P. Pfefferle

Most-cited papers

High levels of butyrate and propionate in early life are associated with protection against atopy
C. Roduit, R. Frei, Ruth Ferstl, Susanne Loeliger +33 more
2018Allergy. European Journal of Allergy and Clinical Immunology448 citations
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Farm-like indoor microbiota in non-farm homes protects children from asthma development
P. Kirjavainen, A. Karvonen, R. Adams, M. Täubel +15 more
2019Nature Medicine277 citations Open access
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Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood
C. Roduit, R. Frei, M. Depner, A. Karvonen +21 more
2017JAMA pediatrics268 citations Open access
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Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood.
A. Lluis, M. Depner, B. Gaugler, P. Saas +33 more
2014Journal of Allergy and Clinical Immunology204 citations Open access
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Clinical and epidemiologic phenotypes of childhood asthma.
M. Depner, O. Fuchs, J. Genuneit, A. Karvonen +15 more
2013American Journal of Respiratory and Critical Care Medicine186 citations Open access
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Neurobiology of the major psychoses: a translational perspective on brain structure and function—the FOR2107 consortium
T. Kircher, M. Wöhr, I. Nenadić, R. Schwarting +16 more
2018European Archives of Psychiatry and Clinical Neuroscience167 citations
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DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma.
S. Brand, D. Kesper, R. Teich, Esma Kilic-Niebergall +6 more
2012Journal of Allergy and Clinical Immunology145 citations
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The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21.
G. Loss, M. Depner, A. Hose, J. Genuneit +12 more
2016American Journal of Respiratory and Critical Care Medicine142 citations Open access
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Food , drug , insect sting allergy , and anaphylaxis Increased food diversity in the first year of life is inversely associated with allergic diseases
C. Roduit, R. Frei, M. Depner, B. Schaub +11 more
2014117 citations
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The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells
Friederike Raczkowski, J. Ritter, Kira Heesch, Valéa Schumacher +12 more
2013Proceedings of the National Academy of Sciences of the United States of America106 citations Open access
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Consumption of unprocessed cow's milk protects infants from common respiratory infections.
G. Loss, M. Depner, L. Ulfman, R. V. van Neerven +16 more
2015Journal of Allergy and Clinical Immunology104 citations Open access
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The Hygiene Hypothesis – Learning From but Not Living in the Past
P. Pfefferle, C. Keber, R. Cohen, H. Garn
2021Frontiers in Immunology101 citations Open access
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ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk.
Tabea Brick, Y. Schober, Christian Böcking, J. Pekkanen +19 more
2016Journal of Allergy and Clinical Immunology93 citations Open access
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Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases
Stefanie Metzler, R. Frei, E. Schmausser-Hechfellner, E. von Mutius +21 more
2019Pediatric Allergy and Immunology90 citations
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Moisture Damage and Asthma: A Birth Cohort Study
A. Karvonen, A. Hyvärinen, M. Korppi, U. Haverinen-Shaughnessy +5 more
2015Pediatrics87 citations Open access
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Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts
A. Hose, M. Depner, S. Illi, S. Lau +38 more
2017Journal of Allergy and Clinical Immunology85 citations Open access
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Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study
L. Orivuori, G. Loss, C. Roduit, J. Dalphin +11 more
2014Clinical and Experimental Allergy85 citations Open access
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Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche
A. Hupfer, A. Brichkina, Anke Koeniger, C. Keber +6 more
2021Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
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IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts
F. Picard, V. Lutz, A. Brichkina, Felix Neuhaus +26 more
2023Gut81 citations Open access
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Farm‐derived Gram‐positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM‐ and OVA‐exposed mice
S. Hagner, Hani Harb, M. Zhao, K. Stein +10 more
2013Allergy. European Journal of Allergy and Clinical Immunology81 citations
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Microbes and asthma: Opportunities for intervention.
H. Smits, P. Hiemstra, C. U. Prazeres da Costa, M. Ege +16 more
2016Journal of Allergy and Clinical Immunology79 citations Open access
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Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas
A. Karvonen, A. Hyvärinen, U. Gehring, M. Korppi +14 more
2012Clinical and Experimental Allergy76 citations Open access
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Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study
A. Karvonen, A. Hyvärinen, H. Rintala, M. Korppi +11 more
2014Allergy. European Journal of Allergy and Clinical Immunology74 citations Open access
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The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate
H. Garn, D. Potaczek, P. Pfefferle
2021Frontiers in Immunology72 citations Open access
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Microbial influence on tolerance and opportunities for intervention with prebiotics/probiotics and bacterial lysates.
P. Pfefferle, S. Prescott, M. Kopp
2013Journal of Allergy and Clinical Immunology66 citations Open access
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Atopic sensitization in the first year of life.
