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S. Sieg · SciRah

Researcher profile · Semantic Scholar

S. Sieg

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S. Sieg — researcher profile on SciRah

h-index: 43
Works: 140
Citations: 7,929

Most-cited papers

Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral-Treated HIV Infection
Wei Jiang, M. Lederman, P. Hunt, S. Sieg +9 more
2009Journal of Infectious Diseases619 citations Open access
Semantic Scholar
Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control
Adam R. Hersperger, F. Pereyra, M. Nason, K. Demers +14 more
2010PLoS Pathogens377 citations Open access
Semantic Scholar
Faculty Opinions recommendation of Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.
S. Sieg, Nicholas T. Funderburg
2009363 citations
Semantic Scholar
Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells.
M. Lederman, L. Calabrese, Nicholas T. Funderburg, B. Clagett +14 more
2011Journal of Infectious Diseases337 citations Open access
Semantic Scholar
Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.
Nicholas T. Funderburg, E. Mayne, S. Sieg, R. Asaad +8 more
2010Blood294 citations Open access
Semantic Scholar
Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome.
Nicholas T. Funderburg, David A. Zidar, C. Shive, A. Lioi +7 more
2012Blood216 citations Open access
Semantic Scholar
Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers
G. Hardy, S. Sieg, B. Rodriguez, D. Anthony +10 more
2013PLoS ONE174 citations Open access
Semantic Scholar
CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection.
M. Freeman, Joseph C. Mudd, C. Shive, Souheil-Antoine Younes +8 more
2016Clinical Infectious Diseases143 citations Open access
Semantic Scholar
Increased platelet and microparticle activation in HIV infection: upregulation of Pselectin and tissue factor expression
E. Mayne, Nicholas T. Funderburg, S. Sieg, R. Asaad +5 more
2012Journal of Acquired Immune Deficiency Syndromes136 citations Open access
Semantic Scholar
Faculty Opinions recommendation of Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection.
S. Sieg, Nicholas T. Funderburg
2012114 citations
Semantic Scholar
IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.
Souheil-Antoine Younes, M. Freeman, Joseph C. Mudd, C. Shive +19 more
2016Journal of Clinical Investigation105 citations Open access
Semantic Scholar
Oxidized LDL levels are increased in HIV infection and may drive monocyte activation
David A. Zidar, Steven M Juchnowski, B. Ferrari, B. Clagett +8 more
2015Journal of Acquired Immune Deficiency Syndromes101 citations Open access
Semantic Scholar
The Toll‐like receptor 1/2 agonists Pam3CSK4 and human β‐defensin‐3 differentially induce interleukin‐10 and nuclear factor‐κB signalling patterns in human monocytes
Nicholas T. Funderburg, Julie K. Jadlowsky, M. M. Lederman, Zhimin Feng +2 more
2011Immunology94 citations Open access
Semantic Scholar
Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA
Lechuang Chen, Zhimin Feng, Hong Yue, D. Bazdar +8 more
2018Nature Communications87 citations Open access
Semantic Scholar
Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.
C. Shive, Joseph C. Mudd, Nicholas T. Funderburg, S. Sieg +12 more
2014Journal of Infectious Diseases84 citations Open access
Semantic Scholar
Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction
Souheil-Antoine Younes, A. Talla, S. Pereira Ribeiro, E. Saidakova +16 more
2018Journal of Clinical Investigation81 citations Open access
Semantic Scholar
The Yin and Yang of Human Beta-Defensins in Health and Disease
A. Weinberg, G. Jin, S. Sieg, T. McCormick
2012Front. Immun.70 citations Open access
Semantic Scholar
