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Yoshichika Kawai · SciRah

Researcher profile · Semantic Scholar

Yoshichika Kawai

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Yoshichika Kawai — researcher profile on SciRah

h-index: 39
Works: 88
Citations: 4,373

Most-cited papers

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress
I. H. Lee, Yoshichika Kawai, M. Fergusson, I. Rovira +4 more
2012Science333 citations Open access
Semantic Scholar
Macrophage as a Target of Quercetin Glucuronides in Human Atherosclerotic Arteries
Yoshichika Kawai, T. Nishikawa, Y. Shiba, Satomi Saito +6 more
2008Journal of Biological Chemistry286 citations Open access
Semantic Scholar
Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats.
A. Ishisaka, Satomi Ichikawa, H. Sakakibara, M. Piskuła +7 more
2011Free Radical Biology & Medicine281 citations
Semantic Scholar
Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo.
J. Terao, Kaeko Murota, Yoshichika Kawai
2011Food & Function150 citations
Semantic Scholar
Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats.
Kyuichi Kawabata, Yoshichika Kawai, J. Terao
2010Journal of Nutritional Biochemistry129 citations
Semantic Scholar
Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites.
Y. Shiba, T. Kinoshita, H. Chuman, Y. Taketani +7 more
2008Chemical Research in Toxicology121 citations
Semantic Scholar
Dietary defatted sesame flour decreases susceptibility to oxidative stress in hypercholesterolemic rabbits.
Myung-Hwa Kang, Yoshichika Kawai, Michitaka Naito, Toshihiko Osawa
1999Journal of NutriLife119 citations Open access
Semantic Scholar
Vegetable flavonoids and cardiovascular disease.
J. Terao, Yoshichika Kawai, Kaeko Murota
2008Asia Pacific Journal of Clinical Nutrition103 citations
Semantic Scholar
Mitochondrial Dysfunction Leads to Deconjugation of Quercetin Glucuronides in Inflammatory Macrophages
A. Ishisaka, Kyuichi Kawabata, Satomi Miki, Y. Shiba +5 more
2013PLoS ONE102 citations Open access
Semantic Scholar
Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis.
K. Ishizawa, M. Yoshizumi, Yoshichika Kawai, J. Terao +6 more
2011Journal of Pharmacological Sciences102 citations Open access
Semantic Scholar
Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice
M. Tsuji, Hironori Yamamoto, Tadatoshi Sato, Yoko Mizuha +6 more
2009Journal of Bone and Mineral Metabolism100 citations
Semantic Scholar
Covalent modification of lysine residues by allyl isothiocyanate in physiological conditions: plausible transformation of isothiocyanate from thiol to amine.
Toshiyuki Nakamura, Yoshichika Kawai, N. Kitamoto, T. Osawa +1 more
2009Chemical Research in Toxicology90 citations
Semantic Scholar
Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria.
Saki Yoshino, A. Hara, H. Sakakibara, Kyuichi Kawabata +4 more
2011Nutrition (Burbank, Los Angeles County, Calif.)86 citations
Semantic Scholar
Antidepressant-Like Effect of Onion (Allium cepa L.) Powder in a Rat Behavioral Model of Depression
H. Sakakibara, Saki Yoshino, Yoshichika Kawai, J. Terao
2008Bioscience, biotechnology and biochemistry85 citations Open access
Semantic Scholar
Lipidomic analysis for lipid peroxidation-derived aldehydes using gas chromatography-mass spectrometry.
Yoshichika Kawai, Sayaka Takeda, J. Terao
2007Chemical Research in Toxicology82 citations
Semantic Scholar
Antioxidant capacity of albumin-bound quercetin metabolites after onion consumption in humans.
Kaeko Murota, Azusa Hotta, Hikaru Ido, Yoshichika Kawai +5 more
2007Journal of Medical Investigation77 citations Open access
Semantic Scholar
Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acidss⃞s⃞ The online version of this article (available at http://www.jlr.org) contains an additional two figures. Published, JLR Papers in Press, January 16, 2004. DOI 10.1194/jlr.M300376-JLR200
