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K. Higai · SciRah

Researcher profile · Semantic Scholar

K. Higai

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K. Higai — researcher profile on SciRah

h-index: 20
Works: 65
Citations: 1,156

Most-cited papers

Glycosylation of site-specific glycans of alpha1-acid glycoprotein and alterations in acute and chronic inflammation.
K. Higai, Yutaka Aoki, Y. Azuma, Kojiro Matsumoto
2005Biochimica et Biophysica Acta89 citations
Semantic Scholar
Altered glycosylation of α1-acid glycoprotein in patients with inflammation and diabetes mellitus
K. Higai, Y. Azuma, Yutaka Aoki, Kojiro Matsumoto
200375 citations
Semantic Scholar
Amadori-modified glycated albumin predominantly induces E-selectin expression on human umbilical vein endothelial cells through NADPH oxidase activation.
K. Higai, Ayano Shimamura, Kojiro Matsumoto
2006Clinica chimica acta; international journal of clinical chemistry71 citations
Semantic Scholar
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
Wei Li, Songpei Li, K. Higai, Tatsunori Sasaki +3 more
2013Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
Interleukin‐1β induces sialyl Lewis X on hepatocellular carcinoma HuH‐7 cells via enhanced expression of ST3Gal IV and FUT VI gene
K. Higai, N. Miyazaki, Y. Azuma, Kojiro Matsumoto
2006FEBS Letters53 citations
Semantic Scholar
Transcriptional regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene during differentiation of the HL-60 cell line
A. Taniguchi, Y. Hasegawa, K. Higai, Kojiro Matsumoto
200043 citations Open access
Semantic Scholar
Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.
Tatsunori Sasaki, Wei Li, K. Higai, K. Koike
2015Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Protein Tyrosine Phosphatase 1B Inhibitory Activity of Lavandulyl Flavonoids from Roots of Sophora flavescens
Tatsunori Sasaki, Wei Li, K. Higai, Quang Hong Tran +2 more
2014Planta Medica40 citations
Semantic Scholar
Altered glycosylation of alpha1-acid glycoprotein in patients with inflammation and diabetes mellitus.
K. Higai, Y. Azuma, Yutaka Aoki, Kojiro Matsumoto
2003Clinica chimica acta; international journal of clinical chemistry38 citations
Semantic Scholar
Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein.
K. Higai, A. Ichikawa, Kojiro Matsumoto
2006Biochimica et Biophysica Acta33 citations
Semantic Scholar
NFκB-p65 Dependent Transcriptional Regulation of Glycosyltransferases in Human Colon Adenocarcinoma HT-29 by Stimulation with Tumor Necrosis Factor α
K. Higai, Saki Ishihara, Kojiro Matsumoto
200632 citations Open access
Semantic Scholar
Differentiation elicits negative regulation of human β‐galactoside α2,6‐sialyltransferase at the mRNA level in the HL‐60 cell line
A. Taniguchi, K. Higai, Y. Hasegawa, K. Utsumi +1 more
199828 citations
Semantic Scholar
Sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus.
H. Nagai, T. Mukozu, Y. Ogino, Daigo Matsui +6 more
2015Anticancer Research26 citations
Semantic Scholar
Targeted Proteo-Glycomics Analysis of Sialyl Lewis X Antigen Expressing Glycoproteins Secreted by Human Hepatoma Cell Line
K. Higai, Kumiko Shibukawa, S. Muto, Kojiro Matsumoto
2003Analytical Sciences26 citations
Semantic Scholar
Isolation, Structural Elucidation, and Liquid Chromatography-Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum.
Qing-Bo Liu, Wei Li, K. Nagata, Hong-Wei Fu +10 more
2018Journal of Agricultural and Food Chemistry25 citations
Semantic Scholar
Flavonoid glycosides from Japanese Camellia oil cakes and their inhibitory activity against advanced glycation end-products formation
Naoko Sato, Wei Li, M. Tsubaki, K. Higai +5 more
201724 citations Open access
Semantic Scholar
Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan.
T. Onoda, Wei Li, Tatsunori Sasaki, Megumi Miyake +2 more
2016Journal of Ethnopharmacology24 citations
Semantic Scholar
Unlike natural killer (NK) p30, natural cytotoxicity receptor NKp44 binds to multimeric α2,3-NeuNAc-containing N-glycans.
