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K. Althoff · SciRah

Researcher profile · Semantic Scholar

K. Althoff

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K. Althoff — researcher profile on SciRah

h-index: 19
Works: 37
Citations: 1,586

Most-cited papers

Mutational dynamics between primary and relapse neuroblastomas
A. Schramm, J. Köster, Y. Assenov, K. Althoff +31 more
2015Nature Genetics311 citations
Semantic Scholar
Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition
A. Henssen, K. Althoff, A. Odersky, Anneleen Beckers +19 more
2015Clinical Cancer Research172 citations
Semantic Scholar
BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
A. Henssen, T. Thor, A. Odersky, L. Heukamp +10 more
2013OncoTarget142 citations Open access
Semantic Scholar
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
K. Althoff, Anneleen Beckers, Emma Bell, M. Nortmeyer +14 more
2014Oncogene141 citations Open access
Semantic Scholar
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression
J. Layer, Marie Kronmüller, T. Quast, D. van den Boorn-Konijnenberg +12 more
2017Oncoimmunology111 citations Open access
Semantic Scholar
MiR‐137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A
K. Althoff, Anneleen Beckers, A. Odersky, P. Mestdagh +10 more
2013International Journal of Cancer100 citations Open access
Semantic Scholar
miR‐542‐3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin
K. Althoff, S. Lindner, A. Odersky, P. Mestdagh +14 more
2015International Journal of Cancer96 citations Open access
Semantic Scholar
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
Phyllis F. Cheung, Jiajin Yang, Rui Fang, Arianna Borgers +31 more
2022Nature Communications72 citations Open access
Semantic Scholar
Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity
Lena Quambusch, I. Landel, Laura Depta, J. Weisner +6 more
2019Angewandte Chemie65 citations Open access
Semantic Scholar
MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma
Anneleen Beckers, G. Van Peer, Daniel R. Carter, Moritz Gartlgruber +14 more
2015Cancer Letters49 citations Open access
Semantic Scholar
Cellular model system to dissect the isoform-selectivity of Akt inhibitors
Lena Quambusch, Laura Depta, I. Landel, Melissa Lubeck +12 more
2021Nature Communications47 citations Open access
Semantic Scholar
The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models
Kristian W. Pajtler, Natalie Sadowski, S. Ackermann, K. Althoff +15 more
2016OncoTarget42 citations Open access
Semantic Scholar
MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation
Anneleen Beckers, G. Van Peer, Daniel R. Carter, E. Mets +8 more
2014OncoTarget40 citations Open access
Semantic Scholar
Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
J. A. Seier, J. Reinhardt, Kritika Saraf, Susanna S. Ng +7 more
2021Journal for ImmunoTherapy of Cancer39 citations Open access
Semantic Scholar
MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma
J. Fabian, Desirée Opitz, K. Althoff, M. Lodrini +36 more
2016OncoTarget36 citations Open access
Semantic Scholar
Targeting tachykinin receptors in neuroblastoma
A. Henssen, A. Odersky, A. Szymansky, Marleen Seiler +11 more
2016OncoTarget28 citations Open access
Semantic Scholar
Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
K. Fielitz, K. Althoff, K. De Preter, J. Nonnekens +14 more
2016OncoTarget24 citations Open access
Semantic Scholar
Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.
You-Jia Han, S. Lindner, Yi Bei, H. García +10 more
2019Cancer Letters23 citations
Semantic Scholar
ALK positively regulates MYCN activity through repression of HBP1 expression
Shana Claeys, G. Denecker, K. Durinck, Bieke Decaesteker +24 more
2018Oncogene22 citations Open access
Semantic Scholar
Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.
Phyllis F. Cheung, Florian Neff, Christian Neander, Anna Bazarna +11 more
2018Cancer Research11 citations
Semantic Scholar
Pharmaceutically inhibiting polo‐like kinase 1 exerts a broad anti‐tumour activity in retinoblastoma cell lines
M. Schwermer, S. Dreesmann, A. Eggert, K. Althoff +4 more
2017Clinical and Experimental Ophthalmology9 citations
Semantic Scholar
RITA displays anti-tumor activity in medulloblastomas independent of TP53 status
A. Gottlieb, K. Althoff, Laura Grunewald, T. Thor +8 more
2017OncoTarget6 citations Open access
Semantic Scholar
MYCN-mediated murine cancer models
K. Althoff, A. Schramm
2017Aging2 citations Open access
Semantic Scholar
Towards diagnostic application of non-coding RNAs in neuroblastoma
K. Althoff, J. Schulte, A. Schramm
2016Expert Review of Molecular Diagnostics2 citations
Semantic Scholar
Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression
Phyllis F. Cheung, Jiajin Yang, Kirsten Krengel, K. Althoff +28 more
2021bioRxiv1 citations Open access
Semantic Scholar
Abstract 3967: BET protein inhibitor OTX015 has selective anti-tumoral activity in preclinical models of MYCN- amplified neuroblastoma
J. Schulte, K. Althoff, E. Bell, A. Odersky +9 more
20141 citations
Semantic Scholar
P01.18 Metabolic status and immune activation influence clinical outcomes in patients after allogeneic hematopoietic stem cell transplantation
K. Althoff, S. Leitzke, C. Herling, L. Frenzel +5 more
2020Journal for ImmunoTherapy of Cancer0 citations Open access
Semantic Scholar
Abstract 5815: The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
G. Denecker, Shana Claeys, I. Lambertz, E. Janssens +14 more
20170 citations
Semantic Scholar
HBP1 is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex
Shana Claeys, G. Denecker, I. Lambertz, E. Janssens +13 more
20170 citations
Semantic Scholar
The HBP1 tumor suppressor is an epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex
Shana Claeys, I. Lambertz, Alan Van Goethem, C. Kumps +8 more
20160 citations
Semantic Scholar
HBP1 downregulation through mutant ALK represents a novel mechanism for cooperative MYCN activation in neuroblastoma
Shana Claeys, I. Lambertz, Alan Van Goethem, C. Kumps +8 more
20150 citations
Semantic Scholar
MYCN and MicroRNAs
K. Althoff, J. Schulte
20150 citations
Semantic Scholar
MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma
J. Fabian, Desirée Opitz, K. Althoff, M. Lodrini +33 more
2015Molecular and Cellular Pediatrics0 citations Open access
Semantic Scholar
Abstract 4731: Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma
A. Henssen, K. Althoff, R. Koche, A. Odersky +15 more
20150 citations
Semantic Scholar
Etablierung eines MYCN-vermittelten murinen Neuroblastommodells und Analyse tumorsuppressiver mikroRNAs
K. Althoff
20140 citations
Semantic Scholar
High-throughput lncRNA expression profiling identifies candidate cancer lncRNAs
P. Mestdagh, Steve Lefever, K. Althoff, C. Leonelli +4 more
20130 citations
Semantic Scholar
Identification and functional characterization of lncRNAs in cancer
P. Mestdagh, Steve Lefever, K. Althoff, C. Leonelli +4 more
20130 citations
Semantic Scholar

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