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W. Brennen · SciRah

Researcher profile · Semantic Scholar

W. Brennen

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W. Brennen — researcher profile on SciRah

h-index: 28
Works: 73
Citations: 2,794

Most-cited papers

Rationale Behind Targeting Fibroblast Activation Protein–Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy
W. Brennen, J. Isaacs, S. Denmeade
2012Molecular Cancer Therapeutics244 citations Open access
Semantic Scholar
Concise Review: Mesenchymal Stem Cell‐Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise
Timothy E. G. Krueger, D. Thorek, S. Denmeade, John T. Isaacs +1 more
2018Stem Cells Translational Medicine221 citations Open access
Semantic Scholar
Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy
S. Denmeade, A. Mhaka, D. Rosen, W. Brennen +12 more
2012Science Translational Medicine211 citations Open access
Semantic Scholar
Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug.
W. Brennen, D. Rosen, Hao Wang, J. Isaacs +1 more
2012Journal of the National Cancer Institute190 citations Open access
Semantic Scholar
Disulfiram Is a DNA Demethylating Agent and Inhibits Prostate Cancer Cell Growth
Jian-Qing Lin, Michael C. Haffner, Yong-Gang Zhang, Byron H. Lee +8 more
2010The Prostate178 citations Open access
Semantic Scholar
Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin
Aaron M. LeBeau, W. Brennen, S. Aggarwal, S. Denmeade
2009Molecular Cancer Therapeutics147 citations Open access
Semantic Scholar
Tasquinimod is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment
J. Isaacs, L. Antony, Susan L. Dalrymple, W. Brennen +10 more
2012Cancer Research116 citations Open access
Semantic Scholar
Role of androgen receptor splice variant 7 (AR-V7) in prostate cancer resistance to 2nd generation androgen receptor signaling inhibitors
Yezi Zhu, Susan L. Dalrymple, I. Coleman, S. Zheng +11 more
2020Oncogene92 citations Open access
Semantic Scholar
Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites.
S. Aggarwal, W. Brennen, T. Kole, E. Schneider +4 more
2008Biochemistry89 citations Open access
Semantic Scholar
Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?
Timothy E. G. Krueger, Daniel L. J. Thorek, A. Meeker, J. T. Isaacs +1 more
2018The Prostate84 citations Open access
Semantic Scholar
Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer
W. Brennen, Shuang-Ling Chen, S. Denmeade, J. Isaacs
2012OncoTarget78 citations Open access
Semantic Scholar
Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient‐derived xenograft (PDX) models
N. Navone, W. V. van Weerden, R. Vessella, E. Williams +27 more
2018The Prostate76 citations Open access
Semantic Scholar
A Prodrug-doped Cellular Trojan Horse for the Potential Treatment of Prostate Cancer
O. Levy, W. Brennen, Edward Han, D. Rosen +13 more
2016Biomaterials71 citations Open access
Semantic Scholar
Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment
W. Brennen, S. Denmeade, J. T. Isaacs
2013Endocrine-Related Cancer71 citations Open access
Semantic Scholar
Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression
Robert M. Hughes, B. Simons, Hamda Khan, Rebecca M. Miller +16 more
2019Cancer Research63 citations Open access
Semantic Scholar
A Phase I Study to Assess the Safety and Cancer‐Homing Ability of Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer
M. Schweizer, Hao Wang, T. Bivalacqua, A. Partin +10 more
2019Stem Cells Translational Medicine61 citations Open access
Semantic Scholar
IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry
Peng Lu, K. Oetjen, D. Bender, M. Ruzinova +7 more
2022bioRxiv58 citations Open access
Semantic Scholar
Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer
W. Brennen, Yezi Zhu, I. Coleman, Susan L. Dalrymple +17 more
2021JCI Insight56 citations Open access
Semantic Scholar
Mesenchymal stem cells and the embryonic reawakening theory of BPH
W. Brennen, J. T. Isaacs
2018Nature reviews. Urology45 citations Open access
Semantic Scholar
Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer
B. Kumar, Avi Z. Rosenberg, S. Choi, K. Fox‐Talbot +6 more
2018bioRxiv44 citations Open access
Semantic Scholar
Supraphysiological testosterone induces ferroptosis and activates immune pathways through nucleophagy in prostate cancer
Raj Kumar, Janet Mendonca, Olutosin Owoyemi, K. Boyapati +21 more
2021Cancer Research43 citations Open access
Semantic Scholar
Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC
Laura A. Sena, Raj Kumar, David E Sanin, Elizabeth A. Thompson +21 more
2022Journal of Clinical Investigation36 citations Open access
Semantic Scholar
Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype
A. D. de Groot, Kayla V. Myers, T. Krueger, W. Brennen +2 more
2022Neoplasia31 citations Open access
Semantic Scholar
Mipsagargin: The Beginning—Not the End—of Thapsigargin Prodrug-Based Cancer Therapeutics
J. Isaacs, W. Brennen, S. Christensen, S. Denmeade
2021Molecules30 citations Open access
Semantic Scholar
Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy.
W. Brennen, Daniel L. J. Thorek, Wen Jiang, T. Krueger +3 more
2020Immunotherapy30 citations Open access
