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H. Cen · SciRah

Researcher profile · Semantic Scholar

H. Cen

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H. Cen — researcher profile on SciRah

h-index: 14
Works: 47
Citations: 547

Most-cited papers

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation.
A. Zhang, Y. Xia, Jeffrey S. H. Lin, Ken H. Chu +14 more
2023Cell Metabolism65 citations Open access
Semantic Scholar
Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells
Tobias Boothe, Gareth E. Lim, H. Cen, Søs Skovsø +5 more
2016Molecular Metabolism50 citations Open access
Semantic Scholar
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data
Jessica D. Ewald, Yao Lu, Cara E. Ellis, Jessica Worton +28 more
2024Cell Metabolism47 citations Open access
Semantic Scholar
Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain
Melissa M. Page, Søs Skovsø, H. Cen, Amy P Chiu +9 more
2017The FASEB Journal44 citations Open access
Semantic Scholar
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
Søs Skovsø, E. Panzhinskiy, J. Kolic, H. Cen +32 more
2022Nature Communications41 citations Open access
Semantic Scholar
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
J. Kolic, W. Sun, H. Cen, Jessica D. Ewald +17 more
2024Cell Metabolism34 citations Open access
Semantic Scholar
Differential Effects of Voclosporin and Tacrolimus on Insulin Secretion From Human Islets
J. Kolic, Leanne Beet, Peter Overby, H. Cen +5 more
2020bioRxiv28 citations Open access
Semantic Scholar
Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase*
M. Bround, Rich Wambolt, H. Cen, Parisa Asghari +16 more
2016Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation
A. Zhang, Y. Xia, Jeffrey S. H. Lin, Ken H. Chu +14 more
2023bioRxiv25 citations Open access
Semantic Scholar
Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia‐associated insulin resistance
H. Cen, Bahira Hussein, J. Botezelli, Su Wang +6 more
2021The FASEB Journal25 citations Open access
Semantic Scholar
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
J. Kolic, W. Sun, H. Cen, J. Ewald +17 more
2023medRxiv20 citations Open access
Semantic Scholar
Transcriptomics for Clinical and Experimental Biology Research: Hang on a Seq
Tanner Stokes, H. Cen, P. Kapranov, I. Gallagher +7 more
2023Advanced genetics20 citations Open access
Semantic Scholar
Dynamic Ins2 Gene Activity Defines β-cell Maturity States.
Chieh Min Jamie Chu, H. Modi, C. Ellis, Nicole A. J. Krentz +13 more
2022Diabetes17 citations Open access
Semantic Scholar
Dynamic Ins2 gene activity defines β-cell maturity states
Chieh Min Jamie Chu, H. Modi, Søs Skovsø, C. Ellis +13 more
2019bioRxiv15 citations Open access
Semantic Scholar
Flow‐Induced Secretion of Endothelial Heparanase Regulates Cardiac Lipoprotein Lipase and Changes Following Diabetes
C. Lee, Ya-Jie Zhai, Rui Shang, T. Wong +6 more
2022Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease14 citations Open access
Semantic Scholar
The effect of acute and 14-day exogenous ketone supplementation on glycaemic control in adults with type 2 diabetes: two randomized controlled trials.
K. Falkenhain, B. Oliveira, Hashim Islam, H. Neudorf +6 more
2023American Journal of Physiology. Endocrinology and Metabolism9 citations
Semantic Scholar
PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system
Jia Zhao, Shenghui Liang, H. Cen, Yanjun Li +11 more
2024Nature Communications8 citations Open access
Semantic Scholar
HumanIslets: An integrated platform for human islet data access and analysis
Jessica D. Ewald, Yao Lu, Cara E. Ellis, Jessica Worton +29 more
2024bioRxiv8 citations Open access
Semantic Scholar
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition
E. Panzhinskiy, Søs Skovsø, H. Cen, Kwan Y. Chu +11 more
2021bioRxiv8 citations Open access
Semantic Scholar
Modulation of muscle cell Insr and insulin receptor signaling by hyperinsulinemia in vitro and in vivo
H. Cen, J. Botezelli, Su Wang, Nilou Noursadeghi +3 more
2019bioRxiv7 citations Open access
Semantic Scholar
Signal transduction pathways controlling Ins2 gene activity and beta cell state transitions
Chieh Min Jamie Chu, Bhavya Sabbineni, H. Cen, Xiaoke Hu +5 more
2025bioRxiv5 citations Open access
Semantic Scholar
Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes
Michael G. Atser, Chelsea D. Wenyonu, Elyn M. Rowe, C. L. Leung +10 more
2024bioRxiv5 citations Open access
Semantic Scholar
77 - Ins2 Gene Bursting Activity Defines a Mature β-Cell State
H. Modi, J. Chu, Søs Skovsø, C. Ellis +11 more
20205 citations
Semantic Scholar
: Hyperinsulinemia acts via acinar insulin receptors to drive obesity-associated pancreatic cancer
A. Zhang, Yi-Han Xia, Jeffrey H. Lin, Ken H. Chu +16 more
20234 citations
Semantic Scholar
Spatially Resolved Obesity-Driven Molecular Changes in Early Breast Cancer.
Cole Hladik, M. Sekhri, H. Cen, S. Elayapillai +8 more
2026American Journal of Pathology3 citations Open access
