature Communications20 citations Open access
Semantic Scholar
Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3.
E. Gibbs, S. Chakrapani
2021Sub-cellular biochemistry17 citations
Semantic Scholar
A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation
Nicolaus Schmandt, Phanindra Velisetty, Sreevatsa V. Chalamalasetti, R. Stein +7 more
2015The Journal of General Physiology16 citations Open access
Semantic Scholar
How to gate an ion channel: lessons from MthK
S. Chakrapani, E. Perozo
2007Nature Structural &Molecular Biology15 citations
Semantic Scholar
EPR Studies of Gating Mechanisms in Ion Channels
S. Chakrapani
2015Methods in Enzymology11 citations Open access
Semantic Scholar
Structural basis for partial agonism in 5-HT3A receptors
Kevin C. Felt, Madeleine Stauffer, Leslie Salas-Estrada, Peter R. Guzzo +4 more
2024Nature Structural & Molecular Biology10 citations
Semantic Scholar
Cryo-EM structure of 5HT3A receptor in presence of granisetron
S. Basak, S. Chakrapani
20199 citations Open access
Semantic Scholar
Photoinduced Homolytic Bond Cleavage of the Central Si-C Bond in Porphyrin Macrocycles Is a Charge Polarization Driven Process.
B. Maiti, A. Manna, Christopher L McCleese, Tennyson L. Doane +3 more
2016Journal of Physical Chemistry A9 citations
Semantic Scholar
Mechanisms underlying modulation of human GlyRα3 by Zn2+ and pH
Kayla J Kindig, Eric Gibbs, David Seiferth, P. Biggin +1 more
2024Science Advances8 citations Open access
Semantic Scholar
Mechanisms of activation and desensitization of full-length glycine receptor in membranes
Arvind Kumar, S. Basak, Shanlin Rao, Yvonne Gicheru +3 more
2019bioRxiv7 citations Open access
Semantic Scholar
Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels.
S. Basak, Soumili Chatterjee, S. Chakrapani
2016Journal of Visualized Experiments7 citations Open access
Semantic Scholar
Structure and function of the RNA polymerase complex of Borna disease virus, a nuclear-replicating non-segmented negative-strand RNA virus
Eric Gibbs, Minako Ogino, Takehiro Kanda, Dean E. Watkins +4 more
2026Nucleic Acids Research6 citations Open access
Semantic Scholar
Conformational transitions underlying pore opening and desensitization in membrane-embedded GLIC
Phanindra Velisetty, Sreevatsa V. Chalamalasetti, S. Chakrapani
20136 citations Open access
Semantic Scholar
Structural Basis For The Coupling Between Activation And Inactivation Gating In Potassium Channels
L. G. Cuello, V. Jogini, D. Cortes, Albert C. Pan +5 more
20095 citations Open access
Semantic Scholar
Recombinant expression and purification of pentameric ligand-gated ion channels for Cryo-EM structural studies.
Arvind Kumar, S. Basak, S. Chakrapani
2021Methods in Enzymology4 citations
Semantic Scholar
Direct visualization of ion-channel gating in a native environment
Yvonne Gicheru, S. Chakrapani
2018Proceedings of the National Academy of Sciences of the United States of America4 citations Open access
Semantic Scholar
Human GlyRα2 Pore Dynamics in Gating and Inhibition
Emily Klemm, Eric Gibbs, Madeleine Stauffer, Devesh Mohapatra +2 more
2026Structure2 citations Open access
Semantic Scholar
Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist
Eric Gibbs, Bjarne Feddersen, Kayla J Kindig, David Seiferth +2 more
2026Science Advances1 citations Open access
Semantic Scholar
Elucidate the Binding Mechanism of Various Setrons to 5-HT3AR
S. Basak, Yvonne Gicheru, Arvind Kumar, S. Chakrapani
20201 citations Open access
Semantic Scholar
Author response: Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel
S. Basak, Nicolaus Schmandt, Yvonne Gicheru, S. Chakrapani
20171 citations Open access
Semantic Scholar
Structural Mechanisms Underlying PUFA Modulation in Pentameric Ligand Gated Ion Channels
Yvonne Gicheru, S. Basak, S. Chakrapani
20171 citations Open access
Semantic Scholar
Structural Basis for Allosteric Coupling at the Membrane-Protein Interface in GLIC
Phanindra Velisetty, Sreevatsa V. Chalamalasetti, S. Chakrapani
20141 citations Open access
Semantic Scholar
On the Structure-Function correlates of Ion Occupancy and modulation of C-type Inactivation
S. Chakrapani, V. Jogini, L. G. Cuello, Marien Cortes +1 more
20091 citations Open access
Semantic Scholar
BPS2026 – Structural characterization of a 5-HT3 receptor allosteric modulator and its effects on orthosteric agonism
Madeleine Stauffer, Kevin C. Felt, Henock B Befekadu, Anshul Assaiya +1 more
2026Biophysical Journal0 citations
Semantic Scholar

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S. Basak×16
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E. Perozo×11
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Yvonne Gicheru×10
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Arvind Kumar×7
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J. Cordero-Morales

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Phanindra Velisetty×6

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Sreevatsa V. Chalamalasetti×6

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V. Jogini — researcher profile on SciRah

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L. G. Cuello×4

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Albert C. Pan×4

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