S. Yamada, T. Funada, N. Shibata, Makio Kobayashi +4 more
2004Journal of Lipid Research77 citations Open access
Semantic Scholar
Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.
Hiroko Takumi, Hiroyasu Nakamura, T. Simizu, Ryoko Harada +6 more
2012Food & Function74 citations
Semantic Scholar
Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models.
H. Sakakibara, Kaori Ishida, O. Grundmann, J. Nakajima +7 more
2006Biological and Pharmaceutical Bulletin74 citations Open access
Semantic Scholar
Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation.
Yoshichika Kawai, H. Kiyokawa, Y. Kimura, Y. Kato +2 more
2006Biochemistry70 citations
Semantic Scholar
Specific localization of quercetin-3-O-glucuronide in human brain.
A. Ishisaka, Rie Mukai, J. Terao, N. Shibata +1 more
2014Archives of Biochemistry and Biophysics67 citations
Semantic Scholar
Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells
Mutsuko Shirai, Yoshichika Kawai, R. Yamanishi, T. Kinoshita +2 more
2006Free radical research65 citations
Semantic Scholar
Identification of a Lipid Peroxidation Product as a Potential Trigger of the p53 Pathway*
T. Shibata, K. Iio, Yoshichika Kawai, N. Shibata +6 more
2006Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Formation of Acrolein-derived 2′-Deoxyadenosine Adduct in an Iron-induced Carcinogenesis Model*
Yoshichika Kawai, A. Furuhata, S. Toyokuni, Y. Aratani +1 more
2003Journal of Biological Chemistry62 citations Open access
Semantic Scholar
The hydrogen peroxide/copper ion system, but not other metal-catalyzed oxidation systems, produces protein-bound dityrosine.
Yoji Kato, N. Kitamoto, Yoshichika Kawai, Toshihiko Osawa
2001Free Radical Biology & Medicine60 citations
Semantic Scholar
Endogenous Formation of Novel Halogenated 2′-Deoxycytidine
Yoshichika Kawai, H. Morinaga, Hajime Kondo, Noriyuki Miyoshi +3 more
2004Journal of Biological Chemistry59 citations Open access
Semantic Scholar
(-)-Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: implication in the anti-atherosclerotic actions of tea catechins.
Yoshichika Kawai, Hiroko Tanaka, Kaeko Murota, Michitaka Naito +1 more
2008Biochemical and Biophysical Research Communications - BBRC58 citations
Semantic Scholar
Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity.
S. Ichihara, Yoshiji Yamada, Yoshichika Kawai, T. Osawa +3 more
2007Biochemical and Biophysical Research Communications - BBRC56 citations
Semantic Scholar
Nuclear glutathione S-transferase pi prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA products.
K. Kamada, S. Goto, T. Okunaga, Y. Ihara +7 more
2004Free Radical Biology & Medicine54 citations
Semantic Scholar
2'-deoxycytidine in free nucleosides and double-stranded DNA as the major target of lipid peroxidation products.
Yoshichika Kawai, K. Uchida, T. Osawa
2004Free Radical Biology & Medicine51 citations
Semantic Scholar
Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.
Shinya Akatsuka, T. Aung, K. Dutta, Li Jiang +18 more
2006American Journal of Pathology46 citations Open access
Semantic Scholar
Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage.
Yoshichika Kawai, Y. Matsui, Hajime Kondo, H. Morinaga +4 more
2008Chemical Research in Toxicology45 citations
Semantic Scholar
Formation of Nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification.
Yoshichika Kawai, Hiroyuki Fujii, Miki Okada, Yoshikazu Tsuchie +2 more
2006Journal of Lipid Research45 citations Open access
Semantic Scholar
Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense
Kohta Ohnishi, S. Ohkura, Erina Nakahata, A. Ishisaka +11 more
2013PLoS ONE42 citations Open access
Semantic Scholar
