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A. Aleshin · SciRah

Researcher profile · Semantic Scholar

A. Aleshin

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A. Aleshin — researcher profile on SciRah

h-index: 29
Works: 105
Citations: 2,758

Most-cited papers

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold
A. Aleshin, S. Shiryaev, A. Strongin, R. Liddington
2007Protein Science232 citations Open access
Semantic Scholar
Crystal structure of glucoamylase from Aspergillus awamori var. X100 to 2.2-A resolution.
A. Aleshin, A. Golubev, L. Firsov, R. Honzatko
1994Journal of Biological Chemistry192 citations
Semantic Scholar
Vaccinia virus N1L protein resembles a B cell lymphoma‐2 (Bcl‐2) family protein
M. Aoyagi, D. Zhai, C. Jin, A. Aleshin +3 more
2006Protein Science134 citations Open access
Semantic Scholar
Refined structure for the complex of acarbose with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.
A. Aleshin, L. M. Firsov, Richard B. Honzatko
1994Journal of Biological Chemistry129 citations
Semantic Scholar
The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
A. Aleshin, C. Zeng, G. Bourenkov, H. Bartunik +2 more
1998Structure127 citations Open access
Semantic Scholar
Crystal structure of a glucose/H+ symporter and its mechanism of action
C. Iancu, Jamillah Zamoon, Sang B. Woo, A. Aleshin +1 more
2013Proceedings of the National Academy of Sciences of the United States of America125 citations Open access
Semantic Scholar
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
A. Aleshin, C. Kirby, Xiaofeng S. Liu, G. Bourenkov +3 more
2000Journal of Molecular Biology116 citations
Semantic Scholar
Refined structure for the complex of 1-deoxynojirimycin with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.
E. M. Harris, A. Aleshin, L. Firsov, R. Honzatko
1993Biochemistry107 citations
Semantic Scholar
Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)*♦
A. Aleshin, Ingrid U. Schraufstatter, B. Stec, L. Bankston +2 more
2012Journal of Biological Chemistry103 citations Open access
Semantic Scholar
Vaccinia Virus Virulence Factor N1L is a Novel Promising Target for Antiviral Therapeutic Intervention
Anton V. Cheltsov, M. Aoyagi, A. Aleshin, E. Yu +6 more
2010Journal of Medicinal Chemistry93 citations Open access
Semantic Scholar
Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
A. Aleshin, C. Zeng, H. Bartunik, H. Fromm +1 more
1998Journal of Molecular Biology93 citations
Semantic Scholar
The Wnt/Planar Cell Polarity Protein-tyrosine Kinase-7 (PTK7) Is a Highly Efficient Proteolytic Target of Membrane Type-1 Matrix Metalloproteinase
V. Golubkov, Alexei V. Chekanov, P. Cieplak, A. Aleshin +6 more
2010Journal of Biological Chemistry92 citations Open access
Semantic Scholar
Crystal structure and evolution of a prokaryotic glucoamylase.
A. Aleshin, P. Feng, R. Honzatko, P. J. Reilly
2003Journal of Molecular Biology82 citations Open access
Semantic Scholar
Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex*
A. Aleshin, R. Discipio, B. Stec, R. Liddington
2012Journal of Biological Chemistry75 citations Open access
Semantic Scholar
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus.
S. Shiryaev, A. Chernov, A. Aleshin, Tatiana N. Shiryaeva +1 more
2009Journal of General Virology75 citations Open access
Semantic Scholar
Definition of a novel feed-forward mechanism for glycolysis-HIF1α signaling in hypoxic tumors highlights adolase A as a therapeutic target
Geoff Grandjean, P. de Jong, B. James, M. Koh +12 more
2016Cancer Research71 citations Open access
Semantic Scholar
Diabetes reversal by inhibition of the low molecular weight tyrosine phosphatase
S. Stanford, A. Aleshin, Vida Zhang, R. Ardecky +19 more
2017Nature Chemical Biology66 citations Open access
Semantic Scholar
The Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 Helicase*
A. Chernov, S. Shiryaev, A. Aleshin, B. Ratnikov +3 more
2008Journal of Biological Chemistry51 citations Open access
Semantic Scholar
Switching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based Mutagenesis
S. Shiryaev, B. Ratnikov, A. Aleshin, I. Kozlov +5 more
2007Journal of Virology49 citations Open access
Semantic Scholar
ATP-binding site of human brain hexokinase as studied by molecular modeling and site-directed mutagenesis.
C. Zeng, A. Aleshin, J. Hardie, Robert W. Harrison +1 more
1996Biochemistry49 citations
Semantic Scholar
Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells
D. Rozanov, A. Savinov, V. Golubkov, Olga L. Rozanova +7 more
2009Molecular Cancer Therapeutics45 citations Open access
Semantic Scholar
Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site of RXRα
Liqun Chen, Zhi-gang Wang, A. Aleshin, Fan Chen +13 more
2014Chemistry and Biology43 citations Open access
Semantic Scholar
Crystal and Solution Structures of a Prokaryotic M16B Peptidase: an Open and Shut Case
A. Aleshin, S. Gramatikova, G. Hura, A. Bobkov +5 more
2009Structure38 citations Open access
Semantic Scholar
Identification of a Phosphate Regulatory Site and a Low Affinity Binding Site for Glucose 6-Phosphate in the N-terminal Half of Human Brain Hexokinase*
Tsuei-Yun Fang, Olga Alechina, A. Aleshin, H. Fromm +1 more