Kenichiro Ito, K. Higai, Chihiro Shinoda, Mizuha Sakurai +3 more
2012Biological and Pharmaceutical Bulletin21 citations Open access
Semantic Scholar
Binding of natural cytotoxicity receptor NKp46 to sulfate- and α2,3-NeuAc-containing glycans and its mutagenesis.
Kenichiro Ito, K. Higai, Mizuha Sakurai, Chihiro Shinoda +3 more
2011Biochemical and Biophysical Research Communications - BBRC21 citations
Semantic Scholar
Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.
Jie Zhang, Tatsunori Sasaki, Wei Li, K. Nagata +5 more
2018Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Protein tyrosine phosphatase 1B inhibitory activities of ursane- and lupane-type triterpenes from Sorbus pohuashanensis
Dong-Xia Li, Wei Li, K. Higai, K. Koike
2013Journal of Natural Medicines20 citations
Semantic Scholar
Glycated human serum albumin enhances macrophage inflammatory protein-1beta mRNA expression through protein kinase C-delta and NADPH oxidase in macrophage-like differentiated U937 cells.
K. Higai, M. Satake, Haruka Nishioka, Y. Azuma +1 more
2008Biochimica et Biophysica Acta20 citations
Semantic Scholar
NFkappaB-p65 dependent transcriptional regulation of glycosyltransferases in human colon adenocarcinoma HT-29 by stimulation with tumor necrosis factor alpha.
K. Higai, Saki Ishihara, Kojiro Matsumoto
2006Biological and Pharmaceutical Bulletin20 citations
Semantic Scholar
Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis.
Y. Azuma, Hirotaka Sato, K. Higai, Kojiro Matsumoto
2007Biological and Pharmaceutical Bulletin19 citations Open access
Semantic Scholar
Docosahexaenoic Acid Suppresses Oxidative Stress-Induced Autophagy and Cell Death via the AMPK-Dependent Signaling Pathway in Immortalized Fischer Rat Schwann Cells 1
Y. Tatsumi, Ayako Kato, N. Niimi, H. Yako +9 more
2022International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
NKG2D and CD94 bind to multimeric alpha2,3-linked N-acetylneuraminic acid.
Yuzo Imaizumi, K. Higai, Chiho Suzuki, Y. Azuma +1 more
2009Biochemical and Biophysical Research Communications - BBRC18 citations
Semantic Scholar
Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells
K. Higai, N. Miyazaki, Y. Azuma, Kojiro Matsumoto
2008Glycoconjugate Journal18 citations
Semantic Scholar
Transcriptional Regulation of Fucosyltransferase 1 Gene Expression in Colon Cancer Cells
Fumiko Taniuchi, K. Higai, Tomomi Tanaka, Y. Azuma +1 more
2013TheScientificWorldJournal17 citations Open access
Semantic Scholar
Binding affinities of NKG2D and CD94 to sialyl Lewis X-expressing N-glycans and heparin.
K. Higai, Chiho Suzuki, Yuzo Imaizumi, Xin Xin +2 more
2011Biological and Pharmaceutical Bulletin15 citations Open access
Semantic Scholar
Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra
Bing-Yang Zhang, Di Liu, Wenying Ji, Kouharu Otsuki +5 more
2021Frontiers in Chemistry13 citations Open access
Semantic Scholar
Decreases in CD31 and CD47 levels on the cell surface during etoposide-induced Jurkat cell apoptosis.
Y. Azuma, H. Nakagawa, Kanae Dote, K. Higai +1 more
2011Biological and Pharmaceutical Bulletin13 citations Open access
Semantic Scholar
NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides.
K. Higai, Yuzo Imaizumi, Chiho Suzuki, Y. Azuma +1 more
2009Biochemical and Biophysical Research Communications - BBRC13 citations
Semantic Scholar
Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis.
Y. Azuma, Y. Kurusu, Hirotaka Sato, K. Higai +1 more
2007Biological and Pharmaceutical Bulletin12 citations Open access
Semantic Scholar
Down-Regulation of Human Galβ1,3GalNAc/Galβ1,4GlcNAc α2,3-Sialyltransferase (hST3Gal IV) Gene during Differentiation of the HL-60 Cell Line
A. Taniguchi, Y. Hasegawa, K. Higai, Kojiro Matsumoto
199912 citations
Semantic Scholar
Prolonged high glucose suppresses phorbol 12-myristate 13-acetate and ionomycin-induced interleukin-2 mRNA expression in Jurkat cells.
K. Higai, Masatoshi Tsukada, Yumiko Moriya, Y. Azuma +1 more
2009Biochimica et Biophysica Acta11 citations
Semantic Scholar
