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R. Wiltrout · SciRah

Researcher profile · Semantic Scholar

R. Wiltrout

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R. Wiltrout — researcher profile on SciRah

h-index: 68
Works: 286
Citations: 14K

Most-cited papers

The CD95 receptor: apoptosis revisited.
M. Peter, R. Budd, J. Desbarats, Stephen M. Hedrick +10 more
2007Cell416 citations Open access
Semantic Scholar
Common Molecular Subtypes among Asian Hepatocellular Carcinoma and Cholangiocarcinoma
Jittiporn Chaisaingmongkol, A. Budhu, Hien Dang, S. Rabibhadana +33 more
2017Cancer Cell383 citations Open access
Semantic Scholar
Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies.
S. Kummar, R. Kinders, M. Gutierrez, L. Rubinstein +16 more
2009Journal of Clinical Oncology331 citations Open access
Semantic Scholar
Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FoxP3+ regulatory T cells in human peripheral blood
Xin Chen, J. Subleski, Ryoko Hamano, O. M. Zack Howard +2 more
2010European Journal of Immunology228 citations Open access
Semantic Scholar
Immunotherapy of cancer by IL-12-based cytokine combinations
Jonathan M. Weiss, J. Subleski, J. Wigginton, R. Wiltrout
2007Expert Opinion on Biological Therapy227 citations Open access
Semantic Scholar
Compressing drug development timelines in oncology using phase '0' trials
S. Kummar, R. Kinders, L. Rubinstein, R. Parchment +11 more
2007Nature Reviews. Cancer216 citations
Semantic Scholar
IFN-γ mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy
V. Berner, Hai-Yan Liu, Qing Zhou, Kory L. Alderson +9 more
2007Nature Medicine179 citations
Semantic Scholar
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy
M. Bouchlaka, G. Sckisel, Mingyi Chen, Annie Mirsoian +15 more
2013Journal of Experimental Medicine148 citations Open access
Semantic Scholar
Chronic Inflammation, Immune Escape and Oncogenesis In the Liver: A Unique Neighborhood for Novel Intersections
J. Stauffer, Anthony J. Scarzello, Q. Jiang, R. Wiltrout
2012Hepatology133 citations Open access
Semantic Scholar
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice
Annie Mirsoian, M. Bouchlaka, G. Sckisel, Mingyi Chen +15 more
2014Journal of Experimental Medicine124 citations Open access
Semantic Scholar
Dissociation of NKT Stimulation, Cytokine Induction, and NK Activation In Vivo by the Use of Distinct TCR-Binding Ceramides1
J. Ortaldo, H. Young, R. Winkler-Pickett, E. Bere +2 more
2004Journal of Immunology111 citations Open access
Semantic Scholar
Designing Phase 0 Cancer Clinical Trials
A. Murgo, S. Kummar, L. Rubinstein, M. Gutierrez +12 more
2008Clinical Cancer Research109 citations Open access
Semantic Scholar
Out-of-sequence Signal 3 paralyzes primary CD4+ T cell dependent immunity
G. Sckisel, M. Bouchlaka, A. Monjazeb, M. Crittenden +13 more
2015Immunity104 citations Open access
Semantic Scholar
Nitric Oxide Is a Key Component in Inflammation-Accelerated Tumorigenesis
S. Hussain, Peijun He, Jeffery J. Subleski, L. Hofseth +15 more
2008Cancer Research103 citations Open access
Semantic Scholar
The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas
Zou-Xiang Xiao, Q. Jiang, J. Willette-Brown, S. Xi +17 more
2013Cancer Cell102 citations Open access
Semantic Scholar
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy
Jonathan M. Weiss, L. Ridnour, T. Back, S. Hussain +7 more
2010Journal of Experimental Medicine96 citations Open access
Semantic Scholar
Phase 0 clinical trials in cancer drug development: from FDA guidance to clinical practice.
R. Kinders, R. Parchment, Jay Ji, S. Kummar +14 more
2007Molecular Interventions93 citations
Semantic Scholar
Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver.
J. Subleski, Veronica L. Hall, T. Back, J. Ortaldo +1 more
2006Cancer Research93 citations Open access
Semantic Scholar
Co-activation of AKT and β-catenin in Mice Rapidly Induces Formation of Lipogenic Liver Tumors
