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C. Newgard · SciRah

Researcher profile · Semantic Scholar

C. Newgard

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C. Newgard — researcher profile on SciRah

h-index: 104
Works: 451
Citations: 44K

Most-cited papers

Mechanisms controlling pancreatic islet cell function in insulin secretion
J. Campbell, C. Newgard
2021Nature reviews. Molecular cell biology529 citations Open access
Semantic Scholar
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang, M. Hibberd +33 more
2019Science389 citations Open access
Semantic Scholar
Cardiovascular Metabolomics
R. McGarrah, Scott B. Crown, Guo-Fang Zhang, Svati H. Shah +1 more
2018Circulation Research336 citations Open access
Semantic Scholar
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
S. Softic, M. Gupta, Guo-Xiao Wang, S. Fujisaka +9 more
2017Journal of Clinical Investigation313 citations Open access
Semantic Scholar
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street
P. White, R. McGarrah, M. Herman, J. Bain +2 more
2021Molecular Metabolism269 citations Open access
Semantic Scholar
Branched-chain amino acids and cardiometabolic diseases: biomarker, causal agent, or both?
P. White, C. Newgard
2019Science262 citations Open access
Semantic Scholar
Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
S. Softic, J. Meyer, Guo-Xiao Wang, Manoj K. Gupta +13 more
2019Cell Metabolism199 citations Open access
Semantic Scholar
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation
Guo-Xiao Wang, Jesse G. Meyer, Weikang Cai, S. Softic +5 more
2019Molecules and Cells198 citations Open access
Semantic Scholar
Interrupted Glucagon Signaling Reveals Hepatic-α-Cell Axis and Role for L-Glutamine in α-Cell Proliferation
E. D. Dean, Ming-Yu Li, Nripesh Prasad, S. Wisniewski +24 more
2017Cell Metabolism183 citations Open access
Semantic Scholar
Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion
Guo-Fang Zhang, M. Jensen, S. Gray, K. El +5 more
2020Cell Metabolism132 citations Open access
Semantic Scholar
Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects with Type 2 Diabetes.
V. Pirro, K. Roth, Yanzhu Lin, Jill A. Willency +6 more
2021Journal of Clinical Endocrinology and Metabolism97 citations Open access
Semantic Scholar
Maternal BMI and Glycemia Impact the Fetal Metabolome
W. Lowe, J. Bain, M. Nodzenski, Anna C. Reisetter +7 more
2017Diabetes Care97 citations Open access
Semantic Scholar
Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure
Noelle E. Younge, C. Newgard, C. Cotten, R. Goldberg +7 more
2019Scientific Reports93 citations Open access
Semantic Scholar
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Jacquelyn M. Walejko, Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang +17 more
2021Nature Communications83 citations Open access
Semantic Scholar
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
Daniel C. Levine, Hsin-Yu Kuo, Heekyung Hong, J. Cedernaes +15 more
2021Nature Metabolism79 citations Open access
Semantic Scholar
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue
R. Samms, Guofang Zhang, Wentao He, O. Ilkayeva +10 more
2022Molecular Metabolism78 citations Open access
Semantic Scholar
Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure with Reduced Ejection Fraction: DEFINE-HF
S. Selvaraj, Zhuxuan Fu, Philip G. Jones, L. Kwee +15 more
2022Circulation75 citations Open access
Semantic Scholar
Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries
Rachel Kadakia, M. Nodzenski, Octavious Talbot, A. Kuang +10 more
2018Diabetologia57 citations Open access
Semantic Scholar
Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition
Hao-Wei Chang, Evan M. Lee, Yi Wang, Cyrus Zhou +28 more
2024Nature Microbiology55 citations Open access
Semantic Scholar
Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats.
R. McGarrah, Guo-Fang Zhang, Bridgette A. Christopher, Yann Deleye +5 more
2019American Journal of Physiology. Endocrinology and Metabolism52 citations Open access
Semantic Scholar
The prohormone VGF regulates β-cell function via insulin secretory granule biogenesis
S. Stephens, R. Edwards, M. Sadahiro, Wei-Jye Lin +3 more
2017Cell Reports51 citations Open access
Semantic Scholar
De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics
Leslie A. Rowland, A. Guilherme, Felipe Henriques, Chloe DiMarzio +10 more
2023Nature Communications50 citations Open access
Semantic Scholar
Near-roadway Air Pollution Exposure and Altered Fatty Acid Oxidation Among Adolescents and Young Adults – the Interplay with Obesity
Zhang-Hua Chen, C. Newgard, Jeniffer S. Kim, O. IIkayeva +12 more
2019Environment International49 citations Open access
Semantic Scholar
Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups
S. Jacob, M. Nodzenski, Anna C. Reisetter, J. Bain +8 more
2017Diabetes Care48 citations Open access
Semantic Scholar
Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction
Jianyang Fu, Xiao-Qing Dai, G. Plummer, Kunimasa Suzuki +10 more
