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H. Szpurka · SciRah

Researcher profile · Semantic Scholar

H. Szpurka

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H. Szpurka — researcher profile on SciRah

h-index: 21
Works: 59
Citations: 3,188

Most-cited papers

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms.
A. Jankowska, H. Szpurka, R. Tiu, H. Makishima +6 more
2009Blood394 citations Open access
Semantic Scholar
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.
A. Jankowska, H. Makishima, R. Tiu, H. Szpurka +12 more
2011Blood350 citations Open access
Semantic Scholar
250K SNP array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies
A. Dunbar, Lukasz P. Gondek, C. O'Keefe, H. Makishima +6 more
2008Cancer Research309 citations Open access
Semantic Scholar
Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
F. Traina, V. Visconte, P. Elson, A. Tabarroki +14 more
2014Leukemia300 citations
Semantic Scholar
Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation.
Andrew E. Schade, G. Schieven, R. Townsend, A. Jankowska +4 more
2008Blood294 citations Open access
Semantic Scholar
Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.
H. Makishima, Heather Cazzolli, H. Szpurka, A. Dunbar +11 more
2009Journal of Clinical Oncology219 citations Open access
Semantic Scholar
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
H. Makishima, A. Jankowska, R. Tiu, H. Szpurka +11 more
2010Leukemia201 citations Open access
Semantic Scholar
Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation.
H. Szpurka, R. Tiu, G. Murugesan, Samer Aboudola +4 more
2006Blood196 citations Open access
Semantic Scholar
SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.
V. Visconte, H. Rogers, Jarnail Singh, J. Barnard +19 more
2012Blood186 citations Open access
Semantic Scholar
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.
H. Makishima, A. Jankowska, Michael A. Mcdevitt, C. O'Keefe +12 more
2011Blood160 citations Open access
Semantic Scholar
SNP Array Karyotyping Allows for the Detection of Uniparental Disomy and Cryptic Chromosomal Abnormalities in MDS/MPD-U and MPD
Lukasz P. Gondek, A. Dunbar, H. Szpurka, Michael A. Mcdevitt +1 more
2007PLoS ONE86 citations Open access
Semantic Scholar
Identification of the JAK2 V617F mutation in chronic myeloproliferative disorders using FRET probes and melting curve analysis.
G. Murugesan, Samer Aboudola, H. Szpurka, M. A. Verbic +3 more
2006American Journal of Clinical Pathology81 citations
Semantic Scholar
UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation
H. Szpurka, Lukasz P. Gondek, Sanjay R. Mohan, Eric D. Hsi +2 more
2009Leukemia50 citations Open access
Semantic Scholar
Bone Marrow Phospho-STAT5 Expression in Non-CML Chronic Myeloproliferative Disorders Correlates With JAK2 V617F Mutation and Provides Evidence of In Vivo JAK2 Activation
Samer Aboudola, G. Murugesan, H. Szpurka, G. Ramsingh +5 more
2007American Journal of Surgical Pathology47 citations
Semantic Scholar
Base excision repair dysfunction in a subgroup of patients with myelodysplastic syndrome
A. Jankowska, Lukasz P. Gondek, H. Szpurka, Z. Nearman +2 more
2008Leukemia42 citations Open access
Semantic Scholar
Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations
H. Szpurka, A. Jankowska, H. Makishima, J. Bodo +4 more
2010Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis41 citations Open access
Semantic Scholar
Hemochromatosis‐associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts
