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F. Sime · SciRah

Researcher profile · Semantic Scholar

F. Sime

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F. Sime — researcher profile on SciRah

h-index: 27
Works: 112
Citations: 2,706

Most-cited papers

The global prevalence of multidrug-resistance among Acinetobacter baumannii causing hospital-acquired and ventilator-associated pneumonia and its associated mortality: A systematic review and meta-analysis.
S. Lim, A. Abidin, S. Liew, J. A. Roberts +1 more
2019Journal of Infection182 citations
Semantic Scholar
What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review
Chandra Datta Sumi, A. Heffernan, J. Lipman, J. Roberts +1 more
2019Clinical Pharmacokinetics162 citations Open access
Semantic Scholar
Solid nanoparticles for oral antimicrobial drug delivery: a review.
A. Raza, F. Sime, P. Cabot, Faheem Maqbool +2 more
2019Drug Discovery Today117 citations
Semantic Scholar
Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by Gram-negative bacilli: A systematic review.
A. Heffernan, F. Sime, J. Lipman, J. Dhanani +4 more
2019International Journal of Antimicrobial Agents58 citations Open access
Semantic Scholar
Individualising Therapy to Minimize Bacterial Multidrug Resistance
A. Heffernan, F. Sime, J. Lipman, J. Roberts
2018Drugs50 citations
Semantic Scholar
Population Pharmacokinetics of Unbound Ceftolozane and Tazobactam in Critically Ill Patients without Renal Dysfunction
F. Sime, Melissa M. Lassig-Smith, T. Starr, J. Stuart +5 more
2019Antimicrobial Agents and Chemotherapy48 citations Open access
Semantic Scholar
The global epidemiology of ventilator-associated pneumonia caused by multi-drug resistant Pseudomonas aeruginosa: a systematic review and meta-analysis.
Yixuan Li, J. Roberts, Mikaela M. Walker, A. T. Aslan +2 more
2023International Journal of Infectious Diseases46 citations Open access
Semantic Scholar
Current and Emerging Treatment Options for Multidrug Resistant Escherichia coli Urosepsis: A Review
Mikaela M. Walker, J. Roberts, B. Rogers, P. Harris +1 more
2022Antibiotics44 citations Open access
Semantic Scholar
Current practices and challenges of outpatient parenteral antimicrobial therapy: a narrative review
Z. Wolie, J. Roberts, M. Gilchrist, K. McCarthy +1 more
2024Journal of Antimicrobial Chemotherapy40 citations Open access
Semantic Scholar
Oral meropenem for superbugs: challenges and opportunities.
A. Raza, Shih Chen Ngieng, F. Sime, P. Cabot +4 more
2020Drug Discovery Today39 citations
Semantic Scholar
Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study
J. Roberts, F. Sime, J. Lipman, M. P. Hernández-Mitre +16 more
2025Intensive Care Medicine38 citations Open access
Semantic Scholar
Ex Vivo Characterization of Effects of Renal Replacement Therapy Modalities and Settings on Pharmacokinetics of Meropenem and Vaborbactam
F. Sime, S. Pandey, Nermin Karamujic, S. Parker +7 more
2018Antimicrobial Agents and Chemotherapy36 citations Open access
Semantic Scholar
Liquid CO2 Formulated Mesoporous Silica Nanoparticles for pH-Responsive Oral Delivery of Meropenem.
A. Raza, F. Sime, P. Cabot, J. Roberts +3 more
2021ACS Biomaterials Science & Engineering32 citations
Semantic Scholar
Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia
F. Sime, U. Hahn, M. Warner, I. Tiong +4 more
2017Antimicrobial Agents and Chemotherapy32 citations Open access
Semantic Scholar
Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients
F. Sime, C. Byrne, S. Parker, J. Stuart +6 more
2019Critical Care31 citations Open access
Semantic Scholar
Population Pharmacokinetics of Levetiracetam in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage Exhibiting Augmented Renal Clearance
F. Sime, J. Roberts, R. Jeffree, S. Pandey +7 more
2021Clinical Pharmacokinetics30 citations