2017Diabetes47 citations Open access
Semantic Scholar
Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity
Thomas Grenier-Larouche, Lydia Coulter Kwee, Yann Deleye, P. León-Mimila +14 more
2022medRxiv46 citations Open access
Semantic Scholar
BCAA Supplementation in Mice with Diet-Induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis.
Jennifer Lee, A. Vijayakumar, P. White, Yuping Xu +4 more
2021Endocrinology44 citations Open access
Semantic Scholar
Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.
Rachel Kadakia, Octavious Talbot, A. Kuang, J. Bain +8 more
2019Journal of Clinical Endocrinology and Metabolism42 citations Open access
Semantic Scholar
APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease
Somenath Datta, Brett M. Antonio, Nathan Zahler, Jonathan W. Theile +19 more
2024Journal of Clinical Investigation41 citations Open access
Semantic Scholar
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
S. Softic, Manoj K. Gupta, Guo-Xiao Wang, S. Fujisaka +9 more
2018Journal of Clinical Investigation41 citations Open access
Semantic Scholar
Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival
Heather L Hayes, Brett S. Peterson, Jonathan M. Haldeman, C. Newgard +2 more
2017PLoS ONE39 citations Open access
Semantic Scholar
Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
Anna C. Reisetter, M. Muehlbauer, J. Bain, M. Nodzenski +6 more
2017BMC Bioinformatics37 citations Open access
Semantic Scholar
Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition
Brett S. Peterson, J. Campbell, O. Ilkayeva, Paul A. Grimsrud +2 more
2018Cell Reports36 citations Open access
Semantic Scholar
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
Gina M. Many, James A. Sanford, Tyler J. Sagendorf, Zhen-Xin Hou +108 more
2024Nature Metabolism34 citations Open access
Semantic Scholar
The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights
J. McCann, Nathan A. Bihlmeyer, Kimberly Roche, C. Catherine +21 more
2020medRxiv33 citations Open access
Semantic Scholar
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
A. Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki +15 more
2023Cell Reports32 citations Open access
Semantic Scholar
Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice
Batuhan Yenilmez, Mark Kelly, Guofang Zhang, Nicole Wetoska +16 more
2022Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis.
Liyan Fan, David R. Sweet, D. Prosdocimo, Vinesh Vinayachandran +8 more
2021Journal of Clinical Investigation32 citations Open access
Semantic Scholar
Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.
S. Bhupathiraju, M. Guasch-Ferré, M. Gadgil, C. Newgard +7 more
2018Journal of NutriLife32 citations Open access
Semantic Scholar
Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non‐targeted metabolomics analysis
Brian C. Jensen, T. Parry, Wei Huang, J. Beak +7 more
2017British Journal of Pharmacology31 citations Open access
Semantic Scholar
Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry
Ross Summer, Jamie L. Todd, M. L. Neely, L. Lobo +12 more
2024Respiratory Research30 citations Open access
Semantic Scholar
Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing
Jonathan M. Haldeman, Amanda E Conway, M. Arlotto, D. Slentz +3 more
2018Nucleic Acids Research30 citations Open access
Semantic Scholar
Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo
Muhammad Abdullah, J. Kornegay, Aubree C. Honcoop, T. Parry +7 more
2017Metabolites30 citations Open access
Semantic Scholar
Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
M. Chondronikola, F. Magkos, Jun Yoshino, Adewole L. Okunade +4 more
2018Obesity27 citations Open access
Semantic Scholar
Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers
J. T. Teh, Wan-Long Zhu, C. Newgard, P. Casey +1 more
2019Molecular Cancer Therapeutics26 citations Open access
Semantic Scholar
Maternal Metabolites Associated with Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism.
Yu Liu, A. Kuang, J. Bain, M. Muehlbauer +6 more
2021Journal of Clinical Endocrinology and Metabolism25 citations Open access
Semantic Scholar
Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys
K. Kavanagh, Stephen M. Day, Morgan C. Pait, William R. Mortiz +4 more
2019bioRxiv25 citations Open access
Semantic Scholar
Metabolites and diabetes remission after weight loss
L. Kwee, O. Ilkayeva, M. Muehlbauer, Nathan A. Bihlmeyer +8 more
2021Nutrition & Diabetes24 citations Open access
Semantic Scholar
Plasma acylcarnitines are associated with pulmonary hypertension
N. Luo, D. Craig, O. Ilkayeva, M. Muehlbauer +4 more
2017Pulmonary Circulation24 citations Open access
Semantic Scholar
Gut microbiome contributions to altered metabolism in a pig model of undernutrition
Hao-Wei Chang, N. McNulty, M. Hibberd, D. O’Donnell +10 more
2021Proceedings of the National Academy of Sciences of the United States of America22 citations Open access
Semantic Scholar

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