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Michaela U. Gack · SciRah

Researcher profile · Semantic Scholar

Michaela U. Gack

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Michaela U. Gack — researcher profile on SciRah

h-index: 49
Works: 132
Citations: 17K

Most-cited papers

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, M. Abdellatif +496 more
2021Autophagy4,016 citations Open access
Semantic Scholar
RIG-I-like receptors: their regulation and roles in RNA sensing
J. Rehwinkel, Michaela U. Gack
2020Nature reviews. Immunology1,531 citations Open access
Semantic Scholar
Viral evasion of intracellular DNA and RNA sensing
Y. Chan, Michaela U. Gack
2016Nature Reviews Microbiology431 citations Open access
Semantic Scholar
Dysregulation of type I interferon responses in COVID-19
D. Acharya, Guanqun Liu, Michaela U. Gack
2020Nature reviews. Immunology410 citations Open access
Semantic Scholar
TRIM Proteins and Their Roles in Antiviral Host Defenses
M. van Gent, K. M. Sparrer, Michaela U. Gack
2018Annual Review of Virology303 citations Open access
Semantic Scholar
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
Guanqun Liu, Jung-Hyun Lee, Zachary M. Parker, D. Acharya +7 more
2021Nature Microbiology278 citations Open access
Semantic Scholar
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity
Jessica J. Chiang, K. Sparrer, M. van Gent, Charlotte Lässig +4 more
2017Nature Immunology234 citations Open access
Semantic Scholar
TRIM23 mediates virus-induced autophagy via activation of TBK1
K. M. Sparrer, Sebastian Gableske, Matthew A. Zurenski, Zachary M. Parker +9 more
2017Nature Microbiology209 citations Open access
Semantic Scholar
Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway
Jacint G. Sanchez, Jessica J. Chiang, K. M. Sparrer, S. L. Alam +5 more
2016Cell Reports135 citations Open access
Semantic Scholar
Post-translational Control of Intracellular Pathogen Sensing Pathways
C. Chiang, Michaela U. Gack
2016Trends in immunology132 citations Open access
Semantic Scholar
The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling
C. Chiang, E. Pauli, J. Biryukov, Katharina F. Feister +6 more
2017Journal of Virology130 citations Open access
Semantic Scholar
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity
Guanqun Liu, Michaela U. Gack
2020Immunity128 citations Open access
Semantic Scholar
Zika virus NS3 mimics a cellular 14-3-3-binding motif to antagonize RIG-I- and MDA5-mediated innate immunity
W. Riedl, D. Acharya, Jung-Hyun Lee, Guanqun Liu +5 more
2019Cell Host and Microbe120 citations Open access
Semantic Scholar
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
Ya-Di Zhou, Yuan Hou, Jiayu Shen, R. Mehra +14 more
2020PLoS Biology118 citations Open access
Semantic Scholar
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation
Da-Yuan Chen, C. Chin, D. Kenney, A. H. Tavares +20 more
2023Nature115 citations Open access
Semantic Scholar
A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity
Y. Chan, Michaela U. Gack
2016Nature Immunology105 citations Open access
Semantic Scholar
The antiviral activities of TRIM proteins
L. Koepke, Michaela U. Gack, K. Sparrer
2020Current Opinion in Microbiology97 citations Open access
Semantic Scholar
TRIM25 binds RNA to modulate cellular anti-viral defense
Jacint G. Sanchez, K. M. Sparrer, C. Chiang, Rebecca A Reis +5 more
2018Journal of Molecular Biology86 citations Open access
Semantic Scholar
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19
Ya-Di Zhou, Yuan Hou, Jiayu Shen, A. Kallianpur +14 more
2020ChemRxiv78 citations Open access
Semantic Scholar
Innate immune escape by Dengue and West Nile viruses
Michaela U. Gack, M. Diamond
2016Current Opinion in Virology75 citations Open access
Semantic Scholar
Actin Cytoskeleton Remodeling Primes RIG-I-like Receptor Activation
D. Acharya, Rebecca A Reis, Meta Volcic, Guanqun Liu +8 more
2022Cell74 citations Open access
Semantic Scholar
Evasion of Innate and Intrinsic Antiviral Pathways by the Zika Virus
Taryn M. Serman, Michaela U. Gack
2019Viruses60 citations Open access
Semantic Scholar
High-throughput RNA sequencing of paraformaldehyde-fixed single cells
Hoang Van Phan, M. van Gent, N. Drayman, Anindita Basu +2 more
2021Nature Communications54 citations Open access
Semantic Scholar
Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity
F. Full, M. van Gent, K. Sparrer, C. Chiang +9 more
2018Nature Microbiology54 citations Open access
Semantic Scholar
Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity
Q. Ma, Hongyu Ruan, Li-Sheng Peng, Ming-Jie Zhang +2 more
2017Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2
H. Mou, Brian D. Quinlan, Haiyong Peng, Guanqun Liu +14 more
2021PLoS Pathogens47 citations Open access
