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T. Kadlecek · SciRah

Researcher profile · Semantic Scholar

T. Kadlecek

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T. Kadlecek — researcher profile on SciRah

h-index: 30
Works: 43
Citations: 4,736

Most-cited papers

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway
T. S. Finco, T. Kadlecek, Weiguo Zhang, L. Samelson +1 more
1998523 citations Open access
Semantic Scholar
ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
Andrew C. Chan, T. Kadlecek, M. Elder, A. Filipovich +4 more
1994Science482 citations
Semantic Scholar
Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.
D. Yablonski, Michelle Kuhne, T. Kadlecek, Arthur Weiss
1998Science458 citations
Semantic Scholar
ZAP-70: an essential kinase in T-cell signaling.
Haopeng Wang, T. Kadlecek, Byron B. Au-Yeung, Hanna E. Sjölin Goodfellow +3 more
2010Cold Spring Harbor Perspectives in Biology395 citations Open access
Semantic Scholar
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.
Arthur Weiss, G. Koretzky, R. Schatzman, T. Kadlecek
1991Proceedings of the National Academy of Sciences of the United States of America294 citations Open access
Semantic Scholar
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape
Mingchao Xie, C. Hong, Bo Zhang, Rebecca F. Lowdon +23 more
2013Nature Genetics232 citations Open access
Semantic Scholar
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.
Sebastian Deindl, T. Kadlecek, Tomáš Brdička, Xiaoxian Cao +2 more
2007Cell222 citations Open access
Semantic Scholar
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
Bo Zhang, Yan Zhou, Nan Lin, Rebecca F. Lowdon +29 more
2013Genome Research202 citations Open access
Semantic Scholar
Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT
D. Yablonski, T. Kadlecek, A. Weiss
2001Molecular and Cellular Biology196 citations Open access
Semantic Scholar
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
T. S. Finco, T. Kadlecek, W. Zhang, L. Samelson +1 more
1998Immunity170 citations
Semantic Scholar
Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases
Tomáš Brdička, T. Kadlecek, J. Roose, A. Pastuszak +1 more
2005Molecular and Cellular Biology138 citations Open access
Semantic Scholar
Differential requirements for ZAP-70 in TCR signaling and T cell development.
T. Kadlecek, N. V. van Oers, Leo Lefrançois, S. Olson +5 more
1998Journal of Immunology126 citations Open access
Semantic Scholar
Expression and Function of Tec, Itk, and Btk in Lymphocytes: Evidence for a Unique Role for Tec
M. G. Tomlinson, L. Kane, Jennifer Su, T. Kadlecek +2 more
2004Molecular and Cellular Biology113 citations Open access
Semantic Scholar
Stimulation of the phosphatidyl-inositol pathway can induce T-cell activation
D. M. Desai, M. Newton, T. Kadlecek, A. Weiss
1990Nature109 citations
Semantic Scholar
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
Q. Yan, Tiago F. Barros, P. R. Visperas, S. Deindl +3 more
2013Molecular and Cellular Biology105 citations Open access
Semantic Scholar
Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes
E. W. Gelfand, K. Weinberg, B. Mazer, T. Kadlecek +1 more
1995Journal of Experimental Medicine105 citations Open access
Semantic Scholar
Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases
Sayak Mukherjee, Jing W. Zhu, J. Zikherman, Ramya Parameswaran +7 more
2013Science Signaling87 citations Open access
Semantic Scholar
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
Neel H. Shah, Qi Wang, Q. Yan, Deepti Karandur +6 more
2016eLife82 citations Open access
Semantic Scholar
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70
Alice Y. Chan, D. Punwani, T. Kadlecek, M. Cowan +9 more
2016Journal of Experimental Medicine82 citations Open access
Semantic Scholar
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT.
D. Yablonski, T. Kadlecek, A. Weiss
2001Molecular and Cellular Biology78 citations
Semantic Scholar
Distinct T Cell Developmental Consequences in Humans and Mice Expressing Identical Mutations in the DLAARN Motif of ZAP-701
M. Elder, S. Skoda-Smith, T. Kadlecek, Fengling Wang +2 more
2001Journal of Immunology68 citations Open access
