G. Supinski

Most-cited papers

Sepsis-induced myopathy
L. A. Callahan, G. Supinski
2009Critical Care Medicine278 citations Open access
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Diaphragm weakness in mechanically ventilated critically ill patients
G. Supinski, Leigh Ann Callahan
2013Critical Care244 citations Open access
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Diaphragm Dysfunction in Critical Illness
G. Supinski, P. Morris, S. Dhar, L. A. Callahan
2017Chest176 citations Open access
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Contemporary Review in Critical Care Medicine:Mitochondria and Critical Illness.
G. Supinski, Elizabeth A. Schroder, L. A. Callahan
2020Chest156 citations Open access
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Free radical-mediated skeletal muscle dysfunction in inflammatory conditions.
G. Supinski, L. A. Callahan
2007Journal of applied physiology156 citations
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MitoQ administration prevents endotoxin-induced cardiac dysfunction.
G. Supinski, Michael P. Murphy, L. A. Callahan
2009American Journal of Physiology. Regulatory Integrative and Comparative Physiology152 citations Open access
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Sepsis induces diaphragm electron transport chain dysfunction and protein depletion.
L. A. Callahan, G. Supinski
2005American Journal of Respiratory and Critical Care Medicine126 citations
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Free radical-induced contractile protein dysfunction in endotoxin-induced sepsis.
L. A. Callahan, D. Nethery, D. Stofan, A. DiMarco +1 more
2001American Journal of Respiratory Cell and Molecular Biology120 citations
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PLA2 dependence of diaphragm mitochondrial formation of reactive oxygen species
D. Nethery, L. A. Callahan, D. Stofan, R. Mattera +2 more
2000117 citations
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Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent.
D. Nethery, D. Stofan, L. A. Callahan, A. DiMarco +1 more
1999Journal of applied physiology112 citations
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Caspase activation contributes to endotoxin-induced diaphragm weakness.
G. Supinski, L. A. Callahan
2006Journal of applied physiology104 citations
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Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness.
G. Supinski, Wenyi Wang, L. A. Callahan
2009Journal of applied physiology94 citations Open access
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Free radical induced respiratory muscle dysfunction
G. Supinski
1998Molecular and Cellular Biochemistry90 citations
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Effect of free radical scavengers on diaphragmatic fatigue.
G. Supinski, D. Nethery, D. Stofan, A. DiMarco
1997American Journal of Respiratory and Critical Care Medicine89 citations
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Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis.
L. A. Callahan, G. Supinski
2005Journal of applied physiology78 citations
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Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis.
L. A. Callahan, Daniel A. Stofan, L. I. Szweda, D. Nethery +1 more
2001Free Radical Biology & Medicine72 citations
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Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction.
G. Supinski, J. Vanags, L. A. Callahan
2009American Journal of Physiology - Lung cellular and Molecular Physiology71 citations Open access
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Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction.
G. Supinski, L. A. Callahan
2006American Journal of Respiratory and Critical Care Medicine63 citations Open access
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Modulation of release of reactive oxygen species by the contracting diaphragm.
D. Stofan, L. A. Callahan, A. DiMarco, D. Nethery +1 more
2000American Journal of Respiratory and Critical Care Medicine63 citations
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The effect of elastase-induced emphysema on diaphragmatic muscle structure in hamsters.
Steven G. Kelsen, Terrence Wolanski, G. Supinski, U. Roessmann
2015American Review of Respiratory Disease61 citations
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Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction.
G. Supinski, L. A. Callahan
2010American Journal of Respiratory Cell and Molecular Biology61 citations Open access
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Endotoxin administration alters the force vs. pCa relationship of skeletal muscle fibers.
G. Supinski, D. Nethery, T. Nosek, L. A. Callahan +2 more
2000American Journal of Physiology. Regulatory Integrative and Comparative Physiology61 citations
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Hyperglycemia-induced diaphragm weakness is mediated by oxidative stress
L. A. Callahan, G. Supinski
2014Critical Care53 citations Open access
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PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygen species.
D. Nethery, L. A. Callahan, D. Stofan, R. Mattera +2 more
2000Journal of applied physiology52 citations
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Correlation of maximal inspiratory pressure to transdiaphragmatic twitch pressure in intensive care unit patients
G. Supinski, Phillip M. Westgate, L. A. Callahan
2016Critical Care49 citations Open access
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Extracellular calcium modulates generation of reactive oxygen species by the contracting diaphragm.
G. Supinski, D. Nethery, D. Stofan, A. DiMarco
1999Journal of applied physiology47 citations
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Diaphragmatic free radical generation increases in an animal model of heart failure.