Semantic Scholar
Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS
Jung-Hyun Lee, C. Chiang, Michaela U. Gack
2019Journal of Interferon and Cytokine Research47 citations Open access
Semantic Scholar
ISG15: Its Roles in SARS-CoV-2 and Other Viral Infections
Lucky Sarkar, Guanqun Liu, Michaela U. Gack
2023Trends in Microbiology46 citations Open access
Semantic Scholar
TRIM proteins: New players in virus-induced autophagy
K. M. Sparrer, Michaela U. Gack
2018PLoS Pathogens43 citations Open access
Semantic Scholar
Viral evasion of the interferon response at a glance.
Junji Zhu, C. Chiang, Michaela U. Gack
2023Journal of Cell Science41 citations Open access
Semantic Scholar
Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus
Quanyuan Wan, Leah Tavakoli, Ting-Yu Wang, Andrew J Tucker +7 more
2024Nature Communications38 citations Open access
Semantic Scholar
Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy
Xing Liu, Rachel Matrenec, Michaela U. Gack, B. He
2019Journal of Virology38 citations Open access
Semantic Scholar
The RIG-I-like receptor family of immune proteins
M. van Huizen, Michaela U. Gack
2025Molecules and Cells34 citations Open access
Semantic Scholar
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141
L. Naesens, Santoshi Muppala, D. Acharya, Josephine Nemegeer +17 more
2022Science immunology32 citations Open access
Semantic Scholar
Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication
Taryn M. Serman, C. Chiang, Guanqun Liu, Zuberwasim Sayyad +9 more
2023Cell Host and Microbe30 citations Open access
Semantic Scholar
The US3 Kinase of Herpes Simplex Virus Phosphorylates the RNA Sensor RIG-I To Suppress Innate Immunity
M. van Gent, Jessica J. Chiang, Santoshi Muppala, C. Chiang +5 more
2021Journal of Virology30 citations Open access
Semantic Scholar
Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylation
C. Chiang, Guanqun Liu, Michaela U. Gack
2021Viruses29 citations Open access
Semantic Scholar
Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer
M. Afsar, Guanqun Liu, Lijia Jia, E. A. Ruben +11 more
2023Nature Communications28 citations Open access
Semantic Scholar
The herpesvirus accessory protein γ134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I
Xing Liu, Yijie Ma, Kathleen M. Voss, M. van Gent +4 more
2021PLoS Pathogens28 citations Open access
Semantic Scholar
CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins
Helene Hoenigsperger, L. Koepke, Dhiraj Acharya, V. Hunszinger +6 more
2023Autophagy26 citations Open access
Semantic Scholar
The RNA polymerase III-RIG-I axis in antiviral immunity and inflammation
L. Naesens, F. Haerynck, Michaela U. Gack
2023Trends in immunology25 citations Open access
Semantic Scholar
The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25’s RNA Binding Ability
C. Chiang, Steve Dvorkin, Jessica J. Chiang, R. Potter +1 more
2021mBio25 citations Open access
Semantic Scholar
TRIM23 mediates cGAS-induced autophagy in anti-HSV defense
Dhiraj Acharya, Zuberwasim Sayyad, Helene Hoenigsperger, M. Hirschenberger +10 more
2025Nature Communications23 citations Open access
Semantic Scholar
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease
Guanqun Liu, Jung-Hyun Lee, Zachary M. Parker, D. Acharya +7 more
2020bioRxiv23 citations Open access
Semantic Scholar
ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection
Lindsey E. Bazzone, Jun-Ji Zhu, Michael King, Guanqun Liu +14 more
2024Nature Communications22 citations Open access
Semantic Scholar
ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis
Jun-Ji Zhu, Guan-Qun Liu, Zuberwasim Sayyad, C. Goins +2 more
2024Journal of Virology21 citations Open access
Semantic Scholar
Virology under the Microscope—a Call for Rational Discourse
Felicia D. Goodrum, Anice C. Lowen, S. Lakdawala, James Alwine +152 more
2023Journal of Virology21 citations Open access
Semantic Scholar
Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients
Yuan Hou, Ya-Di Zhou, L. Jehi, Yuan Luo +6 more
2021medRxiv21 citations Open access
Semantic Scholar
FBXO38 Drives PD-1 to Destruction.
Taryn M. Serman, Michaela U. Gack
2019Trends in immunology21 citations
Semantic Scholar
Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, A. Sugie +36 more
2024Nature Communications20 citations Open access
Semantic Scholar

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Guanqun Liu×13
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C. Chiang×13
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M. van Gent×9
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D. Acharya×7
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Jessica J. Chiang

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K. M. Sparrer×6

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