Quantitative analysis of acrolein-specific adducts generated during lipid peroxidation-modification of proteins in vitro: identification of N(τ)-(3-propanal)histidine as the major adduct.
Takuya Maeshima, K. Honda, Miho Chikazawa, T. Shibata +3 more
2012Chemical Research in Toxicology42 citations
Semantic Scholar
Effects of dietary phosphate on glucose and lipid metabolism.
Maerjianghan Abuduli, Hirokazu Ohminami, Tamaki Otani, H. Kubo +8 more
2016American Journal of Physiology. Endocrinology and Metabolism41 citations Open access
Semantic Scholar
Understanding metabolic conversions and molecular actions of flavonoids in vivo:toward new strategies for effective utilization of natural polyphenols in human health.
Yoshichika Kawai
2018Journal of Medical Investigation40 citations Open access
Semantic Scholar
The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis.
H. Kobayashi, Y. Yamashita, A. Iwase, Y. Yoshikawa +8 more
2012Fertility and Sterility40 citations Open access
Semantic Scholar
Covalent Binding of Oxidized Cholesteryl Esters to Protein
Yoshichika Kawai, A. Saito, N. Shibata, Makio Kobayashi +3 more
2003Journal of Biological Chemistry40 citations Open access
Semantic Scholar
β-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents
Yoshichika Kawai
2014Journal of clinical biochemistry and nutrition39 citations Open access
Semantic Scholar
Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats
Akiyuki Yokoyama, H. Sakakibara, A. Crozier, Yoshichika Kawai +4 more
2009Free radical research39 citations
Semantic Scholar
Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells
Rie Mukai, Kyuichi Kawabata, Seiko Otsuka, A. Ishisaka +4 more
2012Free radical research38 citations
Semantic Scholar
Peroxidized cholesterol-induced matrix metalloproteinase-9 activation and its suppression by dietary beta-carotene in photoaging of hairless mouse skin.
Yuko Minami, Kyuichi Kawabata, Y. Kubo, S. Arase +5 more
2009Journal of Nutritional Biochemistry35 citations
Semantic Scholar
Identification and quantification of Nɛ-(Hexanoyl)lysine in human urine by liquid chromatography/tandem mass spectrometry
Y. Kato, A. Yoshida, Michitaka Naito, Yoshichika Kawai +4 more
200435 citations
Semantic Scholar
Plasma HDL Reduces Nonesterified Fatty Acid Hydroperoxides Originating from Oxidized LDL: a Mechanism for Its Antioxidant Ability
Mari Kotosai, S. Shimada, Mai Kanda, Namiko Matsuda +7 more
2013Lipids34 citations Open access
Semantic Scholar
Immunogenicity of a brominated protein and successive establishment of a monoclonal antibody to dihalogenated tyrosine.
Y. Kato, Yoshichika Kawai, H. Morinaga, Hajime Kondo +3 more
2005Free Radical Biology & Medicine34 citations
Semantic Scholar
Immunohistochemical detection of a substituted 1,N(2)-ethenodeoxyguanosine adduct by omega-6 polyunsaturated fatty acid hydroperoxides in the liver of rats fed a choline-deficient, L-amino acid-defined diet.
Yoshichika Kawai, Y. Kato, D. Nakae, O. Kusuoka +3 more
2002Carcinogenesis33 citations
Semantic Scholar
An integrated database of flavonoids
T. Kinoshita, Z. Lepp, Yoshichika Kawai, J. Terao +1 more
2006Biofactors32 citations
Semantic Scholar
DHA Hydroperoxides as a Potential Inducer of Neuronal Cell Death: a Mitochondrial Dysfunction-Mediated Pathway
Xuebo Liu, T. Shibata, Shinsuke Hisaka, Yoshichika Kawai +1 more
2008Journal of clinical biochemistry and nutrition31 citations Open access
Semantic Scholar
Bispecific abs against modified protein and DNA with oxidized lipids.
M. Akagawa, S. Ito, Kazuyo Toyoda, Yoshihisa Ishii +12 more
2006Proceedings of the National Academy of Sciences of the United States of America31 citations
Semantic Scholar

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