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K. Broersen · SciRah

Researcher profile · Semantic Scholar

K. Broersen

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K. Broersen — researcher profile on SciRah

h-index: 31
Works: 73
Citations: 3,926

Most-cited papers

Alzheimer’s Disease: Treatment Strategies and Their Limitations
Elodie Passeri, K. Elkhoury, Margreet Morsink, K. Broersen +5 more
2022International Journal of Molecular Sciences543 citations Open access
Semantic Scholar
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
I. Kuperstein, K. Broersen, I. Benilova, J. Rozenski +14 more
2010EMBO Journal503 citations Open access
Semantic Scholar
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
L. Chávez-Gutiérrez, Leen Bammens, I. Benilova, A. Vandersteen +14 more
2012EMBO Journal478 citations Open access
Semantic Scholar
Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease*
K. Pauwels, T. Williams, K. Morris, W. Jonckheere +7 more
2011Journal of Biological Chemistry207 citations Open access
Semantic Scholar
Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease
F. Cioffi, Rayan Hassan Ibrahim Adam, K. Broersen
2019Journal of Alzheimer's Disease166 citations Open access
Semantic Scholar
The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
K. Broersen, F. Rousseau, J. Schymkowitz
2010Alzheimer's Research & Therapy161 citations Open access
Semantic Scholar
A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease.
K. Broersen, W. Jonckheere, J. Rozenski, A. Vandersteen +4 more
2011Protein engineering, design & selection : PEDS120 citations Open access
Semantic Scholar
Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling
L. Papamichail, Lena S. Koch, D. Veerman, K. Broersen +1 more
2025Frontiers in Bioengineering and Biotechnology113 citations Open access
Semantic Scholar
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation
Lujia Zhou, N. Brouwers, I. Benilova, A. Vandersteen +10 more
2011EMBO Molecular Medicine109 citations Open access
Semantic Scholar
Glycoforms of β‐lactoglobulin with improved thermostability and preserved structural packing
K. Broersen, A. G. Voragen, R. Hamer, H. D. de Jongh
2004Biotechnology and Bioengineering105 citations Open access
Semantic Scholar
Transient dynamics of Aβ contribute to toxicity in Alzheimer’s disease
E. Hubin, N. V. van Nuland, K. Broersen, K. Pauwels
2014Cellular and Molecular Life Sciences94 citations Open access
Semantic Scholar
Mechanism of arachidonic acid action on syntaxin–Munc18
E. Connell, F. Darios, K. Broersen, Naomi Gatsby +3 more
2007EMBO Reports92 citations Open access
Semantic Scholar
α-synuclein adopts an α-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation
K. Broersen, D. M. van den Brink, G. Fraser, M. Goedert +1 more
200684 citations
Semantic Scholar
Optimized Triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins
M. Teodorowicz, Olaf Perdijk, Iris C. Verhoek, C. Govers +4 more
2017PLoS ONE80 citations Open access
Semantic Scholar
Do sulfhydryl groups affect aggregation and gelation properties of ovalbumin?
K. Broersen, Annemarie M. M. van Teeffelen, A. Vries, A. G. Voragen +2 more
2006Journal of Agricultural and Food Chemistry75 citations Open access
Semantic Scholar
A comparative analysis of the aggregation behavior of amyloid‐β peptide variants
A. Vandersteen, E. Hubin, Rabia Sarroukh, G. D. De Baets +7 more
2012FEBS Letters70 citations Open access
Semantic Scholar
Mechanistic insights in glycation-induced protein aggregation.
M. Adrover, Laura Mariño, P. Sanchís, K. Pauwels +6 more
2014Biomacromolecules66 citations Open access
Semantic Scholar
A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease
F. Cioffi, Rayan Hassan Ibrahim Adam, Ruchi Bansal, K. Broersen
2021Journal of Alzheimer's Disease60 citations Open access
Semantic Scholar
Milk Processing Affects Structure, Bioavailability and Immunogenicity of β-lactoglobulin
K. Broersen
2020Foods57 citations Open access
Semantic Scholar
Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation
E. Hubin, P. Verghese, N. V. van Nuland, K. Broersen
2019FEBS Letters55 citations Open access
Semantic Scholar
Glucosylation of β‐lactoglobulin lowers the heat capacity change of unfolding; a unique way to affect protein thermodynamics
Annemarie M. M. van Teeffelen, K. Broersen, H. D. de Jongh
2005Protein Science55 citations Open access
Semantic Scholar
Effect of protein charge on the generation of aggregation-prone conformers.
K. Broersen, M. Weijers, J. de Groot, R. Hamer +1 more
2007Biomacromolecules43 citations Open access
Semantic Scholar
Net charge affects morphology and visual properties of ovalbumin aggregates.
M. Weijers, K. Broersen, P. A. Barneveld, M. A. Cohen Stuart +3 more
2008Biomacromolecules42 citations Open access
Semantic Scholar
Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation
Daniela Marasco, Caterina Vicidomini, P. Krupa, F. Cioffi +6 more
2020Chemico-Biological Interactions41 citations Open access
Semantic Scholar
Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins
J. Vaneyck, I. Segers-Nolten, K. Broersen, M. Claessens