Interleukin-7 Receptor Signaling Is Deficient in CD4+ T Cells from HIV-infected Persons and Is Inversely Associated with Aging
D. Bazdar, M. Kalinowska, S. Sieg
2009Journal of Infectious Diseases62 citations Open access
Semantic Scholar
Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection
C. Shive, B. Clagett, Marie R. McCausland, Joseph C. Mudd +9 more
2016Journal of Acquired Immune Deficiency Syndromes61 citations Open access
Semantic Scholar
Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection.
Nicole L. Yonkers, S. Sieg, B. Rodriguez, D. Anthony
2011Journal of Infectious Diseases58 citations Open access
Semantic Scholar
Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression.
G. Hardy, S. Sieg, B. Rodriguez, Wei Jiang +3 more
2009Blood56 citations Open access
Semantic Scholar
"Inflammescent" CX3CR1+CD57+ CD8 T cells are generated and expanded by IL-15.
S. Morris, Bonnie Chen, Joseph C. Mudd, S. Panigrahi +10 more
2020JCI Insight53 citations Open access
Semantic Scholar
Determinants of Protection among High Risk HIV Seronegative Persons – an overview
M. Lederman, G. Alter, D. Daskalakis, B. Rodriguez +12 more
2010Journal of Infectious Diseases53 citations Open access
Semantic Scholar
Interferon-Alpha Administration Enhances CD8+ T Cell Activation in HIV Infection
M. Manion, B. Rodriguez, K. Medvik, G. Hardy +11 more
2012PLoS ONE48 citations Open access
Semantic Scholar
Prevention of SHIV transmission by topical IFN-β treatment
R. Veazey, Heather A. Pilch Cooper, T. Hope, G. Alter +9 more
2016Mucosal Immunology46 citations Open access
Semantic Scholar
Altered Lipidome Composition Is Related to Markers of Monocyte and Immune Activation in Antiretroviral Therapy Treated Human Immunodeficiency Virus (HIV) Infection and in Uninfected Persons
Emily R. Bowman, M. Kulkarni, Janelle Gabriel, Morgan J. Cichon +10 more
2019Frontiers in Immunology43 citations Open access
Semantic Scholar
Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection
M. Kulkarni, Emily R. Bowman, Janelle Gabriel, Taylor Amburgy +9 more
2016Open Forum Infectious Diseases43 citations Open access
Semantic Scholar
Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions.
Joseph C. Mudd, S. Panigrahi, B. Kyi, So-Hee Moon +7 more
2016Journal of Infectious Diseases41 citations Open access
Semantic Scholar
HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease
C. Shive, A. Biancotto, Nicholas T. Funderburg, Heather A. Pilch-Cooper +6 more
2012Journal of Acquired Immune Deficiency Syndromes41 citations Open access
Semantic Scholar
Human β defensin‐3 induces chemokines from monocytes and macrophages: diminished activity in cells from HIV‐infected persons
V. Petrov, Nicholas T. Funderburg, A. Weinberg, S. Sieg
2013Immunology40 citations Open access
Semantic Scholar
Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes.
Joseph C. Mudd, P. Murphy, M. Manion, R. Debernardo +16 more
2013Blood37 citations Open access
Semantic Scholar
Presentation of Soluble Antigens to CD8+ T Cells by CpG Oligodeoxynucleotide-Primed Human Naive B Cells
Wei Jiang, M. Lederman, C. Harding, S. Sieg
2011Journal of Immunology35 citations Open access
Semantic Scholar
Neonatal T-cell maturation and homing receptor responses to Toll-like receptor ligands differ from those of adult naive T cells: relationship to prematurity
M. Crespo, Denise G. Martinez, Adam Cerissi, Brenda M. Rivera-Reyes +4 more
2011Pediatric Research34 citations Open access
Semantic Scholar
CYTOMEGALOVIRUS COINFECTION IS ASSOCIATED WITH INCREASED VASCULAR-HOMING CD57+ CD4 T CELLS IN HIV INFECTION
Bonnie Chen, S. Morris, S. Panigrahi, G. Michaelson +16 more
2020Journal of Immunology33 citations Open access
