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R. Lear · SciRah

Researcher profile · Semantic Scholar

R. Lear

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R. Lear — researcher profile on SciRah

h-index: 6
Works: 23
Citations: 114

Most-cited papers

99mTc-NC100692--a tracer for imaging vitronectin receptors associated with angiogenesis: a preclinical investigation.
David Edwards, P. Jones, H. Haramis, M. Battle +6 more
2008Nuclear Medicine and Biology33 citations
Semantic Scholar
Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes
Nalini Marino, Sam Illingworth, Prithvi Kodialbail, Ashvin Patel +5 more
2017PLoS ONE32 citations Open access
Semantic Scholar
T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice
Olmo Sonzogni, Daniel E. Zak, M. Sasso, R. Lear +5 more
2022Oncoimmunology13 citations Open access
Semantic Scholar
99mTc-NC100668, a new tracer for imaging venous thromboemboli: pre-clinical biodistribution and incorporation into plasma clots in vivo and in vitro
David Edwards, Joanne Lewis, M. Battle, R. Lear +6 more
2006European Journal of Nuclear Medicine and Molecular Imaging8 citations
Semantic Scholar
Abstract 4294: GE152:In vivodetection of tumor apoptosis as a tool for assessment of therapeutic efficacy
D. Hiscock, G. McRobbie, R. Lear, Antonios Danikas +7 more
20127 citations
Semantic Scholar
99mTc-NC100668, an agent for imaging venous thromboembolism: The effect of anticoagulant or thrombolytic therapy on the uptake and retention of radioactivity in blood clots in vivo
David Edwards, Joanne Lewis, M. Battle, R. Lear +6 more
2007Nuclear medicine communications6 citations
Semantic Scholar
THE IN VIVO AND IN VITRO METABOLIC PROFILE OF 99MTC-NC100668, A NEW TRACER FOR IMAGING VENOUS THROMBOEMBOLISM: IDENTIFICATION AND BIODISTRIBUTION OF THE PRINCIPAL RADIOLABELED METABOLITE
David Edwards, M. Battle, R. Lear, G. Farrar +5 more
2006Drug Metabolism And Disposition4 citations
Semantic Scholar
The biodistribution of NC100668 and the effect of excess NC100668 on the biodistribution and kidney retention of (99m)Tc-NC100668 in the rat.
David Edwards, Joanne Lewis, M. Battle, R. Lear +6 more
2007Nuclear Medicine and Biology3 citations
Semantic Scholar
Abstract 4875: Developing tumor-localized, combination immunotherapies
B. Champion, Nalini Rasiah, Sam Illingworth, Matthieu Besneux +4 more
20162 citations
Semantic Scholar
(99m)Tc-NC100668, a new tracer for imaging venous thromboemboli: pre-clinical biodistribution and incorporation into plasma clots in vivo and in vitro.
David Edwards, Joanne Lewis, M. Battle, R. Lear +6 more
2006European Journal of Nuclear Medicine and Molecular Imaging2 citations
Semantic Scholar
1003 Tumor-specific replication and immunoactivity of aCD40-producing T-SIGn vectors
Maria Stella Sasso, Meg Snowden, R. Lear, Linnea Drexhage +7 more
2024Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
Abstract 2740: Safe and effective delivery of antibody fragments to the solid tumor microenvironment
R. Bergin, Amandine Pelletier, M. Zonca, A. Muntzer +9 more
2023Cancer Research1 citations
Semantic Scholar
Abstract 5098: NG-348: a novel oncolytic virus designed to mediate anti-tumour activity via the potent and selective polyclonal activation of tumor-infiltrating T-cells
B. Champion, Matthieu Besneux, Nalini Marino, D. Plumb +4 more
20171 citations
Semantic Scholar
Fluorine-18 Labelling and Biological Evaluation of the HER2-binding Affibody Molecule Z(HER2:2891)
P. Iveson, M. Glaser, T. Wilson, Bård Indrevoll +6 more
20111 citations
Semantic Scholar
Abstract 5746: Flexible tumor-specific cytokine and antigen delivery through the T-SIGn vector platform enables effective CAR-T cell therapy against solid tumors
M. Sasso, R. Bergin, R. Lear, D. Plumb +9 more
2023Cancer Research0 citations
Semantic Scholar
208 T-SIGn vector-mediated antigen “spray painting” and tumor microenvironment (TME) reprogramming to enable CAR-T cell targeting of solid tumors
M. Sasso, R. Bergin, M. Zonca, Eva Vainiute +8 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
1223 NG-796A: A T-SIGn vector designed to reprogram the tumor microenvironment and drive anti-tumor immunity
M. Zonca, K. West, Carla Cerqueira, A. Muntzer +8 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
12.04 Re-directing CAR-T cells against solid tumors using T-SIGn-mediated antigen delivery and tumor microenvironment reprogramming
M. Sasso, R. Bergin, M. Zonca, A. Muntzer +4 more
2022Oral Presentations0 citations Open access
Semantic Scholar
Abstract 1582: T-SIGn cancer gene therapy and anti-EGFR CAR-T cells synergize in combination therapy to clear A549 lung tumor xenografts and lung metastases in NSG mice
Olmo Sonzogni, Daniel E. Zak, K. West, R. Lear +3 more
2021Immunology0 citations
Semantic Scholar
Abstract 1469: Optimizing the tolerability of intravenous oncolytic viral immunotherapy administration: investigation of a low-high-high dose schedule of enadenotucirev (EnAd) administration
H. McElwaine-Johnn, Sam Illingworth, R. Lear, Richard J. P. Brown +1 more
2019Clinical research0 citations
Semantic Scholar
Arming the oncolytic virus enadenotucirev (EnAd) to generate enhanced locally-acting immunotherapies for cancer
B. Champion, Nalini Rasiah, Sam Illingworth, H. Calderon +5 more
2015Journal of Immunotherapy for Cancer0 citations Open access
Semantic Scholar
Monitoring tumour response to anti-angiogenic therapy with an F18-labeled angiogenesis imaging agent
L. Allen, M. Battle, J. Goggi, Luisa Contreras Brava +3 more
20090 citations
Semantic Scholar
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 203 Pre-Clinical Evaluation of a Novel Radiotracer for the Diagnosis of DVT and Pulmonary Embolism
David Edwards, Joanne Lewis, R. Lear, M. Battle +7 more
20060 citations
Semantic Scholar

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