M. Depner, M. Ege, J. Genuneit, J. Pekkanen +12 more
2013Journal of Allergy and Clinical Immunology56 citations Open access
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A switch in regulatory T cells through farm exposure during immune maturation in childhood
P. C. Schröder, S. Illi, V. Casaca, A. Lluis +27 more
2017Allergy. European Journal of Allergy and Clinical Immunology49 citations
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Exposure to nonmicrobial N‐glycolylneuraminic acid protects farmers' children against airway inflammation and colitis
R. Frei, Ruth Ferstl, C. Roduit, M. Ziegler +62 more
2018Journal of Allergy and Clinical Immunology48 citations Open access
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Identification of extracellular vesicle microRNA signatures specifically linked to inflammatory and metabolic mechanisms in obesity‐associated low type‐2 asthma
F. Alhamdan, T. Greulich, C. Daviaud, L. Marsh +7 more
2023Allergy. European Journal of Allergy and Clinical Immunology42 citations Open access
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TNFAIP3 is a key player in childhood asthma development and environment-mediated protection.
Johanna Krusche, M. Twardziok, K. Rehbach, A. Böck +33 more
2019Journal of Allergy and Clinical Immunology40 citations Open access
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Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation
Hani Harb, M. Amarasekera, S. Ashley, M. Tulic +6 more
2016International Archives of Allergy and Immunology39 citations
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Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
C. Wagner, K. Uliczka, J. Bossen, X. Niu +20 more
2021Cell Reports38 citations Open access
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IL‐33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort
P. C. Schröder, V. Casaca, S. Illi, M. Schieck +18 more
2016Pediatric Allergy and Immunology34 citations
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Allergic diseases, gene–environment interactions
Harald Renz, M. Conrad, S. Brand, R. Teich +2 more
2011Allergy. European Journal of Allergy and Clinical Immunology32 citations
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Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study
B. Nwaru, S. Virtanen, G. Alfthan, A. Karvonen +12 more
2014Allergy. European Journal of Allergy and Clinical Immunology31 citations Open access
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The mucosal microbiome in shaping health and disease
P. Pfefferle, H. Renz
2014F1000Prime Reports30 citations Open access
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Evidence of an anti-inflammatory toll-like receptor 9 (TLR 9) pathway in adipocytes.
Miriam Thomalla, A. Schmid, E. Neumann, P. Pfefferle +3 more
2019Journal of Endocrinology28 citations Open access
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Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype
F. Alhamdan, L. Marsh, F. Pedersen, B. A. Alhamwe +6 more
2021International Journal of Molecular Sciences26 citations Open access
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Moisture damage in home associates with systemic inflammation in children.
K. Mustonen, A. Karvonen, P. Kirjavainen, M. Roponen +8 more
2016Indoor Air: International Journal of Indoor Environment and Health24 citations Open access
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omega-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk
Tabea Brick, Y. Schober, Christian Boecking, J. Pekkanen +12 more
201624 citations
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Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery
J. Brock, A. Schmid, T. Karrasch, P. Pfefferle +13 more
2019Clinical Endocrinology23 citations
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High Indoor Microbial Levels Are Associated with Reduced Th1 Cytokine Secretion Capacity in Infancy
M. Lappalainen, A. Hyvärinen, M. Hirvonen, H. Rintala +6 more
2012International Archives of Allergy and Immunology22 citations Open access
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Immunoglobulin A and immunoglobulin G antibodies against β‐lactoglobulin and gliadin at age 1 associate with immunoglobulin E sensitization at age 6
L. Orivuori, K. Mustonen, C. Roduit, C. Braun-Fahrländer +9 more
2014Pediatric Allergy and Immunology20 citations Open access
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Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples
Martin Bomert, G. Köllisch, M. Roponen, R. Lauener +3 more
2011Clinical Chemistry and Laboratory Medicine20 citations
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Production of interleukin‐5, ‐10 and interferon‐γ in cord blood is strongly associated with the season of birth
L. Keski-Nisula, M. Lappalainen, K. Mustonen, M. Hirvonen +4 more
2010Clinical and Experimental Allergy20 citations
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Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers.
S. Illi, M. Depner, P. Pfefferle, H. Renz +17 more
2021American Journal of Respiratory and Critical Care Medicine18 citations
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Circulating Dendritic Cells, Farm Exposure and Asthma at Early Age
H. Kääriö, J. Nieminen, A. Karvonen, K. Huttunen +8 more
2016Scandinavian Journal of Immunology18 citations Open access
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Increased food diversity in the first year of life is inversely associated with allergic diseases.
C. Roduit, R. Frei, M. Depner, B. Schaub +11 more
2014Journal of Allergy and Clinical Immunology18 citations Open access
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Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources
Christian Böcking, W. Nockher, M. Schreiner, H. Renz +1 more
2010Clinical Chemistry and Laboratory Medicine18 citations
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Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis
N. Enukashvily, N. Ponomartsev, A. Ketkar, R. Suezov +12 more
2023Cell Death and Disease17 citations Open access
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