Semantic Scholar
Prospective Analysis of Lipid Composition Changes with Antiretroviral Therapy and Immune Activation in Persons Living with HIV
M. Belury, Emily R. Bowman, Janelle Gabriel, Brandon Snyder +13 more
2017Pathogens and Immunity33 citations Open access
Semantic Scholar
Decreased IL-7 Responsiveness Is Related to Oxidative Stress in HIV Disease
M. Kalinowska, D. Bazdar, M. Lederman, Nicholas T. Funderburg +1 more
2013PLoS ONE33 citations Open access
Semantic Scholar
Probing the Interface of HIV and Inflammaging
S. Sieg, C. Shive, S. Panigrahi, M. Freeman
2021Current HIV/AIDS Reports32 citations
Semantic Scholar
Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms
Emily R. Bowman, C. Cameron, B. Richardson, M. Kulkarni +16 more
2020PLoS Pathogens32 citations Open access
Semantic Scholar
CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis
S. Panigrahi, Bonnie Chen, Mike Fang, D. Potashnikova +19 more
2020PLoS Pathogens32 citations Open access
Semantic Scholar
Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy
Marie R. McCausland, Steven M Juchnowski, David A. Zidar, D. Kuritzkes +4 more
2015PLoS ONE32 citations Open access
Semantic Scholar
Endosomal toll‐like receptors play a key role in activation of primary human monocytes by cowpea mosaic virus
Marwah Albakri, Frank A. Veliz, S. Fiering, N. Steinmetz +1 more
2019Immunology31 citations Open access
Semantic Scholar
SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction.
S. Panigrahi, M. Freeman, Nicholas T. Funderburg, Joseph C. Mudd +9 more
2016Journal of Infectious Diseases31 citations Open access
Semantic Scholar
Cycling Memory CD4+ T Cells in HIV Disease Have a Diverse T Cell Receptor Repertoire and a Phenotype Consistent with Bystander Activation
Wei Jiang, Souheil-Antoine Younes, Nicholas T. Funderburg, Joseph C. Mudd +5 more
2014Journal of Virology29 citations Open access
Semantic Scholar
Human beta defensin-3 increases CD86 expression on monocytes by activating the ATP-gated channel P2X7
A. Lioi, B. Ferrari, G. Dubyak, A. Weinberg +1 more
2015Journal of Immunology28 citations Open access
Semantic Scholar
CD56bright NK IL‐7Rα expression negatively associates with HCV level, and IL‐7‐induced NK function is impaired during HCV and HIV infections
Chelsey J. Judge, L. Kostadinova, K. Sherman, A. Butt +7 more
2017Journal of Leukocyte Biology24 citations Open access
Semantic Scholar
Responsiveness to IL-7 but not to IFN-α is diminished in CD4 T cells from treated HIV infected patients who experience poor CD4 T cell recovery
T. Nguyen, Supriya Shukla, R. Asaad, M. Freeman +3 more
2016AIDS (London)24 citations Open access
Semantic Scholar
Pre-vaccine plasma levels of soluble inflammatory indices negatively predict responses to HAV, HBV, and tetanus vaccines in HCV and HIV infection
C. Shive, Chelsey J. Judge, B. Clagett, R. Kalayjian +10 more
2017Vaccine21 citations Open access
Semantic Scholar
SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis
S. Panigrahi, T. Goswami, B. Ferrari, Christopher J. Antonelli +5 more
2021Microbiology spectrum20 citations Open access
Semantic Scholar
Interferon‐α inhibits CD4 T cell responses to interleukin‐7 and interleukin‐2 and selectively interferes with Akt signaling
T. Nguyen, Doug A. Bazdar, Joseph C. Mudd, M. M. Lederman +3 more
2015Journal of Leukocyte Biology20 citations Open access
Semantic Scholar
Membrane damage and repair in primary monocytes exposed to human β‐defensin‐3
A. Lioi, Angel L. Reyes Rodriguez, Nicholas T. Funderburg, Zhimin Feng +2 more
2012Journal of Leukocyte Biology19 citations Open access
Semantic Scholar

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