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M. Karmazyn · SciRah

Researcher profile · Semantic Scholar

M. Karmazyn

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M. Karmazyn — researcher profile on SciRah

h-index: 55
Works: 279
Citations: 9,441

Most-cited papers

Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure After Myocardial Infarction in the Rat
X. Gan, Grace Ettinger, C. Huang, J. Burton +8 more
2014Circulation: Heart Failure286 citations Open access
Semantic Scholar
Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases
S. Javadov, M. Karmazyn, Nelson Escobales
2009Journal of Pharmacology and Experimental Therapeutics248 citations
Semantic Scholar
Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart.
M. Karmazyn, D. Purdham, V. Rajapurohitam, A. Zeidan
2008Cardiovascular Research117 citations
Semantic Scholar
The role of NHE-1 in myocardial hypertrophy and remodelling.
M. Karmazyn, Ana Kilić, S. Javadov
2008Journal of Molecular and Cellular Cardiology115 citations
Semantic Scholar
NHE-1: still a viable therapeutic target.
M. Karmazyn
2013Journal of Molecular and Cellular Cardiology110 citations
Semantic Scholar
Therapeutic Potential of Ginseng in the Management of Cardiovascular Disorders
M. Karmazyn, M. Moey, X. Gan
2011Drugs107 citations
Semantic Scholar
Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei.
A. Zeidan, S. Javadov, S. Chakrabarti, M. Karmazyn
2008Cardiovascular Research101 citations Open access
Semantic Scholar
Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes.
A. Zeidan, S. Javadov, M. Karmazyn
2006Cardiovascular Research98 citations
Semantic Scholar
Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia.
Ling Chen, Jin Zhang, Tracey X. Gan, Y. Chen-Izu +4 more
2008Journal of applied physiology96 citations
Semantic Scholar
Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition
S. Javadov, V. Rajapurohitam, Ana Kilić, J. Hunter +4 more
2010Basic Research in Cardiology94 citations
Semantic Scholar
NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.
S. Javadov, A. Choi, V. Rajapurohitam, A. Zeidan +2 more
2008Cardiovascular Research90 citations
Semantic Scholar
Ginseng Inhibits Cardiomyocyte Hypertrophy and Heart Failure via NHE-1 Inhibition and Attenuation of Calcineurin Activation
Juan Guo, X. Gan, J. Haist, V. Rajapurohitam +3 more
2011Circulation: Heart Failure78 citations Open access
Semantic Scholar
Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy
B. Álvarez, D. E. Johnson, Daniel Sowah, D. Soliman +4 more
2007Journal of Physiology77 citations Open access
Semantic Scholar
Leptin as a cardiac hypertrophic factor: a potential target for therapeutics.
M. Karmazyn, D. Purdham, V. Rajapurohitam, A. Zeidan
2007Trends in cardiovascular medicine72 citations
Semantic Scholar
Antihypertrophic Effect of Na+/H+ Exchanger Isoform 1 Inhibition Is Mediated by Reduced Mitogen-Activated Protein Kinase Activation Secondary to Improved Mitochondrial Integrity and Decreased Generation of Mitochondrial-Derived Reactive Oxygen Species
S. Javadov, D. Baetz, V. Rajapurohitam, A. Zeidan +2 more
2006Journal of Pharmacology and Experimental Therapeutics68 citations
Semantic Scholar
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
S. Javadov, V. Rajapurohitam, Ana Kilić, A. Zeidan +2 more
2009Journal of Molecular and Cellular Cardiology64 citations
Semantic Scholar
A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart.
D. Purdham, V. Rajapurohitam, A. Zeidan, C. Huang +2 more
2008American Journal of Physiology. Heart and Circulatory Physiology61 citations
Semantic Scholar
Deficiency of Capn4 Gene Inhibits Nuclear Factor-κB (NF-κB) Protein Signaling/Inflammation and Reduces Remodeling after Myocardial Infarction*
