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L. Hondebrink · SciRah

Researcher profile · Semantic Scholar

L. Hondebrink

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L. Hondebrink — researcher profile on SciRah

h-index: 18
Works: 57
Citations: 1,052

Most-cited papers

Monitoring new psychoactive substances (NPS) in The Netherlands: data from the drug market and the Poisons Information Centre.
L. Hondebrink, J. J. Nugteren-van Lonkhuyzen, D. van der Gouwe, T. Brunt
2015Drug and Alcohol Dependence107 citations Open access
Semantic Scholar
Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?
L. Hondebrink, A. Zwartsen, R. Westerink
2017Pharmacology and Therapeutics80 citations Open access
Semantic Scholar
Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons?
A. Tukker, M. de Groot, Fiona M. J. Wijnolts, E. Kasteel +2 more
2016ALTEX72 citations Open access
Semantic Scholar
Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings.
L. Hondebrink, A. Verboven, W. S. Drega, S. Schmeink +6 more
2016Neurotoxicology70 citations Open access
Semantic Scholar
Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings.
A. Zwartsen, T. de Korte, P. Nacken, D. de Lange +2 more
2019Journal of Molecular and Cellular Cardiology54 citations Open access
Semantic Scholar
Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay.
A. Zwartsen, A. Verboven, R. V. van Kleef, Fiona M. J. Wijnolts +2 more
2017Toxicology in Vitro50 citations Open access
Semantic Scholar
Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug–drug interactions
S. Rietjens, L. Hondebrink, R. Westerink, J. Meulenbelt
2012Critical Reviews in Toxicology50 citations
Semantic Scholar
Neurotoxicity screening of new psychoactive substances (NPS): Effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA)
A. Zwartsen, L. Hondebrink, R. Westerink
2018Neurotoxicology42 citations Open access
Semantic Scholar
Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans.
J. J. Nugteren-van Lonkhuyzen, A. van Riel, T. Brunt, L. Hondebrink
2015Drug and Alcohol Dependence42 citations Open access
Semantic Scholar
New psychoactive substances (NPS) in the Netherlands: occurrence in forensic drug samples, consumer drug samples and poisons center exposures between 2013 and 2017
L. Hondebrink, J. J. Nugteren-van Lonkhuyzen, C. Hunault, J. van den Berg +2 more
2020Addiction35 citations Open access
Semantic Scholar
Neuropharmacological characterization of the new psychoactive substance methoxetamine
L. Hondebrink, E. Kasteel, A. Tukker, Fiona M. J. Wijnolts +2 more
2017Neuropharmacology35 citations Open access
Semantic Scholar
Alarming increase in poisonings from recreational nitrous oxide use after a change in EU-legislation, inquiries to the Dutch Poisons Information Center.
A. van Riel, C. Hunault, I. S. van den Hengel-Koot, J. J. Nugteren-van Lonkhuyzen +2 more
2021The International journal on drug policy32 citations Open access
Semantic Scholar
Fatalities, Cerebral Hemorrhage, and Severe Cardiovascular Toxicity After Exposure to the New Psychoactive Substance 4‐Fluoroamphetamine: A Prospective Cohort Study
L. Hondebrink, J. J. Nugteren-van Lonkhuyzen, S. Rietjens, T. Brunt +5 more
2017Annals of Emergency Medicine32 citations Open access
Semantic Scholar
High concentrations of MDMA ('ecstasy') and its metabolite MDA inhibit calcium influx and depolarization-evoked vesicular dopamine release in PC12 cells.
L. Hondebrink, J. Meulenbelt, M. Meijer, M. van den Berg +1 more
2011Neuropharmacology25 citations
Semantic Scholar
Pregabalin poisoning: Evaluation of dose‐toxicity relationship
S. Rietjens, M. Sikma, C. Hunault, D. de Lange +1 more
2021British Journal of Clinical Pharmacology20 citations Open access
Semantic Scholar
Synthetic cathinones and their potential interactions with prescription drugs.
Ramon R Contrucci, T. Brunt, F. Inan, E. Franssen +1 more
2020Therapeutic Drug Monitoring20 citations Open access
Semantic Scholar
Changes in neuronal activity in rat primary cortical cultures induced by illicit drugs and new psychoactive substances (NPS) following prolonged exposure and washout to mimic human exposure scenarios.
A. Zwartsen, L. Hondebrink, R. Westerink
2019Neurotoxicology20 citations Open access
Semantic Scholar
Hazard Characterization of Synthetic Cathinones Using Viability, Monoamine Reuptake, and Neuronal Activity Assays
