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F. Couture · SciRah

Researcher profile · Semantic Scholar

F. Couture

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F. Couture — researcher profile on SciRah

h-index: 16
Works: 45
Citations: 745

Most-cited papers

Therapeutic uses of furin and its inhibitors: a patent review
F. Couture, A. Kwiatkowska, Y. Dory, R. Day
2015Expert Opinion on Therapeutic Patents82 citations
Semantic Scholar
On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications
F. Couture, François D'Anjou, R. Day
2011Biomolecular Concepts64 citations Open access
Semantic Scholar
Role of proprotein convertases in prostate cancer progression.
F. Couture, François D'Anjou, Roxane Desjardins, F. Boudreau +1 more
2012Neoplasia58 citations Open access
Semantic Scholar
Gastrointestinal Stability and Cytotoxicity of Bacteriocins From Gram-Positive and Gram-Negative Bacteria: A Comparative in vitro Study
S. Soltani, S. Zirah, S. Rebuffat, F. Couture +4 more
2022Frontiers in Microbiology49 citations Open access
Semantic Scholar
The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells
Christine Levesque, M. Fugère, A. Kwiatkowska, F. Couture +11 more
2012Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
A Naked Eye‐Invisible Ratiometric Fluorescent Microneedle Tattoo for Real‐Time Monitoring of Inflammatory Skin Conditions
Samuel Babity, F. Couture, E. Campos, S. Hedtrich +4 more
2021Advanced Healthcare Materials40 citations Open access
Semantic Scholar
PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer.
F. Couture, R. Sabbagh, A. Kwiatkowska, Roxane Desjardins +3 more
2017Cancer Research39 citations Open access
Semantic Scholar
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target
Rémi Longuespée, F. Couture, Christine Levesque, A. Kwiatkowska +7 more
2014Translational Oncology37 citations Open access
Semantic Scholar
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation
Christine Levesque, F. Couture, A. Kwiatkowska, Roxane Desjardins +3 more
2015OncoTarget35 citations Open access
Semantic Scholar
Design, Synthesis, and Structure−Activity Relationship Studies of a Potent PACE4 Inhibitor
A. Kwiatkowska, F. Couture, Christine Levesque, Kevin Ly +7 more
201433 citations Open access
Semantic Scholar
Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin.
H. Gagnon, Sophie Beauchemin, A. Kwiatkowska, F. Couture +10 more
2014Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function.
Samuel Babity, Anna K. Polomska, F. Couture, Mathias Bonmarin +3 more
2020Journal of Controlled Release26 citations Open access
Semantic Scholar
In vitro investigation of gastrointestinal stability and toxicity of 3-hyrdoxypropionaldehyde (reuterin) produced by Lactobacillus reuteri
S. Soltani, F. Couture, Y. Boutin, L. Ben Said +4 more
2021Toxicology Reports19 citations Open access
Semantic Scholar
The Path to Therapeutic Furin Inhibitors: From Yeast Pheromones to SARS-CoV-2
G. Thomas, F. Couture, A. Kwiatkowska
2022International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
François Panet, F. Couture, A. Kwiatkowska, Roxane Desjardins +2 more
2017European Journal of Cell Biology18 citations
Semantic Scholar
In vitro assessment of skin sensitization, irritability and toxicity of bacteriocins and reuterin for possible topical applications
S. Soltani, Yvan Boutin, F. Couture, É. Biron +2 more
2022Scientific Reports17 citations Open access
Semantic Scholar
PACE4-Based Molecular Targeting of Prostate Cancer Using an Engineered 64Cu-Radiolabeled Peptide Inhibitor
F. Couture, Christine Levesque, V. Dumulon-Perreault, S. Ait-Mohand +3 more
2014Neoplasia16 citations Open access
Semantic Scholar
Novel Insights into Structure–Activity Relationships of N‐Terminally Modified PACE4 Inhibitors
A. Kwiatkowska, F. Couture, Christine Levesque, Kevin Ly +5 more
2016ChemMedChem14 citations
Semantic Scholar
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss
A. Mohammad, S. Assadian, F. Couture, Karen J. Lefebvre +13 more
2019OncoTarget12 citations Open access
Semantic Scholar
Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.
I. Małuch, Christine Levesque, A. Kwiatkowska, F. Couture +5 more
2017Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug
A. Kwiatkowska, F. Couture, S. Ait-Mohand, Roxane Desjardins +3 more
2019Scientific Reports10 citations Open access
Semantic Scholar
Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo
K. Kulhankova, Soumba Traore, Xue Cheng, Hadrien Benk-Fortin +10 more
2023Research Square9 citations Open access
Semantic Scholar
Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations.
T. Lepek, A. Kwiatkowska, F. Couture, Kevin Ly +4 more
2017European Journal of Cell Biology9 citations
Semantic Scholar