Jian Ma, Meng Wei, Qiang Wang, Jianmin Li +7 more
2012Journal of Biological Chemistry59 citations Open access
Semantic Scholar
Endothelial Nitric Oxide Synthase Promotes Bone Marrow Stromal Cell Migration to the Ischemic Myocardium via Upregulation of Stromal Cell‐Derived Factor‐1α
Na Li, Xiang-Ru Lu, Xiao-Hui Zhao, F. Xiang +3 more
2009Stem Cells58 citations
Semantic Scholar
Role of endothelin‐1, sodium hydrogen exchanger‐1 and mitogen activated protein kinase (MAPK) activation in glucose‐induced cardiomyocyte hypertrophy
S. Chen, Z. Khan, M. Karmazyn, S. Chakrabarti
2007Diabetes/Metabolism Research Reviews58 citations
Semantic Scholar
Leptin and endothelin‐1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease
Pijush Majumdar, S. Chen, Biju George, S. Sen +2 more
2009Diabetes/Metabolism Research Reviews50 citations
Semantic Scholar
Activated NHE1 is required to induce early cardiac hypertrophy in mice
F. Mraiche, Tatsujiro Oka, X. Gan, M. Karmazyn +1 more
2011Basic Research in Cardiology49 citations
Semantic Scholar
Actin Cytoskeleton Dynamics Promotes Leptin-Induced Vascular Smooth Muscle Hypertrophy via RhoA/ROCK- and Phosphatidylinositol 3-Kinase/Protein Kinase B-Dependent Pathways
A. Zeidan, Ben Paylor, K. Steinhoff, S. Javadov +3 more
2007Journal of Pharmacology and Experimental Therapeutics49 citations
Semantic Scholar
Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy.
Ana Kilić, S. Javadov, M. Karmazyn
2009Journal of Molecular and Cellular Cardiology48 citations
Semantic Scholar
The Myocardial Na+/H+ Exchanger
M. Karmazyn, J. V. Sostaric, X. Gan
2012Drugs47 citations
Semantic Scholar
Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.
Jin Xue, F. Mraiche, Dan Zhou, M. Karmazyn +3 more
2010Physiological Genomics46 citations Open access
Semantic Scholar
mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy
A. Zeidan, J. Hunter, S. Javadov, M. Karmazyn
2011Molecular and Cellular Biochemistry45 citations
Semantic Scholar
Chemical components of ginseng, their biotransformation products and their potential as treatment of hypertension
M. Karmazyn, X. Gan
2020Molecular and Cellular Biochemistry43 citations
Semantic Scholar
Identification of Fat Mass and Obesity Associated (FTO) Protein Expression in Cardiomyocytes: Regulation by Leptin and Its Contribution to Leptin-Induced Hypertrophy
X. Gan, Gan-Jian Zhao, C. Huang, Adrianna C. Rowe +2 more
2013PLoS ONE43 citations Open access
Semantic Scholar
Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.
J. Hunter, A. Zeidan, S. Javadov, Ana Kilić +2 more
2009Journal of Molecular and Cellular Cardiology40 citations
Semantic Scholar
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
J. Huber, Jörg Bentzien, S. Boyer, J. Burke +16 more
2012Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway.
Ana Kilić, V. Rajapurohitam, Sharon M. Sandberg, A. Zeidan +5 more
2010Cardiovascular Research35 citations Open access
Semantic Scholar
Leptin-induced cardiomyocyte hypertrophy reveals both calcium-dependent and calcium-independent/RhoA-dependent calcineurin activation and NFAT nuclear translocation.
V. Rajapurohitam, Farzad Izaddoustdar, E. Martínez-Abundis, M. Karmazyn
2012Cellular Signalling33 citations
Semantic Scholar
Ginseng Reverses Established Cardiomyocyte Hypertrophy and Postmyocardial Infarction-Induced Hypertrophy and Heart Failure
M. Moey, X. Gan, C. Huang, V. Rajapurohitam +3 more
2012Circulation: Heart Failure32 citations Open access
Semantic Scholar
The Obesity-Related Peptide Leptin Sensitizes Cardiac Mitochondria to Calcium-Induced Permeability Transition Pore Opening and Apoptosis
E. Martínez-Abundis, V. Rajapurohitam, J. Haist, X. Gan +1 more
2012PLoS ONE32 citations Open access
