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A. Ebneth · SciRah

Researcher profile · Semantic Scholar

A. Ebneth

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A. Ebneth — researcher profile on SciRah

h-index: 28
Works: 60
Citations: 4,373

Most-cited papers

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.
G. Drewes, A. Ebneth, U. Preuss, E. Mandelkow +1 more
1997Cell892 citations Open access
Semantic Scholar
Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease
A. Ebneth, R. Godemann, K. Stamer, S. Illenberger +3 more
1998Journal of Cell Biology826 citations Open access
Semantic Scholar
MAPs, MARKs and microtubule dynamics.
G. Drewes, A. Ebneth, E. Mandelkow
1998TIBS -Trends in Biochemical Sciences. Regular ed355 citations
Semantic Scholar
Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles.
B. Trinczek, A. Ebneth, E. Mandelkow, E. Mandelkow
1999Journal of Cell Science353 citations
Semantic Scholar
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
I. Espuny-Camacho, Amaia M. Arranz, M. Fiers, An Snellinx +16 more
2017Neuron228 citations Open access
Semantic Scholar
MARK4 Is a Novel Microtubule-associated Proteins/Microtubule Affinity-regulating Kinase That Binds to the Cellular Microtubule Network and to Centrosomes*
B. Trinczek, Miro Brajenovic, A. Ebneth, G. Drewes
2004Journal of Biological Chemistry180 citations Open access
Semantic Scholar
Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.
A. Ebneth, G. Drewes, E. Mandelkow
1999Cell Motility and the Cytoskeleton159 citations
Semantic Scholar
Screening lead compounds for QT interval prolongation.
Rainer Netzer, A. Ebneth, Ulrike Bischoff, Olaf Pongs
2001Drug Discovery Today83 citations
Semantic Scholar
The Structure of Mammalian Serine Racemase
Myron A. Smith, V. Mack, A. Ebneth, I. Moraes +6 more
2010Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
N. Carty, Nadège Berson, Karsten Tillack, C. Thiede +10 more
2015PLoS ONE72 citations Open access
Semantic Scholar
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis
L. A. Miles, S. Hermans, G. Crespi, J. Gooi +11 more
2019iScience68 citations Open access
Semantic Scholar
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
Michael E. Prime, O. Andersen, J. Barker, M. Brooks +26 more
2012Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format
X. Medda, Liesbeth Mertens, Sofie Versweyveld, Annick Diels +7 more
2016Journal of biomolecular screening65 citations Open access
Semantic Scholar
Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition
A. Dorn, Francis Hermann, A. Ebneth, Hendrick Bothmann +3 more
2005Journal of biomolecular screening65 citations Open access
Semantic Scholar
Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics
D. Isbrandt, P. Friederich, A. Solth, W. Haverkamp +7 more
2002Journal of molecular medicine64 citations
Semantic Scholar
Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models
M. Latta-Mahieu, Bradford M. Elmer, A. Bretteville, Ya-Ming Wang +28 more
2018Glia60 citations
Semantic Scholar
Differential cross section of the 2H(n, nnp)-reaction at En = 13MeV
J. Strate, K. Geißdörfer, R. Lin, W. Bielmeier +7 more
198959 citations
Semantic Scholar
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.
V. Beaumont, L. Mrzljak, U. Dijkman, R. Freije +21 more
2016Experimental Neurology57 citations
Semantic Scholar
Fragment-based discovery of BACE1 inhibitors using functional assays.
R. Godemann, J. Madden, Joachim Krämer, Myron A. Smith +8 more
2009Biochemistry54 citations Open access
Semantic Scholar
Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule‐associated protein TAU mutations which displays several phenotypes linked to neurodegeneration
J. García-León, A. Cabrera-Socorro, K. Eggermont, A. Swijsen +16 more
2018Alzheimer's & Dementia48 citations Open access
Semantic Scholar
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET ligand.
Long-Bin Liu, Michael E. Prime, Matthew R. Lee, V. Khetarpal +51 more
2020Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
A. Verheyen, Annick Diels, J. Reumers, K. Van Hoorde +15 more
2019Stem Cell Reports43 citations Open access
Semantic Scholar
HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery.
R. Netzer, U. Bischoff, A. Ebneth
2003Current opinion in drug discovery & development41 citations
Semantic Scholar
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System
K. Neyrinck, Johanna Van Den Daele, T. Vervliet, J. De Smedt +16 more
2021Stem Cell Reviews and Reports40 citations Open access
Semantic Scholar
Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.
Benjamin Schmid, Kennie R Prehn, Natakarn Nimsanor, Blanca Irene Aldana García +13 more
2019Stem Cell Research36 citations Open access
Semantic Scholar
Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
A. Verheyen, Annick Diels, J. Reumers, K. Van Hoorde +15 more
2018Stem Cell Reports34 citations Open access
Semantic Scholar
Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus.
Benjamin Schmid, B. Holst, Ulla B. Poulsen, I. Jørring +7 more
2021Stem Cell Research29 citations Open access
Semantic Scholar
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
F. Herrmann, Manuela Hessmann, Sabine Schaertl, Karola Berg-Rosseburg +25 more
2021Scientific Reports28 citations Open access
Semantic Scholar
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
M. Ermann, Doris Riether, E. Walker, Innocent Mushi +14 more
2008Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Scalable expansion of iPSC and their derivatives across multiple lineages.
Chee Keong Kwok, I. Sébastien, Krithika Hariharan, I. Meiser +14 more
2022Reproductive Toxicology21 citations Open access
Semantic Scholar
Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.
Pei-Yu Shih, M. Kreir, Devesh Kumar, F. Seibt +9 more
2021Stem Cell Research21 citations Open access
Semantic Scholar
Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.
P. D. De Sousa, Rachel Steeg, E. Wachter, K. Bruce +64 more
2017Stem Cell Research21 citations Open access
Semantic Scholar
Morpholine containing CB2 selective agonists.
Renee M. Zindell, Doris Riether, T. Bosanac, Angela K Berry +7 more
2009Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
The EBiSC iPSC bank for disease studies.
Rachel Steeg, J. Neubauer, S. Müller, A. Ebneth +1 more
2020Stem Cell Research17 citations Open access
Semantic Scholar
Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders.
Carlos M Martínez-Viturro, A. Trabanco, Jordi Royes, E. Fernández +13 more
2020Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO)
D. Winkler, M. Beconi, L. Toledo-Sherman, Michael E. Prime +3 more
2013Journal of biomolecular screening16 citations Open access
Semantic Scholar
Biophysical characterization of the c-Myb DNA-binding domain.
A. Ebneth, Olaf Schweers, Hubert Thole, Ursula Fagin +3 more
1994Biochemistry16 citations
Semantic Scholar
Deploying human pluripotent stem cells to treat central nervous system disorders: facts, challenges and realising the potential.
T. Allsopp, A. Ebneth, A. Cabrera-Socorro
2019Stem Cell Research14 citations Open access
Semantic Scholar
Using Electrophysiology and In Silico Three-Dimensional Modeling to Reduce Human Ether-à-go-go Related Gene K+ Channel Inhibition in a Histamine H3 Receptor Antagonist Program
Adam J. Davenport, Clemens C. Möller, Alexander Heifetz, Michael P. Mazanetz +3 more
2010Assay and drug development technologies13 citations
Semantic Scholar
Corrigendum to "Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line" [Stem Cell Res. 34/1873-5061 (2019) 101349-55].
Benjamin Schmid, Kennie R Prehn, Natakarn Nimsanor, Blanca Irene Aldana García +13 more
2020Stem Cell Research12 citations Open access
Semantic Scholar
SliceMap: an algorithm for automated brain region annotation
Michaël Barbier, A. Bottelbergs, R. Nuydens, A. Ebneth +1 more
2018Bioinform.6 citations
Semantic Scholar
IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau.
S. Bijttebier, Dina Rodrigues Martins, Liesbeth Mertens, Karolien Grauwen +7 more
2023Journal of Proteome Research5 citations
Semantic Scholar
Ion channel screening technologies: will they revolutionize drug discovery?
A. Ebneth
2002Drug Discovery Today5 citations
Semantic Scholar
Does a synthetic peptide containing the leucine‐zipper domain of c‐myb form an α‐helical structure in solution?
A. Ebneth, K. Adermann, H. Wolfes
1994FEBS Letters5 citations Open access
Semantic Scholar
Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.
Benjamin Schmid, B. Holst, C. Clausen, Lamia’a Bahnassawy +13 more
2021Stem Cell Research3 citations Open access
Semantic Scholar
Tau Protein: Role in Intracellular Traffic and Development of Cell Polarity
E. Mandelkow, J. Biernat, A. Ebneth, K. Stamer +3 more
20002 citations
Semantic Scholar
[P4–047]: ANTI‐TAU ANTIBODY PROFILING FOR PASSIVE IMMUNIZATION THERAPY: COMPARING SEEDS DERIVED FROM TRANSGENIC ANIMALS AND HUMAN BRAIN TISSUE
M. Borgers, Koen Dockx, I. van de Weyer, Sofie Versweyveld +6 more
20171 citations Open access
Semantic Scholar
Tau protein and Alzheimer's disease: Phosphorylation and role in intracellular trafficking
E. Mandelkow, A. Ebneth, K. Stamer, Robert Godemann Aventis +4 more
20001 citations
Semantic Scholar
Discovery of 5‑Azaindole Inhibitors of O‑GlcNAcase for the Treatment of Alzheimer's Disease and Related Tauopathies.
Jakob Bouton, A. Bretteville, Gary Tresadern, Paul Shaffer +15 more
2026ACS Medicinal Chemistry Letters0 citations Open access
Semantic Scholar
Chimeric hippocampal organotypic slices enable the in vitro investigation of human iPSC‐derived microglia in a three‐dimensional environment with preserved neural network activity
Jens Devoght, Annelies Nonneman, Sofie Swijsen, Dirk Wuyts +6 more
2024Alzheimer's & Dementia0 citations Open access
Semantic Scholar

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