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J. Rothuizen · SciRah

Researcher profile · Semantic Scholar

J. Rothuizen

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J. Rothuizen — researcher profile on SciRah

h-index: 39
Works: 184
Citations: 5,179

Most-cited papers

Development and evaluation of canine reference genes for accurate quantification of gene expression.
B. Brinkhof, B. Spee, J. Rothuizen, L. Penning
2006Analytical Biochemistry260 citations Open access
Semantic Scholar
Primary hepatitis in dogs: a retrospective review (2002-2006).
J. Poldervaart, R. Favier, L. Penning, T. V. D. van den Ingh +1 more
2009Journal of Veterinary Internal Medicine150 citations
Semantic Scholar
Diseases of the gallbladder and biliary tree.
P. J. Armstrong, J. Rothuizen
2009117 citations
Semantic Scholar
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids
Sathidpak Nantasanti, B. Spee, Hedwig S. Kruitwagen, Cheng Chen +15 more
2015Stem Cell Reports104 citations Open access
Semantic Scholar
Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G. W. H. Vernooij, Ingrid M. Schrall +17 more
2017Stem Cell Reports100 citations Open access
Semantic Scholar
Diagnostic value of fasting plasma ammonia and bile acid concentrations in the identification of portosystemic shunting in dogs.
M. J. Gerritzen-Bruning, T. V. D. van den Ingh, J. Rothuizen
2006Journal of Veterinary Internal Medicine99 citations Open access
Semantic Scholar
Liver biopsy techniques.
J. Rothuizen, D. Twedt
2009The Veterinary clinics of North America. Small animal practice83 citations
Semantic Scholar
A validation of 10 feline reference genes for gene expression measurements in snap-frozen tissues.
L. Penning, H. Vrieling, B. Brinkhof, F. Riemers +3 more
2007Veterinary Immunology and Immunopathology82 citations
Semantic Scholar
Coagulation disorders in dogs with hepatic disease.
Marrit Prins, C. J. M. M. Schellens, M. Van Leeuwen, J. Rothuizen +1 more
2010The Veterinary Journal81 citations
Semantic Scholar
The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders
H. Fieten, Yadvinder Gill, Alan J. Martin, Mafalda Concilli +17 more
2016Disease Models & Mechanisms78 citations Open access
Semantic Scholar
Copper metabolism and oxidative stress in chronic inflammatory and cholestatic liver diseases in dogs.
B. Spee, B. Arends, T. V. D. van den Ingh, L. Penning +1 more
2006Journal of Veterinary Internal Medicine70 citations Open access
Semantic Scholar
Important clinical syndromes associated with liver disease.
J. Rothuizen
2009The Veterinary clinics of North America. Small animal practice65 citations
Semantic Scholar
Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease
Hedwig S. Kruitwagen, Loes A. Oosterhoff, M. V. van Wolferen, Chen Chen +19 more
2020Cells54 citations Open access
Semantic Scholar
Enabling Technologies for Cell-Based Clinical Translation Concise Review : Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals
Sathidpak Nantasanti, A. de Bruin, J. Rothuizen, L. Penning +1 more
201652 citations
Semantic Scholar
Hepatic volume measurements in dogs with extrahepatic congenital portosystemic shunts before and after surgical attenuation.
A. Kummeling, D. Vrakking, J. Rothuizen, K. Gerritsen +1 more
2010Journal of Veterinary Internal Medicine51 citations Open access
Semantic Scholar
Classification of primary hepatic tumours in the dog.
Renee G. H. M. van Sprundel, T. V. D. van den Ingh, F. Guscetti, O. Kershaw +5 more
2013The Veterinary Journal50 citations Open access
Semantic Scholar
Randomly amplified DNA polymorphisms in dogs are reproducible and display Mendelian transmission.
J. Rothuizen, M. V. van Wolferen
2009Animal Genetics49 citations
Semantic Scholar
COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis
R. Favier, B. Spee, B. Schotanus, T. V. D. van den Ingh +5 more
2012PLoS ONE48 citations Open access
Semantic Scholar
Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver
J. Ijzer, T. Roskams, R. F. Molenbeek, Ton Ultee +3 more
2006Comparative Hepatology46 citations Open access
Semantic Scholar
Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers
K. Dirksen, I. Burgener, J. Rothuizen, T. V. D. van den Ingh +3 more
2017Journal of Veterinary Internal Medicine43 citations Open access
Semantic Scholar
Molecular Cancer Specific Down-regulation of Xiap with Rna Interference Enhances the Sensitivity of Canine Tumor Cell-lines to Trail and Doxorubicin
B. Spee, Martijn Db, Jonkers, B. Arends +13 more
200642 citations
Semantic Scholar
Classification of primary hepatic tumours in the cat.
Renee G. H. M. van Sprundel, T. V. D. van den Ingh, F. Guscetti, O. Kershaw +3 more
2014The Veterinary Journal39 citations
Semantic Scholar
Cross‐species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease
B. Schotanus, T. V. D. van den Ingh, L. Penning, J. Rothuizen +2 more
2009Liver international (Print)39 citations Open access
Semantic Scholar
Feline biliary tree and gallbladder disease: Aetiology, diagnosis and treatment
C. Otte, L. Penning, J. Rothuizen
2017Journal of feline medicine and surgery38 citations
Semantic Scholar
Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: an immunohistochemical comparison between dog and man.
J. Ijzer, B. Schotanus, S. V. Borght, T. Roskams +4 more
2010The Veterinary Journal38 citations