Semantic Scholar
A model of poorly controlled type 1 Diabetes Mellitus and its treatment with aerobic exercise training.
C. J. Melling, Kenneth N. Grisé, C. Hasilo, B. Fier +3 more
2013Diabetes & Metabolism31 citations
Semantic Scholar
Prevention of RhoA activation and cofilin-mediated actin polymerization mediates the antihypertrophic effect of adenosine receptor agonists in angiotensin II- and endothelin-1-treated cardiomyocytes
A. Zeidan, X. Gan, Ashley Thomas, M. Karmazyn
2013Molecular and Cellular Biochemistry30 citations
Semantic Scholar
Exercise training improves myocardial tolerance to ischemia in male but not in female rats.
David B. Thorp, J. Haist, J. Leppard, K. Milne +2 more
2007American Journal of Physiology. Regulatory Integrative and Comparative Physiology30 citations
Semantic Scholar
Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes.
T. Pang, V. Rajapurohitam, M. A. Cook, M. Karmazyn
2010American Journal of Physiology. Heart and Circulatory Physiology28 citations
Semantic Scholar
Leptin-induced cardiomyocyte hypertrophy is associated with enhanced mitochondrial fission
C. Jong, J. Yeung, Emily Tseung, M. Karmazyn
2018Molecular and Cellular Biochemistry26 citations
Semantic Scholar
Early and Transient Sodium-Hydrogen Exchanger Isoform 1 Inhibition Attenuates Subsequent Cardiac Hypertrophy and Heart Failure Following Coronary Artery Ligation
Ana Kilić, C. Huang, V. Rajapurohitam, J. Madwed +1 more
2014Journal of Pharmacology and Experimental Therapeutics25 citations Open access
Semantic Scholar
CD73-TNAP crosstalk regulates the hypertrophic response and cardiomyocyte calcification due to α1 adrenoceptor activation
X. Gan, S. Taniai, Gan-Jian Zhao, C. Huang +4 more
2014Molecular and Cellular Biochemistry25 citations
Semantic Scholar
Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy
V. Rajapurohitam, Ana Kilić, S. Javadov, M. Karmazyn
2012Molecular and Cellular Biochemistry24 citations
Semantic Scholar
Ginseng (Panax quinquefolius) Attenuates Leptin-Induced Cardiac Hypertrophy through Inhibition of p115Rho Guanine Nucleotide Exchange Factor-RhoA/Rho-Associated, Coiled-Coil Containing Protein Kinase-Dependent Mitogen-Activated Protein Kinase Pathway Activation
M. Moey, V. Rajapurohitam, A. Zeidan, M. Karmazyn
2011Journal of Pharmacology and Experimental Therapeutics24 citations
Semantic Scholar
Treatment of the cardiac hypertrophic response and heart failure with ginseng, ginsenosides, and ginseng-related products.
M. Karmazyn, X. Gan
2017Canadian Journal of Physiology and Pharmacology20 citations Open access
Semantic Scholar
Probiotics as potential treatments to reduce myocardial remodelling and heart failure via the gut-heart axis: State-of-the-art review
M. Karmazyn, X. Gan
2023Molecular and Cellular Biochemistry19 citations
Semantic Scholar
Cardioprotection by ginseng: experimental and clinical evidence and underlying mechanisms.
X. Gan, M. Karmazyn
2018Canadian Journal of Physiology and Pharmacology19 citations Open access
Semantic Scholar
Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
T. Pang, X. Gan, D. Freeman, M. A. Cook +1 more
2010American Journal of Physiology. Heart and Circulatory Physiology19 citations
Semantic Scholar
Leptin as a cardiac pro-hypertrophic factor and its potential role in the development of heart failure.
M. Karmazyn, V. Rajapurohitam
2014Current pharmaceutical design17 citations
Semantic Scholar
Distinct KATP Channels Mediate the Antihypertrophic Effects of Adenosine Receptor Activation in Neonatal Rat Ventricular Myocytes
Ying Xia, S. Javadov, Tracey X. Gan, T. Pang +2 more
2007Journal of Pharmacology and Experimental Therapeutics16 citations
Semantic Scholar

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