1998Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.
Ilian A Radichev, S. Shiryaev, A. Aleshin, B. Ratnikov +3 more
2008Journal of General Virology35 citations Open access
Semantic Scholar
Proteolysis of the Membrane Type-1 Matrix Metalloproteinase Prodomain
V. Golubkov, Alexei V. Chekanov, S. Shiryaev, A. Aleshin +6 more
2007Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.
S. Shiryaev, A. Aleshin, B. Ratnikov, J. Smith +2 more
2007Protein Expression and Purification33 citations Open access
Semantic Scholar
Potential Relation of Aberrant Proteolysis of Human Protein Tyrosine Kinase 7 (PTK7) chuzhoi by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) to Congenital Defects*
V. Golubkov, A. Aleshin, A. Strongin
2011Journal of Biological Chemistry31 citations Open access
Semantic Scholar
A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis
Lei Zhang, J. E. Kent, Meredith Whitaker, D. Young +9 more
2022Nature Communications27 citations Open access
Semantic Scholar
Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
Liqun Chen, A. Aleshin, Gulimiran Alitongbieke, Yuqi Zhou +19 more
2017Nature Communications27 citations Open access
Semantic Scholar
Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island
S. Shiryaev, A. Aleshin, Norihito Muranaka, Muskan Kukreja +6 more
2014The FEBS Journal25 citations Open access
Semantic Scholar
Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution.
A. Aleshin, M. Malfois, Xiao-Fang Liu, Chang Sup Kim +4 more
1999Biochemistry25 citations
Semantic Scholar
Internal Cleavages of the Autoinhibitory Prodomain Are Required for Membrane Type 1 Matrix Metalloproteinase Activation, although Furin Cleavage Alone Generates Inactive Proteinase*
V. Golubkov, P. Cieplak, Alexei V. Chekanov, B. Ratnikov +8 more
2010Journal of Biological Chemistry24 citations Open access
Semantic Scholar
The Roles of Glycine Residues in the ATP Binding Site of Human Brain Hexokinase*
C. Zeng, A. Aleshin, Guan-Jun Chen, R. Honzatko +1 more
1998Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Biochemical Properties of Mutant and Wild-type Fructose-1,6-bisphosphatases Are Consistent with the Coupling of Intra- and Intersubunit Conformational Changes in the T- and R-state Transition*
L. Shyur, A. Aleshin, R. Honzatko, H. Fromm
1996Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids
A. Aleshin, Yong Yao, Amer Iftikhar, A. Bobkov +9 more
2020bioRxiv20 citations Open access
Semantic Scholar
Mycobacterial Nicotinate Mononucleotide Adenylyltransferase
I. Rodionova, H. Zuccola, L. Sorci, A. Aleshin +6 more
2015Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis
S. Shiryaev, P. Cieplak, A. Aleshin, Qing Sun +4 more
2011The FEBS Journal17 citations Open access
Semantic Scholar
Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L*
A. Aleshin, M. Drąg, Naran Gombosuren, George Wei +5 more
2012Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Site-directed Mutagenesis of Residues at Subunit Interfaces of Porcine Fructose-1,6-bisphosphatase (*)
L. Shyur, A. Aleshin, R. Honzatko, H. Fromm
1996Journal of Biological Chemistry15 citations Open access
Semantic Scholar
TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response
D. Rozanov, Anton V. Cheltsov, E. Sergienko, S. Vasile +11 more
2015PLoS ONE14 citations Open access
Semantic Scholar
The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase
S. Shiryaev, A. Chernov, Tatiana N. Shiryaeva, A. Aleshin +1 more
2010Archives of Virology12 citations Open access
Semantic Scholar
PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer
H. Jeung, Roisin Puentes, A. Aleshin, M. Indarte +13 more
2021Experimental Cell Research8 citations Open access
Semantic Scholar
NS 4 A regulates the ATPase activity of the NS 3 helicase : a novel cofactor role of the non-structural protein NS 4 A from West Nile virus
S. Shiryaev, A. Chernov, A. Aleshin, Tatiana N. Shiryaeva +1 more
20098 citations
Semantic Scholar
Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase
Jiaqian Wu, M. R. Baranowski, A. Aleshin, E. Isiorho +10 more
2025ACS Omega7 citations Open access
Semantic Scholar
A study of subunit interface residues of fructose-1,6-bisphosphatase by site-directed mutagenesis: effects on AMP and Mg2+ affinities.
Lie-Fen Shyur, A. Aleshin, Herbert J. Fromm
1996Biochemistry7 citations
Semantic Scholar
Calcium-induced environmental adaptability of the blood protein vitronectin
Ye Tian, K. Shin, A. Aleshin, W. Im +1 more
2022bioRxiv6 citations Open access
Semantic Scholar
Optimization of the technological and thermal conditions in a reversing cold rolling mill
E. Garber, A. Aleshin, S. S. Degtev, A. Traino
2015Russian metallurgy. Metally6 citations
Semantic Scholar
Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B–NS3 proteinase of West Nile virus
S. Shiryaev, Ilian A Radichev, B. Ratnikov, A. Aleshin +5 more
2010Biochemical Journal5 citations Open access
Semantic Scholar
Short Communication NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus
S. Shiryaev, A. Chernov, A. Aleshin, Tatiana N. Shiryaeva +1 more
20093 citations
Semantic Scholar

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