Semantic Scholar
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway
HA Goodfellow, Maria P. Frushicheva, Qin-Qin Ji, Debra A. Cheng +6 more
2015Science Signaling62 citations Open access
Semantic Scholar
A PHOSPHOSITE WITHIN THE SH2 DOMAIN OF LCK REGULATES ITS ACTIVATION BY CD45
Adam H. Courtney, J. Amacher, T. Kadlecek, M. Mollenauer +3 more
2017Molecules and Cells61 citations Open access
Semantic Scholar
Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling
Susan E. Levin, Chao Zhang, T. Kadlecek, K. Shokat +1 more
2008Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization
J. Chung, Laura M. Nocka, Aubrianna Decker, Qi Wang +4 more
2018Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Stimulation of the phosphatidylinositol pathway can induce T-cell activation.
D. M. Desai, M. Newton, T. Kadlecek, A. Weiss
1990Nature47 citations
Semantic Scholar
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells
Veronika Horková, A. Drobek, Darina Paprckova, Veronika Niederlova +16 more
2022Nature Immunology45 citations Open access
Semantic Scholar
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response
S. Deindl, T. Kadlecek, Xiaoxian Cao, J. Kuriyan +1 more
2009Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
TCR signaling promotes formation of a STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments
Yuan-Li Tsai, Marcel Arias-Badia, T. Kadlecek, Yee May Lwin +7 more
2023Immunity35 citations Open access
Semantic Scholar
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-yl
A. Weiss, G. Koretzky, Randall C. SCHATZMANt, T. Kadlecek
34 citations
Semantic Scholar
Molecular and genetic insights into T cell antigen receptor signal transduction.
A. Weiss, M. Iwashima, B. Irving, N. V. van Oers +3 more
1994Advances in Experimental Medicine and Biology19 citations
Semantic Scholar
Molecular and Genetic Insights into T‐Cell Antigen Receptor Signaling
A. Weiss, T. Kadlecek, M. Iwashima, A. Chan +1 more
1995Annals of the New York Academy of Sciences9 citations
Semantic Scholar
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self ligands
Lin Shen, M. Matloubian, T. Kadlecek, A. Weiss
2021Science Signaling8 citations Open access
Semantic Scholar
1 INHIBITION OF ZAP-70 KINASE ACTIVITY VIA AN ANALOG-SENSITIVE ALLELE BLOCKS T CELL RECEPTOR AND CD 28 SUPERAGONIST SIGNALING
Susan E. Levin, Chao Zhang, T. Kadlecek, K. Shokat +1 more
20086 citations
Semantic Scholar
Overcoming inhibitory constraints to TCR signaling by targeting the pH-sensitive phosphatase suppressor of T-cell receptor signaling 1 (STS1)
Yuan-Li Tsai, Marcel Arias Badia, T. Kadlecek, Neel H. Shah +2 more
2022Journal of Immunology0 citations
Semantic Scholar
Bruton's Tyrosine Kinase Membrane Dynamics and Signaling
Laura M. Nocka, J. Chung, Aubrianna Decker, T. Kadlecek +3 more
20200 citations Open access
Semantic Scholar
Author response: An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
Neel H. Shah, Qi Wang, Q. Yan, Deepti Karandur +6 more
20160 citations Open access
Semantic Scholar
Title An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
Neel H. Shah, Qi Wang, Q. Yan, Deepti Karandur +6 more
20160 citations
Semantic Scholar
Abstract B042: Regulation of Lck activity by a cryptic phosphosite
Adam H. Courtney, Hanna Sjolin-Goodfellow, Qin-Qin Ji, T. Kadlecek +2 more
20160 citations
Semantic Scholar
Abstract A074: A Zap70-dependent negative feedback loop governs Lck activation by CD45
Adam H. Courtney, T. Kadlecek, Byron B. Au-Yeung, A. Weiss
20160 citations
Semantic Scholar
Flow Cytometric Analysis of Immunofluorescent Staining of PBMC and Thymocytes
E. Gelfand, K. Weinberg, B. Mazer, T. Kadlecek +1 more
20030 citations
Semantic Scholar
Mutations in the DLAARN Motif of ZAP-70 in Humans and Mice Expressing Identical Distinct T Cell Developmental Consequences
M. Elder, S. Skoda-Smith, T. Kadlecek, Fengling Wang +2 more
20000 citations
Semantic Scholar
This information is current as Signaling and T Cell Development Differential Requirements for ZAP-70 in TCR
N. Killeen, A. Weiss, S. Olson, D. Finlay +5 more
19980 citations
Semantic Scholar

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