Zachary P. Nearman, H. Szpurka, B. Serio, Ilka Warshawksy +4 more
2007American journal of hematology/oncology34 citations Open access
Semantic Scholar
Impact of Molecular Mutations on Treatment Response to Hypomethylating Agents in MDS
F. Traina, A. Jankowska, V. Visconte, Y. Sugimoto +12 more
201132 citations
Semantic Scholar
Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide
Y. Sugimoto, M. Sekeres, H. Makishima, F. Traina +11 more
2012Journal of Hematology & Oncology28 citations Open access
Semantic Scholar
Molecular lesions in childhood and adult acute megakaryoblastic leukaemia
A. Hama, H. Muramatsu, H. Makishima, Y. Sugimoto +13 more
2012British Journal of Haematology22 citations
Semantic Scholar
Altered lipid raft composition and defective cell death signal transduction in glycosylphosphatidylinositol anchor‐deficient PIG‐A mutant cells
H. Szpurka, Andrew E. Schade, A. Jankowska, J. Maciejewski
2008British Journal of Haematology22 citations Open access
Semantic Scholar
Immunohistochemical application of a highly sensitive and specific murine monoclonal antibody recognising the extracellular domain of the human hepatocyte growth factor receptor (MET)
Aaron M. Gruver, Ling Liu, P. Vaillancourt, S. Yan +19 more
2014Histopathology15 citations Open access
Semantic Scholar
Phospho-STAT5 expression pattern with the MPL W515L mutation is similar to that seen in chronic myeloproliferative disorders with JAK2 V617F.
Sarah E. Gibson, Andrew E. Schade, H. Szpurka, B. Bąk +2 more
2008Human Pathology14 citations
Semantic Scholar
Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria
A. Jankowska, H. Szpurka, M. Calabro, Sanjay R. Mohan +4 more
2011Haematologica12 citations Open access
Semantic Scholar
CBL , CBLB , TET 2 , ASXL 1 , and IDH 1 / 2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
H. Makishima, A. Jankowska, Michael A. Mcdevitt, C. O'Keefe +13 more
201111 citations
Semantic Scholar
UTX Mutations and Epigenetic Changes In MDS/MPN and Related Myeloid Malignancies
H. Szpurka, A. Jankowska, B. Przychodzen, Zhen-Bo Hu +3 more
201010 citations
Semantic Scholar
Impaired Hydroxylation of 5-Methylcytosine In TET2 mutated Patients with Myeloid Malignancies
A. Jankowska, Myunggon Ko, Yun Huang, U. Pape +11 more
20106 citations
Semantic Scholar
Mutational Spectrum In Chronic Myelomonocytic Leukemia Includes Genes Associated with Epigenetic Regulation Such as UTX and EZH2
A. Jankowska, H. Makishima, R. Tiu, H. Szpurka +10 more
20105 citations
Semantic Scholar
Association of SF3B1 with Ring Sideroblasts in patients, In Vivo, and In Vitro models of Spliceosomal Dysfunction
V. Visconte, H. Makishima, A. Jankowska, F. Traina +18 more
20114 citations
Semantic Scholar
Involvement of TET2 in Regulation of Epigenetic Silencing in MDS and Related Myeloid Malignancies.
H. Szpurka, A. Jankowska, K. Ng, Joshua R. Clevenger +2 more
20094 citations
Semantic Scholar
Mutational determinants of epigenetic instablity in myeloid malignancies.
A. Jankowska, H. Szpurka
2012Seminars in Oncology3 citations
Semantic Scholar
Dysfunction of Lipid Raft Microdomains and Defective Apoptotic Signal Transduction in PNH.
H. Szpurka, Andrew E. Schade, M. Ganapathi, J. Maciejewski
20063 citations
Semantic Scholar
New TET2, ASXL1 and CBL Mutations Have Poor Prognostic Impact In Systemic Mastocytosis and Related Disorders
F. Traina, A. Jankowska, H. Makishima, F. Hsieh +15 more
20102 citations
Semantic Scholar