Semantic Scholar
Iterative Design of Emetine-Based Prodrug Targeting Fibroblast Activation Protein (FAP) and Dipeptidyl Peptidase IV DPPIV Using a Tandem Enzymatic Activation Strategy
Emmanuel S. Akinboye, W. Brennen, D. Rosen, O. Bakare +1 more
2016The Prostate30 citations Open access
Semantic Scholar
Pharmacokinetics and Toxicology of a Fibroblast Activation Protein (FAP)-activated Prodrug in Murine Xenograft Models of Human Cancer
W. Brennen, D. Rosen, Alcides Chaux, G. Netto +2 more
2014The Prostate30 citations Open access
Semantic Scholar
CHARACTERIZATION OF HOXB13 EXPRESSION PATTERNS IN LOCALIZED AND METASTATIC CASTRATION RESISTANT PROSTATE CANCER
Radhika A. Patel, E. Sayar, I. Coleman, Martine P. Roudier +24 more
2023Journal of Pathology29 citations Open access
Semantic Scholar
Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate
W. Brennen, Bao-Hui Zhang, Ibrahim Kulac, L. N. Kisteman +7 more
2017OncoTarget28 citations Open access
Semantic Scholar
Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers.
R. Sikes, Alison M. Walls, W. Brennen, James D. Anderson +3 more
2003Clinical Prostate Cancer28 citations
Semantic Scholar
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
Joakin O. Mori, Isra Elhussin, W. Brennen, M. Graham +10 more
2023Nature reviews. Urology26 citations
Semantic Scholar
Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment
Hawley C. Pruitt, Ya Guan, H. Liu, Alexis E Carey +7 more
2023Matrix Biology25 citations Open access
Semantic Scholar
Rapid Selection of Mesenchymal Stem and Progenitor Cells in Primary Prostate Stromal Cultures
W. Brennen, L. Nelleke Kisteman, John T. Isaacs
2016The Prostate23 citations Open access
Semantic Scholar
Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling
J. Low, W. Brennen, A. Meeker, Elina Ikonen +2 more
2020Molecular Cancer Research21 citations Open access
Semantic Scholar
Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy.
W. Brennen, J. T. Isaacs
2017Cancer Cell21 citations Open access
Semantic Scholar
Thalidomide and analogues: current proposed mechanisms and therapeutic usage.
W. Brennen, C. Cooper, Scott M. Capitosti, Milton L. Brown +1 more
2004Clinical Prostate Cancer20 citations
Semantic Scholar
Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay
W. Brennen, H. Nguyen, Susan L. Dalrymple, Stephanie Reppert-Gerber +3 more
2016OncoTarget19 citations Open access
Semantic Scholar
PSA-alpha-2-macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones
M. Kostova, W. Brennen, D. López, L. Anthony +3 more
2018The Prostate16 citations Open access
Semantic Scholar
Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer
Emmanuel S. Akinboye, W. Brennen, S. Denmeade, J. Isaacs
2018Asian Journal of Urology16 citations Open access
Semantic Scholar
Rationale for bipolar androgen therapy (BAT) for metastatic prostate cancer
J. T. Isaacs, W. Brennen, S. Denmeade
2017Cell Cycle15 citations Open access
Semantic Scholar
The what, when, and why of human prostate cancer xenografts
W. Brennen, J. T. Isaacs
2018The Prostate14 citations
Semantic Scholar
A hemi‐spleen injection model of liver metastasis for prostate cancer
B. Simons, Susan Dalrymple, M. Rosen, Lei Zheng +1 more
2020The Prostate13 citations
Semantic Scholar
Serial bipolar androgen therapy (sBAT) using cyclic supraphysiologic testosterone (STP) to treat metastatic castration-resistant prostate cancer (mCRPC).
J. Isaacs, W. Brennen, S. Denmeade
2019Annals of Translational Medicine11 citations Open access
Semantic Scholar
Defining the challenges and opportunities for using patient-derived models in prostate cancer research
W. Brennen, C. Le Magnen, S. Karkampouna, N. Anselmino +21 more
2024The Prostate9 citations Open access
Semantic Scholar
Prostate cancer androgen receptor activity dictates efficacy of Bipolar Androgen Therapy
Laura A. Sena, Raj Kumar, David E Sanin, Elizabeth A. Thompson +21 more
2022medRxiv8 citations Open access
Semantic Scholar
PSA-selective activation of cytotoxic human serine proteases within the tumor microenvironment as a therapeutic strategy to target prostate cancer
O. Rogers, L. Anthony, D. Rosen, W. Brennen +1 more
2018OncoTarget8 citations Open access
Semantic Scholar
Third Generation Quinoline-3-Carboxamide Transcriptional Disrupter of HDAC4, HIF-1α, and MEF-2 Signaling for Metastatic Castration-Resistant Prostate Cancer
John T. Isaacs, Susan L. Dalrymple, L. Antony, D. Rosen +8 more
2023The Prostate7 citations Open access
Semantic Scholar
There are Gremlins in Prostate Cancer
L. Sena, W. Brennen, J. Isaacs
2022Nature Cancer6 citations Open access
Semantic Scholar
A novel method for detection of exfoliated prostate cancer cells in urine by RNA in situ hybridization
J. Eskra, D. Rabizadeh, L. Mangold, E. Fabian +7 more
2020Prostate Cancer and Prostatic Diseases5 citations
Semantic Scholar
Supraphysiological testosterone induces ferroptosis and activates NF-kappaB mediated immune pathways in prostate cancer through nucleophagy
Janet Mendonca, Rajesh Kumar, Olutosin Owoyemi, K. Boyapati +21 more
2020bioRxiv2 citations Open access
Semantic Scholar

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