J. Stauffer, Anthony J. Scarzello, J. Andersen, R. D. deKluyver +4 more
2011Cancer Research90 citations Open access
Semantic Scholar
Phase 0 Clinical Trials: Conceptions and Misconceptions
S. Kummar, L. Rubinstein, R. Kinders, R. Parchment +13 more
2008Cancer Journal89 citations Open access
Semantic Scholar
Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy.
J. Tietze, Danice E. C. Wilkins, G. Sckisel, M. Bouchlaka +11 more
2012Blood88 citations Open access
Semantic Scholar
mTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment
Q. Jiang, Jonathan M. Weiss, T. Back, T. Chan +3 more
2011Cancer Research86 citations Open access
Semantic Scholar
CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor immunity
Gui‐quan Zhu, Hannah H. Yan, Y. Pang, J. Jian +6 more
2015OncoTarget76 citations Open access
Semantic Scholar
Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment
Jonathan M. Weiss, T. Back, Anthony J. Scarzello, J. Subleski +7 more
2009Proceedings of the National Academy of Sciences of the United States of America73 citations Open access
Semantic Scholar
NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression
H. Okayama, M. Saito, N. Oue, Jonathan M. Weiss +5 more
2012International Journal of Cancer67 citations Open access
Semantic Scholar
Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/αCD40 therapy
Jonathan M. Weiss, J. Subleski, T. Back, Xin Chen +5 more
2014Journal of Immunology56 citations Open access
Semantic Scholar
Immunotherapeutic modulation of the suppressive liver and tumor microenvironments
T. Chan, R. Wiltrout, Jonathan M. Weiss
2011International Immunopharmacology56 citations Open access
Semantic Scholar
Application of tissue-specific NK and NKT cell activity for tumor immunotherapy
J. Subleski, R. Wiltrout, Jonathan M. Weiss
2009Journal of Autoimmunity55 citations Open access
Semantic Scholar
NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay
L. Ridnour, Robert Y. S. Cheng, Jonathan M. Weiss, Sukhbir Kaur +14 more
2015Cancer Research52 citations Open access
Semantic Scholar
The split personality of NKT cells in malignancy, autoimmune and allergic disorders
J. Subleski, Q. Jiang, Jonathan M. Weiss, R. Wiltrout
2011Immunotherapy48 citations Open access
Semantic Scholar
Antigen Presented by Tumors in Vivo Determines the Nature of CD8+ T Cell Cytotoxicity
A. Shanker, A. Brooks, Kristen M. Jacobsen, J. Wine +3 more
2009Cancer Research45 citations Open access
Semantic Scholar
In Vivo Hydrodynamic Delivery of cDNA Encoding IL-2: Rapid, Sustained Redistribution, Activation of Mouse NK Cells, and Therapeutic Potential in the Absence of NKT Cells1
J. Ortaldo, R. Winkler-Pickett, E. Bere, Morihiro Watanabe +2 more
2005Journal of Immunology34 citations Open access
Semantic Scholar
CD40 expression in renal cell carcinoma is associated with tumor apoptosis, CD8+ T cell frequency and patient survival
Jonathan M. Weiss, W. G. Alvord, Octavio A. Quiñones, J. Stauffer +1 more
2014Human Immunology33 citations Open access
Semantic Scholar
Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors
H. Yazawa, T. Murakami, H.-M. Li, T. Back +8 more
2006Cancer Gene Therapy30 citations
Semantic Scholar
Bystander Activation and Anti-Tumor Effects of CD8+ T Cells Following Interleukin-2 Based Immunotherapy Is Independent of CD4+ T Cell Help
A. Monjazeb, J. Tietze, S. Grossenbacher, Hui-Hua Hsiao +8 more
2014PLoS ONE29 citations Open access
Semantic Scholar
Regulatory and Conventional CD4+ T Cells Show Differential Effects Correlating with PD-1 and B7-H1 Expression after Immunotherapy12
Kory L. Alderson, Qing Zhou, V. Berner, Danice E. C. Wilkins +6 more
2008Journal of Immunology26 citations Open access
Semantic Scholar
LTβR signalling preferentially accelerates oncogenic AKT-initiated liver tumours
Anthony J. Scarzello, Q. Jiang, T. Back, Hien Dang +13 more
2015Gut24 citations Open access
Semantic Scholar
