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Sangyeul Han · SciRah

Researcher profile · Semantic Scholar

Sangyeul Han

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Sangyeul Han — researcher profile on SciRah

h-index: 14
Works: 19
Citations: 2,309

Most-cited papers

Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
D. Ehninger, Sangyeul Han, Carrie Shilyansky, Yu Zhou +4 more
2008Nature Medicine863 citations Open access
Semantic Scholar
Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.
Jin-Sung Park, I. Kim, Sangyeul Han, Intae Park +11 more
2016Cancer Cell301 citations Open access
Semantic Scholar
NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth
Marianne F. James, Sangyeul Han, C. Polizzano, S. Plotkin +4 more
2009Molecular and Cellular Biology300 citations Open access
Semantic Scholar
Amelioration of sepsis by TIE2 activation–induced vascular protection
Sangyeul Han, Seung-Jun Lee, Kyung Eun Kim, H. Lee +25 more
2016Science Translational Medicine201 citations
Semantic Scholar
Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types
Marianne F. James, E. Stivison, R. Beauchamp, Sangyeul Han +5 more
2012Molecular Cancer Research105 citations Open access
Semantic Scholar
Phosphorylation of Tuberin as a Novel Mechanism for Somatic Inactivation of the Tuberous Sclerosis Complex Proteins in Brain Lesions
Sangyeul Han, Túlio Marcos Santos, A. Puga, J. Roy +4 more
2004Cancer Research94 citations Open access
Semantic Scholar
Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.
Sangyeul Han, Rochelle M. Witt, Túlio Marcos Santos, C. Polizzano +2 more
2008Cellular Signalling86 citations Open access
Semantic Scholar
Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1·TSC2 Complex*
Vanishree Murthy, Sangyeul Han, R. Beauchamp, Nicole A. Smith +3 more
2004Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration
Jaeryung Kim, J. Park, Jeongwoon Choi, Intae Park +12 more
2019Science Advances70 citations Open access
Semantic Scholar
Aberrant hyperactivation of Akt and mammalian target of rapamycin complex 1 (mTORC1) signaling in sporadic chordomas
Sangyeul Han, C. Polizzano, G. Nielsen, F. Hornicek +2 more
2009Clinical Cancer Research55 citations Open access
Semantic Scholar
The E3 Ubiquitin Ligase Protein Associated with Myc (Pam) Regulates Mammalian/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling in Vivo through N- and C-terminal Domains*
Sangyeul Han, S. Kim, S. Bahl, Lin Li +7 more
2012Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Gln-362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with α5β1 Integrin
H. Lee, S. Oh, Kwang-Hoon Lee, Yoon‐Sook Lee +8 more
2014Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Erratum: Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment (Cancer Cell (2016) 30(6) (953–967) (S1535610816305050) (10.1016/j.ccell.2016.10.018))
Jin-Sung Park, Il Kim, Sangyeul Han, Intae Park +11 more
201726 citations Open access
Semantic Scholar
Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model
S. Prabhakar, Xuan Zhang, J. Goto, Sangyeul Han +7 more
2015Neurobiology of Disease16 citations Open access
Semantic Scholar
Alternative splicing in protein associated with Myc (Pam) influences its binding to c‐Myc
Túlio Marcos Santos, Sangyeul Han, M. Bowser, Karen Sazani +4 more
2006Journal of Neuroscience Research14 citations
Semantic Scholar
Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.
Jin-Sung Park, I. Kim, Sangyeul Han, Intae Park +11 more
2017Cancer Cell8 citations Open access
Semantic Scholar
Identification of Tie2 as a sensor for reactive oxygen species and its therapeutic implication
An Vuong Quynh Pham, Yongwoo Na, G. Suk, Chansik Yang +9 more
2025Redox Biology7 citations Open access
Semantic Scholar
Signaling and Regulation Regulation of mTOR Complex 2 Signaling in Neuro fi bromatosis 2 – De fi cient Target Cell Types
Marianne F. James, E. Stivison, R. Beauchamp, Sangyeul Han +5 more
20126 citations
Semantic Scholar
Calmodulin Mediates Ca2+-Dependent Inhibition of Tie2 Signaling and Acts as a Developmental Brake During Embryonic Angiogenesis
Chansik Yang, J. Ohk, Ji Yeun Lee, Eun Jin Kim +5 more
2016Arteriosclerosis, Thrombosis and Vascular Biology5 citations Open access
Semantic Scholar

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