Presence of JAK2 Mutations in MDS/MPD-u WHO Classified Patients and Not Other Forms of MDS Suggests Their Derivation from Classical Myeloproliferative Syndrome.
H. Szpurka, R. Tiu, E. Hsi, A. Lichtin +3 more
20052 citations
Semantic Scholar
Abstract A12: The CDK4/CDK6 inhibitor abemaciclib inhibits transcriptional targets which facilitate growth in ER+ breast cancer cells
A. McNulty, T. Burke, J. Dempsey, C. Marchal +10 more
20161 citations
Semantic Scholar
Consequences of UTX Dysfunction in Myelodysplastic Syndrome
A. Jankowska, H. Szpurka, V. Cheriyath, K. Ng +4 more
20111 citations
Semantic Scholar
Mechanisms of Defective Hydroxylation of 5-Methylcytosine in MDS Include Pathways Other Than TET2 and IDH1/2
A. Jankowska, Yun Huang, Myunggon Ko, U. Pape +8 more
20111 citations
Semantic Scholar
Identification of Oncogenic EZH2 Mutations In Myelodysplastic Syndromes and Related Myeloid Malignancies
H. Makishima, A. Jankowska, R. Tiu, H. Szpurka +12 more
20101 citations
Semantic Scholar
Next Generation Exome Sequencing for Identification of the Gene Mutations Associated with Loss of Heterozygozity on Chromosome 7 In Myeloid Malignancies
Y. Sugimoto, H. Makishima, H. Szpurka, A. Jankowska +9 more
20101 citations
Semantic Scholar
P045 TET2 gene harbors mutations associated with myeloid malignancies
A. Jankowska, H. Szpurka, R. Tiu, H. Makishima +6 more
20091 citations
Semantic Scholar
Hemochromatois-Associated Gene Mutations in Patients with Myelodysplastic Syndromes with Refractory Anemia and Ringed Sideroblasts.
Z. Nearman, B. Serio, H. Szpurka, I. Warshawsky +3 more
20061 citations
Semantic Scholar
401 Distribution and Significance of EZH2 Mutations in MDS and Related Myeloid Malignancies
H. Makishima, A. Jankowska, H. Szpurka, A. List +6 more
20110 citations
Semantic Scholar
Spliceosome GENE MUTATIONS ARE Also PRESENT In the Diverse Mutational Spectrum of CHRONIC Myelomonocytic LEUKEMIA
H. Makishima, A. Jankowska, V. Visconte, R. Tiu +8 more
20110 citations
Semantic Scholar
1 CBL , CBLB , TET 2 , ASXL 1 and IDH 1 / 2 Mutations and Additional Chromosomal Aberrations Constitute Molecular Events in Chronic Myelogenous Leukemia
H. Makishima, A. Jankowska, Michael A. Mcdevitt, C. O'Keefe +12 more
20110 citations
Semantic Scholar
TET2 Mutations Are Frequent in RARS-T.
H. Szpurka, A. Jankowska, H. Makishima, N. Bejanyan +3 more
20090 citations
Semantic Scholar
Sensitivity of a Homozygous c-Cbl Mutant AML Cell Line (JPM11) to Tyrosine Kinase Inhibitors, Implications for Potential Targeted Molecular Therapy.
H. Makishima, Y. Sugimoto, H. Szpurka, C. Prince +4 more
20090 citations
Semantic Scholar
Proteinase-3 Deficiency Contributes to Thrombotic Risk in PNH
A. Jankowska, H. Szpurka, Andrew E. Schade, Sanjay R. Mohan +1 more
20080 citations
Semantic Scholar
Acquired 1p Uniparental Disomy Is Associated with Biallelic MPL W515L Mutation in RARS-T.
H. Szpurka, Lukasz P. Gondek, Sanjay R. Mohan, E. Hsi +3 more
20080 citations
Semantic Scholar
Hypermethylation of DNA and Increased Expression of DNMT1 May Represent a Protective Mechanism from Oxidative Stress and DNA Damage in MDS.
A. Jankowska, Lukasz P. Gondek, H. Szpurka, Z. Nearman +2 more
20070 citations
Semantic Scholar
Detection of Recurrent Uniparental Disomy and Cryptic Chromosomal Abnormalities in MDS/MPD-U and MDS/MPD-Derived Secondary AML
Lukasz P. Gondek, A. Dunbar, Michael A. Mcdevitt, H. Szpurka +2 more
20070 citations
Semantic Scholar

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