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells.
François D'Anjou, F. Couture, Roxane Desjardins, R. Day
2014Methods in molecular biology8 citations
Semantic Scholar
Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.
Vahid Dianati, Pauline Navals, F. Couture, Roxane Desjardins +4 more
2018Journal of Medicinal Chemistry7 citations Open access
Semantic Scholar
Evaluation of PACE4 isoforms as biomarkers in thyroid cancer
Laurent Fradet, R. Temmar, F. Couture, M. Belzile +2 more
2018Journal of Otolaryngology - Head and Neck Surgery6 citations Open access
Semantic Scholar
Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity
F. Couture, Kevin Ly, Christine Levesque, A. Kwiatkowska +4 more
2015BioMed Research International6 citations Open access
Semantic Scholar
In Situ Non‐Invasive Imaging of Neutrophil Myeloperoxidase and Skin Reactive Oxygen Species in Experimental Murine Atopic Dermatitis
Samuel Babity, Shi-Hao Pei, Julia Galimi, Vanessa Lapointe +2 more
2023Advanced Sensor Research5 citations Open access
Semantic Scholar
PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer
F. Couture, Luo-Jun Wang, F. Dufour, Keena Chabot-Maheux +3 more
2022Scientific Reports5 citations Open access
Semantic Scholar
Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host-Guest Inclusion Complex with β-Cyclodextrin.
Pauline Navals, A. Kwiatkowska, N. Mekdad, F. Couture +3 more
2023Molecular Pharmaceutics3 citations
Semantic Scholar
Efficacy of PACE4 pharmacotherapy in JHU-LNCaP-SM preclinical model of androgen independent prostate cancer
N. Mekdad, Thi-Minh-Trang Tran, Roxane Desjardins, A. Kwiatkowska +2 more
2022Scientific Reports3 citations Open access
Semantic Scholar
Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
Vahid Dianati, A. Kwiatkowska, F. Couture, Roxane Desjardins +2 more
2018Journal of Medicinal Chemistry3 citations Open access
Semantic Scholar
WITHDRAWN: PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity.
Kazushi Okada, Hee-Jung Moon, Joel Finney, F. Couture +2 more
2017Journal of Biological Chemistry1 citations
Semantic Scholar
EJCB - Molecular basis of protein fates in the secretory and endocytic pathways, and beyond.
F. Couture, A. Jansen, P. Taghert, K. Brix
2017European Journal of Cell Biology1 citations
Semantic Scholar
Structure-Based Optimization of a Potent PACE4 Inhibitor Containing a Decarboxylated P1 Arginine Mimetic
A. Kwiatkowska, Christine Levesque, F. Couture, Kevin Ly +2 more
20151 citations Open access
Semantic Scholar
Abstract 1707: PACE4-dependent cellular uptake and retention of the Multi-Leucine peptide inhibitor into cancer cells
F. Couture, Kevin Ly, Christine Levesque, A. Kwiatkowska +3 more
20151 citations
Semantic Scholar
Development of an Albumin-Bound PSA-Activated Delivery System of a Potent PACE4 Inhibitor for the Treatment of Prostate Cancer
A. Kwiatkowska, F. Couture, Christine Levesque, Kevin Ly +1 more
20131 citations Open access
Semantic Scholar
Intralesional Treatment of Basal Cell Carcinoma in a Genetically Inducible Mouse Model
N. Messier, F. Couture, Vanessa Théberge, M. Harvey +1 more
2023SKIN The Journal of Cutaneous Medicine0 citations Open access
Semantic Scholar
Cleavage of the V-ATPase associated prorenin receptor is mediated by PACE4 and is essential for growth of prostate cancer cells
A. Mohammad, F. Couture, I. Gamache, Owen J. Chen +6 more
2023PLoS ONE0 citations Open access
Semantic Scholar
Immunotherapy: PHASE I CLINICAL TRIAL OF ANTI-MINOR HISTOCOMPATIBILITY ANTIGEN EXPANDED T CELLS TO TARGET LEUKEMIA RELAPSING AFTER ALLOGENEIC HLA-MATCHED TRANSPLANTATION
Denis Roy, J. Delisle, I. Ahmad, B. Leber +17 more
2023Cytotherapy0 citations
Semantic Scholar
Therapeutic Targeting of the Proteolytic Enzymes
F. Couture
2022International Journal of Molecular Sciences0 citations Open access
Semantic Scholar
In vitro assessment of skin sensitization, irritability and toxicity of bacteriocins and reuterin for possible topical applications
S. Soltani, Yvan Boutin, F. Couture, É. Biron +2 more
2022Scientific Reports0 citations Open access
Semantic Scholar
PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer
F. Couture, Luo-Jun Wang, F. Dufour, Keena Chabot-Maheux +3 more
2022Scientific Reports0 citations Open access
Semantic Scholar
PACE4 proteolytically processes LOXL2 with little impact on its catalytic activity*
Kazushi Okada, Hee-Jung Moon, Joel Finney, F. Couture +2 more
20170 citations
Semantic Scholar
Inside Cover: Novel Insights into Structure–Activity Relationships of N‐Terminally Modified PACE4 Inhibitors (ChemMedChem 3/2016)
A. Kwiatkowska, F. Couture, Christine Levesque, Kevin Ly +5 more
20160 citations
Semantic Scholar

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