G. Supinski, L. A. Callahan
2005Journal of applied physiology44 citations
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Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administration
G. Supinski, J. Vanags, L. A. Callahan
2010Critical Care41 citations Open access
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The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation.
G. Supinski, Xin-Ying Ji, L. A. Callahan
2009American Journal of Physiology. Regulatory Integrative and Comparative Physiology40 citations Open access
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Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis.
G. Supinski, L. A. Callahan
2006Free Radical Biology & Medicine36 citations
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MitoTEMPOL, a Mitochondrial Targeted Antioxidant, Prevents Sepsis Induced Diaphragm Dysfunction.
G. Supinski, Lin Wang, Elizabeth A. Schroder, L. A. Callahan
2020American Journal of Physiology - Lung cellular and Molecular Physiology31 citations Open access
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Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction.
G. Supinski, A. Alimov, Lin Wang, Xiao-Hong Song +1 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology30 citations Open access
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Mechanism of expiratory muscle activation during lower thoracic spinal cord stimulation.
A. DiMarco, K. Kowalski, G. Supinski, J. Romaniuk
2002Journal of applied physiology29 citations
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The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction.
G. Supinski, Xin-Ying Ji, Wenyi Wang, L. A. Callahan
2007Journal of applied physiology28 citations
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Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis.
L. A. Callahan, G. Supinski
2007Journal of applied physiology26 citations
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Diaphragmatic lipid peroxidation in chronically loaded rats.
G. Supinski, D. Nethery, D. Stofan, W. Hirschfield +1 more
1999Journal of applied physiology26 citations
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Oxypurinol administration fails to prevent free radical-mediated lipid peroxidation during loaded breathing.
G. Supinski, D. Nethery, D. Stofan, L. I. Szweda +1 more
1999Journal of applied physiology25 citations
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Mitoquinone Mesylate (MitoQ) Prevents Sepsis Induced Diaphragm Dysfunction.
G. Supinski, Elizabeth A. Schroder, Lin Wang, A. Morris +1 more
2021Journal of applied physiology23 citations Open access
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Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation.
G. Supinski, A. Alimov, Lin Wang, Xiao-Hong Song +1 more
2015American Journal of Physiology - Lung cellular and Molecular Physiology22 citations Open access
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p38 Mitogen-activated protein kinase modulates endotoxin-induced diaphragm caspase activation.
G. Supinski, Xin-Ying Ji, L. A. Callahan
2010American Journal of Respiratory Cell and Molecular Biology22 citations Open access
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A randomized controlled trial to determine whether beta-hydroxy-beta-methylbutyrate and/or eicosapentaenoic acid improves diaphragm and quadriceps strength in critically Ill mechanically ventilated patients
G. Supinski, P. Netzel, P. Westgate, Elizabeth A. Schroder +2 more
2021Critical Care21 citations Open access
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Muscle-specific calpastatin overexpression prevents diaphragm weakness in cecal ligation puncture-induced sepsis.
G. Supinski, Lin Wang, Xiao-Hong Song, J. Moylan +1 more
2014Journal of applied physiology20 citations Open access
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Double-stranded RNA-dependent protein kinase activation modulates endotoxin-induced diaphragm weakness.
G. Supinski, L. A. Callahan
2011Journal of applied physiology20 citations Open access
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Hyperglycemia and acquired weakness in critically ill patients: potential mechanisms
L. A. Callahan, G. Supinski
2009Critical Care17 citations Open access
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SS31, a Mitochondrially Targeted Antioxidant, Prevents Sepsis Induced Reductions in Diaphragm Strength and Endurance.
G. Supinski, Lin Wang, Elizabeth A. Schroder, L. A. Callahan
2020Journal of applied physiology14 citations Open access
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Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance.
R. Ciufo, A. DiMarco, Daniel Stofan, D. Nethery +1 more
2001American Journal of Respiratory and Critical Care Medicine14 citations
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Determination and Interpretation of Inspiratory and Expiratory Pressure Measurements
G. Supinski
199912 citations
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Diaphragm weakness and mechanical ventilation - what's the critical issue?
L. A. Callahan, G. Supinski
2010Critical Care11 citations Open access
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Review of Tracheostomy Usage: Complications and Decannulation Procedures. Part II
G. Bourjeily, F. Habr, G. Supinski
200210 citations
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Prevention and Treatment of ICU Acquired Weakness – Is There a Stimulating Answer?
L. A. Callahan, G. Supinski
2013Critical Care Medicine8 citations Open access
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