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Douglas Losordo · SciRah

Researcher profile · Semantic Scholar

Douglas Losordo

Caladrius Biosciences

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Douglas Losordo — researcher profile on SciRah

ORCID iD 0000-0002-6857-7506Homepage

h-index: 95
Works: 429
Citations: 33K

Most-cited papers

Critical re-evaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use
G. Fadini, Douglas Losordo, S. Dimmeler
2012Circulation Research644 citations Open access
Semantic Scholar
Exosomes and cardiac repair after myocardial infarction.
S. Sahoo, Douglas Losordo
2014Circulation Research478 citations Open access
Semantic Scholar
Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb
P. Mathiyalagan, Ya-Xuan Liang, David J Kim, S. Misener +6 more
2017Circulation Research247 citations Open access
Semantic Scholar
Cell Therapy of Peripheral Arterial Disease
Z. Raval, Douglas Losordo
2013Circulation Research219 citations Open access
Semantic Scholar
Modulating the Vascular Response to Limb Ischemia Angiogenic and Cell Therapies
J. Cooke, Douglas Losordo
2015Circulation Research208 citations Open access
Semantic Scholar
Sonic Hedgehog Modified Human CD34+ Cells Preserve Cardiac Function Following Acute Myocardial Infarction
A. Mackie, Ekaterina Klyachko, T. Thorne, Kathryn M. Schultz +9 more
2012Circulation Research184 citations Open access
Semantic Scholar
A Randomized, Controlled Pilot Study of Autologous CD34+ Cell Therapy for Critical Limb Ischemia
Douglas Losordo, M. Kibbe, F. Mendelsohn, W. Marston +16 more
2012Circulation. Cardiovascular Interventions184 citations Open access
Semantic Scholar
Global position paper on cardiovascular regenerative medicine
F. Fernández-Avilés, R. Sanz-Ruiz, A. Climent, L. Badimón +54 more
2017European Heart Journal138 citations Open access
Semantic Scholar
An Open-Label Dose Escalation Study to Evaluate the Safety of Administration of Nonviral Stromal Cell-Derived Factor-1 Plasmid to Treat Symptomatic Ischemic Heart Failure
M. Penn, F. Mendelsohn, G. Schaer, W. Sherman +6 more
2013Circulation Research135 citations Open access
Semantic Scholar
The RENEW Trial: Efficacy and Safety of Intramyocardial Autologous CD34(+) Cell Administration in Patients With Refractory Angina.
T. Povsic, T. Henry, J. Traverse, F. Fortuin +16 more
2016JACC: Cardiovascular Interventions115 citations Open access
Semantic Scholar
Abstract 17457: PreSERVE-AMI: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intracoronary Administration of Autologous CD34+ Cells in Patients with Left Ventricular Dysfunction Post STEMI
A. Quyyumi, A. Vasquez, Marc Klapholz, D. Kereiakes +27 more
201496 citations
Semantic Scholar
Autologous CD34+ cell therapy improves exercise capacity, angina frequency and reduces mortality in no-option refractory angina: a patient-level pooled analysis of randomized double-blinded trials
T. Henry, Douglas Losordo, J. Traverse, R. Schatz +11 more
2018European Heart Journal95 citations Open access
Semantic Scholar
Enhanced Angiogenic and Cardiomyocyte Differentiation Capacity of Epigenetically Reprogrammed Mouse and Human Endothelial Progenitor Cells Augments their Efficacy for Ischemic Myocardial Repair
M. Thal, P. Krishnamurthy, A. Mackie, E. Hoxha +6 more
2012Circulation Research95 citations Open access
Semantic Scholar
A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heart
M. Cheng, Kai Huang, Junlan Zhou, De-Wen Yan +6 more
2015Journal of Molecular and Cellular Cardiology85 citations Open access
Semantic Scholar
A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial autologous CD34+ cell administration in patients with refractory angina: design of the RENEW study.
T. Povsic, Candice E. Junge, A. Nada, R. Schatz +12 more
2013American Heart Journal84 citations
Semantic Scholar
CXCR4 Antagonist AMD3100 Promotes Cardiac Functional Recovery After Ischemia-Reperfusion Injury via eNOS-Dependent Mechanism
K. Jujo, Masaaki Ii, H. Sekiguchi, Ekaterina Klyachko +14 more