Adaptation of lenvatinib treatment in patients with hepatocellular carcinoma and portal vein tumor thrombosis
T. Mukozu, H. Nagai, Daigo Matsui, Kunihide Mohri +13 more
2021Cancer Chemotherapy and Pharmacology10 citations
Semantic Scholar
Natural killer group 2A (NKG2A) and natural killer group 2C (NKG2C) bind to sulfated glycans and α2,3-NeuAc-containing glycoproteins.
Xin Xin, K. Higai, Yuzo Imaizumi, Chiho Suzuki +5 more
2011Biological and Pharmaceutical Bulletin10 citations Open access
Semantic Scholar
Lenvatinib Might Induce Activation of Host Immunity in Patients with Hepatocellular Carcinoma
H. Nagai, T. Mukozu, Kojiro Kobayashi, Akira Nogami +14 more
2022Oncology9 citations Open access
Semantic Scholar
Protein O-N-acetylglucosaminylation modulates promoter activities of cyclic AMP response element and activator protein 1 and enhances E-selectin expression on HuH-7 human hepatoma cells.
Y. Azuma, Kana Miura, K. Higai, Kojiro Matsumoto
2007Biological and Pharmaceutical Bulletin9 citations Open access
Semantic Scholar
Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents
T. Onoda, Wei Li, K. Higai, K. Koike
2014BMC Complementary and Alternative Medicine8 citations Open access
Semantic Scholar
Biphasic increases of cell surface calreticulin following treatment with mitoxantrone.
Y. Azuma, Kenichi Suzuki, K. Higai, Kojiro Matsumoto +1 more
2020Biological and Pharmaceutical Bulletin7 citations Open access
Semantic Scholar
Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent
Naoko Sato, Wei Li, Hiroaki Takemoto, Mio Takeuchi +9 more
2018Journal of Natural Medicines7 citations
Semantic Scholar
Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins.
Hirotaka Sato, Y. Azuma, K. Higai, Kojiro Matsumoto
2009Biochimica et Biophysica Acta7 citations
Semantic Scholar
Tivantinib Decreases Hepatocyte Growth Factor-Induced BCRP Expression in Hepatocellular Carcinoma HepG2 Cells.
Kojiro Kobayashi, K. Higai, T. Mukozu, Daigo Matsui +10 more
2020Biological and Pharmaceutical Bulletin6 citations Open access
Semantic Scholar
Influence of Sorafenib on Host Immunity in Patients with Liver Cirrhosis With Advanced Hepatocellular Carcinoma Stratified by Etiology
H. Nagai, T. Mukozu, Kojiro Kobayashi, M. Amanuma +11 more
2019Anticancer Research6 citations Open access
Semantic Scholar
Glycated human serum albumin induces interleukin 8 mRNA expression through reactive oxygen species and NADPH oxidase-dependent pathway in monocyte-derived U937 cells.
K. Higai, Risa Sano, M. Satake, Y. Azuma +1 more
2007Biological and Pharmaceutical Bulletin6 citations Open access
Semantic Scholar
Differentiation elicits negative regulation of human beta-galactoside alpha2,6-sialyltransferase at the mRNA level in the HL-60 cell line.
A. Taniguchi, K. Higai, Y. Hasegawa, K. Utsumi +1 more
1998FEBS Letters6 citations
Semantic Scholar
Risk Factors for Lenvatinib-Induced High-Grade Hypothyroidism in Patients with Hepatocellular Carcinoma: A Retrospective Study
Shusuke Uekusa, Maho Nemoto, Yuki Hanai, Misaki Nakashin +8 more
2023Pharmacology5 citations
Semantic Scholar
Noradrenaline-Induced Relaxation of Urinary Bladder Smooth Muscle Is Primarily Triggered through the β3-Adrenoceptor in Rats.
Keisuke Obara, S. Suzuki, H. Shibata, Naoki Yoneyama +4 more
2019Biological and Pharmaceutical Bulletin5 citations Open access
Semantic Scholar
Transcriptional regulation of human beta-galactoside alpha2, 6-sialyltransferase (hST6Gal I) gene during differentiation of the HL-60 cell line.
A. Taniguchi, Y. Hasegawa, K. Higai, K. Matsumoto
2000Glycobiology5 citations
Semantic Scholar

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Kojiro Matsumoto×29
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Kojiro Matsumoto — researcher profile on SciRah
Y. Azuma×21
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Y. Azuma — researcher profile on SciRah
Wei Li×11
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K. Koike×11
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Tatsunori Sasaki

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