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M. Flydal · SciRah

Researcher profile · Semantic Scholar

M. Flydal

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M. Flydal — researcher profile on SciRah

h-index: 13
Works: 30
Citations: 823

Most-cited papers

Phenylalanine hydroxylase: Function, structure, and regulation
M. Flydal, Aurora Martínez
2013IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology222 citations Open access
Semantic Scholar
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins
Sadaf Ghorbani, Agnete Fossbakk, A. Jorge-Finnigan, M. Flydal +2 more
2016Amino Acids121 citations Open access
Semantic Scholar
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
M. Bueno-Carrasco, J. Cuéllar, M. Flydal, C. Santiago +9 more
2022Nature Communications96 citations Open access
Semantic Scholar
Arc is a flexible modular protein capable of reversible self-oligomerization
Craig Myrum, A. Baumann, H. J. Bustad, M. Flydal +9 more
2015Biochemical Journal71 citations Open access
Semantic Scholar
Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin
M. Flydal, Martín Alcorlo-Pagés, F. Johannessen, S. Martínez-Caballero +4 more
2019Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
G. Korner, D. Noain, Ming Ying, M. Hole +14 more
2015Brain : a journal of neurology37 citations Open access
Semantic Scholar
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif
M. S. Eriksen, O. Nikolaienko, E. Hallin, Sverre Grødem +19 more
2020The FEBS Journal36 citations Open access
Semantic Scholar
Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis
M. Flydal, Christa H. Chatfield, Huaixin Zheng, Felizza F. Gunderson +3 more
2012PLoS ONE28 citations Open access
Semantic Scholar
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
Maria T Bezem, A. Baumann, Lars Skjærven, R. Meyer +3 more
2016Scientific Reports27 citations Open access
Semantic Scholar
Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia—A Focus on Tyrosine Hydroxylase Deficiency
Gyrid Nygaard, Peter D Szigetvari, A. Grindheim, P. Ruoff +4 more
2021Journal of Personalized Medicine22 citations Open access
Semantic Scholar
The Host-Pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains
Sara M. Ø. Solbak, V. Wray, O. Horvli, A. Raae +6 more
2011BMC Structural Biology18 citations Open access
Semantic Scholar
Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications
M. Flydal, Tonje C. Mohn, A. L. Pey, J. Siltberg-Liberles +2 more
2010Amino Acids15 citations
Semantic Scholar
Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila.
Oscar Aubi, M. Flydal, Huaixin Zheng, Lars Skjærven +6 more
2015Journal of Medicinal Chemistry14 citations
Semantic Scholar
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach
Leire Dublang, J. Underhaug, M. Flydal, Lorea Velasco-Carneros +5 more
2021Cancers13 citations Open access
Semantic Scholar
Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase.
M. Flydal, Trond-André Kråkenes, M. D. S. Tai, M. P. Tran +2 more
2020Biochimie13 citations
Semantic Scholar
The structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin
M. Flydal, Martín Alcorlo-Pagés, F. Johannessen, S. Martínez-Caballero +4 more
2019bioRxiv13 citations Open access
Semantic Scholar
Structural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12
M. D. S. Tai, L. Ochoa, M. Flydal, Lorea Velasco-Carneros +12 more
2025Nature Communications12 citations Open access
Semantic Scholar
Molecular determinants of Arc oligomerization and formation of virus-like capsids
M. S. Eriksen, O. Nikolaienko, E. Hallin, Sverre Grødem +18 more
2019bioRxiv6 citations Open access
Semantic Scholar
Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila
H. Leiros, M. Flydal, Aurora Martínez
2013FEBS Open Bio5 citations Open access
Semantic Scholar
The Structure of Human Tyrosine Hydroxylase Reveals the Mechanism for Feedback Inhibition by Dopamine
J. Valpuesta, Teresa Bueno-Carrasco, J. Cuéllar, M. Flydal +8 more
20203 citations Open access
Semantic Scholar
Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins
S. I. Støve, M. Flydal, Emil Hausvik, J. Underhaug +1 more
20203 citations
Semantic Scholar
DNAJC12 Stabilizes Phenylalanine Hydroxylase and Facilitates Its Substrate‐Dependent Activation
M. D. S. Tai, Trond-André Kråkenes, Gloria Gamiz-Arco, Christer F. Didriksen +4 more
2026The FASEB Journal1 citations Open access
Semantic Scholar
DNAJC12 stabilizes activated phenylalanine hydroxylase and reduces the concentration of L-Phe needed for activation
M. D. S. Tai, Trond-André Kråkenes, Gloria Gamiz-Arco, Christer F. Didriksen +4 more
2025bioRxiv1 citations Open access
Semantic Scholar
Early-Onset Stargardt Disease Caused by Homozygosity of a Complex ABCA4 Allele from Eastern Africa: Two Case Reports
Sigrid Aslaksen, E. Bratland, Mari Hamre Bu, I. Aukrust +6 more
2025Case Reports in Ophthalmology0 citations Open access
Semantic Scholar
Slik utvikler vi norske fagtermer i celle- og molekylærbiologi
H. J. Bustad, M. Flydal, Helene Knævelsrud, Ann Helen Langaker +2 more
2022Tidsskrift for Den norske legeforening0 citations Open access
Semantic Scholar
Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms
M. Bueno-Carrasco, J. Cuéllar, C. Santiago, J. Valpuesta +2 more
20210 citations
Semantic Scholar
Partial structure of the substrate-free tyrosine hydroxylase (apo-TH).
M. Bueno-Carrasco, J. Cuéllar, C. Santiago, J. Valpuesta +2 more
20210 citations
Semantic Scholar
Crystallographic structure of the catalytic domain of Human Phenylalanine Hydroxylase (hPAH CD) in complex with iron at 1.6 Angstrom
M. Pagès, M. Flydal
20190 citations
Semantic Scholar
Structural and dynamics studies of human phenylalanine hydroxylase, a highly regulated allosteric enzyme
M. Flydal, Martín Alcorlo, Lars Skjærven, I. G. Muñoz +3 more
20160 citations Open access
Semantic Scholar
Phenylalanine hydroxylase from Legionella pneumophila: a thermostable dimer
M. Flydal, H. Leiros, N. Cianciotto, Aurora Martínez
20120 citations Open access
Semantic Scholar

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