2012Circulation83 citations Open access
Semantic Scholar
Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow derived Progenitor Cell-mediated Myocardial Repair and Function after Myocardial Infarction
V. Garikipati, P. Krishnamurthy, S. Verma, Mohsin Khan +11 more
2015Stem Cells75 citations Open access
Semantic Scholar
On the fabric of the human body.
Z. Raval, Douglas Losordo
2012Circulation73 citations Open access
Semantic Scholar
Phase II clinical trial of CD34+ cell therapy to explore endpoint selection and timing in patients with critical limb ischemia.
Yasuyuki Fujita, M. Kinoshita, Y. Furukawa, T. Nagano +15 more
2014Circulation Journal52 citations Open access
Semantic Scholar
Autologous CD34+ Cell Therapy for Refractory Angina: 2-Year Outcomes from the ACT34-CMI Study
T. Henry, G. Schaer, J. Traverse, T. Povsic +16 more
2016Cell Transplantation49 citations Open access
Semantic Scholar
Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice
J. Asai, Hideya Takenaka, Masaaki Ii, M. Asahi +3 more
2013International Wound Journal49 citations Open access
Semantic Scholar
Autologous CD34+ Stem Cell Therapy Increases Coronary Flow Reserve and Reduces Angina in Patients With Coronary Microvascular Dysfunction
T. Henry, C. N. B. Merz, Janet Wei, M. Corban +13 more
2022Circulation. Cardiovascular Interventions44 citations Open access
Semantic Scholar
PreSERVE-AMI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intracoronary Administration of Autologous CD34+ Cells in Patients with Left Ventricular Dysfunction Post STEMI
A. Quyyumi, A. Vasquez, D. Kereiakes, Marc Klapholz +23 more
2016Circulation Research42 citations Open access
Semantic Scholar
E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression.
Min Wu, Junlan Zhou, M. Cheng, Chan Boriboun +17 more
2014Cardiovascular Research40 citations Open access
Semantic Scholar
Safety and efficacy of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia
M. Kibbe, A. Hirsch, F. Mendelsohn, M. Davies +14 more
2015Gene Therapy37 citations Open access
Semantic Scholar
Gli3 Regulation of Myogenesis Is Necessary for Ischemia-Induced Angiogenesis
M. Renault, Soizic Vandierdonck, C. Chapouly, Yang Yu +10 more
2013Circulation Research31 citations Open access
Semantic Scholar
IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation
S. Verma, V. Garikipati, P. Krishnamurthy, Mohsin Khan +4 more
2016PLoS ONE30 citations Open access
Semantic Scholar
Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve
H. Sekiguchi, Masaaki Ii, K. Jujo, T. Thorne +9 more
2012Angiogenesis28 citations Open access
Semantic Scholar
Enhanced Potency of Cell-based Therapy for Ischemic Tissue Repair Using an Injectable Bioactive Epitope-presenting Nanofiber Support Matrix
J. Tongers, M. Webber, E. Vaughan, Eduard Sleep +16 more
2014Journal of Molecular and Cellular Cardiology27 citations Open access
Semantic Scholar
Estradiol Triggers Sonic-hedgehog–induced Angiogenesis During Peripheral Nerve Regeneration by Downregulating Hedgehog-interacting Protein
H. Sekiguchi, Masaaki Ii, K. Jujo, M. Renault +8 more
2012Laboratory Investigation27 citations Open access
Semantic Scholar
Wnt11 Gene Therapy with Adeno-associated Virus 9 Improves Recovery from Myocardial Infarction by Modulating the Inflammatory Response
Yoshihiro Morishita, Koichi Kobayashi, Ekaterina Klyachko, K. Jujo +3 more
2016Scientific Reports25 citations Open access
Semantic Scholar
E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells
Shi-yue Xu, J. Tao, Liu Yang, Eric Zhang +14 more
2018Circulation Research20 citations Open access
Semantic Scholar
Autologous CD34+ Cell Therapy for Ischemic Tissue Repair.
W. Sietsema, A. Kawamoto, H. Takagi, Douglas Losordo
2019Circulation Journal19 citations Open access
Semantic Scholar
Endothelial Smoothened-dependent Hedgehog Signaling is Not Required for Sonic Hedgehog Induced Angiogenesis or Ischemic Tissue Repair
Rajesh Gupta, A. Mackie, S. Misener, L. Liu +2 more
2018Laboratory Investigation17 citations Open access
