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Yong-Rong Zhang · SciRah

Researcher profile · Semantic Scholar

Yong-Rong Zhang

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Yong-Rong Zhang — researcher profile on SciRah

h-index: 16
Works: 36
Citations: 967

Most-cited papers

Mouse Relapse Model of Clostridium difficile Infection
Xing-Min Sun, Hai-Ying Wang, Yong-Rong Zhang, Kevin Chen +2 more
2011Infection and Immunity122 citations Open access
Semantic Scholar
A probiotic yeast-based immunotherapy against Clostridioides difficile infection
Kevin Chen, Yi-Xuan Zhu, Yong-Rong Zhang, Therwa Hamza +5 more
2020Science Translational Medicine119 citations Open access
Semantic Scholar
Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models.
J. Steele, Kevin Chen, Xing-Min Sun, Yong-Rong Zhang +3 more
2012Journal of Infectious Diseases99 citations Open access
Semantic Scholar
Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab
Zhi-Yong Yang, J. Ramsey, Therwa Hamza, Yong-Rong Zhang +9 more
2014Infection and Immunity98 citations Open access
Semantic Scholar
A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection
Hai-Ying Wang, Xing-Min Sun, Yong-Rong Zhang, Shan Li +8 more
2012Infection and Immunity86 citations Open access
Semantic Scholar
Structure of the full-length Clostridium difficile toxin B
Peng Chen, K. Lam, Zheng Liu, Frank A. Mindlin +10 more
2019Nature Structural & Molecular Biology83 citations
Semantic Scholar
Critical Roles of Clostridium difficile Toxin B Enzymatic Activities in Pathogenesis
Shan Li, Lian-Fa F. Shi, Zhi-Yong Yang, Yong-Rong Zhang +6 more
2014Infection and Immunity40 citations Open access
Semantic Scholar
Mice with Inflammatory Bowel Disease are Susceptible to Clostridium difficile Infection With Severe Disease Outcomes
F. Zhou, Therwa Hamza, Ashley Saint Fleur, Yong-Rong Zhang +6 more
2018Inflammatory Bowel Diseases35 citations Open access
Semantic Scholar
Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
Rudo L. Simeon, Mengqiu Jiang, A. Chamoun-Emanuelli, Hua Yu +7 more
2019PLoS Biology33 citations Open access
Semantic Scholar
Gut Microbiome and Immune System Crosstalk in Chronic Inflammatory Diseases: A Narrative Review of Mechanisms and Therapeutic Opportunities
Jefferson J Feng, Nikhil R. Maddirala, Ashley Saint Fleur, Fenfen Zhou +3 more
2025Microorganisms27 citations
Semantic Scholar
A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity
Yong-Rong Zhang, Lian-Fa F. Shi, Shan Li, Zhi-Yong Yang +6 more
2013PLoS ONE27 citations Open access
Semantic Scholar
The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota
Yong-Rong Zhang, Ashley Saint Fleur, Han-Ping Feng
2022Gut microbes26 citations Open access
Semantic Scholar
Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection.
Zhi-Yong Yang, Lian-Fa F. Shi, Hua Yu, Yong-Rong Zhang +4 more
2016Pathogens and Disease23 citations Open access
Semantic Scholar
Structure of the full-length Clostridium difficile toxin
Peng, Bao-Hua Chen, Craig B. Gutierrez, Yong-Rong Zhang +2 more
201920 citations
Semantic Scholar
Newly Identified Bacteriolytic Enzymes That Target a Wide Range of Clinical Isolates of Clostridium difficile
Krunal Mehta, E. Paskaleva, Xia Wu, Navdeep Grover +7 more
2016Biotechnology and Bioengineering20 citations Open access
Semantic Scholar
Glucosyltransferase activity of Clostridium difficile Toxin B is essential for disease pathogenesis
Zhi-Yong Yang, Yong-Rong Zhang, Tu-Xiong Huang, Han-Ping Feng
2015Gut microbes18 citations Open access
Semantic Scholar
Masking autoprocessing of Clostridium difficile toxin A by the C-terminus combined repetitive oligo peptides
Yong-Rong Zhang, Therwa Hamza, Si Gao, Han-Ping Feng
2015Biochemical and Biophysical Research Communications - BBRC16 citations Open access
Semantic Scholar
A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein
Bowen Jiang, Hua Yu, Yong-Rong Zhang, Han-Ping Feng +1 more