2021Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Molecular Plasticity Regulates Oligomerization and Cytotoxicity of the Multipeptide-length Amyloid-β Peptide Pool*
A. Vandersteen, M. Masman, G. D. De Baets, W. Jonckheere +9 more
2012Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Chemical processing as a tool to generate ovalbumin variants with changed stability
H. Kosters, K. Broersen, J. de Groot, Jan-Willem F. A. Simons +2 more
2003Biotechnology and Bioengineering39 citations Open access
Semantic Scholar
Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes
E. Hubin, S. Deroo, G. S. Kaminski Schierle, C. Kaminski +6 more
2015Cellular and Molecular Life Sciences36 citations Open access
Semantic Scholar
The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein
David Ruzafa, Yuriko S Hernandez-Gomez, Giovanni Bisello, K. Broersen +2 more
2017PLoS ONE33 citations Open access
Semantic Scholar
α-Galactosidase Aggregation Is a Determinant of Pharmacological Chaperone Efficacy on Fabry Disease Mutants*
A. Siekierska, G. D. De Baets, J. Reumers, R. Gallardo +6 more
2012Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.
K. Broersen, D. M. van den Brink, G. Fraser, M. Goedert +1 more
2006Biochemistry32 citations
Semantic Scholar
Aggregation of β-lactoglobulin regulated by glucosylation
K. Broersen, M. Elshof, J. de Groot, A. G. Voragen +2 more
200728 citations Open access
Semantic Scholar
Transwell‐Integrated 2 µm Thick Transparent Polydimethylsiloxane Membranes with Controlled Pore Sizes and Distribution to Model the Blood‐Brain Barrier
M. Zakharova, M. Tibbe, Lena S. Koch, Hai Le‐The +5 more
2021Advanced Materials & Technologies27 citations Open access
Semantic Scholar
Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound.
Caterina Vicidomini, F. Cioffi, K. Broersen, V. Roviello +6 more
2019Future Medicinal Chemistry23 citations
Semantic Scholar
Application Potential of Food Protein Modification
H. D. de Jongh, K. Broersen
201221 citations Open access
Semantic Scholar
The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration
Natalia Ortí-Casañ, A. Boerema, K. Köpke, Amber Ebskamp +9 more
2023Scientific Reports20 citations Open access
Semantic Scholar
New mimetic peptides inhibitors of Αβ aggregation. Molecular guidance for rational drug design.
Exequiel E. Barrera Guisasola, S. Andújar, E. Hubin, K. Broersen +6 more
2015European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Modulation of the gelation efficiency of fibrillar and spherical aggregates by means of thiolation.
C. Munialo, H. D. de Jongh, K. Broersen, E. van der Linden +1 more
2013Journal of Agricultural and Food Chemistry19 citations Open access
Semantic Scholar
Biopurification using non-growing microorganisms to improve plant protein ingredients
A. Nugroho, Saskia van Schalkwijk, Sabri Cebeci, Simon Jacobs +8 more
2024npj Science of Food15 citations Open access
Semantic Scholar
Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies
David Choy-Buentello, Lena S. Koch, Grissel Trujillo-de Santiago, M. M. Álvarez +1 more
2021bioRxiv15 citations Open access
Semantic Scholar
Structural and Aggregation Properties of Alpha-Synuclein Linked to Phospholipase A2 Action.
K. Broersen, V. Ruipérez, B. Davletov
2018Protein Peptide Letters15 citations
Semantic Scholar
Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states.
E. Hubin, F. Cioffi, J. Rozenski, N. V. van Nuland +1 more
2016Biochimica et Biophysica Acta15 citations Open access
Semantic Scholar
Engineering Organoids for in vitro Modeling of Phenylketonuria
A. C. Borges, K. Broersen, P. Leandro, Tiago G. Fernandes
2022Frontiers in Molecular Neuroscience11 citations Open access
Semantic Scholar
Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.
Filip Claes, S. Rudyak, Angela S. Laird, Nikolaos N. Louros +18 more
2019Protein engineering, design & selection : PEDS8 citations Open access
Semantic Scholar
Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer.
János Gera, Titanilla Szögi, Z. Bozsó, L. Fülöp +9 more
2018Bioorganic chemistry (Print)8 citations Open access
Semantic Scholar
Robust Tissue Fabrication for Long-Term Culture of iPSC-Derived Brain Organoids for Aging Research.
Lena S. Koch, David Choy-Buentello, K. Broersen
2023Journal of Visualized Experiments5 citations Open access
Semantic Scholar
MEA Neurosensor, the Tool for Synaptic Activity Detection: Acute Amyloid- β Oligomers Synaptotoxicity Study
I. Benilova, I. Kuperstein, K. Broersen, J. Schymkowitz +3 more
20094 citations
Semantic Scholar
Could ecosystem management provide a new framework for Alzheimer's disease?
E. Hubin, B. Vanschoenwinkel, K. Broersen, P. de Deyn +3 more
2016Alzheimer's & Dementia3 citations Open access
Semantic Scholar
Abstracts In Vitro Toxicology Society Annual Meeting November 10–11, 2015 Birmingham, United Kingdom
van der Marinke W. Helm, K. Broersen, van der Andries D. Meer, J. Eijkel +2 more
20152 citations Open access
Semantic Scholar
Technical Proteins: A Multitude of Applications to Discover
K. Broersen
20142 citations
Semantic Scholar

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