Semantic Scholar
Pharmacological or genetic inhibition of Scn9a protects beta-cells while reducing insulin secretion in type 1 diabetes.
Peter Overby, S. Provenzano, Natalie S. Nahirney, Xiao-Qing Dai +8 more
20233 citations
Semantic Scholar
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition
E. Panzhinskiy, Søs Skovsø, H. Cen, Amanda Rahardjo +13 more
2025Diabetologia2 citations
Semantic Scholar
Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes
Michael G. Atser, Chelsea D. Wenyonu, Elyn M. Rowe, C. L. Leung +10 more
2025Journal of Biological Chemistry2 citations Open access
Semantic Scholar
Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes
Sing-Young Chen, H. Cen, Charlotte F. Chao, Andrew R. Pepper +2 more
2025bioRxiv2 citations Open access
Semantic Scholar
Insulin receptor trafficking and interactions in muscle cells
H. Cen, Aurora J. Mattison, Alireza Omidi, J. Rogalski +6 more
2021bioRxiv2 citations
Semantic Scholar
Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion [preprint]
Søs Skovsø, E. Panzhinskiy, J. Kolic, Derek A. Dionne +37 more
20202 citations
Semantic Scholar
Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes
Sing-Young Chen, H. Cen, Charlotte F. Chao, Andrew R. Pepper +2 more
2026Endocrinology1 citations Open access
Semantic Scholar
A secondary analysis of indices of hepatic and beta cell function following 12 weeks of carbohydrate and energy restriction vs. free-living control in adults with type 2 diabetes
Cody Durrer, Hashim Islam, H. Cen, M. Garzon +7 more
2024Nutrition and Metabolism1 citations Open access
Semantic Scholar
Corrigendum to “Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells” [Mol Metab 2016 May; 5 (5): 366–378]
Tobias Boothe, Gareth E. Lim, H. Cen, Søs Skovsø +5 more
2024Molecular Metabolism1 citations Open access
Semantic Scholar
Cardiomyocyte pyruvate dehydrogenase kinase 1 knockout activates Rho-mediated remodeling and decreases fatty acyl availability in female mice
Michael G. Atser, Sareh Panahi, Justin J. Hong, Xiaoke Hu +11 more
2026bioRxiv0 citations Open access
Semantic Scholar
Functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in a state of high insulin production and increased fragility
Chieh Min Jamie Chu, Meltem E. Omur, Jasmine Maghera, H. Cen +13 more
2026bioRxiv0 citations Open access
Semantic Scholar
The Ets transcription factor ETV4 regulates FGF1-dependent proliferation and glycolysis in ER-positive breast cancer
B. M. Sankofi, N. Thomas, M. Sekhri, H. Cen +5 more
2026bioRxiv0 citations Open access
Semantic Scholar
Tamoxifen Targets Wisp2 to Impair Subcutaneous Adipocyte Progenitor Self-Renewal and Adipogenic Differentiation
N. Thomas, B. M. Sankofi, H. Cen, S. J. Murguia +2 more
2025bioRxiv0 citations Open access
Semantic Scholar
Loss of brain insulin production impairs learning and memory in female mice
S. Baehring, Timothy P. O’Leary, H. Cen, Danae M Holenka +13 more
2025bioRxiv0 citations Open access
Semantic Scholar
Abstract B055: Hyperinsulinemia acts via acinar cell insulin receptors to drive obesity-associated pancreatic cancer initiation
A. Zhang, Y. Xia, Jeffrey S. H. Lin, Ken H. Chu +14 more
2024Cancer Research0 citations
Semantic Scholar
Title: Insulin receptors in pancreatic acinar cells contribute to Kras G12D -driven cancer initiation in the context of diet-induced obesity
A. Zhang, Yi-Han Xia, Ken H. Chu, Titine J J Ruiter +15 more
20220 citations
Semantic Scholar
Eukaryotic translation initiation factor 2 A protects pancreatic beta cells during 1 endoplasmic reticulum stress while rescuing translation inhibition 2 3
E. Panzhinskiy, Søs Skovsø, H. Cen, Kwan Y. Chu +11 more
20210 citations
Semantic Scholar
Modulation of muscle cell insulin receptor signalling, transcription and trafficking by insulin
H. Cen
20210 citations
Semantic Scholar
TITLE: Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition
E. Panzhinskiy, Søs Skovsø, H. Cen, Kwan Y. Chu +14 more
20210 citations
Semantic Scholar
Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion
Søs Skovsø, E. Panzhinskiy, J. Kolic, Derek A. Dionne +32 more
2020bioRxiv0 citations Open access
Semantic Scholar
: the role of
H. Cen, Aurora J. Mattison, Alireza Omidi, Jason C. Rogalski +6 more
0 citations
Semantic Scholar
Title : Signal transduction pathways controlling Ins2 gene activity and β cell state transitions
Chieh Min, J. Chu, Bhavya Sabbineni, H. Cen +6 more
0 citations
Semantic Scholar

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Søs Skovsø×17
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James D. Johnson×14
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Derek A. Dionne×11
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E. Panzhinskiy×11

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N. Noursadeghi×11

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Jason C. Rogalski×10

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