2017Pharmaceutical Research15 citations Open access
Semantic Scholar
Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity
Yong-Rong Zhang, Shan Li, Zhi-Yong Yang, Lian-Fa F. Shi +4 more
2018Cellular and Molecular Gastroenterology and Hepatology14 citations Open access
Semantic Scholar
The role of purified Clostridium difficile glucosylating toxins in disease pathogenesis utilizing a murine cecum injection model
Yong-Rong Zhang, Zhi-Yong Yang, Si Gao, Therwa Hamza +3 more
2017Anaerobe12 citations Open access
Semantic Scholar
Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism
G. Krautz‐Peterson, Yong-Rong Zhang, Kevin Chen, G. Oyler +2 more
2011Journal of Toxicology9 citations Open access
Semantic Scholar
Spray Layering of Human Immunoglobulin G: Optimization of Formulation and Process Parameters.
Bowen Jiang, Dong-Yue Yu, Yong-Rong Zhang, Hua Yu +2 more
2021International journal of pharmaceutics8 citations
Semantic Scholar
Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.
Yong-Rong Zhang, Han-Ping Feng
2016Pathogens and Disease7 citations Open access
Semantic Scholar
A fine-tuned yeast surface-display/secretion platform enables the rapid discovery of neutralizing antibodies against Clostridioides difficile toxins
Yinghui Sun, Yong-Rong Zhang, Hua Yu, Ashley Saint Fleur +3 more
2023Microbial Cell Factories3 citations Open access
Semantic Scholar
Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
Charlotte Nyblade, V. Parreño, P. Zhou, Casey Hensley +8 more
2022Gut Pathogens3 citations Open access
Semantic Scholar
Delivery of a therapeutic antibody to the lower gastrointestinal tract for the treatment of Clostridium difficile infection (CDI)
Bowen Jiang, Dong-Yue Yu, Yong-Rong Zhang, Therwa Hamza +2 more
2023Pharmaceutical development and technology (Print)2 citations
Semantic Scholar
Rodent Diets Incorporated with Live Biotherapeutic Products (LBPs): An Innovative Dosing Strategy to Support Preclinical Animal Studies on LBP Intervention
Haixi Cui, Yong-Rong Zhang, Hua Yu, R. Hollenbeck +6 more
2025AAPS PharmSciTech1 citations
Semantic Scholar
Correction: Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
Rudo L. Simeon, Mengqiu Jiang, A. Chamoun-Emanuelli, Hua Yu +7 more
2019PLoS Biology1 citations Open access
Semantic Scholar
Toxemia is the Cause of Systemic Disease in Piglet and Mouse Models of Clostridium difficile Infection
J. Steele, Kevin Chen, Xing-Min Sun, Yong-Rong Zhang +3 more
20111 citations Open access
Semantic Scholar
A competitive BB-ELISA for anti-toxin B neutralising antibodies in assessing risk of recurrent Clostridioides difficile infection: a retrospective cohort study from the MODIFY I and II trials.
Hua Yu, E. Bassères, Rachel Lee, Sonali Kumari +8 more
2026The Lancet Microbe0 citations Open access
Semantic Scholar
Engineered Probiotic Saccharomyces boulardii Produces Functional Insulin With Long‐Acting Effect in Mice Model
Jefferson J Feng, Di Yu, Lydia Nyasae, Rachel Lee +3 more
2026Biotechnology Journal0 citations Open access
Semantic Scholar
Clostridium difficileの臨床分離株の広範囲を標的とする新たに同定された溶菌酵素【Powered by NICT】
K. M. Krunal, E. Elena, Xia Wu, Grover Navdeep +7 more
20160 citations
Semantic Scholar
, Infection Primary and Recurrent Clostridium difficile A Chimeric Toxin Vaccine Protects against
Hai-Ying Wang, Xing-Min Sun, Yong-Rong Zhang, Shan Li +8 more
20120 citations
Semantic Scholar
A Novel Mouse Relapse Model of Clostridum Difficile Infection
Xing-Min Sun, Hai-Ying Wang, Yong-Rong Zhang, B. Davis +1 more
20110 citations Open access
Semantic Scholar
Mouse Relapse Model of Clostridium difﬁcile Infection (cid:1)
Xing-Min Sun, Hai-Ying Wang, Yong-Rong Zhang, Kevin Chen +2 more
20110 citations
Semantic Scholar
A Chimeric Vaccine Prevents Primary and Recurrent Clostridium difficile Infection
Hai-Ying Wang, Xing-Min Sun, Yong-Rong Zhang, Lian-Fa F. Shi +7 more
20110 citations Open access
Semantic Scholar

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