A. Zwartsen, M. Olijhoek, R. Westerink, L. Hondebrink
2020Frontiers in Neuroscience18 citations Open access
Semantic Scholar
Modulation of human GABAA receptor function: a novel mode of action of drugs of abuse.
L. Hondebrink, J. Meulenbelt, R. V. van Kleef, M. van den Berg +1 more
2011Neurotoxicology18 citations
Semantic Scholar
Amphetamine reduces vesicular dopamine content in dexamethasone‐differentiated PC12 cells only following l‐DOPA exposure
L. Hondebrink, J. Meulenbelt, J. Timmerman, M. van den Berg +1 more
2009Journal of Neurochemistry18 citations
Semantic Scholar
Clinical effects of cannabis compared to synthetic cannabinoid receptor agonists (SCRAs): a retrospective cohort study of presentations with acute toxicity to European hospitals between 2013 and 2020
M. Waters, P. Dargan, Christopher Yates, A. Dines +58 more
2024Clinical toxicology17 citations Open access
Semantic Scholar
3-Methylmethcathinone (3-MMC) Poisonings: Acute Clinical Toxicity and Time Trend Between 2013 and 2021 in the Netherlands.
J. J. Nugteren-van Lonkhuyzen, S. Essink, S. Rietjens, D. Ohana +3 more
2022Annals of Emergency Medicine17 citations Open access
Semantic Scholar
Acute toxic effects related to 4-fluoroamphetamine.
C. Wijers, R. van Litsenburg, L. Hondebrink, R. Niesink +1 more
2017The Lancet17 citations Open access
Semantic Scholar
Significant toxicity following an increase in poisonings with designer benzodiazepines in the Netherlands between 2010 and 2020.
S. Essink, J. J. Nugteren-van Lonkhuyzen, A. van Riel, D. Dekker +1 more
2021Drug and Alcohol Dependence16 citations Open access
Semantic Scholar
Additive inhibition of human α1β2γ2 GABAA receptors by mixtures of commonly used drugs of abuse.
L. Hondebrink, Si-Jie Tan, Elise J P Hermans, R. V. van Kleef +2 more
2013Neurotoxicology16 citations
Semantic Scholar
High Incidence of Signs of Neuropathy and Self-Reported Substance Use Disorder for Nitrous Oxide in Patients Intoxicated with Nitrous Oxide
J. J. Nugteren-van Lonkhuyzen, Lot van der Ben, I. S. van den Hengel-Koot, D. de Lange +2 more
2023European Addiction Research14 citations Open access
Semantic Scholar
Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.
L. Hondebrink, Elise J P Hermans, S. Schmeink, R. V. van Kleef +2 more
2015Neurotoxicology13 citations Open access
Semantic Scholar
Methamphetamine, amphetamine, MDMA ('ecstasy'), MDA and mCPP modulate electrical and cholinergic input in PC12 cells.
L. Hondebrink, J. Meulenbelt, S. Rietjens, M. Meijer +1 more
2012Neurotoxicology13 citations
Semantic Scholar
Effect of the first wave of COVID-19 on Poison Control Centre activities in 21 European countries: an EAPCCT initiative
L. Hondebrink, M. Zammit, L. C. G. Høgberg, M. Hermanns-Clausen +2 more
2022Clinical toxicology12 citations Open access
Semantic Scholar
The Clinical Toxicology of 4-Bromo-2,5-dimethoxyphenethylamine (2C-B): The Severity of Poisoning After Exposure to Low to Moderate and High Doses.
J. J. Nugteren-van Lonkhuyzen, D. de Lange, A. van Riel, Ruben Q Vrolijk +2 more
2020Annals of Emergency Medicine11 citations Open access
Semantic Scholar
Combining ecstasy and ethanol: higher risk for toxicity? A review
Eefje Vercoulen, L. Hondebrink
2021Critical Reviews in Toxicology10 citations Open access
Semantic Scholar
A quarter of admitted poisoned patients have a mild poisoning and require no treatment: An observational study.
L. Hondebrink, S. Rietjens, Dirk W. Donker, C. Hunault +6 more
2019European journal of internal medicine10 citations Open access
Semantic Scholar
Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT).
A. Zwartsen, Carlijn H. C. Litjens, L. Hondebrink, J. J. van den Heuvel +6 more
2019Toxicology8 citations Open access
Semantic Scholar
Methylphenidate intoxications in children and adults: exposure circumstances and evidence-based dose threshold for pre-hospital triage
L. Hondebrink, S. Rietjens, C. Hunault, R. R. Pereira +6 more
2015Clinical toxicology8 citations Open access
Semantic Scholar
Hyperthermia exacerbates the acute effects of psychoactive substances on neuronal activity measured using microelectrode arrays (MEAs) in rat primary cortical cultures in vitro.
A. Zwartsen, L. Hondebrink, D. de Lange, R. Westerink
2020Toxicology and Applied Pharmacology6 citations Open access
Semantic Scholar