Semantic Scholar
Safety and efficacy of outpatient parenteral antimicrobial therapy: a systematic review and meta-analysis of randomized clinical trials.
S. A. Mohammed, J. Roberts, M. Cotta, Benjamin A Rogers +4 more
2024International Journal of Antimicrobial Agents29 citations Open access
Semantic Scholar
Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?
A. Heffernan, A. Germano, F. Sime, J. Roberts +1 more
2019European Journal of Clinical Pharmacology28 citations Open access
Semantic Scholar
Multicenter Population Pharmacokinetic Study of Unbound Ceftriaxone in Critically Ill Patients
A. Heffernan, F. Sime, Nilesh Kumta, S. Wallis +6 more
2022Antimicrobial Agents and Chemotherapy27 citations Open access
Semantic Scholar
A Population Pharmacokinetic Model-Guided Evaluation of Ceftolozane-Tazobactam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemodiafiltration
F. Sime, Melissa M. Lassig-Smith, T. Starr, J. Stuart +5 more
2019Antimicrobial Agents and Chemotherapy26 citations Open access
Semantic Scholar
What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review
G. M. Assefa, J. Roberts, S. A. Mohammed, F. Sime
2024Journal of Antimicrobial Chemotherapy25 citations Open access
Semantic Scholar
How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients
A. Heffernan, F. Sime, F. Taccone, J. Roberts
2018Current Opinion in Infectious Diseases25 citations
Semantic Scholar
Multidrug-resistant Acinetobacter baumannii infections: Current evidence on treatment options and the role of pharmacokinetics/pharmacodynamics in dose optimisation.
Sazlyna Mohd Sazlly Lim, F. Sime, J. Roberts
2019International Journal of Antimicrobial Agents24 citations
Semantic Scholar
Dosing antibiotic prophylaxis during cardiopulmonary bypass-a higher level of complexity? A structured review.
F. Paruk, F. Sime, J. Lipman, J. Roberts
2017International Journal of Antimicrobial Agents24 citations
Semantic Scholar
A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations
Puteri Juanita Zamri, S. M. S. Lim, F. Sime, Jason A. Roberts +1 more
2025Clinical Pharmacokinetics22 citations Open access
Semantic Scholar
Pharmacokinetics of Intravenous Posaconazole in Critically Ill Patients
F. Sime, J. Stuart, J. Butler, T. Starr +4 more
2018Antimicrobial Agents and Chemotherapy22 citations Open access
Semantic Scholar
Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery.
A. Raza, S. Alavi, F. Sime, Felicity Y. Han +4 more
2021Acta Biomaterialia21 citations
Semantic Scholar
β-lactam antibiotic versus combined β-lactam antibiotic and single-daily dosing regimens of aminoglycosides for the treatment of serious infections: a meta-analysis: Category: Systematic review and meta-analysis.
A. Heffernan, F. Sime, Jing Sun, J. Lipman +5 more
2019International Journal of Antimicrobial Agents21 citations Open access
Semantic Scholar
Ceftolozane-tazobactam in an elastomeric infusion device for ambulatory care: an in vitro stability study.
E. Raby, S. Naicker, F. Sime, L. Manning +3 more
2019European Journal of Hospital Pharmacy: Science and Practice18 citations Open access
Semantic Scholar
Pharmacodynamics of ceftriaxone for the treatment of methicillin-susceptible Staphylococcus aureus: Is it a viable treatment option?
A. Heffernan, F. Sime, Lim S. Mohd Sazlly, S. Adiraju +4 more
2022International Journal of Antimicrobial Agents17 citations Open access
Semantic Scholar
Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain
F. Sime, Melissa M. Lassig-Smith, T. Starr, J. Stuart +5 more
2020Antimicrobial Agents and Chemotherapy17 citations Open access
Semantic Scholar
Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics
M. Alshaer, S. Goutelle, Barbara A. Santevecchi, Bethany R. Shoulders +9 more
2021Antimicrobial Agents and Chemotherapy15 citations Open access