Semantic Scholar
Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours
Renee G. H. M. van Sprundel, T. V. D. van den Ingh, V. Desmet, A. Katoonizadeh +4 more
2010Comparative Hepatology38 citations Open access
Semantic Scholar
Distribution of extrahepatic congenital portosystemic shunt morphology in predisposed dog breeds
L. van den Bossche, F. V. van Steenbeek, R. Favier, A. Kummeling +2 more
2012BMC Veterinary Research37 citations Open access
Semantic Scholar
Transforming growth factor β‐1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies
B. Spee, B. Arends, T. V. D. van den Ingh, B. Brinkhof +5 more
2006Liver international (Print)36 citations
Semantic Scholar
D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.
H. Fieten, K. Dirksen, T. V. D. van den Ingh, E. Winter +3 more
2013The Veterinary Journal35 citations
Semantic Scholar
High intravascular tissue factor expression in dogs with idiopathic immune-mediated haemolytic anaemia.
C. Piek, B. Brinkhof, E. Teske, J. Rothuizen +2 more
2011Veterinary Immunology and Immunopathology35 citations Open access
Semantic Scholar
Diagnostic value of the rectal ammonia tolerance test, fasting plasma ammonia and fasting plasma bile acids for canine portosystemic shunting.
G. van Straten, B. Spee, J. Rothuizen, M. van Straten +1 more
2015The Veterinary Journal32 citations Open access
Semantic Scholar
Nutritional management of inherited copper-associated hepatitis in the Labrador retriever.
H. Fieten, V. Biourge, A. Watson, P. Leegwater +2 more
2014The Veterinary Journal30 citations
Semantic Scholar
A retrospective study of oral prednisolone treatment in canine chronic hepatitis
R. Favier, J. Poldervaart, T. V. D. van den Ingh, L. Penning +1 more
2013Veterinary Quarterly30 citations
Semantic Scholar
Aberrant Gene Expression in Dogs with Portosystemic Shunts
F. V. van Steenbeek, L. van den Bossche, G. Grinwis, A. Kummeling +8 more
2013PLoS ONE30 citations Open access
Semantic Scholar
The Dog Liver Contains a “Side Population” of Cells with Hepatic Progenitor-Like Characteristics
B. Arends, H. Vankelecom, S. Vander Borght, T. Roskams +3 more
2009Stem Cells and Development30 citations
Semantic Scholar
Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein
F. V. van Steenbeek, L. van den Bossche, P. Leegwater, J. Rothuizen
2011Mammalian Genome29 citations Open access
Semantic Scholar
Functional consequences of RNA interference targeting COMMD1 in a canine hepatic cell line in relation to copper toxicosis.
B. Spee, B. Arends, A. V. van Wees, P. Bode +2 more
2007Animal Genetics27 citations Open access
Semantic Scholar
Social Pedagogy: An Approach Without Fixed Recipes
J. Rothuizen, L. Harbo
201726 citations Open access
Semantic Scholar
Evidence of inheritance of intrahepatic portosystemic shunts in Irish Wolfhounds.
F. V. van Steenbeek, P. Leegwater, F. van Sluijs, H. Heuven +1 more
2009Journal of Veterinary Internal Medicine26 citations Open access
Semantic Scholar
Transient hyperammonemia due to urea cycle enzyme deficiency in Irish wolfhounds.
M. Zandvliet, J. Rothuizen
2007Journal of Veterinary Internal Medicine26 citations
Semantic Scholar
Aberrant Expression and Distribution of Enzymes of the Urea Cycle and Other Ammonia Metabolizing Pathways in Dogs with Congenital Portosystemic Shunts
G. van Straten, F. V. van Steenbeek, G. Grinwis, R. Favier +7 more
2014PLoS ONE23 citations Open access
Semantic Scholar
New canine models of copper toxicosis: diagnosis, treatment, and genetics
H. Fieten, L. Penning, P. Leegwater, J. Rothuizen
2014Annals of the New York Academy of Sciences23 citations
Semantic Scholar
American Cocker Spaniel chronic hepatitis in Japan.
H. Kanemoto, M. Sakai, Y. Sakamoto, B. Spee +4 more
2013Journal of Veterinary Internal Medicine23 citations Open access
Semantic Scholar
The Progenitor Cell Compartment in the Feline Liver: An (Immuno)Histochemical Investigation
J. Ijzer, J. Kisjes, L. Penning, J. Rothuizen +1 more
2009Veterinary Pathology-Supplement22 citations Open access
Semantic Scholar
Chapter 3 – Ultrasonographic identification and characterization of congenital portosystemic shunts and portal hypertensive disorders in dogs and cats
V. Szatmári, J. Rothuizen
200621 citations
Semantic Scholar
In Vitro Differentiation of Liver Progenitor Cells Derived from Healthy Dog Livers
B. Arends, B. Spee, B. Schotanus, T. Roskams +3 more
2009Stem Cells and Development20 citations
Semantic Scholar
Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis
B. Spee, B. Arends, T. V. D. van den Ingh, T. Roskams +2 more
2007Comparative Hepatology20 citations Open access
Semantic Scholar
A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis
C. Otte, J. Rothuizen, R. Favier, L. Penning +1 more
2014Journal of feline medicine and surgery19 citations Open access
Semantic Scholar
Comparison of different methods to obtain and store liver biopsies for molecular and histological research
Gaby Hoffmann, J. Ijzer, B. Brinkhof, B. Schotanus +3 more
2009Comparative Hepatology18 citations Open access
Semantic Scholar
Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.
R. Favier, B. Spee, H. Fieten, T. V. D. van den Ingh +4 more
2015Journal of Trace Elements in Medicine and Biology17 citations
Semantic Scholar

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