Are high-throughput measurements of intracellular calcium using plate-readers sufficiently accurate and reliable?
R. Westerink, L. Hondebrink
2010Toxicology and Applied Pharmacology6 citations
Semantic Scholar
Advancing toxicovigilance of recreational drugs, including new psychoactive substances, by using data from four European poison centres
A. Kader, M. Hermanns-Clausen, A. van Riel, K. Faber +1 more
2024Clinical toxicology5 citations Open access
Semantic Scholar
Novel Phenethylamines and their Potential Interactions with Prescription Drugs: A Systematic Critical Review.
F. Inan, T. Brunt, Ramon R Contrucci, L. Hondebrink +1 more
2020Therapeutic Drug Monitoring5 citations Open access
Semantic Scholar
Corrigendum to "Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay" [Toxicology in Vitro (2017) 60-71].
A. Zwartsen, A. Verboven, R. V. van Kleef, Fiona M. J. Wijnolts +2 more
2019Toxicology in Vitro3 citations Open access
Semantic Scholar
Incidents with recreational nitrous oxide use before and after legislation: poisonings and police incidents in the Netherlands between 2020 and 2025.
L. Hondebrink, J. J. Nugteren-van Lonkhuyzen, I. S. van den Hengel-Koot, A. van Riel +2 more
2026The International journal on drug policy2 citations Open access
Semantic Scholar
Methylphenidate poisoning: relatively mild symptoms even after high-dose exposure
S. Rietjens, L. Hondebrink, T. Jorna, I. de Vries
2017Clinical toxicology2 citations Open access
Semantic Scholar
Recreational drug poisonings reported to six European poison centres from 2021 to 2024
L. Hondebrink, K. Faber, A. Kader, Pardeep S. Jagpal +2 more
2026Clinical toxicology1 citations Open access
Semantic Scholar
Differences in the clinical presentation of acute 3,4-methylenedioxymetamfetamine intoxication by co-intoxication and patient sex to European emergency departments
J. J. J. Ouwerkerk, D. Wood, A. Dines, Christopher Yates +63 more
2025Clinical toxicology1 citations Open access
Semantic Scholar
Effects of amphetamine on neurotransmitter release in PC12 and chromaffin cells
L. Hondebrink, J. Timmerman, M. B. Van den, J. Meulenbelt +1 more
20101 citations
Semantic Scholar
Trends in new psychoactive substance poisonings in the Netherlands: A 14‐year retrospective analysis (2012–2025)
J. J. Nugteren-van Lonkhuyzen, I. S. van den Hengel-Koot, C. Hunault, D. de Lange +2 more
2026Addiction0 citations Open access
Semantic Scholar
Deliberate self-poisoning in four European countries: retrospective analysis of poison centre data
A. Koppen, K. Faber, L. Hondebrink, M. Zammit +2 more
2026Clinical toxicology0 citations Open access
Semantic Scholar
Corrigendum to "Incidents with recreational nitrous oxide use before and after legislation: poisonings and police incidents in the Netherlands between 2020 and 2025" [International Journal of Drug Policy 149 (2026) 105170].
L. Hondebrink, J. J. Nugteren-van Lonkhuyzen, I. S. van den Hengel-Koot, A. van Riel +2 more
2026The International journal on drug policy0 citations
Semantic Scholar
[Intoxication with a nitazene; new potent synthetic opioids on a rise].
R. Balster, L. Hondebrink, T. Boel, Bas van de Velde +2 more
2025Nederlandsch tijdschrift voor geneeskunde0 citations
Semantic Scholar
Response to the article of Neicun et al. entitled “Legal Reponses to Novel Psychoactive Substances implemented by ten European Countries: an analysis from legal epidemiology”
L. Hondebrink, Annette Nugteren-van Lonkhuyzen, J. van den Berg, A. van Riel +1 more
2023Emerging Trends in Drugs, Addictions, and Health0 citations Open access
Semantic Scholar
Cardiotoxicity screening of recreational drugs in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings
T. de Korte, P. Nacken, A. Zwartsen, R. Westerink +1 more
20200 citations Open access
Semantic Scholar

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R. Westerink — researcher profile on SciRah
A. van Riel×13
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A. van Riel — researcher profile on SciRah
J. J. Nugteren-van Lonkhuyzen×12
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D. de Lange×11
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A. Zwartsen — researcher profile on SciRah

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C. Hunault — researcher profile on SciRah

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Fiona M. J. Wijnolts — researcher profile on SciRah