Semantic Scholar
Evaluating Mono- and Combination Therapy of Meropenem and Amikacin against Pseudomonas aeruginosa Bacteremia in the Hollow-Fiber Infection Model
M. Avent, K. McCarthy, F. Sime, S. Naicker +4 more
2021bioRxiv14 citations Open access
Semantic Scholar
Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia.
K. Islam, A. Heffernan, S. Naicker, A. Henderson +3 more
2021Future Microbiology14 citations Open access
Semantic Scholar
Challenges in Antifungal Therapy in Diabetes Mellitus
Sazlyna Mohd Sazlly Lim, M. Sinnollareddy, F. Sime
2020Journal of Clinical Medicine14 citations Open access
Semantic Scholar
Ceftriaxone dosing in patients admitted from the emergency department with sepsis
A. Heffernan, R. Curran, K. Denny, F. Sime +5 more
2020European Journal of Clinical Pharmacology13 citations Open access
Semantic Scholar
Quantifying cost savings from outpatient parenteral antimicrobial therapy programme: a systematic review and meta-analysis
S. A. Mohammed, J. A. Roberts, M. Mirón-Rubio, L. E. López Cortés +6 more
2025JAC-Antimicrobial Resistance12 citations
Semantic Scholar
Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime
Jia-Jun Liu, M. Neely, J. Lipman, F. Sime +5 more
2019Clinical Pharmacokinetics12 citations Open access
Semantic Scholar
Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey
Z. Wolie, J. A. Roberts, L. López-Cortés, M. Mirón-Rubio +7 more
2025JAC-Antimicrobial Resistance11 citations Open access
Semantic Scholar
Dynamic In Vitro PK/PD Infection Models for the Development and Optimisation of Antimicrobial Regimens: A Narrative Review
Y. M. Wale, J. A. Roberts, F. Sime
2024Antibiotics11 citations
Semantic Scholar
Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic
A. Raza, D. Kamato, F. Sime, J. A. Roberts +3 more
2022Materials Today Advances11 citations Open access
Semantic Scholar
What are the Predictors for Achieving Therapeutic Levetiracetam Serum Concentrations in Adult Neurological Patients?
M. Cotta, M. Abdul-Aziz, O. Frey, F. Sime +2 more
2020Therapeutic Drug Monitoring11 citations
Semantic Scholar
A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study
S. Parker, S. Pandey, F. Sime, J. Lipman +2 more
2019Analytical and Bioanalytical Chemistry11 citations
Semantic Scholar
Barriers and facilitators for the implementation and expansion of outpatient parenteral antimicrobial therapy: Systematic review.
S. A. Mohammed, M. Cotta, G. M. Assefa, D. Erku +1 more
2024Journal of Hospital Infection10 citations Open access
Semantic Scholar
Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model
K. Islam, F. Sime, S. Wallis, M. Bauer +9 more
2022Antimicrobial Agents and Chemotherapy10 citations Open access
Semantic Scholar
Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae.
Chandra Datta Sumi, A. Heffernan, S. Naicker, K. Islam +6 more
2020Journal of Antimicrobial Chemotherapy10 citations Open access
Semantic Scholar
A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteria
G. M. Assefa, J. Roberts, A. T. Aslan, S. A. Mohammed +1 more
2024Journal of Antimicrobial Chemotherapy9 citations Open access
Semantic Scholar
Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii
Sazlyna Mohd Sazlly Lim, A. Heffernan, H. Zowawi, J. Roberts +1 more
2021European Journal of Clinical Microbiology and Infectious Diseases9 citations Open access
Semantic Scholar
Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections.
S. Lim, S. Naicker, A. Ayfan, H. Zowawi +2 more
2020International Journal of Antimicrobial Agents9 citations
Semantic Scholar
Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli.
P. Bergen, J. Bulitta, F. Sime, J. Lipman +6 more
2018Diagnostic microbiology and infectious disease9 citations
Semantic Scholar

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