Combination Therapy of an Orthotopic Renal Cell Carcinoma Model Using Intratumoral Vector-Mediated Costimulation and Systemic Interleukin-2
C. Kudo-Saito, E. Wansley, M. E. Gruys, R. Wiltrout +2 more
2007Clinical Cancer Research23 citations Open access
Semantic Scholar
Constitutive expression of functional CD40 on mouse renal cancer cells: induction of Fas and Fas-mediated killing by CD40L.
Jong-keuk Lee, N. Seki, T. Sayers, J. Subleski +3 more
2005Cellular Immunology23 citations
Semantic Scholar
Abstract 1083: The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas.
Zuoxiang Xiao, Q. Jiang, J. Willette-Brown, Feng Zhu +13 more
201319 citations
Semantic Scholar
TCR-dependent and –independent activation underlie liver-specific regulation of NKT cells
J. Subleski, Veronica L. Hall, T. Wolfe, Anthony J. Scarzello +6 more
2010Journal of Immunology19 citations Open access
Semantic Scholar
Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma
Y. Pomyen, A. Budhu, Jittiporn Chaisaingmongkol, M. Forgues +17 more
2021Scientific Reports16 citations Open access
Semantic Scholar
Serum-based tracking of de novo-initiated liver cancer progression reveals early immunoregulation and response to therapy
J. Subleski, Anthony J. Scarzello, W. G. Alvord, Q. Jiang +6 more
2015Journal of Hepatology15 citations Open access
Semantic Scholar
Stimulation through CD40 on Mouse and Human Renal Cell Carcinomas Triggers Cytokine Production, Leukocyte Recruitment, and Antitumor Responses that Can Be Independent of Host CD40 Expression12
Lynnette Shorts, Jonathan M. Weiss, Jong-keuk Lee, L. Welniak +4 more
2006Journal of Immunology15 citations Open access
Semantic Scholar
CD40 dependent exacerbation of immune mediated hepatitis by hepatic CD11b+ Gr-1+ myeloid derived suppressor cells in tumor bearing mice
Tamar Kapanadze, J. Medina-Echeverz, Jaba Gamrekelashvili, Jonathan M. Weiss +10 more
2015European Journal of Immunology11 citations Open access
Semantic Scholar
Natural Killer Activity: Early Days, Advances, and Seminal Observations
J. Ortaldo, R. Wiltrout, C. Reynolds
2014Critical reviews in oncogenesis10 citations Open access
Semantic Scholar
Delineation of antigen-speciﬁc and antigen-nonspeciﬁc CD8 (cid:1) memory T-cell responses after cytokine-based cancer immunotherapy
J. Tietze, Danice E. C. Wilkins, G. Sckisel, M. Bouchlaka +11 more
20126 citations
Semantic Scholar
Systemic IL-12 Administration Alters Hepatic Dendritic Cell Stimulation Capabilities
T. Chan, T. Back, J. Subleski, Jonathan M. Weiss +2 more
2012PLoS ONE4 citations Open access
Semantic Scholar
NK and NKT cells: The innate–adaptive interface including humoral responses
J. Subleski, Jonathan M. Weiss, R. Wiltrout, J. Ortaldo
20104 citations
Semantic Scholar
Treatment of adenocarcinoma in the peritoneum of mice: Chemoimmunotherapy with IL-2-stimulated cytotoxic lymphocytes as a model for treatment of minimal residual disease
R. Salup, R. Wiltrout
2004Cancer Immunology and Immunotherapy4 citations Open access
Semantic Scholar

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Jonathan M. Weiss×24
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T. Back×15
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W. Murphy×15
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J. Subleski×14
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J. Ortaldo — researcher profile on SciRah

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B. Blazar — researcher profile on SciRah

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J. Stauffer — researcher profile on SciRah

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Q. Jiang — researcher profile on SciRah

Kory L. Alderson×6

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D. Longo — researcher profile on SciRah

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G. Sckisel — researcher profile on SciRah

Anthony J. Scarzello×6

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Anthony J. Scarzello — researcher profile on SciRah