Semantic Scholar
CD34 + cell therapy significantly reduces adverse cardiac events, health care expenditures, and mortality in patients with refractory angina
Grace L. Johnson, T. Henry, T. Povsic, Douglas Losordo +4 more
2020Stem Cells Translational Medicine16 citations Open access
Semantic Scholar
Incidence and clinical significance of cardiac biomarker elevation during stem cell mobilization, apheresis, and intramyocardial delivery: an analysis from ACT34-CMI.
T. Povsic, Douglas Losordo, K. Story, Candice E. Junge +3 more
2012American Heart Journal14 citations
Semantic Scholar
Manual of Research Techniques in Cardiovascular Medicine
H. Ardehali, R. Bolli, Douglas Losordo
201413 citations
Semantic Scholar
Alcohol Consumption Negates Estrogen-mediated Myocardial Repair in Ovariectomized Mice by Inhibiting Endothelial Progenitor Cell Mobilization and Function*
A. Mackie, P. Krishnamurthy, S. Verma, T. Thorne +6 more
2013Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Navigating the Future of Cardiovascular Drug Development—Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference
T. Povsic, R. Scott, K. Mahaffey, R. Blaustein +16 more
2017Cardiovascular Drugs and Therapy10 citations
Semantic Scholar
Reprint of: Development of bioactive peptide amphiphiles for therapeutic cell delivery.
M. Webber, J. Tongers, M. Renault, J. Roncalli +2 more
2015Acta Biomaterialia7 citations
Semantic Scholar
Genetic deletion of TNFR2 augments inflammatory response and blunts satellite‐cell‐mediated recovery response in a hind limb ischemia model
Sharath P. Sasi, Layla Rahimi, Xin-Hua Yan, Marcy Silver +4 more
2015The FASEB Journal7 citations Open access
Semantic Scholar
New Definition of Aging? Measuring Regenerative Capacity in Patients.
Douglas Losordo, T. Henry
2016Circulation Research6 citations Open access
Semantic Scholar
Going mobile: enhanced recovery from myocardial infarction via stem cell mobilization and homing for tissue repair.
Douglas Losordo, D. Vaughan
2014Journal of the American College of Cardiology6 citations Open access
Semantic Scholar
Phase II Clinical Trial of CD 34 + Cell Therapy to Explore Endpoint Selection and Timing in Patients With Critical Limb Ischemia
Yasuyuki Fujita, M. Kinoshita, Y. Furukawa, T. Nagano +15 more
20146 citations
Semantic Scholar
Erratum: Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair (Proceedings of the National Academy of Sciences (2011) 108, 33 (13438-13443) DOI: 10.1073/ pnas.1016546108)
M. Webber, J. Tongers, C. Newcomb, Katja-Theres Marquardt +3 more
20125 citations Open access
Semantic Scholar
A Path Forward for Regenerative Medicine: Navigating Regulatory Challenges Summary of Findings From the Cardiac Safety Research Consortium/Texas Heart Institute International Symposium on Cardiovascular Regenerative Medicine
Alexander C. Fanaroff, Valarie Morrow, M. Krucoff, Jonathan H. Seltzer +8 more
2018Circulation Research4 citations
Semantic Scholar
Erratum: Safety and efficacy of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia (Gene Therapy (2016) 23 (306-312)) DOI:10.1038/gt.2015.110)
M. Kibbe, A. Hirsch, F. Mendelsohn, M. Davies +14 more
20164 citations Open access
Semantic Scholar
Safety and efficacy of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia
M. Kibbe, A. Hirsch, F. Mendelsohn, M. Davies +14 more
2016Gene Therapy4 citations Open access
Semantic Scholar
A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER TRIAL OF THE SAFETY AND EFFICACY OF PLASMID DNA EXPRESSING 2 ISOFORMS OF HEPATOCYTE GROWTH FACTOR IN PATIENTS WITH CRITICAL LIMB ISCHEMIA
E. Perin, F. Mendelsohn, M. Davies, H. Pham +13 more
20143 citations Open access
Semantic Scholar
Endothelial dysfunction and systemic hypertension by selective cGMP-dependent protein kinase I inhibition using novel cell-penetrating peptide delivered in vivo.
K. Poh, P. Lu, Gangjian Qin, Marcy Silver +3 more
2013International Journal of Cardiology3 citations
Semantic Scholar

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